Paclitaxel_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.283171
VIM vimentin 0.142609
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0938121
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0844246
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0838911
TXNRD1 thioredoxin reductase 1 0.0802853
EEF2 eukaryotic translation elongation factor 2 0.0658886
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0640986
AHNAK AHNAK nucleoprotein 0.0522231
SOD2 superoxide dismutase 2, mitochondrial 0.0521195
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0505595
FTL ferritin, light polypeptide 0.0482762
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0473013
ZFP36L1 ZFP36 ring finger protein-like 1 0.0466515
WARS1 tryptophanyl-tRNA synthetase 1 0.0449498
CANX calnexin 0.0440338
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0438264
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0427673
ANXA1 annexin A1 0.041246
EPHA4 EPH receptor A4 0.0411586
TTC3 tetratricopeptide repeat domain 3 0.0403391
EIF1 eukaryotic translation initiation factor 1 0.0388822
SFTPA2 surfactant protein A2 0.0369588
COL5A2 collagen, type V, alpha 2 0.0368061
EGFR epidermal growth factor receptor 0.0359163
RPS8 ribosomal protein S8 0.0357885
RPS6 ribosomal protein S6 0.0351476
BIRC3 baculoviral IAP repeat containing 3 0.0346364
LDHA lactate dehydrogenase A 0.0345471
ENO2 enolase 2 (gamma, neuronal) 0.034116
MB21D2 Mab-21 domain containing 2 0.0341157
EREG epiregulin 0.0329195
RPL12 ribosomal protein L12 0.0311541
MBNL2 muscleblind-like splicing regulator 2 0.0309392
GOLGA4 golgin A4 0.0300444
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0299817
RPL4 ribosomal protein L4 0.02965
GARS1 glycyl-tRNA synthetase 1 0.0294835
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0288446
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0286312
SPAG9 sperm associated antigen 9 0.0278126
PLK2 polo-like kinase 2 0.0277657
HDLBP high density lipoprotein binding protein 0.0277298
SLC38A2 solute carrier family 38, member 2 0.0276586
RPS13 ribosomal protein S13 0.0268422
CALR calreticulin 0.0256995
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.025152
RACK1 receptor for activated C kinase 1 0.024809
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.024784
RPL35A ribosomal protein L35a 0.0246692
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0244824
RPS23 ribosomal protein S23 0.0243638
EZR ezrin 0.0242532
GOLGB1 golgin B1 0.0240581
JMJD1C jumonji domain containing 1C 0.0239043
RPS3 ribosomal protein S3 0.0237434
FTH1 ferritin, heavy polypeptide 1 0.0233408
KMT2C lysine (K)-specific methyltransferase 2C 0.0233047
RPL5 ribosomal protein L5 0.0229247
RCAN1 regulator of calcineurin 1 0.0223171
POTEF POTE ankyrin domain family, member F 0.0215815
KLHL24 kelch-like family member 24 0.0215715
RPL19 ribosomal protein L19 0.0214773
ENO1 enolase 1, (alpha) 0.0214042
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0211875
LYST lysosomal trafficking regulator 0.021171
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0207329
UBC ubiquitin C 0.0204847
PTMA prothymosin, alpha 0.01982
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0197495
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0197333
APOLD1 apolipoprotein L domain containing 1 0.0197103
CLTC clathrin, heavy chain (Hc) 0.0196552
CLIP1 CAP-GLY domain containing linker protein 1 0.0196475
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0193559
HOOK2 hook microtubule-tethering protein 2 0.0190538
RPS27A ribosomal protein S27a 0.0190277
AKAP9 A kinase (PRKA) anchor protein 9 0.0190132
TRIP12 thyroid hormone receptor interactor 12 0.0189279
IARS1 isoleucyl-tRNA synthetase 1 0.0188512
SEC31A SEC31 homolog A (S. cerevisiae) 0.0187255
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0185348
BIRC2 baculoviral IAP repeat containing 2 0.0183702
RPS17 ribosomal protein S17 0.0183263
SQSTM1 sequestosome 1 0.0181747
TXNIP thioredoxin interacting protein 0.0180566
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0178879
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0177814
MT1E metallothionein 1E 0.0177744
RPS16 ribosomal protein S16 0.0176471
NAMPT nicotinamide phosphoribosyltransferase 0.0174018
KTN1 kinectin 1 (kinesin receptor) 0.0172995
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0172619
RPL31 ribosomal protein L31 0.0172392
HDAC9 histone deacetylase 9 0.0172171
SEC63 SEC63 homolog (S. cerevisiae) 0.0171397
RPLP0 ribosomal protein, large, P0 0.0169672
MTDH metadherin 0.016691
RAB1A RAB1A, member RAS oncogene family 0.0166887
PGK1 phosphoglycerate kinase 1 0.0166373

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.145482
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.119599
PSD3 pleckstrin and Sec7 domain containing 3 -0.0928635
FMNL2 formin-like 2 -0.0927846
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.091437
RAD51B RAD51 paralog B -0.0874745
CADM2 cell adhesion molecule 2 -0.0849413
PDE10A phosphodiesterase 10A -0.0816311
CD44 CD44 molecule (Indian blood group) -0.080922
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0773051
CAPRIN2 caprin family member 2 -0.0769741
PRELID2 PRELI domain containing 2 -0.076064
SDK1 sidekick cell adhesion molecule 1 -0.0664923
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0627672
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0612297
TP63 tumor protein p63 -0.0599003
NPAS2 neuronal PAS domain protein 2 -0.057806
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0552826
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0545799
PTK2 protein tyrosine kinase 2 -0.0536728
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0532808
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0510974
NT5E 5'-nucleotidase, ecto (CD73) -0.0504788
NEK10 NIMA-related kinase 10 -0.0494616
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0490014
DPH6 diphthamine biosynthesis 6 -0.0475891
EXOC4 exocyst complex component 4 -0.043976
BCAR3 breast cancer anti-estrogen resistance 3 -0.0415041
LOXL2 lysyl oxidase-like 2 -0.0411913
THSD4 thrombospondin, type I, domain containing 4 -0.0399828
EHBP1 EH domain binding protein 1 -0.0395966
RTTN rotatin -0.0394268
CFAP299 cilia and flagella associated protein 299 -0.0389515
CMIP c-Maf inducing protein -0.0383608
VCL vinculin -0.0383307
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0371805
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0368232
DENND1A DENN/MADD domain containing 1A -0.0367466
PYGL phosphorylase, glycogen, liver -0.0362158
DIAPH3 diaphanous-related formin 3 -0.0358238
NHSL1 NHS-like 1 -0.0344814
TTC28 tetratricopeptide repeat domain 28 -0.0344517
CEP128 centrosomal protein 128kDa -0.0343659
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.033484
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0329144
PIAS2 protein inhibitor of activated STAT, 2 -0.0327771
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0325524
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0323978
TSC22D1 TSC22 domain family, member 1 -0.031976
DOCK1 dedicator of cytokinesis 1 -0.0319411
RNF213 ring finger protein 213 -0.0313155
TBC1D22A TBC1 domain family, member 22A -0.031124
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0308816
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0304177
CDK6 cyclin-dependent kinase 6 -0.0303494
DOCK11 dedicator of cytokinesis 11 -0.0300817
NSD2 nuclear receptor binding SET domain protein 2 -0.0298102
TMSB4X thymosin beta 4, X-linked -0.0293882
PRKCE protein kinase C, epsilon -0.0290687
MACF1 microtubule-actin crosslinking factor 1 -0.0288692
RFC3 replication factor C (activator 1) 3, 38kDa -0.028852
HPCAL1 hippocalcin-like 1 -0.0288161
CSMD3 CUB and Sushi multiple domains 3 -0.0286298
FLNB filamin B, beta -0.0280906
RAB7A RAB7A, member RAS oncogene family -0.0280485
HLA-B major histocompatibility complex, class I, B -0.0279405
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0278121
SMAD3 SMAD family member 3 -0.0265144
ECE1 endothelin converting enzyme 1 -0.0263813
DNER delta/notch-like EGF repeat containing -0.0254955
RBM39 RNA binding motif protein 39 -0.0254568
HELLS helicase, lymphoid-specific -0.0251432
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0248009
FANCB Fanconi anemia, complementation group B -0.0245436
NF1 neurofibromin 1 -0.0244638
LPP LIM domain containing preferred translocation partner in lipoma -0.024386
ANKRD12 ankyrin repeat domain 12 -0.0243451
FHIT fragile histidine triad -0.0240066
BIRC6 baculoviral IAP repeat containing 6 -0.0239268
NEBL nebulette -0.0239058
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0239014
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0238114
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0237991
DPYSL2 dihydropyrimidinase-like 2 -0.0235853
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0235769
STK17A serine/threonine kinase 17a -0.0234708
TGM2 transglutaminase 2 -0.0234089
ACBD6 acyl-CoA binding domain containing 6 -0.0233032
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0231235
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0231022
RIGI RNA sensor RIG-I -0.0230561
SRPK2 SRSF protein kinase 2 -0.0225358
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0223504
IGF1R insulin-like growth factor 1 receptor -0.0223457
TAS2R14 taste receptor, type 2, member 14 -0.0222282
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0221455
COL6A3 collagen, type VI, alpha 3 -0.0220963
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -0.021998
PRRC2B proline-rich coiled-coil 2B -0.0219474
SMYD3 SET and MYND domain containing 3 -0.0216267