Palmatine (chloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0999506
SEPTIN9 septin 9 0.088957
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0777387
ANXA2 annexin A2 0.0633688
FN1 fibronectin 1 0.0623353
MYH9 myosin, heavy chain 9, non-muscle 0.0581223
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0573641
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.051161
PLEC plectin 0.0502265
COL6A3 collagen, type VI, alpha 3 0.0494435
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0482705
DST dystonin 0.0460083
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0453647
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0436947
LDHA lactate dehydrogenase A 0.0424268
HSPA8 heat shock 70kDa protein 8 0.0377452
ENO1 enolase 1, (alpha) 0.0360043
VCL vinculin 0.0357654
BICD1 bicaudal D homolog 1 (Drosophila) 0.0356706
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0356134
CD44 CD44 molecule (Indian blood group) 0.0324719
CANX calnexin 0.0321483
ZBTB38 zinc finger and BTB domain containing 38 0.0313597
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.031321
FLNA filamin A, alpha 0.0308372
SPTBN1 spectrin, beta, non-erythrocytic 1 0.029736
TPM3 tropomyosin 3 0.0293019
DNMBP dynamin binding protein 0.0279712
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0276393
VMP1 vacuole membrane protein 1 0.0271739
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0269595
RRM2 ribonucleotide reductase M2 0.0264276
MSN moesin 0.0262292
SMAD3 SMAD family member 3 0.0256999
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0249716
BZW1 basic leucine zipper and W2 domains 1 0.0248664
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0243634
NFE2L1 nuclear factor, erythroid 2-like 1 0.0234443
SPRED2 sprouty-related, EVH1 domain containing 2 0.0233224
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0228799
GLIS3 GLIS family zinc finger 3 0.0227321
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0225697
MPRIP myosin phosphatase Rho interacting protein 0.0221889
WWOX WW domain containing oxidoreductase 0.0220574
TNIP1 TNFAIP3 interacting protein 1 0.0218909
APLP2 amyloid beta (A4) precursor-like protein 2 0.0217954
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.0217858
CLTC clathrin, heavy chain (Hc) 0.0205317
WWTR1 WW domain containing transcription regulator 1 0.0200492
JAG1 jagged 1 0.0199114
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0191779
FAT1 FAT atypical cadherin 1 0.0190727
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0183325
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0183323
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0178883
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.017147
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0171183
TXNRD1 thioredoxin reductase 1 0.0166337
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0165261
SMC1A structural maintenance of chromosomes 1A 0.0164625
TGM2 transglutaminase 2 0.0161726
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0160657
MLPH melanophilin 0.0159626
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0159458
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0157672
RBBP7 retinoblastoma binding protein 7 0.0157259
TMED2 transmembrane emp24 domain trafficking protein 2 0.0150247
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0149801
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0149764
ICAM1 intercellular adhesion molecule 1 0.0149148
VEGFC vascular endothelial growth factor C 0.0146853
SMYD3 SET and MYND domain containing 3 0.0145632
ANKRD36 ankyrin repeat domain 36 0.0143959
RAD51B RAD51 paralog B 0.0142833
YBX1 Y box binding protein 1 0.0141006
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0139866
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0139173
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0139005
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.0138789
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0134865
RND3 Rho family GTPase 3 0.0134709
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0134131
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0134082
ECE1 endothelin converting enzyme 1 0.0133823
RPS2 ribosomal protein S2 0.01328
SVIL supervillin 0.0131615
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0130218
WNK1 WNK lysine deficient protein kinase 1 0.0129452
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0128042
ANXA5 annexin A5 0.012735
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0127169
PALLD palladin, cytoskeletal associated protein 0.0126108
APP amyloid beta (A4) precursor protein 0.0125869
PDLIM5 PDZ and LIM domain 5 0.0125226
CAPRIN2 caprin family member 2 0.0124423
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0123851
CALU calumenin 0.0122905
SLIT2 slit homolog 2 (Drosophila) 0.012199
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0121956
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0120959

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.380449
TMSB10 thymosin beta 10 -0.235682
IGF2 insulin-like growth factor 2 -0.161551
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139043
NDRG1 N-myc downstream regulated 1 -0.137584
MT2A metallothionein 2A -0.132458
PTMA prothymosin, alpha -0.0824182
COL6A2 collagen, type VI, alpha 2 -0.0811811
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0811167
CDH13 cadherin 13 -0.0784985
TPT1 tumor protein, translationally-controlled 1 -0.0726361
ASPH aspartate beta-hydroxylase -0.0713283
INHBA inhibin, beta A -0.0679956
ACTG1 actin gamma 1 -0.0664644
HMGA2 high mobility group AT-hook 2 -0.0660664
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0651889
COL6A1 collagen, type VI, alpha 1 -0.0637905
RPS6 ribosomal protein S6 -0.055108
RPL35A ribosomal protein L35a -0.0513193
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.047885
COL1A1 collagen, type I, alpha 1 -0.0471671
CDCP1 CUB domain containing protein 1 -0.0445941
ANKRD12 ankyrin repeat domain 12 -0.0429192
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0419502
S100A10 S100 calcium binding protein A10 -0.0418887
RPL32 ribosomal protein L32 -0.0417467
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0416933
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0415553
RPS19 ribosomal protein S19 -0.0409164
GNAS GNAS complex locus -0.0408726
CCND1 cyclin D1 -0.040759
LAMB3 laminin, beta 3 -0.0395551
EGR1 early growth response 1 -0.0388503
EIF1 eukaryotic translation initiation factor 1 -0.0388066
RPS24 ribosomal protein S24 -0.0383494
LOX lysyl oxidase -0.0380015
STC1 stanniocalcin 1 -0.0379489
IGFBP4 insulin-like growth factor binding protein 4 -0.0366257
RPS8 ribosomal protein S8 -0.0357534
RPL34 ribosomal protein L34 -0.0356293
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0348476
CLMP CXADR-like membrane protein -0.0346157
RPLP2 ribosomal protein, large, P2 -0.0329068
P4HB prolyl 4-hydroxylase, beta polypeptide -0.032497
RPL28 ribosomal protein L28 -0.0312643
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0308921
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0303294
MT1X metallothionein 1X -0.0297256
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0296545
MAML3 mastermind-like 3 (Drosophila) -0.0295273
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0295142
RPS13 ribosomal protein S13 -0.029174
PLAUR plasminogen activator, urokinase receptor -0.0290595
ENO2 enolase 2 (gamma, neuronal) -0.0289226
RPL9 ribosomal protein L9 -0.0286831
TGFBI transforming growth factor, beta-induced, 68kDa -0.0284066
TM4SF1 transmembrane 4 L six family member 1 -0.0279889
RPS21 ribosomal protein S21 -0.0276779
ANKRD11 ankyrin repeat domain 11 -0.0275139
ELL2 elongation factor, RNA polymerase II, 2 -0.027471
FRMD4A FERM domain containing 4A -0.0270534
MRC2 mannose receptor, C type 2 -0.0269059
BTG1 B-cell translocation gene 1, anti-proliferative -0.0268925
RPL36A ribosomal protein L36a -0.0268544
JARID2 jumonji, AT rich interactive domain 2 -0.02659
RPL8 ribosomal protein L8 -0.0265227
RPL37A ribosomal protein L37a -0.0264716
FTL ferritin, light polypeptide -0.0263635
RRBP1 ribosome binding protein 1 -0.0262898
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0261683
RPS23 ribosomal protein S23 -0.0257707
PRSS23 protease, serine, 23 -0.0257023
ASTN2 astrotactin 2 -0.0256066
RPLP1 ribosomal protein, large, P1 -0.0255459
ZMYND8 zinc finger, MYND-type containing 8 -0.0252379
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0250458
S100A9 S100 calcium binding protein A9 -0.0247921
RPS27A ribosomal protein S27a -0.0246756
RPL11 ribosomal protein L11 -0.0246027
RPS14 ribosomal protein S14 -0.0242109
MYO10 myosin X -0.0239682
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0233904
WSB1 WD repeat and SOCS box containing 1 -0.0233231
RPL31 ribosomal protein L31 -0.0228642
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0228481
RPL19 ribosomal protein L19 -0.0227985
RPL37 ribosomal protein L37 -0.0226485
HMGA1 high mobility group AT-hook 1 -0.0225051
DLG1 discs, large homolog 1 (Drosophila) -0.0222667
RPL23 ribosomal protein L23 -0.0219979
RPS3 ribosomal protein S3 -0.0218405
ANTXR2 anthrax toxin receptor 2 -0.0214874
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0212713
RPL12 ribosomal protein L12 -0.0205445
UGCG UDP-glucose ceramide glucosyltransferase -0.0204856
RPS17 ribosomal protein S17 -0.0204182
PRRC2C proline-rich coiled-coil 2C -0.0202775
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0201668
RPL36 ribosomal protein L36 -0.0201516
RPS16 ribosomal protein S16 -0.0199467