Palmatine (chloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.223638
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.180338
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.112987
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.107065
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.103187
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.096145
TENM3 teneurin transmembrane protein 3 0.094657
APLP2 amyloid beta (A4) precursor-like protein 2 0.0917863
RRM2 ribonucleotide reductase M2 0.076107
PCBP2 poly(rC) binding protein 2 0.0718837
INTS6 integrator complex subunit 6 0.0694594
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0674267
ZSWIM6 zinc finger, SWIM-type containing 6 0.0641495
WWOX WW domain containing oxidoreductase 0.0604763
SMYD3 SET and MYND domain containing 3 0.0588982
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0517538
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0509413
CEMIP2 cell migration inducing hyaluronidase 2 0.0474961
FHIT fragile histidine triad 0.046764
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0466745
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0462465
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0457712
RAB7A RAB7A, member RAS oncogene family 0.0456705
FLNA filamin A, alpha 0.0441307
CANX calnexin 0.042827
SFPQ splicing factor proline/glutamine-rich 0.0412412
TXNRD1 thioredoxin reductase 1 0.0411227
RAD51B RAD51 paralog B 0.0404304
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0400628
VCL vinculin 0.0398804
DIAPH3 diaphanous-related formin 3 0.0397175
TPI1 triosephosphate isomerase 1 0.0396806
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0390656
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0386669
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.038046
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0380216
TRAPPC9 trafficking protein particle complex 9 0.0378429
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0371483
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0368648
ATXN1 ataxin 1 0.0366047
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.036498
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0361277
SGMS2 sphingomyelin synthase 2 0.0359927
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0356512
TRA2B transformer 2 beta homolog (Drosophila) 0.0356189
ARID1B AT rich interactive domain 1B (SWI1-like) 0.035461
MCL1 myeloid cell leukemia 1 0.0354123
DSCAM Down syndrome cell adhesion molecule 0.0353975
GPHN gephyrin 0.0353867
EXT1 exostosin glycosyltransferase 1 0.0353387
SMC4 structural maintenance of chromosomes 4 0.0351715
TPM3 tropomyosin 3 0.035083
KDM4C lysine (K)-specific demethylase 4C 0.0350734
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0348845
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0345417
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0343566
CSNK1A1 casein kinase 1, alpha 1 0.0337379
ATAD2 ATPase family, AAA domain containing 2 0.0334023
EXOC6B exocyst complex component 6B 0.0329814
DOCK5 dedicator of cytokinesis 5 0.0329517
TJP1 tight junction protein 1 0.0327998
SAMD4A sterile alpha motif domain containing 4A 0.0325032
YBX1 Y box binding protein 1 0.0324987
FUS FUS RNA binding protein 0.0322365
TBC1D5 TBC1 domain family, member 5 0.0318436
HSPA8 heat shock 70kDa protein 8 0.0313668
PRELID2 PRELI domain containing 2 0.0312434
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0312138
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0309252
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0306431
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0306035
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0304875
POTEF POTE ankyrin domain family, member F 0.0304857
WNK1 WNK lysine deficient protein kinase 1 0.030223
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0299508
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0298716
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.02958
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0294565
DIAPH1 diaphanous-related formin 1 0.0293092
WWC1 WW and C2 domain containing 1 0.0290948
MKI67 marker of proliferation Ki-67 0.0290169
MYH9 myosin, heavy chain 9, non-muscle 0.028542
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0284459
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0283974
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0283958
CEP128 centrosomal protein 128kDa 0.0282364
ANXA2 annexin A2 0.0278425
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0277017
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0276712
PTPRK protein tyrosine phosphatase, receptor type, K 0.0276091
TRIP12 thyroid hormone receptor interactor 12 0.0275302
PDLIM5 PDZ and LIM domain 5 0.0274988
SUMF1 sulfatase modifying factor 1 0.0274772
KTN1 kinectin 1 (kinesin receptor) 0.0273869
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0271818
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0271391
ZFAND3 zinc finger, AN1-type domain 3 0.0270392
PDIA4 protein disulfide isomerase family A, member 4 0.0268857
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0266036
PTK2 protein tyrosine kinase 2 0.0265705

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.302523
TMSB10 thymosin beta 10 -0.133083
ERRFI1 ERBB receptor feedback inhibitor 1 -0.131228
TPT1 tumor protein, translationally-controlled 1 -0.126668
PTMA prothymosin, alpha -0.101904
AHNAK AHNAK nucleoprotein -0.0988802
RPS6 ribosomal protein S6 -0.0880447
RPL35A ribosomal protein L35a -0.0827593
ZNF292 zinc finger protein 292 -0.0528305
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0481689
TBC1D22A TBC1 domain family, member 22A -0.0452749
MXI1 MAX interactor 1, dimerization protein -0.0437778
NPEPPS aminopeptidase puromycin sensitive -0.0423775
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0414321
S100A6 S100 calcium binding protein A6 -0.0405874
RPL4 ribosomal protein L4 -0.0398988
RPL34 ribosomal protein L34 -0.0392522
HMGA1 high mobility group AT-hook 1 -0.0377946
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0373521
HMGA2 high mobility group AT-hook 2 -0.0372324
TPM4 tropomyosin 4 -0.0370071
BACE2 beta-site APP-cleaving enzyme 2 -0.0369382
RPL26 ribosomal protein L26 -0.0367051
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0351905
RPS27A ribosomal protein S27a -0.0344399
RSL1D1 ribosomal L1 domain containing 1 -0.0339171
RPL37A ribosomal protein L37a -0.0339089
HLA-A major histocompatibility complex, class I, A -0.0338667
RPS19 ribosomal protein S19 -0.0334436
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0329859
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0325848
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.032466
RBM25 RNA binding motif protein 25 -0.0323655
CDCP1 CUB domain containing protein 1 -0.0321958
KDM7A lysine (K)-specific demethylase 7A -0.0315165
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0312611
ITGB4 integrin, beta 4 -0.0305676
RPS25 ribosomal protein S25 -0.0304977
ESYT2 extended synaptotagmin-like protein 2 -0.0303794
PGK1 phosphoglycerate kinase 1 -0.0302744
VEGFA vascular endothelial growth factor A -0.0296938
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0295221
CCND1 cyclin D1 -0.0294796
SERINC5 serine incorporator 5 -0.0286829
FTL ferritin, light polypeptide -0.0286706
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0284121
RPS16 ribosomal protein S16 -0.0276955
HLA-B major histocompatibility complex, class I, B -0.0270915
FAM117B family with sequence similarity 117, member B -0.0262202
PLAUR plasminogen activator, urokinase receptor -0.0259255
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0253994
KLF6 Kruppel-like factor 6 -0.0253637
CD2AP CD2-associated protein -0.0250098
RPL8 ribosomal protein L8 -0.0249546
FBXL2 F-box and leucine-rich repeat protein 2 -0.0248142
LOC112694756 uncharaterized LOC112694756 -0.0245487
SCARB1 scavenger receptor class B, member 1 -0.024277
RPL32 ribosomal protein L32 -0.0234792
UBC ubiquitin C -0.0231469
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.022993
RPS8 ribosomal protein S8 -0.0228743
GOLGA4 golgin A4 -0.022786
RPL5 ribosomal protein L5 -0.0226633
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0226555
HOOK2 hook microtubule-tethering protein 2 -0.0225408
RAB5A RAB5A, member RAS oncogene family -0.0224262
RPL37 ribosomal protein L37 -0.0223177
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0220441
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0219839
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0219257
IFITM3 interferon induced transmembrane protein 3 -0.0219
FAM114A1 family with sequence similarity 114, member A1 -0.021835
EEF2 eukaryotic translation elongation factor 2 -0.0216832
DOCK6 dedicator of cytokinesis 6 -0.021568
RPL31 ribosomal protein L31 -0.0215169
RACK1 receptor for activated C kinase 1 -0.0214519
ASTN2 astrotactin 2 -0.0214408
RPS17 ribosomal protein S17 -0.0211765
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0210601
WASF2 WAS protein family, member 2 -0.0210426
ZNF395 zinc finger protein 395 -0.0210343
RPS24 ribosomal protein S24 -0.0208609
PERP PERP, TP53 apoptosis effector -0.0204602
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0203736
RPL7A ribosomal protein L7a -0.0203425
HLA-E major histocompatibility complex, class I, E -0.0203325
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.020196
HMGB1 high mobility group box 1 -0.0201754
PKM pyruvate kinase, muscle -0.0199602
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0199538
RPLP0 ribosomal protein, large, P0 -0.0198945
RPLP2 ribosomal protein, large, P2 -0.0196131
YEATS2 YEATS domain containing 2 -0.0194642
SINHCAF SIN3-HDAC complex associated factor -0.0194491
RPL36A ribosomal protein L36a -0.0191881
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0191302
PKP2 plakophilin 2 -0.0191088
RPL38 ribosomal protein L38 -0.0191
FLNB filamin B, beta -0.0189486
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0188195