Paclitaxel_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TUBB4B tubulin, beta 4B class IVb 0.150548
PABPC1 poly(A) binding protein, cytoplasmic 1 0.120909
FTL ferritin, light polypeptide 0.11733
FN1 fibronectin 1 0.105005
NDRG1 N-myc downstream regulated 1 0.102164
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0826761
EEF2 eukaryotic translation elongation factor 2 0.0775408
BHLHE40 basic helix-loop-helix family, member e40 0.0760588
UPP1 uridine phosphorylase 1 0.0732734
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0714254
TXNRD1 thioredoxin reductase 1 0.0712762
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0702716
CENPF centromere protein F, 350/400kDa 0.0698738
TUBA1B tubulin, alpha 1b 0.0672168
MKI67 marker of proliferation Ki-67 0.0665829
TUBB tubulin, beta class I 0.0632986
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0620683
HSPA8 heat shock 70kDa protein 8 0.0610657
RBM25 RNA binding motif protein 25 0.0591355
BRD2 bromodomain containing 2 0.0586652
PCBP2 poly(rC) binding protein 2 0.0571911
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0556321
HDAC9 histone deacetylase 9 0.0541367
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0537648
PRRC2C proline-rich coiled-coil 2C 0.0528503
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0521801
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0496902
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0486004
APLP2 amyloid beta (A4) precursor-like protein 2 0.0477334
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0476544
IGFBP3 insulin-like growth factor binding protein 3 0.0469164
DSPP dentin sialophosphoprotein 0.046732
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0454711
POTEF POTE ankyrin domain family, member F 0.0454345
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0446671
SMC4 structural maintenance of chromosomes 4 0.0440403
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0430964
EIF5 eukaryotic translation initiation factor 5 0.0419356
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.039881
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.039462
MATR3 matrin 3 0.039343
RAB7A RAB7A, member RAS oncogene family 0.0381019
ENO1 enolase 1, (alpha) 0.037559
SQSTM1 sequestosome 1 0.0373943
TUBA1C tubulin, alpha 1c 0.0370141
INTS6 integrator complex subunit 6 0.036539
MYO5B myosin VB 0.0363546
HMGA1 high mobility group AT-hook 1 0.034927
TPR translocated promoter region, nuclear basket protein 0.0346675
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0343418
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0343364
SPAG9 sperm associated antigen 9 0.0340145
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0337333
DTNA dystrobrevin, alpha 0.0336499
CENPE centromere protein E, 312kDa 0.0330957
KTN1 kinectin 1 (kinesin receptor) 0.0330062
GPBP1 GC-rich promoter binding protein 1 0.0329673
TPX2 TPX2, microtubule-associated 0.0328063
DUSP10 dual specificity phosphatase 10 0.0327951
RPL4 ribosomal protein L4 0.0323413
NUP58 nucleoporin 58 0.0315794
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0313294
PAPOLA poly(A) polymerase alpha 0.0312867
KIF5B kinesin family member 5B 0.0310476
PKM pyruvate kinase, muscle 0.0310425
DST dystonin 0.0309721
NAMPT nicotinamide phosphoribosyltransferase 0.0308174
EIF1 eukaryotic translation initiation factor 1 0.0306639
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0304982
SEPTIN11 septin 11 0.0304332
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0301809
MSN moesin 0.0301448
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0298978
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0297406
VGLL3 vestigial-like family member 3 0.0295177
RICTOR RPTOR independent companion of MTOR, complex 2 0.0290276
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0288873
XPOT exportin, tRNA 0.0286732
FOSL1 FOS-like antigen 1 0.0286037
PHACTR4 phosphatase and actin regulator 4 0.0283717
KPNB1 karyopherin (importin) beta 1 0.027948
CCNL1 cyclin L1 0.0279163
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0278892
TOP1 topoisomerase (DNA) I 0.0273164
SP100 SP100 nuclear antigen 0.0272075
TFRC transferrin receptor 0.0270581
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0267787
RAD21 RAD21 homolog (S. pombe) 0.0267454
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0265191
IL6ST interleukin 6 signal transducer 0.0264807
EGR1 early growth response 1 0.0264678
FAM3C family with sequence similarity 3, member C 0.0264603
MED13 mediator complex subunit 13 0.0263891
TJP1 tight junction protein 1 0.0260523
SNX9 sorting nexin 9 0.0260037
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0259497
MCL1 myeloid cell leukemia 1 0.0258875
TPM3 tropomyosin 3 0.0256867
IARS1 isoleucyl-tRNA synthetase 1 0.0256324
F11R F11 receptor 0.0255489

decreased expression

Symbol Name Standardized Value
LIMCH1 LIM and calponin homology domains 1 -0.153789
LPP LIM domain containing preferred translocation partner in lipoma -0.146073
TRIO trio Rho guanine nucleotide exchange factor -0.120064
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.111424
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10686
PDLIM5 PDZ and LIM domain 5 -0.10492
FNDC3B fibronectin type III domain containing 3B -0.103911
EXT1 exostosin glycosyltransferase 1 -0.0979707
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0938018
TMSB10 thymosin beta 10 -0.0872718
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0787105
FBXO32 F-box protein 32 -0.0660509
VCL vinculin -0.0619287
NPEPPS aminopeptidase puromycin sensitive -0.0618156
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.06093
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0607176
MYO1E myosin IE -0.0573744
EFNA5 ephrin-A5 -0.0551623
ALCAM activated leukocyte cell adhesion molecule -0.0546095
GRB10 growth factor receptor-bound protein 10 -0.0531312
LMO7 LIM domain 7 -0.0525301
RPL34 ribosomal protein L34 -0.0502937
SOX4 SRY (sex determining region Y)-box 4 -0.0500486
MCU mitochondrial calcium uniporter -0.0472705
S100A6 S100 calcium binding protein A6 -0.0471177
LAMC2 laminin, gamma 2 -0.0469106
TSC22D2 TSC22 domain family, member 2 -0.0465715
ARHGAP20 Rho GTPase activating protein 20 -0.0464808
TMSB4X thymosin beta 4, X-linked -0.0457855
FAM13A family with sequence similarity 13, member A -0.0441516
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0435566
RPL23 ribosomal protein L23 -0.043048
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0427081
CD2AP CD2-associated protein -0.0425373
ESYT2 extended synaptotagmin-like protein 2 -0.0420533
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0414958
SACK1A scaffolding CK1 anchoring protein A -0.0412205
RASA2 RAS p21 protein activator 2 -0.0410753
FLNB filamin B, beta -0.0409892
WSB1 WD repeat and SOCS box containing 1 -0.0402534
RAI14 retinoic acid induced 14 -0.0401839
GNAS GNAS complex locus -0.0385117
FBXL2 F-box and leucine-rich repeat protein 2 -0.0384085
FBXO34 F-box protein 34 -0.037341
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0370257
ITCH itchy E3 ubiquitin protein ligase -0.0369644
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0348564
ATP11A ATPase, class VI, type 11A -0.0346548
C15ORF48 chromosome 15 open reading frame 48 -0.0331953
RPL32 ribosomal protein L32 -0.0321385
PALLD palladin, cytoskeletal associated protein -0.0318765
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0317035
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0316967
TMEM165 transmembrane protein 165 -0.0313361
KMT2C lysine (K)-specific methyltransferase 2C -0.030999
FRMD5 FERM domain containing 5 -0.0307963
CTNND1 catenin (cadherin-associated protein), delta 1 -0.030619
RRBP1 ribosome binding protein 1 -0.030216
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.029986
S100A10 S100 calcium binding protein A10 -0.0299858
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0299183
SEC23A Sec23 homolog A (S. cerevisiae) -0.0292403
NRIP1 nuclear receptor interacting protein 1 -0.0289129
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0288105
KRT7 keratin 7, type II -0.0287276
BZW1 basic leucine zipper and W2 domains 1 -0.0287104
FHIT fragile histidine triad -0.0286242
MAML2 mastermind-like 2 (Drosophila) -0.028118
CAB39 calcium binding protein 39 -0.0281027
FAM114A1 family with sequence similarity 114, member A1 -0.0276662
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0275504
MYOF myoferlin -0.0275233
TXNIP thioredoxin interacting protein -0.0273302
MRPS6 mitochondrial ribosomal protein S6 -0.0269819
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0267814
MGST1 microsomal glutathione S-transferase 1 -0.0267735
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0266229
SEC24D SEC24 family member D -0.026564
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0265584
BASP1 brain abundant, membrane attached signal protein 1 -0.0262581
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0259175
ARHGAP29 Rho GTPase activating protein 29 -0.0255968
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0253918
SBF2 SET binding factor 2 -0.0251492
OSMR oncostatin M receptor -0.0250665
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0250574
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0244123
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0242188
ARHGAP42 Rho GTPase activating protein 42 -0.0239963
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0239748
HDLBP high density lipoprotein binding protein -0.0236345
LY6E lymphocyte antigen 6 complex, locus E -0.0236175
PDIA5 protein disulfide isomerase family A, member 5 -0.0235761
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0234712
ISG15 ISG15 ubiquitin-like modifier -0.0233369
ARF1 ADP-ribosylation factor 1 -0.0232322
APAF1 apoptotic peptidase activating factor 1 -0.0227413
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0227411
NEBL nebulette -0.0227015
H1-0 H1.0 linker histone -0.0225913