Paclitaxel_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.165998
SAMD4A sterile alpha motif domain containing 4A 0.138736
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.127559
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0931977
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0834466
DST dystonin 0.083005
VCL vinculin 0.0799631
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0677424
LPP LIM domain containing preferred translocation partner in lipoma 0.0639046
BCL2L1 BCL2-like 1 0.0607993
VMP1 vacuole membrane protein 1 0.060363
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0594455
ATXN1 ataxin 1 0.058605
ASPH aspartate beta-hydroxylase 0.0583597
FRMD5 FERM domain containing 5 0.0564576
PDLIM5 PDZ and LIM domain 5 0.0549756
RIGI RNA sensor RIG-I 0.0520585
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.051964
FAM107B family with sequence similarity 107, member B 0.0518376
ITGAV integrin, alpha V 0.0509206
EXT1 exostosin glycosyltransferase 1 0.0497234
SP100 SP100 nuclear antigen 0.0489366
GPC6 glypican 6 0.0477683
DTNA dystrobrevin, alpha 0.0477368
INTS6 integrator complex subunit 6 0.0469131
BRD2 bromodomain containing 2 0.0455421
GRB10 growth factor receptor-bound protein 10 0.0454052
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0440033
MCL1 myeloid cell leukemia 1 0.0438486
TRIO trio Rho guanine nucleotide exchange factor 0.0434081
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0424247
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0412671
SDC4 syndecan 4 0.0404348
RNF213 ring finger protein 213 0.0401445
PALLD palladin, cytoskeletal associated protein 0.0400167
MT2A metallothionein 2A 0.0396414
SLC38A2 solute carrier family 38, member 2 0.0384106
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0380295
EGR1 early growth response 1 0.0359995
LIMS1 LIM and senescent cell antigen-like domains 1 0.0359199
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0345674
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.034133
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.033128
ZNF644 zinc finger protein 644 0.0330769
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0327374
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0324927
CLIC4 chloride intracellular channel 4 0.0323318
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0316702
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.031298
DSPP dentin sialophosphoprotein 0.0310491
TUBB4B tubulin, beta 4B class IVb 0.0307726
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0305604
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0304438
DNAH17 dynein, axonemal, heavy chain 17 0.0302596
ENAH enabled homolog (Drosophila) 0.0300535
RPL11 ribosomal protein L11 0.0299387
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0298557
SMAD3 SMAD family member 3 0.0294874
TUBA1C tubulin, alpha 1c 0.0288399
DIAPH1 diaphanous-related formin 1 0.0287848
ITCH itchy E3 ubiquitin protein ligase 0.0287344
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0279082
ANKRD11 ankyrin repeat domain 11 0.0277272
NABP1 nucleic acid binding protein 1 0.0275055
ANXA5 annexin A5 0.0274452
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0273554
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0272105
FAT1 FAT atypical cadherin 1 0.0270279
RTN4 reticulon 4 0.0269626
ZBTB20 zinc finger and BTB domain containing 20 0.026796
KYNU kynureninase 0.0264672
ZSWIM6 zinc finger, SWIM-type containing 6 0.0264526
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.026168
MYO5B myosin VB 0.0261175
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0251797
RPL37A ribosomal protein L37a 0.0248534
RASA2 RAS p21 protein activator 2 0.0248073
HSPA8 heat shock 70kDa protein 8 0.0245329
GLIPR1 GLI pathogenesis-related 1 0.0242181
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0242179
TIMP2 TIMP metallopeptidase inhibitor 2 0.0235393
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0231915
BCAS3 breast carcinoma amplified sequence 3 0.0231608
FTL ferritin, light polypeptide 0.0231297
CCNY cyclin Y 0.0230638
HPCAL1 hippocalcin-like 1 0.0230066
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0226806
MRTFA myocardin related transcription factor A 0.0226771
ACTG1 actin gamma 1 0.0222007
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0221432
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.02211
KRT8 keratin 8, type II 0.0220894
ARHGAP26 Rho GTPase activating protein 26 0.0219864
TRIP12 thyroid hormone receptor interactor 12 0.0219172
RAB3B RAB3B, member RAS oncogene family 0.021861
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0217813
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0217674
EXOC4 exocyst complex component 4 0.0217333
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.021718
PICALM phosphatidylinositol binding clathrin assembly protein 0.0215934

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.249337
APOB apolipoprotein B -0.195475
FN1 fibronectin 1 -0.150912
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.100945
FNDC3B fibronectin type III domain containing 3B -0.0965547
C3 complement component 3 -0.0758402
GPC3 glypican 3 -0.0655174
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0639658
A2M alpha-2-macroglobulin -0.0634515
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0619379
PEG3 paternally expressed 3 -0.0563572
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0561478
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0558641
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0544441
MAML2 mastermind-like 2 (Drosophila) -0.0537723
FBF1 Fas (TNFRSF6) binding factor 1 -0.0531854
ELL2 elongation factor, RNA polymerase II, 2 -0.0505613
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0501175
TRIM26 tripartite motif containing 26 -0.0493559
EML4 echinoderm microtubule associated protein like 4 -0.045205
CP ceruloplasmin (ferroxidase) -0.0442125
CFB complement factor B -0.0426325
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0408457
MBNL3 muscleblind-like splicing regulator 3 -0.0408374
ZMYND8 zinc finger, MYND-type containing 8 -0.0390253
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0373461
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0362979
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0340796
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0339741
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0332654
PEG10 paternally expressed 10 -0.0321014
TM4SF1 transmembrane 4 L six family member 1 -0.0308762
KDM7A lysine (K)-specific demethylase 7A -0.0308272
MBNL1 muscleblind-like splicing regulator 1 -0.030025
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0298697
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0297503
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0289993
GMDS GDP-mannose 4,6-dehydratase -0.028842
OSMR oncostatin M receptor -0.0282816
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0281107
ITGA1 integrin, alpha 1 -0.0280369
MTUS1 microtubule associated tumor suppressor 1 -0.0270968
AFDN afadin, adherens junction formation factor -0.0266035
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0264741
MAPK14 mitogen-activated protein kinase 14 -0.0260329
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0258167
DOCK4 dedicator of cytokinesis 4 -0.0252144
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0250884
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0250744
RB1CC1 RB1-inducible coiled-coil 1 -0.025064
TMEM51 transmembrane protein 51 -0.0247293
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0247066
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0240835
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0238094
RUNX1 runt-related transcription factor 1 -0.02361
HLF hepatic leukemia factor -0.0234865
ENO1 enolase 1, (alpha) -0.0227264
IL1RAP interleukin 1 receptor accessory protein -0.022598
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0223869
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -0.0222382
F5 coagulation factor V (proaccelerin, labile factor) -0.0221827
PDGFB platelet-derived growth factor beta polypeptide -0.0221343
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.022011
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0218497
ZNF292 zinc finger protein 292 -0.0218047
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0217833
TF transferrin -0.0211028
FGA fibrinogen alpha chain -0.0207107
PTBP3 polypyrimidine tract binding protein 3 -0.0205498
FOXN3 forkhead box N3 -0.0204113
NCOA7 nuclear receptor coactivator 7 -0.0203662
LMCD1 LIM and cysteine-rich domains 1 -0.0203501
SCAF11 SR-related CTD-associated factor 11 -0.020102
SESTD1 SEC14 and spectrin domains 1 -0.0198466
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0197207
RNASET2 ribonuclease T2 -0.0196275
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0195677
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0195668
STK17A serine/threonine kinase 17a -0.0195508
PRKCSH protein kinase C substrate 80K-H -0.0195308
WDFY2 WD repeat and FYVE domain containing 2 -0.0192759
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0191237
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0189516
TPST1 tyrosylprotein sulfotransferase 1 -0.0189297
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0188128
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0187865
DUSP6 dual specificity phosphatase 6 -0.0185706
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0184735
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0183854
RRBP1 ribosome binding protein 1 -0.0181565
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0179423
ARHGAP12 Rho GTPase activating protein 12 -0.0176634
METTL9 methyltransferase like 9 -0.0174498
H1-0 H1.0 linker histone -0.0172205
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0171567
MALT1 MALT1 paracaspase -0.0171352
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0169229
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0167979
CRY1 cryptochrome circadian clock 1 -0.0166446
ARHGAP18 Rho GTPase activating protein 18 -0.0166421