Paclitaxel_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.235543
TXNRD1 thioredoxin reductase 1 0.131796
EEF2 eukaryotic translation elongation factor 2 0.108121
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0983377
GRAMD1B GRAM domain containing 1B 0.0852774
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0802377
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0800893
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0784301
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0766213
ADAR adenosine deaminase, RNA-specific 0.0750977
PDE10A phosphodiesterase 10A 0.0643844
ENO1 enolase 1, (alpha) 0.0634245
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0627139
MKI67 marker of proliferation Ki-67 0.0575957
HLA-B major histocompatibility complex, class I, B 0.056787
CANX calnexin 0.0535695
ZNFX1 zinc finger, NFX1-type containing 1 0.0534309
IFI6 interferon, alpha-inducible protein 6 0.0532258
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0510537
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0509382
PDE4D phosphodiesterase 4D, cAMP-specific 0.0506591
RPL37 ribosomal protein L37 0.049159
GOLGB1 golgin B1 0.0491281
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.049065
VCL vinculin 0.0486168
UBE2H ubiquitin-conjugating enzyme E2H 0.0477219
RPS27 ribosomal protein S27 0.0474179
PTMA prothymosin, alpha 0.0468801
YAP1 Yes-associated protein 1 0.0459836
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0457765
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0447461
TPI1 triosephosphate isomerase 1 0.044589
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.044283
VMP1 vacuole membrane protein 1 0.0430201
TUBB tubulin, beta class I 0.0399492
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.039389
MED13 mediator complex subunit 13 0.038815
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0385217
RPL4 ribosomal protein L4 0.0384661
ZFAND3 zinc finger, AN1-type domain 3 0.0383145
KDM3A lysine (K)-specific demethylase 3A 0.0366371
VIM vimentin 0.0361798
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0360143
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0352741
DSPP dentin sialophosphoprotein 0.0351263
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0351042
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0350347
EXOC6B exocyst complex component 6B 0.0350042
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0343765
RPS3 ribosomal protein S3 0.0342256
ADGRG6 adhesion G protein-coupled receptor G6 0.0341856
IFIH1 interferon induced with helicase C domain 1 0.0340157
TAOK1 TAO kinase 1 0.0339235
RIGI RNA sensor RIG-I 0.0337838
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0337514
DENND5B DENN/MADD domain containing 5B 0.0331464
BBS9 Bardet-Biedl syndrome 9 0.0330468
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0330272
SFTPA2 surfactant protein A2 0.0326796
SNAP25 synaptosomal-associated protein, 25kDa 0.0324756
FNDC3B fibronectin type III domain containing 3B 0.032418
PLSCR1 phospholipid scramblase 1 0.0320756
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0320197
LATS2 large tumor suppressor kinase 2 0.0319001
PDE4B phosphodiesterase 4B, cAMP-specific 0.0318598
BPTF bromodomain PHD finger transcription factor 0.031743
N4BP2L2 NEDD4 binding protein 2-like 2 0.031571
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0314185
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0314028
RPL35A ribosomal protein L35a 0.0306856
TAPBP TAP binding protein (tapasin) 0.0303792
NCOA7 nuclear receptor coactivator 7 0.0303237
SERINC3 serine incorporator 3 0.0302705
NIPBL Nipped-B homolog (Drosophila) 0.0299937
ZSWIM6 zinc finger, SWIM-type containing 6 0.0297774
PCLO piccolo presynaptic cytomatrix protein 0.0295744
COPA coatomer protein complex, subunit alpha 0.0293851
BRD2 bromodomain containing 2 0.0293573
RAB10 RAB10, member RAS oncogene family 0.029177
RPS27A ribosomal protein S27a 0.0290168
TUBA1B tubulin, alpha 1b 0.0288436
RPS8 ribosomal protein S8 0.0285586
FTH1 ferritin, heavy polypeptide 1 0.0285515
PLS3 plastin 3 0.0282427
BIRC2 baculoviral IAP repeat containing 2 0.0282389
B2M beta-2-microglobulin 0.0281652
IL6ST interleukin 6 signal transducer 0.0281458
ATXN2 ataxin 2 0.0281009
KDM2A lysine (K)-specific demethylase 2A 0.0280709
TPT1 tumor protein, translationally-controlled 1 0.0280257
RPS6 ribosomal protein S6 0.0279879
NF1 neurofibromin 1 0.0266139
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0265408
XPOT exportin, tRNA 0.0265407
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0261289
RAP1B RAP1B, member of RAS oncogene family 0.0259848
RPL36A ribosomal protein L36a 0.0257098
RPL37A ribosomal protein L37a 0.0256806
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.025571
TPM4 tropomyosin 4 0.0255043

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.15177
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.127964
RAD51B RAD51 paralog B -0.10013
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0950758
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0938792
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0886213
HMGA2 high mobility group AT-hook 2 -0.086767
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0800482
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0789288
FMNL2 formin-like 2 -0.0741937
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0698989
TFPI2 tissue factor pathway inhibitor 2 -0.0679469
AFF3 AF4/FMR2 family, member 3 -0.0639091
NTSR1 neurotensin receptor 1 (high affinity) -0.0632623
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0615788
NABP1 nucleic acid binding protein 1 -0.0597135
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0566742
EGFR epidermal growth factor receptor -0.0559353
RYR3 ryanodine receptor 3 -0.0539987
THSD4 thrombospondin, type I, domain containing 4 -0.0520094
PRELID2 PRELI domain containing 2 -0.0500494
KTN1 kinectin 1 (kinesin receptor) -0.0460187
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0459751
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0455341
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0453647
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0433405
EGR1 early growth response 1 -0.0424397
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0421435
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0399331
DIAPH2 diaphanous-related formin 2 -0.0398918
NEK10 NIMA-related kinase 10 -0.0395803
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0388462
EXT1 exostosin glycosyltransferase 1 -0.0378533
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0371865
WNT2B wingless-type MMTV integration site family, member 2B -0.0369901
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0369506
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0369332
MCL1 myeloid cell leukemia 1 -0.0368946
MACF1 microtubule-actin crosslinking factor 1 -0.0368458
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0354494
RBM25 RNA binding motif protein 25 -0.0353896
DENND1A DENN/MADD domain containing 1A -0.0352496
GPHN gephyrin -0.0349437
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0345356
SNX14 sorting nexin 14 -0.0343628
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0341834
TRIO trio Rho guanine nucleotide exchange factor -0.0340144
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0335148
ATP11A ATPase, class VI, type 11A -0.0334388
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0328567
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0321609
SON SON DNA binding protein -0.0319698
EXOC4 exocyst complex component 4 -0.0309829
ACTN1 actinin, alpha 1 -0.0304691
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.030289
DNAH14 dynein, axonemal, heavy chain 14 -0.0288664
RIMS2 regulating synaptic membrane exocytosis 2 -0.0281092
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0279247
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0275301
RRM2 ribonucleotide reductase M2 -0.0273978
PTBP1 polypyrimidine tract binding protein 1 -0.0266137
PFN1 profilin 1 -0.0262631
EIF5B eukaryotic translation initiation factor 5B -0.0258478
EML4 echinoderm microtubule associated protein like 4 -0.0253345
MCTP1 multiple C2 domains, transmembrane 1 -0.0253089
RUNX1 runt-related transcription factor 1 -0.0252367
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0251992
MARCHF4 membrane associated ring-CH-type finger 4 -0.0249175
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0249098
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -0.0246692
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0243961
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0239304
ZNF638 zinc finger protein 638 -0.0233381
STYK1 serine/threonine/tyrosine kinase 1 -0.0230616
BIRC6 baculoviral IAP repeat containing 6 -0.0223861
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0223527
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0220924
DCLK1 doublecortin-like kinase 1 -0.0218654
RYK receptor-like tyrosine kinase -0.0218424
RPTOR regulatory associated protein of MTOR, complex 1 -0.0215856
FLRT2 fibronectin leucine rich transmembrane protein 2 -0.0214844
STC1 stanniocalcin 1 -0.0213308
DOCK5 dedicator of cytokinesis 5 -0.0211131
LRPPRC leucine-rich pentatricopeptide repeat containing -0.020812
TRIM59 tripartite motif containing 59 -0.0208101
ACTG1 actin gamma 1 -0.0207552
E2F3 E2F transcription factor 3 -0.0206272
GON4L gon-4-like (C. elegans) -0.0205876
TBC1D22A TBC1 domain family, member 22A -0.0200769
EHBP1 EH domain binding protein 1 -0.0198008
CAPRIN2 caprin family member 2 -0.0197054
CMIP c-Maf inducing protein -0.0195574
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0194389
SSB Sjogren syndrome antigen B (autoantigen La) -0.0191611
RCC1 regulator of chromosome condensation 1 -0.0190116
SLC25A51 solute carrier family 25, member 51 -0.0187681
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0186237
FMN1 formin 1 -0.0184413
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0183917
SRPK1 SRSF protein kinase 1 -0.0183796