PXN Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description paxillin|This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 5829)
External Link http://www.ncbi.nlm.nih.gov/gene/5829
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Genes

393 interacting proteins for PXN from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACO1 aconitase 1, soluble
ACTG1 actin gamma 1
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
AHCY adenosylhomocysteinase
ANXA2 annexin A2
APC adenomatous polyposis coli
AR androgen receptor
ARF6 ADP-ribosylation factor 6
ARHGAP5 Rho GTPase activating protein 5
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATXN10 ataxin 10
BANF1 barrier to autointegration factor 1
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BLK BLK proto-oncogene, Src family tyrosine kinase
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAPRIN1 cell cycle associated protein 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CATSPER1 cation channel, sperm associated 1
CATSPER2 cation channel, sperm associated 2
CATSPER3 cation channel, sperm associated 3
CATSPER4 cation channel, sperm associated 4
CATSPERB catsper channel auxiliary subunit beta
CATSPERD catsper channel auxiliary subunit delta
CATSPERG catsper channel auxiliary subunit gamma
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC80 coiled-coil domain containing 80
CDC42 cell division cycle 42
CDCP1 CUB domain containing protein 1
CDK1 cyclin-dependent kinase 1
CDK5 cyclin-dependent kinase 5
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHMP5 charged multivesicular body protein 5
CKAP4 cytoskeleton-associated protein 4
CLIC2 chloride intracellular channel 2
CLTC clathrin, heavy chain (Hc)
CNGA1 cyclic nucleotide gated channel alpha 1
CNGB1 cyclic nucleotide gated channel beta 1
CNTROB centrobin, centrosomal BRCA2 interacting protein
COG5 component of oligomeric golgi complex 5
COL12A1 collagen, type XII, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COL8A1 collagen, type VIII, alpha 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSK c-src tyrosine kinase
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DBT dihydrolipoamide branched chain transacylase E2
DCTN4 dynactin 4 (p62)
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DGUOK deoxyguanosine kinase
DNAH3 dynein, axonemal, heavy chain 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOK2 docking protein 2, 56kDa
DSTN destrin (actin depolymerizing factor)
DVL1 dishevelled segment polarity protein 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EFNB1 ephrin-B1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EMD emerin
ENO1 enolase 1, (alpha)
EPHA2 EPH receptor A2
EPHB1 EPH receptor B1
EPHB4 EPH receptor B4
ERBB2 erb-b2 receptor tyrosine kinase 2
EWSR1 EWS RNA-binding protein 1
FAAH fatty acid amide hydrolase
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FGR FGR proto-oncogene, Src family tyrosine kinase
FHL2 four and a half LIM domains 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLNA filamin A, alpha
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAB1 GRB2-associated binding protein 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRB2 growth factor receptor-bound protein 2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HCK HCK proto-oncogene, Src family tyrosine kinase
HIST1H1E histone cluster 1, H1e
HIST1H1T histone cluster 1, H1t
HIST1H2AD histone cluster 1, H2ad
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H4F histone cluster 1, H4f
HMGA2 high mobility group AT-hook 2
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPM heterogeneous nuclear ribonucleoprotein M
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
ILK integrin-linked kinase
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGA9 integrin, alpha 9
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK2 Janus kinase 2
KDR kinase insert domain receptor
KPNB1 karyopherin (importin) beta 1
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS1 lectin, galactoside-binding, soluble, 1
LIMK1 LIM domain kinase 1
LMNA lamin A/C
LRP1 low density lipoprotein receptor-related protein 1
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRC59 leucine rich repeat containing 59
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP4 microtubule-associated protein 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MATK megakaryocyte-associated tyrosine kinase
MCOLN1 mucolipin 1
MCOLN2 mucolipin 2
MCOLN3 mucolipin 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MVP major vault protein
MYH9 myosin, heavy chain 9, non-muscle
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NARS asparaginyl-tRNA synthetase
NCK1 NCK adaptor protein 1
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NF2 neurofibromin 2 (merlin)
NLRP12 NLR family, pyrin domain containing 12
NONO non-POU domain containing, octamer-binding
NUDCD2 NudC domain containing 2
ORAI1 ORAI calcium release-activated calcium modulator 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HB prolyl 4-hydroxylase, beta polypeptide
PABPC1 poly(A) binding protein, cytoplasmic 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARVA parvin, alpha
PCOLCE procollagen C-endopeptidase enhancer
PDIA3 protein disulfide isomerase family A, member 3
PDPK1 3-phosphoinositide dependent protein kinase 1
PEX19 peroxisomal biogenesis factor 19
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKLR pyruvate kinase, liver and RBC
PKM pyruvate kinase, muscle
PKP2 plakophilin 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRDX1 peroxiredoxin 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTBP1 polypyrimidine tract binding protein 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRH protein tyrosine phosphatase, receptor type, H
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRO protein tyrosine phosphatase, receptor type, O
PTPRT protein tyrosine phosphatase, receptor type, T
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB8B RAB8B, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
REPS2 RALBP1 associated Eps domain containing 2
RET ret proto-oncogene
RGS1 regulator of G-protein signaling 1
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPL10 ribosomal protein L10
RPL11 ribosomal protein L11
RPL13 ribosomal protein L13
RPL14 ribosomal protein L14
RPL15 ribosomal protein L15
RPL17 ribosomal protein L17
RPL19 ribosomal protein L19
RPL21 ribosomal protein L21
RPL22 ribosomal protein L22
RPL23 ribosomal protein L23
RPL26 ribosomal protein L26
RPL27 ribosomal protein L27
RPL28 ribosomal protein L28
RPL29 ribosomal protein L29
RPL3 ribosomal protein L3
RPL38 ribosomal protein L38
RPL4 ribosomal protein L4
RPL5 ribosomal protein L5
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPL8 ribosomal protein L8
RPLP0 ribosomal protein, large, P0
RPLP2 ribosomal protein, large, P2
RPS23 ribosomal protein S23
RPS24 ribosomal protein S24
RPS27 ribosomal protein S27
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS7 ribosomal protein S7
RPSA ribosomal protein SA
RRBP1 ribosome binding protein 1
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
S100A11 S100 calcium binding protein A11
SDC4 syndecan 4
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24D SEC24 family member D
SELE selectin E
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SORBS1 sorbin and SH3 domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRI sorcin
SRSF3 serine/arginine-rich splicing factor 3
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIM1 stromal interaction molecule 1
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
TBRG4 transforming growth factor beta regulator 4
TFCP2 transcription factor CP2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM2 transglutaminase 2
TLN1 talin 1
TM7SF2 transmembrane 7 superfamily member 2
TMPO thymopoietin
TNC tenascin C
TNK2 tyrosine kinase, non-receptor, 2
TPCN1 two pore segment channel 1
TPCN2 two pore segment channel 2
TRDN triadin
TRIM29 tripartite motif containing 29
TRIP6 thyroid hormone receptor interactor 6
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA3C tubulin, alpha 3c
TUBA8 tubulin, alpha 8
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TUBG2 tubulin, gamma 2
TXN thioredoxin
UBB ubiquitin B
UBC ubiquitin C
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VEGFA vascular endothelial growth factor A
VIM vimentin
WASF2 WAS protein family, member 2
XPO1 exportin 1
XPOT exportin, tRNA
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFYVE27 zinc finger, FYVE domain containing 27
ZYX zyxin