| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/219104 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in PX-12 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HBB | hemoglobin, beta | 1.43 |
| CPA4 | carboxypeptidase A4 | 1.28 |
| SMTN | smoothelin | 1.26 |
| JUN | jun proto-oncogene | 1.19 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 1.05 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.98 |
| TP53 | tumor protein p53 | 0.97 |
| KIF20A | kinesin family member 20A | 0.91 |
| NCKAP1L | NCK-associated protein 1-like | 0.88 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.87 |
| GJB3 | gap junction protein, beta 3, 31kDa | 0.87 |
| FHIT | fragile histidine triad | 0.85 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | 0.81 |
| INCENP | inner centromere protein antigens 135/155kDa | 0.76 |
| HAL | histidine ammonia-lyase | 0.76 |
| ANLN | anillin, actin binding protein | 0.75 |
| ATF3 | activating transcription factor 3 | 0.75 |
| FOSL1 | FOS-like antigen 1 | 0.75 |
| GPR161 | G protein-coupled receptor 161 | 0.74 |
| LAMC3 | laminin, gamma 3 | 0.73 |
| AURKA | aurora kinase A | 0.73 |
| CDCA3 | cell division cycle associated 3 | 0.73 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 0.72 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.72 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | 0.72 |
| AEN | apoptosis enhancing nuclease | 0.71 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 0.71 |
| RND3 | Rho family GTPase 3 | 0.68 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.68 |
| VTN | vitronectin | 0.68 |
| TROAP | trophinin associated protein | 0.68 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 0.67 |
| PEX2 | peroxisomal biogenesis factor 2 | 0.67 |
| HSPA8 | heat shock 70kDa protein 8 | 0.66 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.66 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.66 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | 0.66 |
| CDCA8 | cell division cycle associated 8 | 0.65 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.65 |
| CPN1 | carboxypeptidase N, polypeptide 1 | 0.65 |
| LAMA1 | laminin, alpha 1 | 0.65 |
| BAG3 | BCL2-associated athanogene 3 | 0.63 |
| CLU | clusterin | 0.63 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.63 |
| HRH1 | histamine receptor H1 | 0.63 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.62 |
| F8 | coagulation factor VIII, procoagulant component | 0.61 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.61 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.61 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.61 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.6 |
| SGO2 | shugoshin 2 | 0.6 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.6 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.6 |
| PRR11 | proline rich 11 | 0.59 |
| RNASE4 | ribonuclease, RNase A family, 4 | 0.58 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.58 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | 0.58 |
| CCNB1 | cyclin B1 | 0.58 |
| LAMB3 | laminin, beta 3 | 0.58 |
| MAGEA12 | melanoma antigen family A12 | 0.58 |
| CCN2 | cellular communication network factor 2 | 0.58 |
| CCN1 | cellular communication network factor 1 | 0.57 |
| CDT1 | chromatin licensing and DNA replication factor 1 | 0.57 |
| SH2B3 | SH2B adaptor protein 3 | 0.57 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.56 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.55 |
| RAD54L | RAD54-like (S. cerevisiae) | 0.55 |
| FUNDC1 | FUN14 domain containing 1 | 0.55 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.55 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.54 |
| LAMC2 | laminin, gamma 2 | 0.54 |
| ITM2B | integral membrane protein 2B | 0.54 |
| SELENOK | selenoprotein K | 0.54 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.53 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.53 |
| MCPH1 | microcephalin 1 | 0.53 |
| ZGRF1 | zinc finger, GRF-type containing 1 | 0.52 |
| TNNI3 | troponin I type 3 (cardiac) | 0.52 |
| FN1 | fibronectin 1 | 0.51 |
| FSTL1 | follistatin-like 1 | 0.51 |
| ZNF224 | zinc finger protein 224 | 0.51 |
| CENPE | centromere protein E, 312kDa | 0.51 |
| RBM48 | RNA binding motif protein 48 | 0.51 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.5 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.5 |
| TMEM59 | transmembrane protein 59 | 0.5 |
| TPX2 | TPX2, microtubule-associated | 0.5 |
| CDC6 | cell division cycle 6 | 0.5 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.5 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.5 |
| KIF23 | kinesin family member 23 | 0.5 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.5 |
| KIFC1 | kinesin family member C1 | 0.49 |
| CPTP | ceramide-1-phosphate transfer protein | 0.49 |
| NRXN3 | neurexin 3 | 0.49 |
| SERAC1 | serine active site containing 1 | 0.49 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.49 |
| CNTLN | centlein, centrosomal protein | 0.49 |
| ARHGAP19 | Rho GTPase activating protein 19 | 0.48 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMEM39B | transmembrane protein 39B | -2.59 |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 | -1.53 |
| ZNF623 | zinc finger protein 623 | -1.26 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -1.19 |
| H3C1 | H3 clustered histone 1 | -1.08 |
| MIEF1 | mitochondrial elongation factor 1 | -1.0 |
| ZNF37A | zinc finger protein 37A | -0.97 |
| NMU | neuromedin U | -0.88 |
| MT1X | metallothionein 1X | -0.88 |
| ZNF16 | zinc finger protein 16 | -0.87 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | -0.87 |
| HYLS1 | hydrolethalus syndrome 1 | -0.85 |
| FAM160A1 | family with sequence similarity 160, member A1 | -0.81 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.79 |
| ABHD2 | abhydrolase domain containing 2 | -0.73 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | -0.71 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.69 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.67 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.66 |
| FAT4 | FAT atypical cadherin 4 | -0.65 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -0.65 |
| PEG10 | paternally expressed 10 | -0.64 |
| TCTN2 | tectonic family member 2 | -0.64 |
| ZNF101 | zinc finger protein 101 | -0.63 |
| SPICE1 | spindle and centriole associated protein 1 | -0.63 |
| HIST2H2AB | histone cluster 2, H2ab | -0.63 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | -0.62 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.62 |
| KRT222 | keratin 222, type II | -0.61 |
| PRDM16 | PR domain containing 16 | -0.61 |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | -0.6 |
| EHF | ets homologous factor | -0.6 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | -0.59 |
| BOLA1 | bolA family member 1 | -0.59 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | -0.59 |
| B2M | beta-2-microglobulin | -0.58 |
| KIAA1109 | KIAA1109 | -0.58 |
| IRF2 | interferon regulatory factor 2 | -0.57 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.57 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -0.57 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.57 |
| ZNF672 | zinc finger protein 672 | -0.57 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | -0.56 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.56 |
| SLC22A23 | solute carrier family 22, member 23 | -0.56 |
| SP100 | SP100 nuclear antigen | -0.55 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.54 |
| NDRG2 | NDRG family member 2 | -0.54 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) | -0.54 |
| RGN | regucalcin | -0.54 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.54 |
| VEZF1 | vascular endothelial zinc finger 1 | -0.53 |
| CCDC91 | coiled-coil domain containing 91 | -0.53 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | -0.53 |
| RTL8C | retrotransposon Gag like 8C | -0.53 |
| TRAPPC6A | trafficking protein particle complex 6A | -0.53 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.53 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.52 |
| HPCAL4 | hippocalcin like 4 | -0.52 |
| FAM117B | family with sequence similarity 117, member B | -0.52 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | -0.52 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.52 |
| GLG1 | golgi glycoprotein 1 | -0.51 |
| DENND3 | DENN/MADD domain containing 3 | -0.51 |
| RCAN1 | regulator of calcineurin 1 | -0.51 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.51 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.5 |
| PHF1 | PHD finger protein 1 | -0.5 |
| CNTROB | centrobin, centrosomal BRCA2 interacting protein | -0.5 |
| MOCS2 | molybdenum cofactor synthesis 2 | -0.5 |
| HDAC1 | histone deacetylase 1 | -0.49 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.49 |
| SNX8 | sorting nexin 8 | -0.49 |
| ATP5F1D | ATP synthase F1 subunit delta | -0.48 |
| TRAF5 | TNF receptor-associated factor 5 | -0.48 |
| FKTN | fukutin | -0.48 |
| MSX1 | msh homeobox 1 | -0.48 |
| MYPOP | Myb-related transcription factor, partner of profilin | -0.48 |
| DEDD | death effector domain containing | -0.48 |
| ZCCHC17 | zinc finger, CCHC domain containing 17 | -0.48 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.47 |
| ABHD13 | abhydrolase domain containing 13 | -0.47 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.46 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -0.46 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.46 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 | -0.45 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | -0.45 |
| HOXA10 | homeobox A10 | -0.45 |
| CDK8 | cyclin-dependent kinase 8 | -0.45 |
| AXIN1 | axin 1 | -0.45 |
| OSBPL1A | oxysterol binding protein-like 1A | -0.45 |
| PITX2 | paired-like homeodomain 2 | -0.44 |
| TRIR | telomerase RNA component interacting RNase | -0.44 |
| TNS2 | tensin 2 | -0.44 |
| SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28 | -0.44 |
| BSDC1 | BSD domain containing 1 | -0.44 |
| SLC25A39 | solute carrier family 25, member 39 | -0.44 |
| ATF7 | activating transcription factor 7 | -0.44 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.44 |
| MYH15 | myosin, heavy chain 15 | -0.44 |
