Paclitaxel Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. (Chemical Entities of Biological Interest Ontology, CHEBI_45863)
External Link http://ctdbase.org/detail.go?type=chem&acc=D017239
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Genes

356 genes/proteins interacting with the chemical Paclitaxel from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACADL acyl-CoA dehydrogenase, long chain
ADD3 adducin 3 (gamma)
ADSS adenylosuccinate synthase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ALG8 ALG8, alpha-1,3-glucosyltransferase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA1 annexin A1
ANXA8 annexin A8
AOX1 aldehyde oxidase 1
APAF1 apoptotic peptidase activating factor 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
AR androgen receptor
AREG amphiregulin
ARF3 ADP-ribosylation factor 3
ATF3 activating transcription factor 3
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AXL AXL receptor tyrosine kinase
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BGN biglycan
BID BH3 interacting domain death agonist
BIN3 bridging integrator 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BTG3 BTG family, member 3
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CALCA calcitonin-related polypeptide alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCNH cyclin H
CD14 CD14 molecule
CD274 CD274 molecule
CD40LG CD40 ligand
CD68 CD68 molecule
CDA cytidine deaminase
CDC20 cell division cycle 20
CDC25C cell division cycle 25C
CDC27 cell division cycle 27
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPF centromere protein F, 350/400kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CLDN3 claudin 3
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CLU clusterin
CNR2 cannabinoid receptor 2 (macrophage)
COL6A3 collagen, type VI, alpha 3
COL7A1 collagen, type VII, alpha 1
COPE coatomer protein complex, subunit epsilon
COX17 COX17 cytochrome c oxidase copper chaperone
CREG1 cellular repressor of E1A-stimulated genes 1
CSF3 colony stimulating factor 3 (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYR61 cysteine-rich, angiogenic inducer, 61
DCTD dCMP deaminase
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DHCR24 24-dehydrocholesterol reductase
DIABLO diablo, IAP-binding mitochondrial protein
DSP desmoplakin
E2F1 E2F transcription factor 1
EFCAB7 EF-hand calcium binding domain 7
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ELMO3 engulfment and cell motility 3
EPCAM epithelial cell adhesion molecule
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
FADD Fas (TNFRSF6)-associated via death domain
FAM3C family with sequence similarity 3, member C
FANCL Fanconi anemia, complementation group L
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF2 fibroblast growth factor 2 (basic)
FGF5 fibroblast growth factor 5
FHL1 four and a half LIM domains 1
FSCN1 fascin actin-bundling protein 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCHFR GTP cyclohydrolase I feedback regulator
GFAP glial fibrillary acidic protein
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPI glucose-6-phosphate isomerase
GPR35 G protein-coupled receptor 35
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GTSE1 G-2 and S-phase expressed 1
GUSB glucuronidase, beta
H2AFX H2A histone family, member X
HDAC9 histone deacetylase 9
HMGB1 high mobility group box 1
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPB3 heat shock 27kDa protein 3
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1BP1 integrin beta 1 binding protein 1
ITM2B integral membrane protein 2B
JUN jun proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KEAP1 kelch-like ECH-associated protein 1
KLK3 kallikrein-related peptidase 3
KRT7 keratin 7, type II
LAMP2 lysosomal-associated membrane protein 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LDHA lactate dehydrogenase A
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LITAF lipopolysaccharide-induced TNF factor
LTBP2 latent transforming growth factor beta binding protein 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MED4 mediator complex subunit 4
MICB MHC class I polypeptide-related sequence B
MLEC malectin
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MPHOSPH6 M-phase phosphoprotein 6
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL40 mitochondrial ribosomal protein L40
MRPL57 mitochondrial ribosomal protein L57
MRPS15 mitochondrial ribosomal protein S15
MRPS18B mitochondrial ribosomal protein S18B
MSMO1 methylsterol monooxygenase 1
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5A myosin VA (heavy chain 12, myoxin)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCOA3 nuclear receptor coactivator 3
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGF nerve growth factor (beta polypeptide)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY neuropeptide Y
NR1I2 nuclear receptor subfamily 1, group I, member 2
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUSAP1 nucleolar and spindle associated protein 1
OGG1 8-oxoguanine DNA glycosylase
OSBPL10 oxysterol binding protein-like 10
OSMR oncostatin M receptor
PADI2 peptidyl arginine deiminase, type II
PARP1 poly (ADP-ribose) polymerase 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCNA proliferating cell nuclear antigen
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PHGDH phosphoglycerate dehydrogenase
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKM pyruvate kinase, muscle
PKP2 plakophilin 2
PLCE1 phospholipase C, epsilon 1
PLK1 polo-like kinase 1
POMZP3 POM121 and ZP3 fusion
PPAP2A phosphatidic acid phosphatase type 2A
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PRDM4 PR domain containing 4
PRDX2 peroxiredoxin 2
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PTEN phosphatase and tensin homolog
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN7 protein tyrosine phosphatase, non-receptor type 7
QRICH1 glutamine-rich 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RB1 retinoblastoma 1
RBP1 retinol binding protein 1, cellular
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFXANK regulatory factor X-associated ankyrin-containing protein
RHOT2 ras homolog family member T2
RPL10 ribosomal protein L10
RS1 retinoschisin 1
RSRP1 arginine/serine-rich protein 1
RTKN rhotekin
RUVBL2 RuvB-like AAA ATPase 2
S100P S100 calcium binding protein P
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BP2 SH3-domain binding protein 2
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC22A18 solute carrier family 22, member 18
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SP140 SP140 nuclear body protein
SRGN serglycin
SRI sorcin
SRPR signal recognition particle receptor (docking protein)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC1 stanniocalcin 1
STIP1 stress-induced phosphoprotein 1
SUB1 SUB1 homolog (S. cerevisiae)
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
TAC1 tachykinin, precursor 1
TACC3 transforming, acidic coiled-coil containing protein 3
TDG thymine-DNA glycosylase
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TJP3 tight junction protein 3
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TMEM134 transmembrane protein 134
TMEM135 transmembrane protein 135
TMEM168 transmembrane protein 168
TMEM59 transmembrane protein 59
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRIM2 tripartite motif containing 2
TRIOBP TRIO and F-actin binding protein
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TYMP thymidine phosphorylase
TYMS thymidylate synthetase
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNG uracil-DNA glycosylase
UROD uroporphyrinogen decarboxylase
VAMP8 vesicle-associated membrane protein 8
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WDR61 WD repeat domain 61
WIF1 WNT inhibitory factor 1
WRAP73 WD repeat containing, antisense to TP73
WSB2 WD repeat and SOCS box containing 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZFP36L2 ZFP36 ring finger protein-like 2
ZRANB2 zinc finger, RAN-binding domain containing 2