Paclitaxel_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.132404
SAMD4A sterile alpha motif domain containing 4A 0.0721272
HDAC9 histone deacetylase 9 0.0679282
PDE4B phosphodiesterase 4B, cAMP-specific 0.0549467
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0514021
TXNRD1 thioredoxin reductase 1 0.045123
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0416543
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0391229
ANK2 ankyrin 2, neuronal 0.0365366
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0353695
RTN4 reticulon 4 0.0327173
EGFR epidermal growth factor receptor 0.0304103
RBM39 RNA binding motif protein 39 0.0293044
DOCK3 dedicator of cytokinesis 3 0.0286261
PDGFC platelet derived growth factor C 0.0284832
PICALM phosphatidylinositol binding clathrin assembly protein 0.0275409
SMYD3 SET and MYND domain containing 3 0.027172
TBC1D5 TBC1 domain family, member 5 0.0269868
ANKRD11 ankyrin repeat domain 11 0.0267106
VMP1 vacuole membrane protein 1 0.0249833
FLNB filamin B, beta 0.0243978
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0234026
ADAM9 ADAM metallopeptidase domain 9 0.0230113
LPP LIM domain containing preferred translocation partner in lipoma 0.0224664
RPL3 ribosomal protein L3 0.0222791
TGFBR3 transforming growth factor, beta receptor III 0.0222534
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0216114
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0213007
PTBP2 polypyrimidine tract binding protein 2 0.0210945
NT5C2 5'-nucleotidase, cytosolic II 0.020608
SSBP2 single-stranded DNA binding protein 2 0.0202624
MED13L mediator complex subunit 13-like 0.0200876
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0195672
FNIP1 folliculin interacting protein 1 0.0194732
ZNF292 zinc finger protein 292 0.0193698
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0193195
PYGB phosphorylase, glycogen; brain 0.0190552
EXT1 exostosin glycosyltransferase 1 0.0186183
KDM6A lysine (K)-specific demethylase 6A 0.0185667
ECT2 epithelial cell transforming 2 0.018053
PSAT1 phosphoserine aminotransferase 1 0.0176723
PLPP3 phospholipid phosphatase 3 0.0175253
ZFAND3 zinc finger, AN1-type domain 3 0.0171627
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0171197
FNDC3B fibronectin type III domain containing 3B 0.0169642
DOCK1 dedicator of cytokinesis 1 0.0168452
TRIM25 tripartite motif containing 25 0.0167425
MSI2 musashi RNA-binding protein 2 0.0167153
BTBD9 BTB (POZ) domain containing 9 0.0166469
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0165022
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0165003
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0161164
WDR43 WD repeat domain 43 0.0158333
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0157712
SFPQ splicing factor proline/glutamine-rich 0.0156518
SRPK2 SRSF protein kinase 2 0.0153723
TSC22D1 TSC22 domain family, member 1 0.0150878
ADAM10 ADAM metallopeptidase domain 10 0.0150702
ZBTB20 zinc finger and BTB domain containing 20 0.0150609
AHCYL2 adenosylhomocysteinase-like 2 0.0150487
CCNL1 cyclin L1 0.014871
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0148505
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0147777
YAP1 Yes-associated protein 1 0.014726
ZNF608 zinc finger protein 608 0.0144606
RHBDD1 rhomboid domain containing 1 0.0144383
MED13 mediator complex subunit 13 0.0143982
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.014392
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0143459
ZNF644 zinc finger protein 644 0.014343
CEP192 centrosomal protein 192kDa 0.0141804
AZIN1 antizyme inhibitor 1 0.0140973
GARS1 glycyl-tRNA synthetase 1 0.0139913
MON2 MON2 homolog (S. cerevisiae) 0.0138742
CCNY cyclin Y 0.0137174
CLIC4 chloride intracellular channel 4 0.0136283
TCF12 transcription factor 12 0.0135414
SESN2 sestrin 2 0.0134215
TMEM65 transmembrane protein 65 0.0133191
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0132398
TRIO trio Rho guanine nucleotide exchange factor 0.0131906
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0131562
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0131463
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0130975
GSK3B glycogen synthase kinase 3 beta 0.0129636
BCAS3 breast carcinoma amplified sequence 3 0.012953
PTK2 protein tyrosine kinase 2 0.012824
PTPRG protein tyrosine phosphatase, receptor type, G 0.0128177
MDN1 MDN1, midasin homolog (yeast) 0.0127929
ZNFX1 zinc finger, NFX1-type containing 1 0.0127509
LARP4B La ribonucleoprotein domain family, member 4B 0.01273
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0125474
TMCO3 transmembrane and coiled-coil domains 3 0.0125356
ATXN7 ataxin 7 0.0124312
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0124215
WDFY3 WD repeat and FYVE domain containing 3 0.0124064
KLC1 kinesin light chain 1 0.0124038
TRIM44 tripartite motif containing 44 0.0124011
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0123245
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0123069

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.423187
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.419296
RPS6 ribosomal protein S6 -0.14553
TPT1 tumor protein, translationally-controlled 1 -0.133086
RPS8 ribosomal protein S8 -0.131458
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.10234
ACTG1 actin gamma 1 -0.0951862
BMP10 bone morphogenetic protein 10 -0.0943232
RPL35A ribosomal protein L35a -0.0824108
RPLP1 ribosomal protein, large, P1 -0.0811592
TMSB4X thymosin beta 4, X-linked -0.0791227
ARL4C ADP-ribosylation factor-like 4C -0.0783579
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0772982
RPL34 ribosomal protein L34 -0.0731716
PKM pyruvate kinase, muscle -0.0699067
RPL31 ribosomal protein L31 -0.0658851
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0655382
RPL19 ribosomal protein L19 -0.0649399
CCND1 cyclin D1 -0.064401
RPL12 ribosomal protein L12 -0.0630874
HSPB1 heat shock 27kDa protein 1 -0.0620088
RPS19 ribosomal protein S19 -0.0603894
AHNAK AHNAK nucleoprotein -0.060084
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.059674
RPL26 ribosomal protein L26 -0.0555092
RPLP2 ribosomal protein, large, P2 -0.0547938
RPL23 ribosomal protein L23 -0.0544234
RPL37A ribosomal protein L37a -0.053445
ENO1 enolase 1, (alpha) -0.0527537
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0521145
S100A4 S100 calcium binding protein A4 -0.0501483
RPS13 ribosomal protein S13 -0.0494142
LDHA lactate dehydrogenase A -0.0491015
TM4SF1 transmembrane 4 L six family member 1 -0.0482894
DLG1 discs, large homolog 1 (Drosophila) -0.0477144
RPS23 ribosomal protein S23 -0.0471218
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0469398
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0466506
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0453819
CAMKMT calmodulin-lysine N-methyltransferase -0.0449826
RPL9 ribosomal protein L9 -0.044941
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0447775
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0441013
RPLP0 ribosomal protein, large, P0 -0.0437428
S100A6 S100 calcium binding protein A6 -0.043542
LOC112694756 uncharaterized LOC112694756 -0.0433132
RPL7A ribosomal protein L7a -0.0431516
RACK1 receptor for activated C kinase 1 -0.0420472
RPL32 ribosomal protein L32 -0.0419007
NPAS2 neuronal PAS domain protein 2 -0.0416916
RPS16 ribosomal protein S16 -0.0414556
VCL vinculin -0.0407339
RPS3 ribosomal protein S3 -0.0406035
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0405338
S100A9 S100 calcium binding protein A9 -0.0404077
RPS25 ribosomal protein S25 -0.0396193
PGK1 phosphoglycerate kinase 1 -0.0393558
NAP1L1 nucleosome assembly protein 1-like 1 -0.0392149
EBNA1BP2 EBNA1 binding protein 2 -0.0390387
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0389533
RPL8 ribosomal protein L8 -0.0388836
S100A10 S100 calcium binding protein A10 -0.0387996
RPS27A ribosomal protein S27a -0.0380536
RPL18 ribosomal protein L18 -0.0376616
TPI1 triosephosphate isomerase 1 -0.0374551
RPS14 ribosomal protein S14 -0.0368731
RPS24 ribosomal protein S24 -0.0364496
KPNB1 karyopherin (importin) beta 1 -0.0361214
RPL5 ribosomal protein L5 -0.0357862
PFN1 profilin 1 -0.0356477
RPL7 ribosomal protein L7 -0.0355087
GNAS GNAS complex locus -0.035402
RPS21 ribosomal protein S21 -0.0353582
TMSB10 thymosin beta 10 -0.0347192
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0346301
RPL11 ribosomal protein L11 -0.0345894
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0342427
RSL1D1 ribosomal L1 domain containing 1 -0.0342164
RPL35 ribosomal protein L35 -0.0338778
EIF1 eukaryotic translation initiation factor 1 -0.0329807
TPM4 tropomyosin 4 -0.0325143
LOC102724023 ES1 protein homolog, mitochondrial -0.0320717
RPL10A ribosomal protein L10a -0.0319213
MYL12B myosin, light chain 12B, regulatory -0.0315887
RPL37 ribosomal protein L37 -0.0314928
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0308335
ANXA1 annexin A1 -0.0307029
RPL36 ribosomal protein L36 -0.0305739
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0305734
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0304301
RPS12 ribosomal protein S12 -0.0303727
RPL27A ribosomal protein L27a -0.030293
RPS11 ribosomal protein S11 -0.0297892
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0293262
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0291017
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0289114
RPL38 ribosomal protein L38 -0.0284567
RPL30 ribosomal protein L30 -0.0281068
RPS10 ribosomal protein S10 -0.0275859
RPS17 ribosomal protein S17 -0.0274767