Palmatine (chloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.196434
PDE4D phosphodiesterase 4D, cAMP-specific 0.1311
PRKG1 protein kinase, cGMP-dependent, type I 0.107069
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.105718
TSHZ2 teashirt zinc finger homeobox 2 0.0972112
CADM2 cell adhesion molecule 2 0.0888272
CTBP2 C-terminal binding protein 2 0.0872577
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0757801
FNDC3B fibronectin type III domain containing 3B 0.0632802
HMGA2 high mobility group AT-hook 2 0.0627537
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0619454
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.061838
APLP2 amyloid beta (A4) precursor-like protein 2 0.0602291
SENP6 SUMO1/sentrin specific peptidase 6 0.0596036
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0592114
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0585868
SPPL3 signal peptide peptidase like 3 0.0580959
TRIO trio Rho guanine nucleotide exchange factor 0.0530837
FLNB filamin B, beta 0.0525144
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0507603
ANKRD12 ankyrin repeat domain 12 0.0506017
VEGFA vascular endothelial growth factor A 0.0487112
ZFAND3 zinc finger, AN1-type domain 3 0.0485074
JMJD1C jumonji domain containing 1C 0.0484988
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0471314
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0467569
GMDS GDP-mannose 4,6-dehydratase 0.0454332
SMAD3 SMAD family member 3 0.0444127
KDM6A lysine (K)-specific demethylase 6A 0.0440019
SIK3 SIK family kinase 3 0.0422003
SMYD3 SET and MYND domain containing 3 0.042086
PDE10A phosphodiesterase 10A 0.0420181
BBX bobby sox homolog (Drosophila) 0.0411393
WNK1 WNK lysine deficient protein kinase 1 0.0411158
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0410447
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0410188
LPP LIM domain containing preferred translocation partner in lipoma 0.0409362
PCBP2 poly(rC) binding protein 2 0.0404544
FMNL2 formin-like 2 0.0399088
SFTPA2 surfactant protein A2 0.0398016
KMT2C lysine (K)-specific methyltransferase 2C 0.0392998
MYOF myoferlin 0.0391749
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0378648
AFF4 AF4/FMR2 family, member 4 0.0378101
FN1 fibronectin 1 0.0377413
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0377025
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0370828
PHF3 PHD finger protein 3 0.0369073
MEIS2 Meis homeobox 2 0.0368846
SH3RF1 SH3 domain containing ring finger 1 0.0366871
PARD3 par-3 family cell polarity regulator 0.0366478
UBE2H ubiquitin-conjugating enzyme E2H 0.0366153
CUX1 cut-like homeobox 1 0.036574
LCOR ligand dependent nuclear receptor corepressor 0.0364402
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0358485
FNIP1 folliculin interacting protein 1 0.0357871
PRELID2 PRELI domain containing 2 0.0352802
NFIB nuclear factor I/B 0.0351078
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0349211
THSD4 thrombospondin, type I, domain containing 4 0.0347057
OGA O-GlcNAcase 0.0344781
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0343709
MED13 mediator complex subunit 13 0.0340992
RAB7A RAB7A, member RAS oncogene family 0.0340951
GSK3B glycogen synthase kinase 3 beta 0.0337871
ZEB1 zinc finger E-box binding homeobox 1 0.0336967
ATOSA atos homolog A 0.0333427
MACF1 microtubule-actin crosslinking factor 1 0.0331585
UTRN utrophin 0.0329921
EXT1 exostosin glycosyltransferase 1 0.0329066
IGF2R insulin-like growth factor 2 receptor 0.0328896
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0327152
KDM2A lysine (K)-specific demethylase 2A 0.0326381
JARID2 jumonji, AT rich interactive domain 2 0.0323667
CANX calnexin 0.0323429
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0322774
DST dystonin 0.0320806
DSCAM Down syndrome cell adhesion molecule 0.0320037
ERBIN erbb2 interacting protein 0.0318355
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0317724
INTS6 integrator complex subunit 6 0.0315396
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0315223
ADIPOR2 adiponectin receptor 2 0.0314777
SAMD4A sterile alpha motif domain containing 4A 0.0312942
AGO3 argonaute RISC catalytic component 3 0.0310707
ANKRD17 ankyrin repeat domain 17 0.0307267
SFPQ splicing factor proline/glutamine-rich 0.030682
PANK3 pantothenate kinase 3 0.0306718
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0306454
UVRAG UV radiation resistance associated 0.0306405
LRPPRC leucine-rich pentatricopeptide repeat containing 0.030571
EXOC4 exocyst complex component 4 0.0305698
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.030536
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0305317
KMT2E lysine (K)-specific methyltransferase 2E 0.0305314
UST uronyl-2-sulfotransferase 0.030429
COL5A2 collagen, type V, alpha 2 0.030358
CLIP2 CAP-GLY domain containing linker protein 2 0.0303325
KANK1 KN motif and ankyrin repeat domains 1 0.030251
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0300486

decreased expression

Symbol Name Standardized Value
MGP matrix Gla protein -0.126455
VIM vimentin -0.10738
COL1A2 collagen, type I, alpha 2 -0.0864513
RPS6 ribosomal protein S6 -0.0855975
MT2A metallothionein 2A -0.0841917
TMSB4X thymosin beta 4, X-linked -0.0725171
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0653102
PEG10 paternally expressed 10 -0.0617203
TPT1 tumor protein, translationally-controlled 1 -0.0584512
RPL35A ribosomal protein L35a -0.0581172
MATR3 matrin 3 -0.0580349
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0569571
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0566616
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.056551
PTMA prothymosin, alpha -0.0557611
RPS8 ribosomal protein S8 -0.0528703
RPS24 ribosomal protein S24 -0.0506257
SOX4 SRY (sex determining region Y)-box 4 -0.0500141
RPLP2 ribosomal protein, large, P2 -0.0499213
DLG1 discs, large homolog 1 (Drosophila) -0.0495929
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0458842
RPLP1 ribosomal protein, large, P1 -0.0440536
IER3 immediate early response 3 -0.0418609
CALR calreticulin -0.0417216
SEPTIN11 septin 11 -0.0406847
RBM25 RNA binding motif protein 25 -0.0404346
RPS23 ribosomal protein S23 -0.0404164
TMSB10 thymosin beta 10 -0.0391045
RACK1 receptor for activated C kinase 1 -0.0388982
RPL37A ribosomal protein L37a -0.0386497
RPS12 ribosomal protein S12 -0.037952
EEF2 eukaryotic translation elongation factor 2 -0.0376763
PDIA3 protein disulfide isomerase family A, member 3 -0.037457
RPL26 ribosomal protein L26 -0.0372581
RPLP0 ribosomal protein, large, P0 -0.0369326
KPNB1 karyopherin (importin) beta 1 -0.0356102
VDAC1 voltage-dependent anion channel 1 -0.0355468
RPS27A ribosomal protein S27a -0.0353113
SET SET nuclear proto-oncogene -0.0347742
RANBP17 RAN binding protein 17 -0.0343706
RPL37 ribosomal protein L37 -0.0343544
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0343209
RPL19 ribosomal protein L19 -0.0338932
MKI67 marker of proliferation Ki-67 -0.033848
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0331646
RPL38 ribosomal protein L38 -0.0330035
PRRC2C proline-rich coiled-coil 2C -0.0330009
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0327521
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0326258
RPS29 ribosomal protein S29 -0.0321435
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0319819
RPS2 ribosomal protein S2 -0.0315923
HMGB2 high mobility group box 2 -0.0314897
RPL34 ribosomal protein L34 -0.0310207
CBX3 chromobox homolog 3 -0.0303623
RPL31 ribosomal protein L31 -0.030332
RPS20 ribosomal protein S20 -0.0294677
RPS19 ribosomal protein S19 -0.0293115
RPS4X ribosomal protein S4, X-linked -0.029244
FOXC1 forkhead box C1 -0.0290861
RSL1D1 ribosomal L1 domain containing 1 -0.0288439
RPS25 ribosomal protein S25 -0.0279605
RPL8 ribosomal protein L8 -0.0279345
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0278952
ARHGAP11A Rho GTPase activating protein 11A -0.0272975
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0272521
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0271743
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0271461
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0271169
ITGAV integrin, alpha V -0.0267021
CKAP2 cytoskeleton associated protein 2 -0.0266883
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0263195
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0261796
MARCHF6 membrane associated ring-CH-type finger 6 -0.0259037
H1-4 H1.4 linker histone, cluster member -0.0257049
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0256819
LOC112694756 uncharaterized LOC112694756 -0.0255032
S100A9 S100 calcium binding protein A9 -0.025324
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.025077
RPL5 ribosomal protein L5 -0.0249135
KIF23 kinesin family member 23 -0.0248768
RPS14 ribosomal protein S14 -0.0247917
USP3 ubiquitin specific peptidase 3 -0.0246776
LARP1 La ribonucleoprotein domain family, member 1 -0.0244397
CENPF centromere protein F, 350/400kDa -0.0243401
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -0.0236156
ARHGAP21 Rho GTPase activating protein 21 -0.0234172
REEP3 receptor accessory protein 3 -0.0232211
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -0.0229258
RPL23A ribosomal protein L23a -0.0225449
RPL6 ribosomal protein L6 -0.0225437
DSTN destrin (actin depolymerizing factor) -0.0225146
ILF3 interleukin enhancer binding factor 3, 90kDa -0.02235
WBP11 WW domain binding protein 11 -0.022343
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0221102
FTL ferritin, light polypeptide -0.0220273
HSPB1 heat shock 27kDa protein 1 -0.0220248
RPL12 ribosomal protein L12 -0.0219998
RPS5 ribosomal protein S5 -0.0219859
GOLGA4 golgin A4 -0.0219407