Palmatine (chloride)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.205257
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.19331
SPTBN1 spectrin, beta, non-erythrocytic 1 0.142228
SMAD3 SMAD family member 3 0.113655
MYO1E myosin IE 0.106438
VCL vinculin 0.0984885
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0974483
MACC1 metastasis associated in colon cancer 1 0.0954565
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0887346
RUNX1 runt-related transcription factor 1 0.0841542
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0766935
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0758588
ITGA6 integrin, alpha 6 0.0751702
EXT1 exostosin glycosyltransferase 1 0.0675239
EFNB2 ephrin-B2 0.0671546
STK24 serine/threonine kinase 24 0.0661124
ANXA2 annexin A2 0.063941
RNF213 ring finger protein 213 0.0581459
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0521566
SQSTM1 sequestosome 1 0.0511652
ETV6 ets variant 6 0.04996
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0481255
AREG amphiregulin 0.0471422
TJP1 tight junction protein 1 0.0458811
LCN2 lipocalin 2 0.0456094
ATP11A ATPase, class VI, type 11A 0.0446245
CTBP2 C-terminal binding protein 2 0.0444947
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0440454
EPHB2 EPH receptor B2 0.0428394
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0421019
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0420031
CEMIP cell migration inducing protein, hyaluronan binding 0.0411286
MSI2 musashi RNA-binding protein 2 0.0411081
DSCAM Down syndrome cell adhesion molecule 0.0407931
ARHGAP26 Rho GTPase activating protein 26 0.0400944
MACF1 microtubule-actin crosslinking factor 1 0.0399707
KYNU kynureninase 0.0395444
SHB Src homology 2 domain containing adaptor protein B 0.0394667
MX1 MX dynamin-like GTPase 1 0.0386097
FAT1 FAT atypical cadherin 1 0.0385618
AKAP13 A kinase (PRKA) anchor protein 13 0.0383756
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0380543
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0379792
MYH9 myosin, heavy chain 9, non-muscle 0.0376522
YAP1 Yes-associated protein 1 0.0369046
DUSP16 dual specificity phosphatase 16 0.0368523
INTS6 integrator complex subunit 6 0.0365948
ACTN4 actinin, alpha 4 0.0363791
EZR ezrin 0.0362772
TOX3 TOX high mobility group box family member 3 0.0357346
MEIS2 Meis homeobox 2 0.0355902
GMDS GDP-mannose 4,6-dehydratase 0.0352219
VMP1 vacuole membrane protein 1 0.0350275
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0349103
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0348242
TUFT1 tuftelin 1 0.0342953
RNF43 ring finger protein 43 0.0337851
PDLIM5 PDZ and LIM domain 5 0.0335696
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0332826
CATSPERB catsper channel auxiliary subunit beta 0.0332755
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0326196
MECOM MDS1 and EVI1 complex locus 0.0310021
ADAM10 ADAM metallopeptidase domain 10 0.0309037
LURAP1L leucine rich adaptor protein 1-like 0.03059
EPS8 epidermal growth factor receptor pathway substrate 8 0.0303652
RDH10 retinol dehydrogenase 10 (all-trans) 0.0301498
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0301465
ATP10B ATPase, class V, type 10B 0.030086
MAN1A1 mannosidase, alpha, class 1A, member 1 0.029089
KIAA1217 KIAA1217 0.0290566
ABHD2 abhydrolase domain containing 2 0.0287817
LPP LIM domain containing preferred translocation partner in lipoma 0.0283418
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0281843
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0278965
RIGI RNA sensor RIG-I 0.0278381
DPP4 dipeptidyl-peptidase 4 0.0267977
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0266959
BCL2L1 BCL2-like 1 0.0265959
GCLC glutamate-cysteine ligase, catalytic subunit 0.0265679
FNIP2 folliculin interacting protein 2 0.026427
EREG epiregulin 0.0252852
TC2N tandem C2 domains, nuclear 0.0249642
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0248763
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0244497
ARGLU1 arginine and glutamate rich 1 0.0243764
DOCK1 dedicator of cytokinesis 1 0.0243009
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0241748
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0241045
TRIM2 tripartite motif containing 2 0.0239224
SMYD3 SET and MYND domain containing 3 0.0238629
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0238453
MYO5B myosin VB 0.0238183
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.023642
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0235123
SEPTIN9 septin 9 0.0234875
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0.0232624
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.0231948
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0231912
FHL2 four and a half LIM domains 2 0.0231619
APLP2 amyloid beta (A4) precursor-like protein 2 0.0231234

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.172652
NDRG1 N-myc downstream regulated 1 -0.107933
LYZ lysozyme -0.105913
PTMA prothymosin, alpha -0.0923024
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.088022
HLA-B major histocompatibility complex, class I, B -0.0841193
ZMYND8 zinc finger, MYND-type containing 8 -0.0802908
EGR1 early growth response 1 -0.0784775
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0770678
RPL35A ribosomal protein L35a -0.0673623
PHF3 PHD finger protein 3 -0.0673018
MBNL2 muscleblind-like splicing regulator 2 -0.0638808
RPS6 ribosomal protein S6 -0.0636931
IGFBP3 insulin-like growth factor binding protein 3 -0.0633991
FTL ferritin, light polypeptide -0.0619068
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0599675
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0552784
EIF1 eukaryotic translation initiation factor 1 -0.0548655
TMSB10 thymosin beta 10 -0.05421
GOLGB1 golgin B1 -0.0540856
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0535121
MUC20 mucin 20, cell surface associated -0.0520921
B2M beta-2-microglobulin -0.051144
PKM pyruvate kinase, muscle -0.0477668
UBC ubiquitin C -0.0460805
RPL34 ribosomal protein L34 -0.0450321
TXNIP thioredoxin interacting protein -0.0438783
HM13 histocompatibility (minor) 13 -0.0431125
LOC112694756 uncharaterized LOC112694756 -0.0414916
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0414902
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0398002
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0391432
RPL23 ribosomal protein L23 -0.0390022
NPSR1 neuropeptide S receptor 1 -0.0388476
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0380259
GNAS GNAS complex locus -0.0376066
TM9SF3 transmembrane 9 superfamily member 3 -0.0369258
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0363386
PDIA3 protein disulfide isomerase family A, member 3 -0.0357972
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0352608
AHI1 Abelson helper integration site 1 -0.035219
RAB7A RAB7A, member RAS oncogene family -0.0350423
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0346222
MPHOSPH8 M-phase phosphoprotein 8 -0.0343903
SRRM2 serine/arginine repetitive matrix 2 -0.0343437
SLC38A1 solute carrier family 38, member 1 -0.0321955
RPS19 ribosomal protein S19 -0.0315402
RPL26 ribosomal protein L26 -0.0314679
TM4SF19 transmembrane 4 L six family member 19 -0.0310108
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0309579
HLA-E major histocompatibility complex, class I, E -0.0307964
TTC3 tetratricopeptide repeat domain 3 -0.030584
MT2A metallothionein 2A -0.0304481
RPS24 ribosomal protein S24 -0.030169
WDR45B WD repeat domain 45B -0.0299348
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0291985
ARF1 ADP-ribosylation factor 1 -0.029053
ATF4 activating transcription factor 4 -0.0286271
GCC2 GRIP and coiled-coil domain containing 2 -0.0282561
GOLGA4 golgin A4 -0.02784
CSTB cystatin B (stefin B) -0.0275971
VDAC1 voltage-dependent anion channel 1 -0.0274812
COG6 component of oligomeric golgi complex 6 -0.0273413
PGK1 phosphoglycerate kinase 1 -0.0271592
SERF2 small EDRK-rich factor 2 -0.0271304
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0268843
UFM1 ubiquitin-fold modifier 1 -0.0268334
H1-0 H1.0 linker histone -0.0266284
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0265453
RPLP1 ribosomal protein, large, P1 -0.0264755
RPL11 ribosomal protein L11 -0.0259478
RRBP1 ribosome binding protein 1 -0.0254968
XAF1 XIAP associated factor 1 -0.0253089
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.024872
COPA coatomer protein complex, subunit alpha -0.0248664
FNDC3A fibronectin type III domain containing 3A -0.024551
MORF4L2 mortality factor 4 like 2 -0.024536
CTSD cathepsin D -0.0244266
S100A10 S100 calcium binding protein A10 -0.0242941
EPCAM epithelial cell adhesion molecule -0.0242562
GOLPH3L golgi phosphoprotein 3-like -0.0238915
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.023857
JUN jun proto-oncogene -0.0238472
ENO1 enolase 1, (alpha) -0.0237401
SEC24D SEC24 family member D -0.0237173
TMSB4X thymosin beta 4, X-linked -0.0235628
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0235564
HLA-C major histocompatibility complex, class I, C -0.0235292
RPS13 ribosomal protein S13 -0.0234173
FNDC3B fibronectin type III domain containing 3B -0.02324
TM9SF2 transmembrane 9 superfamily member 2 -0.023118
RPL31 ribosomal protein L31 -0.0230933
FNIP1 folliculin interacting protein 1 -0.0230151
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0228915
S100A6 S100 calcium binding protein A6 -0.022766
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0226867
TAOK3 TAO kinase 3 -0.0224223
F11R F11 receptor -0.0223971
RPL19 ribosomal protein L19 -0.022154
RPL37 ribosomal protein L37 -0.0220342