Palmatine (chloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.159098
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0981869
NAV1 neuron navigator 1 0.0924895
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0924198
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0903484
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.087228
FN1 fibronectin 1 0.0835249
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0815808
RSAD2 radical S-adenosyl methionine domain containing 2 0.080104
EFNA5 ephrin-A5 0.0788776
COL5A1 collagen, type V, alpha 1 0.0772711
MAP1B microtubule-associated protein 1B 0.074062
ASPH aspartate beta-hydroxylase 0.0736846
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0621221
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0606614
TRIO trio Rho guanine nucleotide exchange factor 0.0605127
VCL vinculin 0.0589608
DST dystonin 0.0586723
MACF1 microtubule-actin crosslinking factor 1 0.0583565
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0568847
DOCK5 dedicator of cytokinesis 5 0.0561842
CANX calnexin 0.0560572
EXT1 exostosin glycosyltransferase 1 0.0557021
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0553049
HDAC9 histone deacetylase 9 0.0536027
VEGFC vascular endothelial growth factor C 0.0525637
PLXNA2 plexin A2 0.0515338
RIGI RNA sensor RIG-I 0.0513007
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0507559
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.050063
TPM4 tropomyosin 4 0.0496482
FLNA filamin A, alpha 0.0491887
EGFR epidermal growth factor receptor 0.0484652
SMC4 structural maintenance of chromosomes 4 0.0476243
MBNL1 muscleblind-like splicing regulator 1 0.0474839
SAMD9 sterile alpha motif domain containing 9 0.0467977
SEPTIN9 septin 9 0.0460732
DGKG diacylglycerol kinase, gamma 90kDa 0.0456435
SLC39A11 solute carrier family 39, member 11 0.0455905
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.045134
FSTL1 follistatin-like 1 0.044127
TPM3 tropomyosin 3 0.0435505
PBX3 pre-B-cell leukemia homeobox 3 0.043433
CYTH3 cytohesin 3 0.0419835
MPRIP myosin phosphatase Rho interacting protein 0.0414643
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0410957
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0410926
CD44 CD44 molecule (Indian blood group) 0.0408308
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0407952
ANXA2 annexin A2 0.0407439
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0403036
DCLK2 doublecortin-like kinase 2 0.0402417
SP100 SP100 nuclear antigen 0.0400649
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0391716
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.038721
INTS6 integrator complex subunit 6 0.0387033
SDCCAG8 serologically defined colon cancer antigen 8 0.0382773
PDLIM5 PDZ and LIM domain 5 0.0381314
ZSWIM6 zinc finger, SWIM-type containing 6 0.038125
GLIS3 GLIS family zinc finger 3 0.0375347
ALCAM activated leukocyte cell adhesion molecule 0.0374207
PCDH7 protocadherin 7 0.0372606
MCL1 myeloid cell leukemia 1 0.036963
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0362005
RASAL2 RAS protein activator like 2 0.0361929
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0355597
CUX1 cut-like homeobox 1 0.0354677
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0349211
KIAA1549L KIAA1549-like 0.0346459
NEK7 NIMA-related kinase 7 0.0330322
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0329342
PRSS23 protease, serine, 23 0.0325411
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0322693
ANKRD11 ankyrin repeat domain 11 0.0320954
DIAPH3 diaphanous-related formin 3 0.0320421
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0319344
LRRC17 leucine rich repeat containing 17 0.031403
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0309996
MSN moesin 0.0309954
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0306862
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0305088
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0302702
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0300158
DSPP dentin sialophosphoprotein 0.0295305
FMN2 formin 2 0.0293097
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0287729
DNMBP dynamin binding protein 0.0285988
SMAD3 SMAD family member 3 0.0279924
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0277664
RRM2 ribonucleotide reductase M2 0.0277348
ERBIN erbb2 interacting protein 0.0275415
PDE4D phosphodiesterase 4D, cAMP-specific 0.0266786
TRABD2B TraB domain containing 2B 0.026226
WWTR1 WW domain containing transcription regulator 1 0.0259835
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0259196
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0259053
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0257039
ADAM9 ADAM metallopeptidase domain 9 0.0252502
LPP LIM domain containing preferred translocation partner in lipoma 0.0250553
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0250541

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.243307
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.20784
AKAP12 A kinase (PRKA) anchor protein 12 -0.142585
NDRG1 N-myc downstream regulated 1 -0.14075
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.135606
FBN1 fibrillin 1 -0.112329
DLG1 discs, large homolog 1 (Drosophila) -0.111989
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.110112
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0941103
LOXL2 lysyl oxidase-like 2 -0.0883094
COL1A2 collagen, type I, alpha 2 -0.0814715
COL3A1 collagen, type III, alpha 1 -0.0684693
SOD2 superoxide dismutase 2, mitochondrial -0.0655581
VIM vimentin -0.0619995
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.056096
PTMA prothymosin, alpha -0.055445
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0550755
GPC6 glypican 6 -0.0534295
MT2A metallothionein 2A -0.0528246
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0527353
SBF2 SET binding factor 2 -0.0523694
FTH1 ferritin, heavy polypeptide 1 -0.0517738
GOLGA4 golgin A4 -0.0498728
BHLHE40 basic helix-loop-helix family, member e40 -0.0458986
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0455851
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0449257
TMSB4X thymosin beta 4, X-linked -0.0444927
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0429708
DPYSL3 dihydropyrimidinase-like 3 -0.040231
LOX lysyl oxidase -0.0400175
ZFP36L1 ZFP36 ring finger protein-like 1 -0.039842
UBC ubiquitin C -0.0388701
ELL2 elongation factor, RNA polymerase II, 2 -0.0387742
HLA-B major histocompatibility complex, class I, B -0.0371015
STC1 stanniocalcin 1 -0.0356696
EIF1 eukaryotic translation initiation factor 1 -0.0355909
TPT1 tumor protein, translationally-controlled 1 -0.0355102
MXI1 MAX interactor 1, dimerization protein -0.0350544
RPS6 ribosomal protein S6 -0.0340579
IGFBP3 insulin-like growth factor binding protein 3 -0.0337364
KDM3A lysine (K)-specific demethylase 3A -0.0335486
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0334759
RPL35A ribosomal protein L35a -0.0332183
OPTN optineurin -0.0325315
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0320017
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0318995
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0312738
INSIG1 insulin induced gene 1 -0.0312128
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.03105
S100A6 S100 calcium binding protein A6 -0.0307877
THBS2 thrombospondin 2 -0.0306222
CD109 CD109 molecule -0.0305284
AUTS2 autism susceptibility candidate 2 -0.0294963
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0294033
GNAS GNAS complex locus -0.0288583
LRRC49 leucine rich repeat containing 49 -0.0287245
RPS24 ribosomal protein S24 -0.0285735
ATP13A3 ATPase type 13A3 -0.0285401
CSTB cystatin B (stefin B) -0.0284193
SQSTM1 sequestosome 1 -0.0283704
NAP1L1 nucleosome assembly protein 1-like 1 -0.0282925
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0278748
LMNA lamin A/C -0.0278521
OGA O-GlcNAcase -0.0278211
S100A10 S100 calcium binding protein A10 -0.0276497
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0276266
FTL ferritin, light polypeptide -0.0273299
FNIP1 folliculin interacting protein 1 -0.0271707
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0265266
RPS19 ribosomal protein S19 -0.0262432
GARS1 glycyl-tRNA synthetase 1 -0.0262077
WTAP Wilms tumor 1 associated protein -0.0262071
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0260766
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0260598
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0253925
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0250529
WDFY1 WD repeat and FYVE domain containing 1 -0.0248997
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0248262
SOX9 SRY (sex determining region Y)-box 9 -0.0246604
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0245087
C1D C1D nuclear receptor corepressor -0.0243946
PDIA3 protein disulfide isomerase family A, member 3 -0.0243222
UGCG UDP-glucose ceramide glucosyltransferase -0.0236287
CD99 CD99 molecule -0.0233095
ZNF292 zinc finger protein 292 -0.0233045
ARL4C ADP-ribosylation factor-like 4C -0.023287
PLAUR plasminogen activator, urokinase receptor -0.0231916
EPAS1 endothelial PAS domain protein 1 -0.0231675
FRMD5 FERM domain containing 5 -0.023085
TMOD1 tropomodulin 1 -0.0229202
FNDC3B fibronectin type III domain containing 3B -0.0227701
NAMPT nicotinamide phosphoribosyltransferase -0.0226858
RHOQ ras homolog family member Q -0.0224446
CLU clusterin -0.0221938
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0220306
ZBTB20 zinc finger and BTB domain containing 20 -0.0218843
HLA-E major histocompatibility complex, class I, E -0.021821
MMP12 matrix metallopeptidase 12 -0.0214958
COL6A2 collagen, type VI, alpha 2 -0.0214883
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0211879