Paclitaxel_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Paclitaxel perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Paclitaxel_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CENPF centromere protein F, 350/400kDa 0.0692979
EXT1 exostosin glycosyltransferase 1 0.0591121
STC2 stanniocalcin 2 0.0426948
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0417177
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0389745
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.03763
DENND5B DENN/MADD domain containing 5B 0.0354842
MKI67 marker of proliferation Ki-67 0.0344553
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.031739
ENAH enabled homolog (Drosophila) 0.0309339
CANX calnexin 0.0306927
LCORL ligand dependent nuclear receptor corepressor-like 0.0304973
NIPBL Nipped-B homolog (Drosophila) 0.0302982
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0301819
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0298236
PRRC2C proline-rich coiled-coil 2C 0.0295797
UGCG UDP-glucose ceramide glucosyltransferase 0.0272801
ANKRD17 ankyrin repeat domain 17 0.0255508
OGA O-GlcNAcase 0.025487
SQSTM1 sequestosome 1 0.0254426
TPT1 tumor protein, translationally-controlled 1 0.0246314
RPS12 ribosomal protein S12 0.0244115
TMEM178B transmembrane protein 178B 0.0243231
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.024295
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0237027
XPO1 exportin 1 0.0230724
TPX2 TPX2, microtubule-associated 0.022985
RAD21 RAD21 homolog (S. pombe) 0.0225947
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0225665
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0225642
NXN nucleoredoxin 0.0223574
CREBRF CREB3 regulatory factor 0.0222562
HSPA8 heat shock 70kDa protein 8 0.022253
KDM3A lysine (K)-specific demethylase 3A 0.0221659
ZBTB10 zinc finger and BTB domain containing 10 0.0218843
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.02182
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0217634
WAC WW domain containing adaptor with coiled-coil 0.0216669
RB1CC1 RB1-inducible coiled-coil 1 0.0216628
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0215522
CEP350 centrosomal protein 350kDa 0.0214827
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0208172
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0206399
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0204994
ATF6 activating transcription factor 6 0.0204698
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0203609
TUBB4B tubulin, beta 4B class IVb 0.0203334
LIFR leukemia inhibitory factor receptor alpha 0.0201522
TUFT1 tuftelin 1 0.0201014
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0200414
IL6ST interleukin 6 signal transducer 0.0199738
KTN1 kinectin 1 (kinesin receptor) 0.0196216
PUM2 pumilio RNA-binding family member 2 0.019528
PAPOLA poly(A) polymerase alpha 0.0194024
TXNRD1 thioredoxin reductase 1 0.0192916
LRP6 low density lipoprotein receptor-related protein 6 0.0191082
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.019103
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0190775
IFRD1 interferon-related developmental regulator 1 0.0190197
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0189116
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0188631
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0188612
EIF1 eukaryotic translation initiation factor 1 0.0187697
RHEB Ras homolog enriched in brain 0.0186001
SLC38A2 solute carrier family 38, member 2 0.0185481
TUBB tubulin, beta class I 0.0185187
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0183657
GPHN gephyrin 0.0181955
PDS5A PDS5 cohesin associated factor A 0.0181553
RPL26 ribosomal protein L26 0.0180759
NAP1L1 nucleosome assembly protein 1-like 1 0.0178537
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0177931
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0177209
UBAP2 ubiquitin associated protein 2 0.0176987
MTUS1 microtubule associated tumor suppressor 1 0.0175587
EIF5B eukaryotic translation initiation factor 5B 0.0175102
RPS27A ribosomal protein S27a 0.0173365
ANLN anillin, actin binding protein 0.017236
KMT2C lysine (K)-specific methyltransferase 2C 0.0172193
EEF2 eukaryotic translation elongation factor 2 0.0169722
RACK1 receptor for activated C kinase 1 0.0169304
DSCAM Down syndrome cell adhesion molecule 0.0166935
RPL37A ribosomal protein L37a 0.0165458
ANKHD1 ankyrin repeat and KH domain containing 1 0.0165091
ENO1 enolase 1, (alpha) 0.0164606
USP22 ubiquitin specific peptidase 22 0.0164561
KSR1 kinase suppressor of ras 1 0.016432
CKAP2 cytoskeleton associated protein 2 0.0159028
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0158613
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0158541
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0158386
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0157835
TARS1 threonyl-tRNA synthetase 1 0.0157089
PCBP2 poly(rC) binding protein 2 0.0156575
ERBIN erbb2 interacting protein 0.0156441
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0153837
RPS2 ribosomal protein S2 0.0153789
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0152508
KIF14 kinesin family member 14 0.015187
GPBP1 GC-rich promoter binding protein 1 0.0150443

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.240873
NRG1 neuregulin 1 -0.233829
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.204132
FN1 fibronectin 1 -0.167555
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.131361
ASPH aspartate beta-hydroxylase -0.130064
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114871
EFNA5 ephrin-A5 -0.0953392
ITGA1 integrin, alpha 1 -0.0913981
GLIS3 GLIS family zinc finger 3 -0.0904272
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0893229
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0811717
NDRG1 N-myc downstream regulated 1 -0.0746493
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0613796
FNDC3B fibronectin type III domain containing 3B -0.0579367
GRB10 growth factor receptor-bound protein 10 -0.0570706
HIPK2 homeodomain interacting protein kinase 2 -0.0570057
PDE4D phosphodiesterase 4D, cAMP-specific -0.0568568
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0557253
AKAP12 A kinase (PRKA) anchor protein 12 -0.053107
TMEM156 transmembrane protein 156 -0.0518933
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0461334
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0428977
EREG epiregulin -0.0421005
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0417591
LOXL2 lysyl oxidase-like 2 -0.0415739
HPCAL1 hippocalcin-like 1 -0.0412474
DUSP6 dual specificity phosphatase 6 -0.0399869
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0399495
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0373292
TMSB10 thymosin beta 10 -0.0362974
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0361845
MT2A metallothionein 2A -0.0358063
SMAD3 SMAD family member 3 -0.0357649
RAI14 retinoic acid induced 14 -0.0351616
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0344444
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0338049
CD44 CD44 molecule (Indian blood group) -0.033686
NRP1 neuropilin 1 -0.0333658
LMNA lamin A/C -0.0323625
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0320987
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.032003
WWTR1 WW domain containing transcription regulator 1 -0.0317694
EGFR epidermal growth factor receptor -0.03167
ANKRD28 ankyrin repeat domain 28 -0.031391
MTSS1 metastasis suppressor 1 -0.030603
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0301548
MAML2 mastermind-like 2 (Drosophila) -0.0294153
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0290483
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0290125
IGFBP3 insulin-like growth factor binding protein 3 -0.0289542
SVIL supervillin -0.0288528
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0286729
SLC35F3 solute carrier family 35, member F3 -0.0286169
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0282669
OXR1 oxidation resistance 1 -0.0281585
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0271104
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0270001
TFPI2 tissue factor pathway inhibitor 2 -0.0269803
ATXN1 ataxin 1 -0.0265889
NAV1 neuron navigator 1 -0.0264352
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0260085
VEGFC vascular endothelial growth factor C -0.0258521
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0251597
TSC22D1 TSC22 domain family, member 1 -0.0251067
EGR1 early growth response 1 -0.0250216
MCL1 myeloid cell leukemia 1 -0.0246207
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0244286
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0243452
HMGA1 high mobility group AT-hook 1 -0.0242914
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0241262
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0235767
MACF1 microtubule-actin crosslinking factor 1 -0.0233555
TRIO trio Rho guanine nucleotide exchange factor -0.0232626
DOCK5 dedicator of cytokinesis 5 -0.0229066
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -0.0225949
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.022551
TMEM165 transmembrane protein 165 -0.0225182
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0222699
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0222623
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0219534
FLNB filamin B, beta -0.0216267
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.021543
PTK2 protein tyrosine kinase 2 -0.0215381
MYADM myeloid-associated differentiation marker -0.0213696
CDCP1 CUB domain containing protein 1 -0.0213319
BASP1 brain abundant, membrane attached signal protein 1 -0.0211777
MBNL1 muscleblind-like splicing regulator 1 -0.0211677
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.021023
SYT1 synaptotagmin I -0.0210101
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0208792
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0208004
DNAH5 dynein, axonemal, heavy chain 5 -0.0204719
NT5E 5'-nucleotidase, ecto (CD73) -0.0203488
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0202753
KLF12 Kruppel-like factor 12 -0.0202509
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0201532
NRIP1 nuclear receptor interacting protein 1 -0.0200856
RAD51B RAD51 paralog B -0.0199322
PRKCA protein kinase C, alpha -0.0193362