Paclitaxel_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RNF213 ring finger protein 213 0.10074
VCL vinculin 0.0897938
ZSWIM6 zinc finger, SWIM-type containing 6 0.084225
RIGI RNA sensor RIG-I 0.0597345
SLIT2 slit homolog 2 (Drosophila) 0.0576347
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0500922
INTS6 integrator complex subunit 6 0.0493825
DNAH14 dynein, axonemal, heavy chain 14 0.0463993
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0443549
PSD3 pleckstrin and Sec7 domain containing 3 0.0415117
BCAS3 breast carcinoma amplified sequence 3 0.0410689
IGFBP3 insulin-like growth factor binding protein 3 0.0408692
FMN1 formin 1 0.0398503
ZNF638 zinc finger protein 638 0.0391707
THSD4 thrombospondin, type I, domain containing 4 0.03913
RAD51B RAD51 paralog B 0.0378276
LPP LIM domain containing preferred translocation partner in lipoma 0.037372
GOLGB1 golgin B1 0.0372394
FNDC3A fibronectin type III domain containing 3A 0.0365651
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.03444
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0341372
POTEF POTE ankyrin domain family, member F 0.0341142
MAPK10 mitogen-activated protein kinase 10 0.0332787
PBX1 pre-B-cell leukemia homeobox 1 0.0328093
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0326995
ENAH enabled homolog (Drosophila) 0.0325148
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0322092
LINGO2 leucine rich repeat and Ig domain containing 2 0.032047
SENP6 SUMO1/sentrin specific peptidase 6 0.0320353
ZNF609 zinc finger protein 609 0.0317212
TPST1 tyrosylprotein sulfotransferase 1 0.0314055
PTPRD protein tyrosine phosphatase, receptor type, D 0.0310448
BRD2 bromodomain containing 2 0.030866
GLCCI1 glucocorticoid induced 1 0.0305562
TLE4 transducin-like enhancer of split 4 0.0304223
VMP1 vacuole membrane protein 1 0.0300493
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0294666
SKIL SKI-like proto-oncogene 0.0289844
SVIL supervillin 0.0285736
PCBP2 poly(rC) binding protein 2 0.0283028
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0282722
TRIP12 thyroid hormone receptor interactor 12 0.0267635
ZNF644 zinc finger protein 644 0.0266161
MED13 mediator complex subunit 13 0.0266017
KCNIP4 Kv channel interacting protein 4 0.0264766
STK38L serine/threonine kinase 38 like 0.0263532
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0260874
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0260567
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0259547
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0258704
DLG1 discs, large homolog 1 (Drosophila) 0.0254724
MX1 MX dynamin-like GTPase 1 0.0253737
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0252636
AUTS2 autism susceptibility candidate 2 0.0252579
RAP1B RAP1B, member of RAS oncogene family 0.0251798
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.025174
TIMP2 TIMP metallopeptidase inhibitor 2 0.0249914
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0249591
TNS3 tensin 3 0.0249018
FER fer (fps/fes related) tyrosine kinase 0.0244553
SP100 SP100 nuclear antigen 0.024357
GRK5 G protein-coupled receptor kinase 5 0.0241041
BCL2L13 BCL2-like 13 (apoptosis facilitator) 0.0240274
SOX4 SRY (sex determining region Y)-box 4 0.0238739
TNRC6C trinucleotide repeat containing 6C 0.0237988
MX2 MX dynamin-like GTPase 2 0.0237895
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0236243
PMP22 peripheral myelin protein 22 0.0236183
MEIS2 Meis homeobox 2 0.0234611
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0233803
KDM5A lysine (K)-specific demethylase 5A 0.0232684
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0231517
SETX senataxin 0.0230935
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0230679
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0230446
CADM2 cell adhesion molecule 2 0.0229915
TRPS1 trichorhinophalangeal syndrome I 0.0229783
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0228736
TUBB tubulin, beta class I 0.0225572
USP15 ubiquitin specific peptidase 15 0.0224501
TPM1 tropomyosin 1 (alpha) 0.0222204
DIAPH2 diaphanous-related formin 2 0.0221995
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0219537
RAB7A RAB7A, member RAS oncogene family 0.0218479
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0216213
RPL31 ribosomal protein L31 0.0215882
WAC WW domain containing adaptor with coiled-coil 0.0215865
TBX2 T-box 2 0.0215493
RPL11 ribosomal protein L11 0.021549
IFI44L interferon-induced protein 44-like 0.0215362
CDK12 cyclin-dependent kinase 12 0.0213979
DGKH diacylglycerol kinase, eta 0.0213235
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0213155
MCL1 myeloid cell leukemia 1 0.0210041
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0208366
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0207777
PLCB4 phospholipase C, beta 4 0.0206076
TENM1 teneurin transmembrane protein 1 0.0205206
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0204315
ADAR adenosine deaminase, RNA-specific 0.020323

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148871
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.126436
IGF2 insulin-like growth factor 2 -0.102453
LSAMP limbic system-associated membrane protein -0.0985692
PTMA prothymosin, alpha -0.0904241
MAP1B microtubule-associated protein 1B -0.086989
SOS1 son of sevenless homolog 1 (Drosophila) -0.0739833
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0700694
NRG1 neuregulin 1 -0.0697982
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0630597
VIM vimentin -0.0619721
COL3A1 collagen, type III, alpha 1 -0.061563
AKAP12 A kinase (PRKA) anchor protein 12 -0.0607831
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0598513
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0581096
TRIO trio Rho guanine nucleotide exchange factor -0.0554769
WDR45B WD repeat domain 45B -0.0509603
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0503297
FAM13A family with sequence similarity 13, member A -0.050274
CDH10 cadherin 10, type 2 (T2-cadherin) -0.048268
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0479723
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0471681
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0464476
RPL19 ribosomal protein L19 -0.0462378
FNBP1 formin binding protein 1 -0.0400124
COL1A1 collagen, type I, alpha 1 -0.0392273
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0389211
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0379754
RPL38 ribosomal protein L38 -0.0375688
HMGB2 high mobility group box 2 -0.0374727
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0364117
HELZ helicase with zinc finger -0.0350178
GNAS GNAS complex locus -0.034995
LMNA lamin A/C -0.034971
ACTG1 actin gamma 1 -0.0343035
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0342281
H3-3B H3.3 histone B -0.0340658
COL4A2 collagen, type IV, alpha 2 -0.0331718
KLHL13 kelch-like family member 13 -0.0328571
PHF3 PHD finger protein 3 -0.0328475
ZNF292 zinc finger protein 292 -0.0327764
LMAN1 lectin, mannose-binding, 1 -0.0325026
NAMPT nicotinamide phosphoribosyltransferase -0.0323471
KDM3A lysine (K)-specific demethylase 3A -0.0319485
HILPDA hypoxia inducible lipid droplet-associated -0.0318716
TRIB2 tribbles pseudokinase 2 -0.0312621
MEF2A myocyte enhancer factor 2A -0.0307562
SEPTIN7 septin 7 -0.0302312
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0298269
NALF1 NALCN channel auxiliary factor 1 -0.0298061
SYT1 synaptotagmin I -0.0296814
HAND2 heart and neural crest derivatives expressed 2 -0.0296758
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0293615
IER3 immediate early response 3 -0.0288836
AOPEP aminopeptidase O (putative) -0.0286708
EIF1 eukaryotic translation initiation factor 1 -0.0285125
COL4A5 collagen, type IV, alpha 5 -0.0284464
RAB30 RAB30, member RAS oncogene family -0.0284226
GDF15 growth differentiation factor 15 -0.0283731
HDLBP high density lipoprotein binding protein -0.0276226
CD36 CD36 molecule (thrombospondin receptor) -0.0275698
B2M beta-2-microglobulin -0.0266423
GLG1 golgi glycoprotein 1 -0.0265803
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0263679
RPLP1 ribosomal protein, large, P1 -0.0263454
CDC27 cell division cycle 27 -0.0263168
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0260664
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0258128
DDIT4 DNA-damage-inducible transcript 4 -0.0257872
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0255635
LOC112694756 uncharaterized LOC112694756 -0.0255026
SON SON DNA binding protein -0.0254774
RPL34 ribosomal protein L34 -0.0254757
SPAG9 sperm associated antigen 9 -0.0254142
EPAS1 endothelial PAS domain protein 1 -0.0254112
MON2 MON2 homolog (S. cerevisiae) -0.0252372
VGF VGF nerve growth factor inducible -0.0250966
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.025076
TENT5A terminal nucleotidyltransferase 5A -0.0249395
DNMBP dynamin binding protein -0.0247017
KLF6 Kruppel-like factor 6 -0.0246031
IGFBP4 insulin-like growth factor binding protein 4 -0.0234191
IGF1R insulin-like growth factor 1 receptor -0.0232969
RPL23 ribosomal protein L23 -0.0232376
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0230843
CCDC47 coiled-coil domain containing 47 -0.0229959
KIF26A kinesin family member 26A -0.0229831
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0229141
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0228648
RLF rearranged L-myc fusion -0.0228431
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0227897
EXT1 exostosin glycosyltransferase 1 -0.0227713
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0226287
BPTF bromodomain PHD finger transcription factor -0.0226128
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0226007
RPL12 ribosomal protein L12 -0.0225992
KMT2E lysine (K)-specific methyltransferase 2E -0.0225459
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0225243
COL4A6 collagen, type IV, alpha 6 -0.0225124
SCAF11 SR-related CTD-associated factor 11 -0.0225103