PTPRJ Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description protein tyrosine phosphatase, receptor type, J|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5795)
External Link http://www.koehn.embl.de/depod/showp.php?gene=PTPRJ
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Genes

17 substrates of the phosphatase PTPRJ from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CTNND1 catenin (cadherin-associated protein), delta 1
EGFR epidermal growth factor receptor
FYN FYN proto-oncogene, Src family tyrosine kinase
KDR kinase insert domain receptor
LAT linker for activation of T cells
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
OCLN occludin
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
RET ret proto-oncogene
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TJP1 tight junction protein 1