Palmatine (chloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.091695
EHBP1 EH domain binding protein 1 0.0775132
NKD1 naked cuticle homolog 1 (Drosophila) 0.0751158
VCL vinculin 0.0623901
SAMD4A sterile alpha motif domain containing 4A 0.0608858
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0600789
DNAH17 dynein, axonemal, heavy chain 17 0.052902
PTCHD4 patched domain containing 4 0.0468821
MAML2 mastermind-like 2 (Drosophila) 0.0468562
RNF213 ring finger protein 213 0.043553
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0427
SLC38A2 solute carrier family 38, member 2 0.0413702
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0400954
TMSB10 thymosin beta 10 0.0396755
DOCK4 dedicator of cytokinesis 4 0.0396093
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0395374
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0383771
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0370659
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0370396
OSBPL10 oxysterol binding protein-like 10 0.0358025
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0349125
LRMDA leucine rich melanocyte differentiation associated 0.0343799
PDLIM5 PDZ and LIM domain 5 0.0341246
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0340555
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0340026
ZBTB20 zinc finger and BTB domain containing 20 0.0337671
APOA2 apolipoprotein A-II 0.0336065
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0331347
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0329297
FRMD5 FERM domain containing 5 0.0325215
CEMIP2 cell migration inducing hyaluronidase 2 0.0317772
GRB10 growth factor receptor-bound protein 10 0.0311184
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0307842
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0300951
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0300068
HMGA2 high mobility group AT-hook 2 0.02999
SOX5 SRY (sex determining region Y)-box 5 0.0298463
MED13 mediator complex subunit 13 0.0288383
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0287301
BCL2L1 BCL2-like 1 0.0283102
C3 complement component 3 0.0274476
RIGI RNA sensor RIG-I 0.0273554
UTRN utrophin 0.0273409
IQSEC1 IQ motif and Sec7 domain 1 0.0267919
LCOR ligand dependent nuclear receptor corepressor 0.0265837
JARID2 jumonji, AT rich interactive domain 2 0.0261672
EGR1 early growth response 1 0.0257214
FUS FUS RNA binding protein 0.025589
BIRC6 baculoviral IAP repeat containing 6 0.0251138
EPAS1 endothelial PAS domain protein 1 0.0249806
PTPRK protein tyrosine phosphatase, receptor type, K 0.0249581
ASPH aspartate beta-hydroxylase 0.0249116
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0249053
CNKSR3 CNKSR family member 3 0.02487
NABP1 nucleic acid binding protein 1 0.024742
INTS6 integrator complex subunit 6 0.0242579
TBCK TBC1 domain containing kinase 0.023803
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0236555
PRKCA protein kinase C, alpha 0.0227303
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0226038
LIMS1 LIM and senescent cell antigen-like domains 1 0.0224208
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.022208
SEPTIN9 septin 9 0.0221658
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0213761
UBASH3B ubiquitin associated and SH3 domain containing B 0.0211127
ATXN1 ataxin 1 0.0204554
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0203847
KIF21A kinesin family member 21A 0.0203781
IFI27 interferon, alpha-inducible protein 27 0.0203408
LMO7 LIM domain 7 0.0202175
NPAS2 neuronal PAS domain protein 2 0.0198438
IGF1R insulin-like growth factor 1 receptor 0.019672
MBD5 methyl-CpG binding domain protein 5 0.0195535
PDGFB platelet-derived growth factor beta polypeptide 0.019462
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0192778
CDK6 cyclin-dependent kinase 6 0.0192409
OSBPL8 oxysterol binding protein-like 8 0.0189049
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0187459
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0187312
HDAC4 histone deacetylase 4 0.0186995
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0186005
ZNF644 zinc finger protein 644 0.0184991
ZNF638 zinc finger protein 638 0.0184115
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0183703
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0183565
PHF21A PHD finger protein 21A 0.0183565
SYNJ2 synaptojanin 2 0.0181052
ABTB3 ankyrin repeat and BTB domain containing 3 0.0180536
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.018007
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0179735
PTPRG protein tyrosine phosphatase, receptor type, G 0.017939
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0178683
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0177427
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0172921
PHACTR4 phosphatase and actin regulator 4 0.0172077
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0171478
MBNL1 muscleblind-like splicing regulator 1 0.0171456
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0170912
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0170695
FOXP1 forkhead box P1 0.0169802

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.36003
ERRFI1 ERBB receptor feedback inhibitor 1 -0.132512
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.105404
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0856117
AKAP12 A kinase (PRKA) anchor protein 12 -0.082922
MT2A metallothionein 2A -0.0765909
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0764242
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0743603
ENO1 enolase 1, (alpha) -0.0734577
RPS6 ribosomal protein S6 -0.0692311
RPS12 ribosomal protein S12 -0.0626633
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0611796
AHSG alpha-2-HS-glycoprotein -0.0584448
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0570033
RPL37A ribosomal protein L37a -0.0561253
DTNA dystrobrevin, alpha -0.0558406
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0556465
RPS3 ribosomal protein S3 -0.0478013
RPS8 ribosomal protein S8 -0.0476235
RPL9 ribosomal protein L9 -0.0462506
SVIL supervillin -0.0459933
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0436431
RPL11 ribosomal protein L11 -0.0435185
RPS13 ribosomal protein S13 -0.0430937
RPS27A ribosomal protein S27a -0.0430026
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0406676
DDIT4 DNA-damage-inducible transcript 4 -0.0383872
TF transferrin -0.0378927
EEF2 eukaryotic translation elongation factor 2 -0.0373371
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0363551
RPL12 ribosomal protein L12 -0.0353567
RPL26 ribosomal protein L26 -0.0345028
SPAG9 sperm associated antigen 9 -0.0340602
FBF1 Fas (TNFRSF6) binding factor 1 -0.0337313
RPL36 ribosomal protein L36 -0.0334442
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0328109
RACK1 receptor for activated C kinase 1 -0.0324632
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.032407
CPE carboxypeptidase E -0.0322834
AMBP alpha-1-microglobulin/bikunin precursor -0.0321589
EIF1 eukaryotic translation initiation factor 1 -0.0315621
BHLHE40 basic helix-loop-helix family, member e40 -0.0311073
IGFBP1 insulin-like growth factor binding protein 1 -0.0311009
RPS23 ribosomal protein S23 -0.0308284
A2M alpha-2-macroglobulin -0.0304457
RPS29 ribosomal protein S29 -0.0302849
RPLP0 ribosomal protein, large, P0 -0.0288427
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0287926
CTSB cathepsin B -0.0286945
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0282314
PTPRM protein tyrosine phosphatase, receptor type, M -0.0280329
SDC4 syndecan 4 -0.027948
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0277972
RPL13A ribosomal protein L13a -0.0277172
PGK1 phosphoglycerate kinase 1 -0.0273693
GOLGA4 golgin A4 -0.0272852
RPS21 ribosomal protein S21 -0.0271746
RPS24 ribosomal protein S24 -0.0267461
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0266278
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0265146
PEG3 paternally expressed 3 -0.0264689
LDHA lactate dehydrogenase A -0.0264336
RPS2 ribosomal protein S2 -0.0264024
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0262453
GPBP1 GC-rich promoter binding protein 1 -0.0261753
NACA nascent polypeptide-associated complex alpha subunit -0.026059
RPS17 ribosomal protein S17 -0.0250907
TXNRD1 thioredoxin reductase 1 -0.0250707
LOC112694756 uncharaterized LOC112694756 -0.0250175
CANX calnexin -0.0248403
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0246643
WDR45B WD repeat domain 45B -0.0245754
MXI1 MAX interactor 1, dimerization protein -0.0245567
RPL37 ribosomal protein L37 -0.0244496
MYO6 myosin VI -0.023998
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0239806
PDIA6 protein disulfide isomerase family A, member 6 -0.0238136
NDRG1 N-myc downstream regulated 1 -0.0234651
CP ceruloplasmin (ferroxidase) -0.0229684
KLF6 Kruppel-like factor 6 -0.0224822
RPS27 ribosomal protein S27 -0.0219455
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0216423
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0206637
RPL7A ribosomal protein L7a -0.0204908
RPL34 ribosomal protein L34 -0.0204743
RPS25 ribosomal protein S25 -0.0204386
LCN2 lipocalin 2 -0.0204026
SIK3 SIK family kinase 3 -0.0201415
SOD2 superoxide dismutase 2, mitochondrial -0.0199612
RPL7 ribosomal protein L7 -0.0199422
PAWR PRKC, apoptosis, WT1, regulator -0.0197542
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0197434
APOA1 apolipoprotein A-I -0.0197267
TFRC transferrin receptor -0.0196527
JAK1 Janus kinase 1 -0.0194394
CFB complement factor B -0.019372
RPL4 ribosomal protein L4 -0.0193175
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0192476
PKM pyruvate kinase, muscle -0.0191445
HLA-A major histocompatibility complex, class I, A -0.0191334