Palmatine (chloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0848522
FOXP1 forkhead box P1 0.0727937
AOPEP aminopeptidase O (putative) 0.0578742
MBNL1 muscleblind-like splicing regulator 1 0.0544141
BCL2L1 BCL2-like 1 0.0538679
FOXO1 forkhead box O1 0.0534213
PDE4D phosphodiesterase 4D, cAMP-specific 0.053242
BLCAP bladder cancer associated protein 0.048185
BCAR3 breast cancer anti-estrogen resistance 3 0.0475607
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0453601
MECOM MDS1 and EVI1 complex locus 0.0447483
PDLIM5 PDZ and LIM domain 5 0.04474
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0446055
FLNB filamin B, beta 0.0425791
MYOF myoferlin 0.0403757
ZNFX1 zinc finger, NFX1-type containing 1 0.0387896
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0385298
NEK7 NIMA-related kinase 7 0.0382528
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0381179
DST dystonin 0.0378507
RIGI RNA sensor RIG-I 0.0366201
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0361455
RASAL2 RAS protein activator like 2 0.0346704
IFI6 interferon, alpha-inducible protein 6 0.0344625
EFNA5 ephrin-A5 0.0339959
LMO7 LIM domain 7 0.0335926
VCL vinculin 0.033576
MACF1 microtubule-actin crosslinking factor 1 0.0332456
DOCK5 dedicator of cytokinesis 5 0.0330337
PALM2AKAP2 PALM2 and AKAP2 fusion 0.032577
IFI44L interferon-induced protein 44-like 0.0318389
AMOTL1 angiomotin like 1 0.0314525
CTBP2 C-terminal binding protein 2 0.0306318
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0294972
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0293471
LUZP1 leucine zipper protein 1 0.0289215
OSMR oncostatin M receptor 0.0280578
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0276702
DOK5 docking protein 5 0.027472
SMAD3 SMAD family member 3 0.0268974
SEPTIN9 septin 9 0.0267659
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0266767
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0264095
TSC22D1 TSC22 domain family, member 1 0.0262497
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0258001
DPYD dihydropyrimidine dehydrogenase 0.0256447
OSBPL3 oxysterol binding protein-like 3 0.0248807
RIN2 Ras and Rab interactor 2 0.024876
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0248704
PTK2 protein tyrosine kinase 2 0.0247698
PRELID2 PRELI domain containing 2 0.0246035
FNDC3B fibronectin type III domain containing 3B 0.0244078
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.024229
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0241648
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0240268
IFI44 interferon-induced protein 44 0.0235901
NRG1 neuregulin 1 0.0233332
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0232159
ASXL1 additional sex combs like transcriptional regulator 1 0.0229692
YBX3 Y box binding protein 3 0.0227803
RABGAP1L RAB GTPase activating protein 1-like 0.0227517
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0227303
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0224972
ANO1 anoctamin 1, calcium activated chloride channel 0.0224607
MYH9 myosin, heavy chain 9, non-muscle 0.0219656
SOX13 SRY (sex determining region Y)-box 13 0.0217532
NRIP1 nuclear receptor interacting protein 1 0.0216471
LRRC8C leucine rich repeat containing 8 family, member C 0.0214669
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0214662
HMGA2 high mobility group AT-hook 2 0.0214079
PALLD palladin, cytoskeletal associated protein 0.0214008
ARHGAP29 Rho GTPase activating protein 29 0.0211551
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0208655
PICALM phosphatidylinositol binding clathrin assembly protein 0.020854
MPRIP myosin phosphatase Rho interacting protein 0.0207235
NDE1 nudE neurodevelopment protein 1 0.0205146
SEPTIN11 septin 11 0.0203659
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0203401
SVIL supervillin 0.0202823
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0199756
CORO2A coronin, actin binding protein, 2A 0.0198313
BCR breakpoint cluster region 0.0198117
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0197924
NCOA3 nuclear receptor coactivator 3 0.0196659
PITPNB phosphatidylinositol transfer protein, beta 0.0194123
CMIP c-Maf inducing protein 0.0190284
AFAP1 actin filament associated protein 1 0.0189677
ACTN4 actinin, alpha 4 0.0187668
PLSCR1 phospholipid scramblase 1 0.0186993
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0186805
TNS4 tensin 4 0.018489
CEMIP cell migration inducing protein, hyaluronan binding 0.0183643
SAMD9 sterile alpha motif domain containing 9 0.0183577
HDAC9 histone deacetylase 9 0.0183059
DOCK4 dedicator of cytokinesis 4 0.0182344
ATG7 autophagy related 7 0.0181968
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0181581
CAPRIN2 caprin family member 2 0.018155
CTNND1 catenin (cadherin-associated protein), delta 1 0.0180247
KIAA0040 KIAA0040 0.0180125

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.14137
RPS6 ribosomal protein S6 -0.128102
TIMP3 TIMP metallopeptidase inhibitor 3 -0.11812
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111075
PTMA prothymosin, alpha -0.104771
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0876594
TMSB10 thymosin beta 10 -0.0861579
CLU clusterin -0.0846461
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0827452
FTL ferritin, light polypeptide -0.0807281
RPS8 ribosomal protein S8 -0.078125
RPS13 ribosomal protein S13 -0.0766859
RPL11 ribosomal protein L11 -0.0734817
RPLP1 ribosomal protein, large, P1 -0.069429
TPT1 tumor protein, translationally-controlled 1 -0.0686901
FTH1 ferritin, heavy polypeptide 1 -0.0681143
MT2A metallothionein 2A -0.0662553
LDHA lactate dehydrogenase A -0.0660188
RPS21 ribosomal protein S21 -0.0643484
ENO1 enolase 1, (alpha) -0.063763
RPL23 ribosomal protein L23 -0.0634594
RPLP2 ribosomal protein, large, P2 -0.0611041
S100A10 S100 calcium binding protein A10 -0.0593653
RPS25 ribosomal protein S25 -0.0585209
RPS19 ribosomal protein S19 -0.0574888
GOLGA4 golgin A4 -0.0558934
MTSS1 metastasis suppressor 1 -0.0553464
RPL35A ribosomal protein L35a -0.0546898
SQSTM1 sequestosome 1 -0.0540862
TMSB4X thymosin beta 4, X-linked -0.0534612
STC1 stanniocalcin 1 -0.0529761
GNAS GNAS complex locus -0.0527007
PDIA3 protein disulfide isomerase family A, member 3 -0.0520759
HM13 histocompatibility (minor) 13 -0.0520168
RPS24 ribosomal protein S24 -0.0515912
PGK1 phosphoglycerate kinase 1 -0.0502531
RPL34 ribosomal protein L34 -0.0499119
RPL37A ribosomal protein L37a -0.0495888
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0493062
RPS23 ribosomal protein S23 -0.0484411
RPS3 ribosomal protein S3 -0.0478563
S100A2 S100 calcium binding protein A2 -0.0466816
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0463085
RPL31 ribosomal protein L31 -0.0460479
RPS14 ribosomal protein S14 -0.0460034
S100A6 S100 calcium binding protein A6 -0.0436243
RPL37 ribosomal protein L37 -0.0429176
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0424392
IGF2 insulin-like growth factor 2 -0.0421541
RPS29 ribosomal protein S29 -0.0417085
POTEF POTE ankyrin domain family, member F -0.0416145
RPS27 ribosomal protein S27 -0.0414312
IFITM3 interferon induced transmembrane protein 3 -0.0410332
RPL12 ribosomal protein L12 -0.0387294
B2M beta-2-microglobulin -0.0386295
LMNA lamin A/C -0.0383394
HLA-E major histocompatibility complex, class I, E -0.0383313
RPL8 ribosomal protein L8 -0.0377125
RAI14 retinoic acid induced 14 -0.0371293
S100A9 S100 calcium binding protein A9 -0.0370697
EIF1 eukaryotic translation initiation factor 1 -0.0362622
RPL19 ribosomal protein L19 -0.0362079
RPL27A ribosomal protein L27a -0.0356887
ABI3BP ABI family, member 3 (NESH) binding protein -0.0353896
MORF4L2 mortality factor 4 like 2 -0.03428
HLA-B major histocompatibility complex, class I, B -0.0341606
RPS12 ribosomal protein S12 -0.0339979
RPS11 ribosomal protein S11 -0.0337512
RPS16 ribosomal protein S16 -0.0337191
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0335637
PRRC2C proline-rich coiled-coil 2C -0.0335629
RPL5 ribosomal protein L5 -0.0328318
LOC112694756 uncharaterized LOC112694756 -0.0328226
MDK midkine (neurite growth-promoting factor 2) -0.0321564
RACK1 receptor for activated C kinase 1 -0.0320869
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.03203
SQLE squalene epoxidase -0.0318545
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0314221
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0313805
RPL36 ribosomal protein L36 -0.0312069
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0310257
UBC ubiquitin C -0.0306428
NAV2 neuron navigator 2 -0.0304429
PODXL podocalyxin-like -0.0303515
GUK1 guanylate kinase 1 -0.0301322
RPL7A ribosomal protein L7a -0.0300459
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0299841
VDAC1 voltage-dependent anion channel 1 -0.0298
WASF2 WAS protein family, member 2 -0.0295557
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0292896
RPL28 ribosomal protein L28 -0.0290264
PKM pyruvate kinase, muscle -0.0286839
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.028674
HMGA1 high mobility group AT-hook 1 -0.0286521
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.028524
RPL36A ribosomal protein L36a -0.0284615
TRIO trio Rho guanine nucleotide exchange factor -0.0284498
RPS27A ribosomal protein S27a -0.0282899
FSCN1 fascin actin-bundling protein 1 -0.0278119
CSTB cystatin B (stefin B) -0.0277755