Palmatine (chloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.100926
CP ceruloplasmin (ferroxidase) 0.0756553
FNDC3B fibronectin type III domain containing 3B 0.0588734
MMP7 matrix metallopeptidase 7 0.0576978
AHNAK AHNAK nucleoprotein 0.0506957
PARD3 par-3 family cell polarity regulator 0.0482971
RNF213 ring finger protein 213 0.0463653
H1-0 H1.0 linker histone 0.0445482
NPEPPS aminopeptidase puromycin sensitive 0.0439096
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0437069
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0426882
NPAS2 neuronal PAS domain protein 2 0.0421982
WSB1 WD repeat and SOCS box containing 1 0.0391719
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0386281
MAML2 mastermind-like 2 (Drosophila) 0.0362051
ADAM28 ADAM metallopeptidase domain 28 0.0360161
RAD51B RAD51 paralog B 0.0356467
CCNY cyclin Y 0.0337541
LMO7 LIM domain 7 0.0306796
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0304508
PDE4D phosphodiesterase 4D, cAMP-specific 0.0301732
CEMIP cell migration inducing protein, hyaluronan binding 0.0301202
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0301199
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0301127
IFI16 interferon, gamma-inducible protein 16 0.0298367
OGA O-GlcNAcase 0.0297107
ITGA6 integrin, alpha 6 0.0294672
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.029397
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.029343
EHBP1 EH domain binding protein 1 0.0287121
BZW1 basic leucine zipper and W2 domains 1 0.0279602
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0275141
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0268641
LPP LIM domain containing preferred translocation partner in lipoma 0.0262318
NT5C2 5'-nucleotidase, cytosolic II 0.0261911
NRG3 neuregulin 3 0.0261443
MX2 MX dynamin-like GTPase 2 0.0252108
SH3KBP1 SH3-domain kinase binding protein 1 0.0248755
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0248611
LIMCH1 LIM and calponin homology domains 1 0.0244145
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0242662
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0240834
TM4SF1 transmembrane 4 L six family member 1 0.0239705
MARCHF6 membrane associated ring-CH-type finger 6 0.0237337
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0231972
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0227597
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0219093
TMEM123 transmembrane protein 123 0.0215879
ARHGAP32 Rho GTPase activating protein 32 0.0208592
IRAK3 interleukin-1 receptor-associated kinase 3 0.0208544
MAML3 mastermind-like 3 (Drosophila) 0.0201166
VCAN versican 0.0198103
ARHGAP12 Rho GTPase activating protein 12 0.0196221
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0191006
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0188577
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.018819
CD47 CD47 molecule 0.0185478
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0184216
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0181656
BAIAP2L1 BAI1-associated protein 2-like 1 0.0180559
KYNU kynureninase 0.0178145
ARHGAP26 Rho GTPase activating protein 26 0.0174798
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0174354
NCKAP5 NCK-associated protein 5 0.0173875
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0173415
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0171354
TMEM163 transmembrane protein 163 0.0170418
ANXA4 annexin A4 0.0168046
ANKRD11 ankyrin repeat domain 11 0.0165654
TGM2 transglutaminase 2 0.0165434
STRN3 striatin, calmodulin binding protein 3 0.0163077
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.016083
ATG7 autophagy related 7 0.0156562
BCAS3 breast carcinoma amplified sequence 3 0.0156012
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0155204
ANTXR2 anthrax toxin receptor 2 0.015309
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0152814
DAPK1 death-associated protein kinase 1 0.0152488
EXOC4 exocyst complex component 4 0.0152373
ITGA1 integrin, alpha 1 0.0152134
HDAC4 histone deacetylase 4 0.0152084
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0151369
BICC1 BicC family RNA binding protein 1 0.0150868
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0150377
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0150369
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0149116
IFI44L interferon-induced protein 44-like 0.0149072
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0148971
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0148665
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0148592
USP3 ubiquitin specific peptidase 3 0.0147942
NRP1 neuropilin 1 0.0147093
FOXP1 forkhead box P1 0.0145087
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0144698
NRG1 neuregulin 1 0.0143553
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0142872
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0142251
ADGRG6 adhesion G protein-coupled receptor G6 0.0140455
PRELID2 PRELI domain containing 2 0.0139924
STAU1 staufen double-stranded RNA binding protein 1 0.0139878

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.192506
EIF1 eukaryotic translation initiation factor 1 -0.190345
MT2A metallothionein 2A -0.17366
ACTG1 actin gamma 1 -0.150125
NDRG1 N-myc downstream regulated 1 -0.143671
TMSB10 thymosin beta 10 -0.132155
POTEF POTE ankyrin domain family, member F -0.120627
TMSB4X thymosin beta 4, X-linked -0.0968761
PTMA prothymosin, alpha -0.0965177
B2M beta-2-microglobulin -0.0926089
LOC112694756 uncharaterized LOC112694756 -0.0915593
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.082939
RPS2 ribosomal protein S2 -0.077513
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0756911
ASPH aspartate beta-hydroxylase -0.0715051
PKM pyruvate kinase, muscle -0.0707916
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0681655
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0671
HMGA1 high mobility group AT-hook 1 -0.0654312
RPL19 ribosomal protein L19 -0.0651367
UBC ubiquitin C -0.0643401
HLA-B major histocompatibility complex, class I, B -0.0637763
RPS8 ribosomal protein S8 -0.0634632
PLAU plasminogen activator, urokinase -0.0632579
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0627015
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0625176
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0578832
RPL23 ribosomal protein L23 -0.0575305
BRD2 bromodomain containing 2 -0.0565408
CDCP1 CUB domain containing protein 1 -0.056033
RPS3 ribosomal protein S3 -0.0551994
HLA-A major histocompatibility complex, class I, A -0.0536041
RPL11 ribosomal protein L11 -0.0521494
KLF6 Kruppel-like factor 6 -0.0520639
RPL37A ribosomal protein L37a -0.0514227
RACK1 receptor for activated C kinase 1 -0.0513759
LAMC2 laminin, gamma 2 -0.050845
PPARD peroxisome proliferator-activated receptor delta -0.0508177
VIM vimentin -0.0505048
MCTP1 multiple C2 domains, transmembrane 1 -0.0492538
S100A10 S100 calcium binding protein A10 -0.0492474
RPS29 ribosomal protein S29 -0.0490015
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0486896
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.048467
AKAP12 A kinase (PRKA) anchor protein 12 -0.0465625
VEGFA vascular endothelial growth factor A -0.0462801
JMJD1C jumonji domain containing 1C -0.0454629
RPL5 ribosomal protein L5 -0.0443977
FTL ferritin, light polypeptide -0.0443831
SPAG9 sperm associated antigen 9 -0.0439737
RPS12 ribosomal protein S12 -0.0438658
S100A6 S100 calcium binding protein A6 -0.0436766
RPS19 ribosomal protein S19 -0.0435806
DDIT4 DNA-damage-inducible transcript 4 -0.0430262
TNIP1 TNFAIP3 interacting protein 1 -0.0421377
MYO1E myosin IE -0.041588
MYH9 myosin, heavy chain 9, non-muscle -0.0413171
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0408195
RPS17 ribosomal protein S17 -0.0404745
LAMB3 laminin, beta 3 -0.0403636
KTN1 kinectin 1 (kinesin receptor) -0.0395228
RPLP1 ribosomal protein, large, P1 -0.0386369
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0386168
F3 coagulation factor III (thromboplastin, tissue factor) -0.0383054
LMNA lamin A/C -0.0382604
GLS2 glutaminase 2 (liver, mitochondrial) -0.0378618
KMT2E lysine (K)-specific methyltransferase 2E -0.0377586
DSCAM Down syndrome cell adhesion molecule -0.0375635
ISG15 ISG15 ubiquitin-like modifier -0.0368699
LDHA lactate dehydrogenase A -0.0366795
CCNL1 cyclin L1 -0.0365965
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0352782
DENND4A DENN/MADD domain containing 4A -0.0351521
EZR ezrin -0.0347007
RPS27A ribosomal protein S27a -0.0346337
RPL9 ribosomal protein L9 -0.0342713
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0339579
RPS23 ribosomal protein S23 -0.0337996
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0334773
YBX1 Y box binding protein 1 -0.0331867
RPL31 ribosomal protein L31 -0.0331305
CLTC clathrin, heavy chain (Hc) -0.0331021
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0328927
SYNRG synergin, gamma -0.0328569
RAB7A RAB7A, member RAS oncogene family -0.0328508
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0327374
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0323696
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0322463
RPS6 ribosomal protein S6 -0.0322122
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0320568
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0318028
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0317168
MACC1 metastasis associated in colon cancer 1 -0.0315007
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.031421
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0312661
DSTN destrin (actin depolymerizing factor) -0.0312321
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0306265
TPM3 tropomyosin 3 -0.0305293
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0304758
RPS21 ribosomal protein S21 -0.0302644