PTTG1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description pituitary tumor-transforming 1|The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] (NCBI Entrez Gene Database, 9232)
External Link http://www.ncbi.nlm.nih.gov/gene/9232
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38 interacting proteins for PTTG1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC13 anaphase promoting complex subunit 13
ANAPC16 anaphase promoting complex subunit 16
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
AURKA aurora kinase A
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1QBP complement component 1, q subcomponent binding protein
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CCNB1 cyclin B1
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CUL1 cullin 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
NUP98 nucleoporin 98kDa
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PTTG1IP pituitary tumor-transforming 1 interacting protein
RAD23A RAD23 homolog A (S. cerevisiae)
RAE1 ribonucleic acid export 1
RPS10 ribosomal protein S10
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TP53 tumor protein p53
UBC ubiquitin C
UBE4A ubiquitination factor E4A
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6