Palmatine (chloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.173993
INTS6 integrator complex subunit 6 0.120853
ERBIN erbb2 interacting protein 0.0991621
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0974776
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0861148
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0847231
TLE4 transducin-like enhancer of split 4 0.0825729
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0801499
VCL vinculin 0.0758972
ZSWIM6 zinc finger, SWIM-type containing 6 0.0732598
PTK2 protein tyrosine kinase 2 0.0721102
PDLIM5 PDZ and LIM domain 5 0.0717922
DIAPH3 diaphanous-related formin 3 0.0693683
POTEF POTE ankyrin domain family, member F 0.0687486
SLIT2 slit homolog 2 (Drosophila) 0.0658094
TRIO trio Rho guanine nucleotide exchange factor 0.0654591
SMC4 structural maintenance of chromosomes 4 0.0647846
NAV2 neuron navigator 2 0.0636597
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0584787
ASPH aspartate beta-hydroxylase 0.0567792
TPM1 tropomyosin 1 (alpha) 0.0558744
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0522989
VEGFC vascular endothelial growth factor C 0.0516602
ACTN1 actinin, alpha 1 0.051436
MBNL1 muscleblind-like splicing regulator 1 0.051079
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0503248
NALF1 NALCN channel auxiliary factor 1 0.0501695
PLSCR1 phospholipid scramblase 1 0.0499557
PICALM phosphatidylinositol binding clathrin assembly protein 0.0497478
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0489897
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0486368
CALD1 caldesmon 1 0.0482203
DST dystonin 0.0464967
PTPRG protein tyrosine phosphatase, receptor type, G 0.0463557
LPP LIM domain containing preferred translocation partner in lipoma 0.0461503
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0461175
RAD51B RAD51 paralog B 0.0451483
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0441059
SH3RF1 SH3 domain containing ring finger 1 0.0440911
MSN moesin 0.0440139
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0439436
HSPH1 heat shock 105kDa/110kDa protein 1 0.0438926
FLNA filamin A, alpha 0.0438824
SAMD4A sterile alpha motif domain containing 4A 0.0434405
FNDC3B fibronectin type III domain containing 3B 0.0425371
GLS2 glutaminase 2 (liver, mitochondrial) 0.0417058
TENM3 teneurin transmembrane protein 3 0.0412374
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0406932
CD44 CD44 molecule (Indian blood group) 0.0405757
MYH9 myosin, heavy chain 9, non-muscle 0.04022
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0372404
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0370304
SMYD3 SET and MYND domain containing 3 0.0368714
WNT5B wingless-type MMTV integration site family, member 5B 0.0363404
MACF1 microtubule-actin crosslinking factor 1 0.0359973
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0356453
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0353119
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0352317
LMO7 LIM domain 7 0.034771
RNF213 ring finger protein 213 0.0346915
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0345962
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.034551
DOCK5 dedicator of cytokinesis 5 0.0345467
SMAD3 SMAD family member 3 0.0343639
BCAR3 breast cancer anti-estrogen resistance 3 0.0342772
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0340378
UBAP2 ubiquitin associated protein 2 0.0338774
C6ORF62 chromosome 6 open reading frame 62 0.0334906
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0334709
RIMS2 regulating synaptic membrane exocytosis 2 0.0328792
TIMP2 TIMP metallopeptidase inhibitor 2 0.0328774
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0328756
HEG1 heart development protein with EGF-like domains 1 0.0327474
KLF12 Kruppel-like factor 12 0.0327034
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0322047
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0321577
MPRIP myosin phosphatase Rho interacting protein 0.0320653
ATXN1 ataxin 1 0.0316722
APLP2 amyloid beta (A4) precursor-like protein 2 0.0315719
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0315637
RAB7A RAB7A, member RAS oncogene family 0.0308197
TRA2B transformer 2 beta homolog (Drosophila) 0.0307699
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.030589
ANKRD17 ankyrin repeat domain 17 0.0305573
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0302812
CEP128 centrosomal protein 128kDa 0.029851
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0295504
CLIC4 chloride intracellular channel 4 0.0295481
IPO9 importin 9 0.0294294
TSC22D2 TSC22 domain family, member 2 0.0293049
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0291887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0291249
FAF1 Fas (TNFRSF6) associated factor 1 0.0291173
RIGI RNA sensor RIG-I 0.028997
PACS1 phosphofurin acidic cluster sorting protein 1 0.0287936
LHFPL6 LHFPL tetraspan subfamily member 6 0.0287256
ACTG1 actin gamma 1 0.0287054
PODXL podocalyxin-like 0.0285799
FRMD6 FERM domain containing 6 0.0284528
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0283006

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.172169
FN1 fibronectin 1 -0.164203
ABI3BP ABI family, member 3 (NESH) binding protein -0.14001
NDRG1 N-myc downstream regulated 1 -0.134997
MT1X metallothionein 1X -0.122323
NAMPT nicotinamide phosphoribosyltransferase -0.111781
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108811
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0904829
FTL ferritin, light polypeptide -0.0855947
TMSB4X thymosin beta 4, X-linked -0.0751717
AKAP12 A kinase (PRKA) anchor protein 12 -0.0671062
F3 coagulation factor III (thromboplastin, tissue factor) -0.0636655
GOLGA4 golgin A4 -0.0633597
HLA-B major histocompatibility complex, class I, B -0.0624402
IGFBP3 insulin-like growth factor binding protein 3 -0.0605318
PDIA3 protein disulfide isomerase family A, member 3 -0.0599318
LOC112694756 uncharaterized LOC112694756 -0.0567571
UGCG UDP-glucose ceramide glucosyltransferase -0.0534254
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0463809
TMSB10 thymosin beta 10 -0.043669
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0435239
OSMR oncostatin M receptor -0.0430788
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.041569
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0408393
ELL2 elongation factor, RNA polymerase II, 2 -0.0400816
HLA-C major histocompatibility complex, class I, C -0.03781
MMP12 matrix metallopeptidase 12 -0.0373182
ANXA1 annexin A1 -0.0370825
LMAN1 lectin, mannose-binding, 1 -0.0366131
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0363851
FTH1 ferritin, heavy polypeptide 1 -0.0355799
IL1RAP interleukin 1 receptor accessory protein -0.0349904
ARF4 ADP-ribosylation factor 4 -0.0348572
RAD21 RAD21 homolog (S. pombe) -0.0331738
MT2A metallothionein 2A -0.0321781
KPNB1 karyopherin (importin) beta 1 -0.0319088
AHNAK AHNAK nucleoprotein -0.0314397
CAVIN1 caveolae associated protein 1 -0.030766
PGK1 phosphoglycerate kinase 1 -0.0303272
LOX lysyl oxidase -0.0298693
ATP13A3 ATPase type 13A3 -0.0298666
ZFR zinc finger RNA binding protein -0.0296457
KDM3A lysine (K)-specific demethylase 3A -0.0293241
SOD2 superoxide dismutase 2, mitochondrial -0.0288092
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0287061
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0285057
CTSD cathepsin D -0.0284359
GNAS GNAS complex locus -0.0284187
PHACTR1 phosphatase and actin regulator 1 -0.0278189
NPEPPS aminopeptidase puromycin sensitive -0.0275069
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0270715
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0270241
WDR45B WD repeat domain 45B -0.0268521
RIOK3 RIO kinase 3 -0.0262393
ARF1 ADP-ribosylation factor 1 -0.0258928
ZNF841 zinc finger protein 841 -0.0255859
DLG1 discs, large homolog 1 (Drosophila) -0.0255208
HMGB2 high mobility group box 2 -0.0251267
RLF rearranged L-myc fusion -0.0250375
TPD52 tumor protein D52 -0.0249215
ZMYND8 zinc finger, MYND-type containing 8 -0.0248788
STK4 serine/threonine kinase 4 -0.0247546
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0246596
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0246372
RRBP1 ribosome binding protein 1 -0.0245868
ZNF292 zinc finger protein 292 -0.0245016
IGFBP5 insulin-like growth factor binding protein 5 -0.0244955
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0243908
FAM162A family with sequence similarity 162, member A -0.0243645
RPS19 ribosomal protein S19 -0.0240498
PTPRF protein tyrosine phosphatase, receptor type, F -0.0236144
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0231385
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0229003
MPZL1 myelin protein zero-like 1 -0.0226422
NPPB natriuretic peptide B -0.0223758
RAI14 retinoic acid induced 14 -0.0219959
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0219802
PLIN2 perilipin 2 -0.0219556
GPR107 G protein-coupled receptor 107 -0.0219323
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0219234
SUCO SUN domain containing ossification factor -0.0218924
COL3A1 collagen, type III, alpha 1 -0.0216388
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0216002
RNF144B ring finger protein 144B -0.0211079
TMEM41B transmembrane protein 41B -0.0210925
SULF1 sulfatase 1 -0.0209898
WSB1 WD repeat and SOCS box containing 1 -0.0209834
JUN jun proto-oncogene -0.0208836
MXI1 MAX interactor 1, dimerization protein -0.0208578
BHLHE40 basic helix-loop-helix family, member e40 -0.0208227
RPS6 ribosomal protein S6 -0.020527
HDLBP high density lipoprotein binding protein -0.0204171
EIF1 eukaryotic translation initiation factor 1 -0.0203171
IER3 immediate early response 3 -0.0201788
RPL32 ribosomal protein L32 -0.0198016
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0197172
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0196832
TMEM263 transmembrane protein 263 -0.0196026
POSTN periostin, osteoblast specific factor -0.0194156
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0187863