Palmatine (chloride)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.266923
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.174187
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.109372
COL6A3 collagen, type VI, alpha 3 0.0906442
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0776132
TRIO trio Rho guanine nucleotide exchange factor 0.0761208
CD44 CD44 molecule (Indian blood group) 0.0759932
MYO10 myosin X 0.064124
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0632758
WWTR1 WW domain containing transcription regulator 1 0.061518
FTH1 ferritin, heavy polypeptide 1 0.0593864
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0553274
FNDC3B fibronectin type III domain containing 3B 0.0531361
GLIS3 GLIS family zinc finger 3 0.0512555
RUNX1 runt-related transcription factor 1 0.0487569
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0483639
ADAM12 ADAM metallopeptidase domain 12 0.0420494
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0412889
ZBTB38 zinc finger and BTB domain containing 38 0.0405416
LDHA lactate dehydrogenase A 0.0402599
FAT1 FAT atypical cadherin 1 0.0363993
ECE1 endothelin converting enzyme 1 0.0358287
VCAN versican 0.0349296
MYH9 myosin, heavy chain 9, non-muscle 0.0344192
SMAD3 SMAD family member 3 0.0336297
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0322611
EXT1 exostosin glycosyltransferase 1 0.0317579
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0315159
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0314456
JAG1 jagged 1 0.0311396
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0310874
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0310145
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0308205
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.030732
IL6ST interleukin 6 signal transducer 0.0303202
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0301847
LTBP1 latent transforming growth factor beta binding protein 1 0.0293185
NAV1 neuron navigator 1 0.0277953
MSN moesin 0.0274361
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0272618
RIGI RNA sensor RIG-I 0.0272102
EGFR epidermal growth factor receptor 0.0267706
GRB10 growth factor receptor-bound protein 10 0.0266937
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252682
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0248715
ATXN1 ataxin 1 0.0246458
NALF1 NALCN channel auxiliary factor 1 0.0241218
HAS2 hyaluronan synthase 2 0.0237145
SDC2 syndecan 2 0.0233374
TPM1 tropomyosin 1 (alpha) 0.0229686
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0229648
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0229263
ADAM19 ADAM metallopeptidase domain 19 0.0228872
ARRDC3 arrestin domain containing 3 0.0227332
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0223412
SOD2 superoxide dismutase 2, mitochondrial 0.0221299
RICTOR RPTOR independent companion of MTOR, complex 2 0.0219521
EPHB1 EPH receptor B1 0.0218211
CSF1 colony stimulating factor 1 (macrophage) 0.0215681
ASPH aspartate beta-hydroxylase 0.0213348
ANXA5 annexin A5 0.02126
ALCAM activated leukocyte cell adhesion molecule 0.0209348
VCL vinculin 0.0208459
CNTN5 contactin 5 0.0206501
COL5A1 collagen, type V, alpha 1 0.0203144
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.020128
HDAC9 histone deacetylase 9 0.0199197
NOTCH2 notch 2 0.0198089
STK38L serine/threonine kinase 38 like 0.0195219
ADAM9 ADAM metallopeptidase domain 9 0.0194219
MED13L mediator complex subunit 13-like 0.0193852
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0189442
SETBP1 SET binding protein 1 0.0186421
FBXL7 F-box and leucine-rich repeat protein 7 0.0186227
VEGFA vascular endothelial growth factor A 0.0185816
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0183476
FLNA filamin A, alpha 0.0182966
WWOX WW domain containing oxidoreductase 0.01774
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0176799
ZBTB20 zinc finger and BTB domain containing 20 0.017422
ZNF644 zinc finger protein 644 0.0173495
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0172858
PTK2 protein tyrosine kinase 2 0.0170711
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0169429
ITGAV integrin, alpha V 0.0169214
SVIL supervillin 0.0167894
ADAM17 ADAM metallopeptidase domain 17 0.0166109
SQSTM1 sequestosome 1 0.0165612
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0164864
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0163395
TNIP1 TNFAIP3 interacting protein 1 0.016337
MACF1 microtubule-actin crosslinking factor 1 0.0163082
RSAD2 radical S-adenosyl methionine domain containing 2 0.0162299
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.016092
TNS1 tensin 1 0.0160773
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0159986
SPRED2 sprouty-related, EVH1 domain containing 2 0.0159218
ANO6 anoctamin 6 0.015635
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0154338
SEPTIN9 septin 9 0.0152414

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.164832
COL1A1 collagen, type I, alpha 1 -0.16248
NDRG1 N-myc downstream regulated 1 -0.156442
TIMP3 TIMP metallopeptidase inhibitor 3 -0.12566
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.114995
TMSB10 thymosin beta 10 -0.111101
VIM vimentin -0.100874
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0857385
IGFBP3 insulin-like growth factor binding protein 3 -0.0775272
MT2A metallothionein 2A -0.0747149
PTMA prothymosin, alpha -0.0618075
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0580171
TM4SF1 transmembrane 4 L six family member 1 -0.0567957
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0521227
S100A9 S100 calcium binding protein A9 -0.0520633
RRBP1 ribosome binding protein 1 -0.0519684
RPS6 ribosomal protein S6 -0.0467927
LOX lysyl oxidase -0.0466166
RPL35A ribosomal protein L35a -0.0462246
GOLGA4 golgin A4 -0.0456271
COL1A2 collagen, type I, alpha 2 -0.0451289
EIF1 eukaryotic translation initiation factor 1 -0.0449622
HLA-B major histocompatibility complex, class I, B -0.0438209
CALR calreticulin -0.0437685
CAVIN1 caveolae associated protein 1 -0.0436811
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0427189
DPYD dihydropyrimidine dehydrogenase -0.0414261
GARS1 glycyl-tRNA synthetase 1 -0.0401881
ENO1 enolase 1, (alpha) -0.0400866
IER3 immediate early response 3 -0.0393143
CANX calnexin -0.0381688
TPT1 tumor protein, translationally-controlled 1 -0.0364276
RPS8 ribosomal protein S8 -0.0354145
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0343852
MTDH metadherin -0.0324533
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0309108
LMNA lamin A/C -0.0307233
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0302157
STC1 stanniocalcin 1 -0.0300675
ACTG1 actin gamma 1 -0.0300304
RPLP2 ribosomal protein, large, P2 -0.0297465
LMAN1 lectin, mannose-binding, 1 -0.0295998
COL3A1 collagen, type III, alpha 1 -0.0293768
RPS21 ribosomal protein S21 -0.028802
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0286891
CAMTA1 calmodulin binding transcription activator 1 -0.0272642
TMSB4X thymosin beta 4, X-linked -0.0272101
F3 coagulation factor III (thromboplastin, tissue factor) -0.026627
CADM1 cell adhesion molecule 1 -0.0265891
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0260345
FTL ferritin, light polypeptide -0.0256406
MAP4 microtubule-associated protein 4 -0.0251784
EGR1 early growth response 1 -0.0251024
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0235834
RPS13 ribosomal protein S13 -0.0235437
ADM adrenomedullin -0.0234886
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0233538
RPL9 ribosomal protein L9 -0.0232606
HDLBP high density lipoprotein binding protein -0.0232131
LAMB3 laminin, beta 3 -0.0231681
ENO2 enolase 2 (gamma, neuronal) -0.0229744
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0227151
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0226648
RPL37 ribosomal protein L37 -0.0226553
GNAS GNAS complex locus -0.0225397
RPL36 ribosomal protein L36 -0.0225149
SEC63 SEC63 homolog (S. cerevisiae) -0.0223482
RPL5 ribosomal protein L5 -0.0222197
RPL34 ribosomal protein L34 -0.0221225
TTC3 tetratricopeptide repeat domain 3 -0.0219895
EHD2 EH-domain containing 2 -0.0219698
RPL26 ribosomal protein L26 -0.0215073
ANTXR2 anthrax toxin receptor 2 -0.0214737
BIRC6 baculoviral IAP repeat containing 6 -0.0213226
RPS15 ribosomal protein S15 -0.0211522
RPS3 ribosomal protein S3 -0.0211342
SLC38A2 solute carrier family 38, member 2 -0.0209188
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.020848
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0207881
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0207716
RPL37A ribosomal protein L37a -0.020677
HMGA2 high mobility group AT-hook 2 -0.0206214
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0205968
CHD9 chromodomain helicase DNA binding protein 9 -0.0205167
RPS24 ribosomal protein S24 -0.0203952
WSB1 WD repeat and SOCS box containing 1 -0.0203821
MYDGF myeloid-derived growth factor -0.0203786
ZMYND8 zinc finger, MYND-type containing 8 -0.0200691
ATF4 activating transcription factor 4 -0.019993
FKBP10 FK506 binding protein 10, 65 kDa -0.0199051
RPL11 ribosomal protein L11 -0.0195945
WASF2 WAS protein family, member 2 -0.0193224
FBN1 fibrillin 1 -0.0191055
GOLGB1 golgin B1 -0.0190752
CMIP c-Maf inducing protein -0.0190073
PTPRF protein tyrosine phosphatase, receptor type, F -0.0189702
KDM3A lysine (K)-specific demethylase 3A -0.01893
EFNA5 ephrin-A5 -0.0189007
DOCK5 dedicator of cytokinesis 5 -0.0187572
ANKRD11 ankyrin repeat domain 11 -0.0187414