Paclitaxel_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RNF213 ring finger protein 213 0.191781
EXT1 exostosin glycosyltransferase 1 0.154322
GCLC glutamate-cysteine ligase, catalytic subunit 0.136501
INTS6 integrator complex subunit 6 0.127854
MACC1 metastasis associated in colon cancer 1 0.124293
ERN1 endoplasmic reticulum to nucleus signaling 1 0.100851
VCL vinculin 0.100601
DST dystonin 0.0941903
LMO7 LIM domain 7 0.0867913
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0832029
KYNU kynureninase 0.0795163
EPSTI1 epithelial stromal interaction 1 (breast) 0.0783795
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0742508
MX1 MX dynamin-like GTPase 1 0.0720424
RIGI RNA sensor RIG-I 0.0717257
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0702286
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0699397
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0698876
SP100 SP100 nuclear antigen 0.0690965
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0682068
ZSWIM6 zinc finger, SWIM-type containing 6 0.0679914
N4BP2L2 NEDD4 binding protein 2-like 2 0.067607
LURAP1L leucine rich adaptor protein 1-like 0.0670632
DUSP16 dual specificity phosphatase 16 0.0666465
HKDC1 hexokinase domain containing 1 0.0660604
CATSPERB catsper channel auxiliary subunit beta 0.0649276
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0644768
PLSCR2 phospholipid scramblase 2 0.0631925
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.062712
VMP1 vacuole membrane protein 1 0.0617382
MUC13 mucin 13, cell surface associated 0.0591443
RABGAP1L RAB GTPase activating protein 1-like 0.0559719
TJP1 tight junction protein 1 0.0558114
PDZD8 PDZ domain containing 8 0.0550661
BTBD9 BTB (POZ) domain containing 9 0.0542252
AKAP13 A kinase (PRKA) anchor protein 13 0.0541024
MX2 MX dynamin-like GTPase 2 0.053993
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0528717
LYZ lysozyme 0.0522951
ALCAM activated leukocyte cell adhesion molecule 0.0515682
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0513791
SIK3 SIK family kinase 3 0.0504844
ZNF292 zinc finger protein 292 0.049896
FNIP2 folliculin interacting protein 2 0.0487714
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0482479
LPP LIM domain containing preferred translocation partner in lipoma 0.0471337
ETV6 ets variant 6 0.0448434
FNDC3A fibronectin type III domain containing 3A 0.0442978
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0439756
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0426968
EPS8 epidermal growth factor receptor pathway substrate 8 0.0423075
JAK1 Janus kinase 1 0.0411173
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0409662
ZBTB20 zinc finger and BTB domain containing 20 0.0408055
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0404128
MYO5B myosin VB 0.039837
MUC20 mucin 20, cell surface associated 0.0393864
MYO1E myosin IE 0.0387111
RSAD2 radical S-adenosyl methionine domain containing 2 0.0386272
FNIP1 folliculin interacting protein 1 0.0386015
TOX3 TOX high mobility group box family member 3 0.0383746
UBAP2 ubiquitin associated protein 2 0.0362491
RBM47 RNA binding motif protein 47 0.0361176
SERINC5 serine incorporator 5 0.0360961
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.035718
TRIM2 tripartite motif containing 2 0.0356067
PHF3 PHD finger protein 3 0.035476
SYT1 synaptotagmin I 0.0352052
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.035178
MECOM MDS1 and EVI1 complex locus 0.0349143
OCLN occludin 0.034315
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.034226
PLSCR1 phospholipid scramblase 1 0.0340863
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0337525
IFIH1 interferon induced with helicase C domain 1 0.0335448
PTPRK protein tyrosine phosphatase, receptor type, K 0.0331892
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0323875
TUFT1 tuftelin 1 0.0322592
ITGB8 integrin, beta 8 0.0321775
NABP1 nucleic acid binding protein 1 0.0318405
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0315668
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0312768
POF1B premature ovarian failure, 1B 0.0308772
DUSP10 dual specificity phosphatase 10 0.0308548
PHACTR4 phosphatase and actin regulator 4 0.0308534
JUN jun proto-oncogene 0.0303854
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0303113
CLOCK clock circadian regulator 0.0302363
ARHGAP26 Rho GTPase activating protein 26 0.0298026
MTUS1 microtubule associated tumor suppressor 1 0.0297604
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0.02975
RAD51B RAD51 paralog B 0.0294912
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0291621
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0289715
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0286232
WARS1 tryptophanyl-tRNA synthetase 1 0.0281187
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0279186
ZNFX1 zinc finger, NFX1-type containing 1 0.0277905
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0275809
FNDC3B fibronectin type III domain containing 3B 0.0270562

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.148175
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.13735
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.125408
B2M beta-2-microglobulin -0.102117
ITGA6 integrin, alpha 6 -0.0904272
EZR ezrin -0.0792702
TXNIP thioredoxin interacting protein -0.0707667
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0703329
PTBP3 polypyrimidine tract binding protein 3 -0.0630936
ABHD2 abhydrolase domain containing 2 -0.0622617
EGR1 early growth response 1 -0.0606836
EFNB2 ephrin-B2 -0.0581098
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0571378
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0566787
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0551315
TPT1 tumor protein, translationally-controlled 1 -0.0534778
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0533953
RNF149 ring finger protein 149 -0.053251
ASPH aspartate beta-hydroxylase -0.0527276
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0525836
NDRG1 N-myc downstream regulated 1 -0.0510992
H1-0 H1.0 linker histone -0.04996
MAML2 mastermind-like 2 (Drosophila) -0.0485694
RUNX1 runt-related transcription factor 1 -0.0478951
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0446173
SPATA13 spermatogenesis associated 13 -0.0444326
TMPRSS4 transmembrane protease, serine 4 -0.043627
CD46 CD46 molecule, complement regulatory protein -0.0421856
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0413852
PDIA3 protein disulfide isomerase family A, member 3 -0.0412925
RHOBTB3 Rho-related BTB domain containing 3 -0.0411483
WDR45B WD repeat domain 45B -0.0387771
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0370767
TRERF1 transcriptional regulating factor 1 -0.0361957
AFF1 AF4/FMR2 family, member 1 -0.035573
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0349804
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0349434
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0348258
ATP11A ATPase, class VI, type 11A -0.034758
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0347257
GRK3 G protein-coupled receptor kinase 3 -0.0344607
ESYT2 extended synaptotagmin-like protein 2 -0.034214
BCLAF1 BCL2-associated transcription factor 1 -0.0342048
ENO1 enolase 1, (alpha) -0.0340808
PGK1 phosphoglycerate kinase 1 -0.0340092
S100A10 S100 calcium binding protein A10 -0.0335115
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0334809
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0331668
MEIS2 Meis homeobox 2 -0.0330683
ABLIM1 actin binding LIM protein 1 -0.0325264
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0324998
HLA-B major histocompatibility complex, class I, B -0.0324295
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0324185
PTMA prothymosin, alpha -0.0321687
LOC102724023 ES1 protein homolog, mitochondrial -0.031952
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0317533
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0316238
IQGAP1 IQ motif containing GTPase activating protein 1 -0.031436
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0305736
TSC22D1 TSC22 domain family, member 1 -0.0303008
YBX3 Y box binding protein 3 -0.0302976
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0301029
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0295983
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0292505
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.029185
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0289799
SORBS1 sorbin and SH3 domain containing 1 -0.0287249
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.0284833
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0283448
PTEN phosphatase and tensin homolog -0.0282023
S100A6 S100 calcium binding protein A6 -0.0268397
ARHGAP32 Rho GTPase activating protein 32 -0.0266538
NKD1 naked cuticle homolog 1 (Drosophila) -0.0265971
CCNL1 cyclin L1 -0.0265683
PKM pyruvate kinase, muscle -0.0264934
NCOR1 nuclear receptor corepressor 1 -0.0264667
TJP2 tight junction protein 2 -0.0261835
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0259438
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0256455
CEMIP cell migration inducing protein, hyaluronan binding -0.0254788
GNAS GNAS complex locus -0.0252939
C6ORF132 chromosome 6 open reading frame 132 -0.0247602
ZMYM2 zinc finger, MYM-type 2 -0.0240384
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0239971
CDCP1 CUB domain containing protein 1 -0.0239358
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0239296
UBAC2 UBA domain containing 2 -0.0238777
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0236064
DYNC2I1 dynein 2 intermediate chain 1 -0.0235378
EPHB2 EPH receptor B2 -0.0234869
BMP4 bone morphogenetic protein 4 -0.0232663
LOC112694756 uncharaterized LOC112694756 -0.0230617
IRS2 insulin receptor substrate 2 -0.0229705
SDC4 syndecan 4 -0.0229011
MT2A metallothionein 2A -0.0227004
ARHGAP12 Rho GTPase activating protein 12 -0.0225703
ZNF395 zinc finger protein 395 -0.0223254
AHI1 Abelson helper integration site 1 -0.0222413
IL20RA interleukin 20 receptor, alpha -0.0222099
SLC38A1 solute carrier family 38, member 1 -0.02211