Paclitaxel_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.148095
FN1 fibronectin 1 0.0824699
KYNU kynureninase 0.0651481
HIP1 huntingtin interacting protein 1 0.0581953
CDH13 cadherin 13 0.0579661
FNIP1 folliculin interacting protein 1 0.0471742
EXT1 exostosin glycosyltransferase 1 0.0451832
PDLIM5 PDZ and LIM domain 5 0.0449998
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0390366
VEGFC vascular endothelial growth factor C 0.0364363
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0361158
ERRFI1 ERBB receptor feedback inhibitor 1 0.0347526
GOLGB1 golgin B1 0.0345319
NRXN3 neurexin 3 0.034194
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0335201
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0334461
MACF1 microtubule-actin crosslinking factor 1 0.0331969
ZSWIM6 zinc finger, SWIM-type containing 6 0.0327188
SQSTM1 sequestosome 1 0.0307365
INTS6 integrator complex subunit 6 0.0301587
EFNA5 ephrin-A5 0.029394
HMGA2 high mobility group AT-hook 2 0.0289257
UBAP2 ubiquitin associated protein 2 0.0288082
PSD3 pleckstrin and Sec7 domain containing 3 0.0288041
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0286775
BBS9 Bardet-Biedl syndrome 9 0.0286152
BTBD9 BTB (POZ) domain containing 9 0.0282081
AFF4 AF4/FMR2 family, member 4 0.0275611
PTPRM protein tyrosine phosphatase, receptor type, M 0.0274246
ARHGAP24 Rho GTPase activating protein 24 0.0271901
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0269849
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0267494
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0263696
VCL vinculin 0.0261227
ANKRD36 ankyrin repeat domain 36 0.0259315
MKI67 marker of proliferation Ki-67 0.0258652
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0255429
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0253012
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0247152
CLIC4 chloride intracellular channel 4 0.0244778
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0241081
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.023883
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0237238
RND3 Rho family GTPase 3 0.0235306
FTO fat mass and obesity associated 0.0232674
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0224017
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0221095
ALK anaplastic lymphoma receptor tyrosine kinase 0.0219711
SND1 staphylococcal nuclease and tudor domain containing 1 0.0218401
RAD51B RAD51 paralog B 0.0217004
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0215937
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 0.0214696
LIMS1 LIM and senescent cell antigen-like domains 1 0.021213
CDK6 cyclin-dependent kinase 6 0.0212022
ANKHD1 ankyrin repeat and KH domain containing 1 0.0209334
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0208486
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0207943
JARID2 jumonji, AT rich interactive domain 2 0.0207555
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0205791
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0202589
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0200555
TPM1 tropomyosin 1 (alpha) 0.0200405
ARB2A ARB2 cotranscriptional regulator A 0.0200218
CDK13 cyclin-dependent kinase 13 0.01998
ASXL1 additional sex combs like transcriptional regulator 1 0.0199787
WWOX WW domain containing oxidoreductase 0.0199708
SOX5 SRY (sex determining region Y)-box 5 0.0198125
WLS wntless Wnt ligand secretion mediator 0.0197817
BLTP1 bridge-like lipid transfer protein family member 1 0.0197222
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0196472
PTPRK protein tyrosine phosphatase, receptor type, K 0.0196075
EXOC4 exocyst complex component 4 0.0193129
TIMP2 TIMP metallopeptidase inhibitor 2 0.019039
DMXL1 Dmx-like 1 0.0189183
KRIT1 KRIT1, ankyrin repeat containing 0.0187797
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0187186
WDFY3 WD repeat and FYVE domain containing 3 0.0186775
HSPA8 heat shock 70kDa protein 8 0.0184618
AHR aryl hydrocarbon receptor 0.0184519
OPTN optineurin 0.0184101
COPA coatomer protein complex, subunit alpha 0.0183964
MBD5 methyl-CpG binding domain protein 5 0.0183666
CCND1 cyclin D1 0.0180718
ZCCHC7 zinc finger, CCHC domain containing 7 0.0180661
MCTP2 multiple C2 domains, transmembrane 2 0.0180635
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0180034
ATM ATM serine/threonine kinase 0.0179549
TPR translocated promoter region, nuclear basket protein 0.0178987
PHF14 PHD finger protein 14 0.0178459
VMP1 vacuole membrane protein 1 0.017776
COG6 component of oligomeric golgi complex 6 0.0176881
UBE3C ubiquitin protein ligase E3C 0.0176639
BICD1 bicaudal D homolog 1 (Drosophila) 0.0175511
RAB31 RAB31, member RAS oncogene family 0.0174558
DSCAM Down syndrome cell adhesion molecule 0.0174181
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0173423
GPBP1 GC-rich promoter binding protein 1 0.0173213
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0173003
GSE1 Gse1 coiled-coil protein 0.0171016
TENT2 terminal nucleotidyltransferase 2 0.016996

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.233827
TMSB10 thymosin beta 10 -0.203912
MT2A metallothionein 2A -0.140223
VIM vimentin -0.131361
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.110983
COL1A2 collagen, type I, alpha 2 -0.0896374
B2M beta-2-microglobulin -0.0741749
COL6A3 collagen, type VI, alpha 3 -0.0703303
HLA-B major histocompatibility complex, class I, B -0.0683794
TGFBI transforming growth factor, beta-induced, 68kDa -0.0671662
CALU calumenin -0.066298
TIMP3 TIMP metallopeptidase inhibitor 3 -0.063697
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0616711
TRIO trio Rho guanine nucleotide exchange factor -0.0598601
UBC ubiquitin C -0.0597896
FTL ferritin, light polypeptide -0.0570245
MT1X metallothionein 1X -0.0522851
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0517231
PTMA prothymosin, alpha -0.0513012
LDHA lactate dehydrogenase A -0.0506868
ATP13A3 ATPase type 13A3 -0.0452438
NAMPT nicotinamide phosphoribosyltransferase -0.043944
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0431983
LOX lysyl oxidase -0.043162
S100A10 S100 calcium binding protein A10 -0.0414637
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0407041
ZNF292 zinc finger protein 292 -0.0389822
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0386966
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0385968
S100A9 S100 calcium binding protein A9 -0.0372313
TXNIP thioredoxin interacting protein -0.0367111
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0360078
FAM13A family with sequence similarity 13, member A -0.0358299
LMNA lamin A/C -0.0346831
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0345155
RPL34 ribosomal protein L34 -0.0344828
CALD1 caldesmon 1 -0.0342335
S100A6 S100 calcium binding protein A6 -0.0341302
EGFR epidermal growth factor receptor -0.0336776
AKAP12 A kinase (PRKA) anchor protein 12 -0.0328315
PGK1 phosphoglycerate kinase 1 -0.0324573
NDRG1 N-myc downstream regulated 1 -0.0319794
CADM1 cell adhesion molecule 1 -0.0318105
WTAP Wilms tumor 1 associated protein -0.0309493
COL6A1 collagen, type VI, alpha 1 -0.0299153
COL1A1 collagen, type I, alpha 1 -0.0295505
HLA-C major histocompatibility complex, class I, C -0.0291316
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0291163
CCNI cyclin I -0.0287753
HILPDA hypoxia inducible lipid droplet-associated -0.0286938
GOLGA4 golgin A4 -0.0283974
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0278974
ENO1 enolase 1, (alpha) -0.0278813
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0278258
NOP58 NOP58 ribonucleoprotein -0.0274122
EGR1 early growth response 1 -0.0271456
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0271424
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0271067
UGCG UDP-glucose ceramide glucosyltransferase -0.0268197
RPL36 ribosomal protein L36 -0.0264831
RTN4 reticulon 4 -0.0262928
ARRDC3 arrestin domain containing 3 -0.0262915
ITM2B integral membrane protein 2B -0.0258713
RPS24 ribosomal protein S24 -0.0253255
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0251877
TMEM41B transmembrane protein 41B -0.0251687
RPL23 ribosomal protein L23 -0.0247112
TIMP1 TIMP metallopeptidase inhibitor 1 -0.024475
RACK1 receptor for activated C kinase 1 -0.0244413
ANXA2 annexin A2 -0.0243276
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0241045
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0240852
PHF21A PHD finger protein 21A -0.0238076
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0237613
FAM162A family with sequence similarity 162, member A -0.0237205
ZNF395 zinc finger protein 395 -0.0236189
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0233271
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0231159
RPL28 ribosomal protein L28 -0.0230903
GANAB glucosidase, alpha; neutral AB -0.023073
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0229992
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0229866
LOC112694756 uncharaterized LOC112694756 -0.0228226
RRBP1 ribosome binding protein 1 -0.0227485
LOC102724023 ES1 protein homolog, mitochondrial -0.0226652
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0225224
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0223235
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.021989
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0218998
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.021707
COL4A2 collagen, type IV, alpha 2 -0.0216588
TPT1 tumor protein, translationally-controlled 1 -0.021616
GNAS GNAS complex locus -0.0215889
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0214278
PFN1 profilin 1 -0.0212951
TENT5A terminal nucleotidyltransferase 5A -0.0212764
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.021042
SEPTIN7 septin 7 -0.0208661
LMAN1 lectin, mannose-binding, 1 -0.0206449
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0206256