Paclitaxel_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.0849479
MT2A metallothionein 2A 0.0836798
NALF1 NALCN channel auxiliary factor 1 0.0830103
TRIO trio Rho guanine nucleotide exchange factor 0.0821389
COL6A3 collagen, type VI, alpha 3 0.0573252
PTMA prothymosin, alpha 0.0554526
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0538836
PRKCA protein kinase C, alpha 0.0533139
VIM vimentin 0.0530931
PTK2 protein tyrosine kinase 2 0.0504075
MMP1 matrix metallopeptidase 1 0.0480499
APP amyloid beta (A4) precursor protein 0.0477188
KMT2C lysine (K)-specific methyltransferase 2C 0.0466736
FTL ferritin, light polypeptide 0.0447549
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0445742
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0437178
MARCHF6 membrane associated ring-CH-type finger 6 0.0434022
ARHGAP12 Rho GTPase activating protein 12 0.0430135
GOLGA4 golgin A4 0.0429023
EXT1 exostosin glycosyltransferase 1 0.0423274
TENT5A terminal nucleotidyltransferase 5A 0.042146
MYOF myoferlin 0.0414956
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0400022
KMT2A lysine (K)-specific methyltransferase 2A 0.0395812
AMPD3 adenosine monophosphate deaminase 3 0.0395027
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.039379
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0385637
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0385048
MBNL2 muscleblind-like splicing regulator 2 0.038307
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0379364
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0378561
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0377207
TPI1 triosephosphate isomerase 1 0.0375016
RPS3 ribosomal protein S3 0.037468
AFAP1 actin filament associated protein 1 0.0373583
NRIP1 nuclear receptor interacting protein 1 0.0371365
AEBP2 AE binding protein 2 0.03713
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0370908
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0367604
SERINC1 serine incorporator 1 0.0364141
SEPTIN7 septin 7 0.0363404
LAMA4 laminin, alpha 4 0.0361776
TXNRD1 thioredoxin reductase 1 0.0361055
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0360644
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0358689
SDC4 syndecan 4 0.0358129
SCAPER S-phase cyclin A-associated protein in the ER 0.0355078
B2M beta-2-microglobulin 0.0348933
CD44 CD44 molecule (Indian blood group) 0.0348584
FNDC3B fibronectin type III domain containing 3B 0.0347753
MYH9 myosin, heavy chain 9, non-muscle 0.0347396
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0342739
TMCC1 transmembrane and coiled-coil domain family 1 0.0339054
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.033457
CUL4A cullin 4A 0.0334434
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0332708
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0330963
RPL34 ribosomal protein L34 0.0330291
OXR1 oxidation resistance 1 0.0327739
FAM13A family with sequence similarity 13, member A 0.0325774
CCSER1 coiled-coil serine-rich protein 1 0.0322998
MAP4 microtubule-associated protein 4 0.0322782
HIPK3 homeodomain interacting protein kinase 3 0.031886
RNF216 ring finger protein 216 0.0317307
MYO10 myosin X 0.0316698
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0315805
ENO1 enolase 1, (alpha) 0.0314273
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0313894
EPS15 epidermal growth factor receptor pathway substrate 15 0.030998
NDRG1 N-myc downstream regulated 1 0.0309153
ISG15 ISG15 ubiquitin-like modifier 0.0308518
RPS21 ribosomal protein S21 0.030619
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0304818
NUP98 nucleoporin 98kDa 0.0302907
ATP13A3 ATPase type 13A3 0.0302326
NIPSNAP2 nipsnap homolog 2 0.0302084
ITGA6 integrin, alpha 6 0.0298556
ADM adrenomedullin 0.0296912
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0295988
SMYD3 SET and MYND domain containing 3 0.0294554
LTBP1 latent transforming growth factor beta binding protein 1 0.0294329
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0293838
DTNA dystrobrevin, alpha 0.0292155
VEGFA vascular endothelial growth factor A 0.029209
WNK1 WNK lysine deficient protein kinase 1 0.0291301
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0291045
GLS2 glutaminase 2 (liver, mitochondrial) 0.028829
KMT2E lysine (K)-specific methyltransferase 2E 0.0287309
UBE2O ubiquitin-conjugating enzyme E2O 0.0286799
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0286642
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0283777
RRBP1 ribosome binding protein 1 0.0283149
CLASP1 cytoplasmic linker associated protein 1 0.0282
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.028098
CALU calumenin 0.0279753
HELZ helicase with zinc finger 0.0278355
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0277318
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0275257
NME7 NME/NM23 family member 7 0.0275116
SLC38A2 solute carrier family 38, member 2 0.027511

decreased expression

Symbol Name Standardized Value
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.154764
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.146313
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.127035
ANXA2 annexin A2 -0.109166
LMO7 LIM domain 7 -0.104405
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.104186
ATOSA atos homolog A -0.103081
MUC16 mucin 16, cell surface associated -0.102808
SAMD4A sterile alpha motif domain containing 4A -0.100564
LAMB3 laminin, beta 3 -0.0993325
AKAP13 A kinase (PRKA) anchor protein 13 -0.0962166
KRT17 keratin 17, type I -0.0900753
BZW1 basic leucine zipper and W2 domains 1 -0.0869616
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0845621
BACE2 beta-site APP-cleaving enzyme 2 -0.0816627
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0721072
CEMIP cell migration inducing protein, hyaluronan binding -0.0718056
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0715976
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0691271
EZR ezrin -0.0656468
KYNU kynureninase -0.0654926
TJP1 tight junction protein 1 -0.0651381
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0643005
SLMAP sarcolemma associated protein -0.0635048
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0629015
PDLIM5 PDZ and LIM domain 5 -0.0622689
MCL1 myeloid cell leukemia 1 -0.0604595
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0577065
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0554752
IGF2 insulin-like growth factor 2 -0.0539778
PARD3 par-3 family cell polarity regulator -0.0534846
IFIH1 interferon induced with helicase C domain 1 -0.0531954
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0520875
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0518463
PRKCSH protein kinase C substrate 80K-H -0.0480405
CMIP c-Maf inducing protein -0.0478044
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0475498
MACC1 metastasis associated in colon cancer 1 -0.047402
ABHD17C abhydrolase domain containing 17C -0.0467849
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0462415
ACTG1 actin gamma 1 -0.0459887
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.045649
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0451015
JUP junction plakoglobin -0.0447904
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0445931
TXNIP thioredoxin interacting protein -0.0443097
LGALS3 lectin, galactoside-binding, soluble, 3 -0.043801
KLF5 Kruppel-like factor 5 (intestinal) -0.0430629
PARD6B par-6 family cell polarity regulator beta -0.0429916
F3 coagulation factor III (thromboplastin, tissue factor) -0.0421868
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0421507
SLC38A1 solute carrier family 38, member 1 -0.0417879
TM4SF1 transmembrane 4 L six family member 1 -0.0405535
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0403553
MYO1E myosin IE -0.04031
BTG1 B-cell translocation gene 1, anti-proliferative -0.0402222
GRB10 growth factor receptor-bound protein 10 -0.0400026
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0396345
KLHL24 kelch-like family member 24 -0.0395281
FLNB filamin B, beta -0.0395116
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0395114
MRPS6 mitochondrial ribosomal protein S6 -0.0394709
NCOR2 nuclear receptor corepressor 2 -0.0393931
CDH13 cadherin 13 -0.0391667
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0391649
FTH1 ferritin, heavy polypeptide 1 -0.0390514
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0388406
MCU mitochondrial calcium uniporter -0.0382695
ITGB4 integrin, beta 4 -0.0380835
TAOK3 TAO kinase 3 -0.0372232
QKI QKI, KH domain containing, RNA binding -0.0371797
BMAL2 basic helix-loop-helix ARNT like 2 -0.0360722
LPP LIM domain containing preferred translocation partner in lipoma -0.0358354
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0355952
ARRDC3 arrestin domain containing 3 -0.0354938
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0353827
MBD5 methyl-CpG binding domain protein 5 -0.0351851
S100A11 S100 calcium binding protein A11 -0.0347003
SNX9 sorting nexin 9 -0.0344827
GTF2IRD1 GTF2I repeat domain containing 1 -0.0340189
CDK13 cyclin-dependent kinase 13 -0.0338371
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0335638
PDE4D phosphodiesterase 4D, cAMP-specific -0.0332952
SOX4 SRY (sex determining region Y)-box 4 -0.0332227
POTEF POTE ankyrin domain family, member F -0.0330969
EIF1 eukaryotic translation initiation factor 1 -0.0330679
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0328742
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0326341
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0324613
DUSP4 dual specificity phosphatase 4 -0.0322783
WDFY3 WD repeat and FYVE domain containing 3 -0.0315572
FBXL17 F-box and leucine-rich repeat protein 17 -0.0313048
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0310927
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0310901
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0310529
FOXO1 forkhead box O1 -0.0309494
MAP7 microtubule-associated protein 7 -0.0304645
PRDM1 PR domain containing 1, with ZNF domain -0.0301797
CDYL chromodomain protein, Y-like -0.0299207
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.0299077