PTPRU Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description protein tyrosine phosphatase, receptor type, U|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010] (NCBI Entrez Gene Database, 10076)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_PTPRU
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Genes

54 co-expressed genes for PTPRU from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AANAT aralkylamine N-acetyltransferase
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
APOC3 apolipoprotein C-III
AVPR1B arginine vasopressin receptor 1B
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
CCR9 chemokine (C-C motif) receptor 9
CD8B CD8b molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CHIC1 cysteine-rich hydrophobic domain 1
CHRM5 cholinergic receptor, muscarinic 5
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
COL14A1 collagen, type XIV, alpha 1
CSN3 casein kappa
CSPG4 chondroitin sulfate proteoglycan 4
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ERCC4 excision repair cross-complementation group 4
FABP3 fatty acid binding protein 3, muscle and heart
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FEV FEV (ETS oncogene family)
FHL3 four and a half LIM domains 3
FUT2 fucosyltransferase 2 (secretor status included)
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GCK glucokinase (hexokinase 4)
GH2 growth hormone 2
GHRHR growth hormone releasing hormone receptor
HCG8 HLA complex group 8
HMGA2 high mobility group AT-hook 2
IFNA21 interferon, alpha 21
ITSN1 intersectin 1 (SH3 domain protein)
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KRT12 keratin 12, type I
KRT35 keratin 35, type I
KRT83 keratin 83, type II
KRT86 keratin 86, type II
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MVK mevalonate kinase
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NR4A3 nuclear receptor subfamily 4, group A, member 3
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCA protein kinase C, alpha
PTPRU protein tyrosine phosphatase, receptor type, U
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC17A2 solute carrier family 17, member 2
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SSTR3 somatostatin receptor 3
STAT4 signal transducer and activator of transcription 4
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TMEM106A transmembrane protein 106A
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
ZNF8 zinc finger protein 8