Paclitaxel_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.0648491
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0610424
DST dystonin 0.0517897
FNDC3B fibronectin type III domain containing 3B 0.0516723
FMNL2 formin-like 2 0.0506903
ZSWIM6 zinc finger, SWIM-type containing 6 0.0479494
SOD2 superoxide dismutase 2, mitochondrial 0.0462718
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0422583
SLC38A2 solute carrier family 38, member 2 0.0411128
N4BP2L2 NEDD4 binding protein 2-like 2 0.0400635
TUBB4B tubulin, beta 4B class IVb 0.0379992
MACF1 microtubule-actin crosslinking factor 1 0.0365786
HMGA2 high mobility group AT-hook 2 0.035522
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0350907
ZFAND3 zinc finger, AN1-type domain 3 0.0347807
AEBP2 AE binding protein 2 0.0298322
ATM ATM serine/threonine kinase 0.0286888
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0284062
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0270175
RORA RAR-related orphan receptor A 0.0262665
BICD1 bicaudal D homolog 1 (Drosophila) 0.0261655
DSCAM Down syndrome cell adhesion molecule 0.0258146
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0251107
GLS2 glutaminase 2 (liver, mitochondrial) 0.0246711
TUBB tubulin, beta class I 0.0242846
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0233957
TLE4 transducin-like enhancer of split 4 0.0233285
CPNE1 copine I 0.0231723
RIGI RNA sensor RIG-I 0.0221454
GPC5 glypican 5 0.0218878
ARID5B AT rich interactive domain 5B (MRF1-like) 0.021686
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0211667
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0210371
HSPA8 heat shock 70kDa protein 8 0.0210205
CFAP44 cilia and flagella associated protein 44 0.0203951
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.0202695
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0201614
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0201418
MAML3 mastermind-like 3 (Drosophila) 0.0201128
TULP4 tubby like protein 4 0.0196963
JAK1 Janus kinase 1 0.0193841
BBS9 Bardet-Biedl syndrome 9 0.0191938
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0191818
TUBA1C tubulin, alpha 1c 0.0191403
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0191072
SMAD3 SMAD family member 3 0.01908
TRIP12 thyroid hormone receptor interactor 12 0.018846
MB21D2 Mab-21 domain containing 2 0.0185537
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0184847
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0183488
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0183213
NBEA neurobeachin 0.0181819
MCTP1 multiple C2 domains, transmembrane 1 0.0178712
TMEM135 transmembrane protein 135 0.0178037
JARID2 jumonji, AT rich interactive domain 2 0.0176408
XPOT exportin, tRNA 0.0175656
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0175372
ZBTB1 zinc finger and BTB domain containing 1 0.0174209
SKIL SKI-like proto-oncogene 0.0172065
GPHN gephyrin 0.0166778
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0166392
FNDC3A fibronectin type III domain containing 3A 0.0165451
UTRN utrophin 0.0165372
YAP1 Yes-associated protein 1 0.0164726
CYTH1 cytohesin 1 0.0164085
RAD51B RAD51 paralog B 0.0163113
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.016258
TUBA1A tubulin, alpha 1a 0.0159877
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0159493
SATB2 SATB homeobox 2 0.0159225
STAU2 staufen double-stranded RNA binding protein 2 0.0157022
PDGFC platelet derived growth factor C 0.0156045
PHF3 PHD finger protein 3 0.0156015
FMN1 formin 1 0.0154977
USP34 ubiquitin specific peptidase 34 0.0154522
SDC4 syndecan 4 0.0154465
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0152542
ZNF254 zinc finger protein 254 0.0152079
CCDC138 coiled-coil domain containing 138 0.015154
LIMS1 LIM and senescent cell antigen-like domains 1 0.0150559
CANX calnexin 0.0150491
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0149968
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.014969
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0149569
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0149019
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0148553
TASOR2 transcription activation suppressor family member 2 0.0148144
RAB27A RAB27A, member RAS oncogene family 0.0147992
PTK2 protein tyrosine kinase 2 0.0147982
LRRC49 leucine rich repeat containing 49 0.0146847
SYNRG synergin, gamma 0.0146636
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0146585
TTC27 tetratricopeptide repeat domain 27 0.0146475
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0145854
TBL1X transducin (beta)-like 1X-linked 0.0145755
GSK3B glycogen synthase kinase 3 beta 0.0144897
EIF4A2 eukaryotic translation initiation factor 4A2 0.0144748
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0144401
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0143788
TNRC6B trinucleotide repeat containing 6B 0.0142102

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.336772
VIM vimentin -0.119415
TMSB10 thymosin beta 10 -0.105384
CD44 CD44 molecule (Indian blood group) -0.0850564
PTMA prothymosin, alpha -0.0636351
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0600752
YBX3 Y box binding protein 3 -0.056592
RPLP1 ribosomal protein, large, P1 -0.0476076
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0454719
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0447244
MT2A metallothionein 2A -0.0432461
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0413492
HILPDA hypoxia inducible lipid droplet-associated -0.0376457
RPL23 ribosomal protein L23 -0.0369801
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.036523
TXNRD1 thioredoxin reductase 1 -0.0357762
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0335959
EGR1 early growth response 1 -0.0334519
EIF1 eukaryotic translation initiation factor 1 -0.0330032
DIAPH3 diaphanous-related formin 3 -0.0327708
SEPTIN7 septin 7 -0.0327102
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0321886
RPL12 ribosomal protein L12 -0.0319971
LDHA lactate dehydrogenase A -0.0317462
TOP2A topoisomerase (DNA) II alpha 170kDa -0.030584
RACK1 receptor for activated C kinase 1 -0.0302322
AKAP12 A kinase (PRKA) anchor protein 12 -0.0294799
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0291242
UGCG UDP-glucose ceramide glucosyltransferase -0.0290123
ZNF292 zinc finger protein 292 -0.0289812
GNAS GNAS complex locus -0.0285928
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0285286
POTEF POTE ankyrin domain family, member F -0.0282673
NCOR1 nuclear receptor corepressor 1 -0.0280423
B2M beta-2-microglobulin -0.0277481
RPS8 ribosomal protein S8 -0.0271331
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0267475
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0266666
RPL36 ribosomal protein L36 -0.0265827
PFN1 profilin 1 -0.0264646
S100A9 S100 calcium binding protein A9 -0.0262641
RPL32 ribosomal protein L32 -0.0260124
MIS18BP1 MIS18 binding protein 1 -0.0258848
RPL35A ribosomal protein L35a -0.0256169
RPS17 ribosomal protein S17 -0.0253099
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0249887
PRRC2C proline-rich coiled-coil 2C -0.0247277
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0246177
ANXA2 annexin A2 -0.0244697
RBM39 RNA binding motif protein 39 -0.0242772
KIF5B kinesin family member 5B -0.0238865
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0237902
ANKRD28 ankyrin repeat domain 28 -0.0236804
NCEH1 neutral cholesterol ester hydrolase 1 -0.0236634
RTN4 reticulon 4 -0.0234887
IER3 immediate early response 3 -0.0234583
RSRC2 arginine/serine-rich coiled-coil 2 -0.0234489
DIAPH1 diaphanous-related formin 1 -0.0233778
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0231162
PRSS23 protease, serine, 23 -0.0230604
TPI1 triosephosphate isomerase 1 -0.0227955
CHD1 chromodomain helicase DNA binding protein 1 -0.0226774
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0223316
ANXA1 annexin A1 -0.0219922
RPS19 ribosomal protein S19 -0.0209699
ANGPTL4 angiopoietin-like 4 -0.02091
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0208291
SETD5 SET domain containing 5 -0.0207771
BSG basigin (Ok blood group) -0.0207178
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0206794
RPLP2 ribosomal protein, large, P2 -0.0206324
RPL26 ribosomal protein L26 -0.0205039
LOC102724023 ES1 protein homolog, mitochondrial -0.0204928
RPS14 ribosomal protein S14 -0.0204803
ATP5F1E ATP synthase F1 subunit epsilon -0.0204122
ANKRD37 ankyrin repeat domain 37 -0.0204097
RPS13 ribosomal protein S13 -0.020377
EPAS1 endothelial PAS domain protein 1 -0.0203749
ARB2A ARB2 cotranscriptional regulator A -0.0202454
TM4SF1 transmembrane 4 L six family member 1 -0.0202225
PYGL phosphorylase, glycogen, liver -0.0202145
SMC4 structural maintenance of chromosomes 4 -0.0201075
RPS12 ribosomal protein S12 -0.0200349
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0198403
MSN moesin -0.0197454
SDCCAG8 serologically defined colon cancer antigen 8 -0.0197366
RPL37A ribosomal protein L37a -0.0196989
JMJD1C jumonji domain containing 1C -0.0196625
THSD4 thrombospondin, type I, domain containing 4 -0.0196318
WDR45B WD repeat domain 45B -0.019543
RRBP1 ribosome binding protein 1 -0.0193686
ITGA6 integrin, alpha 6 -0.0193362
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0191587
FTL ferritin, light polypeptide -0.0190769
RPL19 ribosomal protein L19 -0.0190269
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0190233
RPS21 ribosomal protein S21 -0.0188952
CCDC88A coiled-coil domain containing 88A -0.0188376
RPS15 ribosomal protein S15 -0.0186968
RPS20 ribosomal protein S20 -0.0186783