Palmatine (chloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0718525
VCL vinculin 0.0643688
CD44 CD44 molecule (Indian blood group) 0.0538548
ALCAM activated leukocyte cell adhesion molecule 0.0419178
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0409588
ADAM19 ADAM metallopeptidase domain 19 0.0374771
AHNAK AHNAK nucleoprotein 0.0373134
MT2A metallothionein 2A 0.0352767
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0351755
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.034906
HMGA2 high mobility group AT-hook 2 0.0348469
PDE4D phosphodiesterase 4D, cAMP-specific 0.0343219
FLNA filamin A, alpha 0.0342673
RIGI RNA sensor RIG-I 0.0323626
PCDH11X protocadherin 11 X-linked 0.0306351
SMAD3 SMAD family member 3 0.0297475
BCAR3 breast cancer anti-estrogen resistance 3 0.0296515
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0292545
NLGN1 neuroligin 1 0.0289308
RPS2 ribosomal protein S2 0.0287164
ASPH aspartate beta-hydroxylase 0.0280904
SDCCAG8 serologically defined colon cancer antigen 8 0.0276796
SAMD4A sterile alpha motif domain containing 4A 0.02539
LPP LIM domain containing preferred translocation partner in lipoma 0.0243219
EXOC4 exocyst complex component 4 0.0242767
SMC4 structural maintenance of chromosomes 4 0.0233524
RIMS2 regulating synaptic membrane exocytosis 2 0.0228119
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0223252
NT5E 5'-nucleotidase, ecto (CD73) 0.0222775
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0219703
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0218246
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0208641
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0200109
ETV6 ets variant 6 0.0192505
SFPQ splicing factor proline/glutamine-rich 0.0191877
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0190817
CENPF centromere protein F, 350/400kDa 0.0190723
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0189964
FOXP1 forkhead box P1 0.0189436
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0184753
ARID1B AT rich interactive domain 1B (SWI1-like) 0.018281
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0181721
CENPE centromere protein E, 312kDa 0.0181542
ANO6 anoctamin 6 0.0180465
RABGAP1L RAB GTPase activating protein 1-like 0.0180027
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0178187
INTS6 integrator complex subunit 6 0.0175856
FMN1 formin 1 0.0173046
TRIO trio Rho guanine nucleotide exchange factor 0.017285
GLIS3 GLIS family zinc finger 3 0.0172125
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0168258
SHB Src homology 2 domain containing adaptor protein B 0.0167611
RPL7 ribosomal protein L7 0.0167386
DOCK4 dedicator of cytokinesis 4 0.0166714
ATXN1 ataxin 1 0.0165622
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0165595
IFI6 interferon, alpha-inducible protein 6 0.0164449
ANKRD36C ankyrin repeat domain 36C 0.0163101
PARP4 poly (ADP-ribose) polymerase family, member 4 0.016294
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0160973
DPYD dihydropyrimidine dehydrogenase 0.0160354
NME7 NME/NM23 family member 7 0.0158516
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0155576
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.0154711
NSD2 nuclear receptor binding SET domain protein 2 0.0154215
PTPRK protein tyrosine phosphatase, receptor type, K 0.0153199
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.015202
FRMD6 FERM domain containing 6 0.0149245
MPRIP myosin phosphatase Rho interacting protein 0.0148406
RRM2 ribonucleotide reductase M2 0.0146863
TAS2R14 taste receptor, type 2, member 14 0.0146306
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0144734
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0144659
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0144034
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0142415
TRAPPC9 trafficking protein particle complex 9 0.0142328
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.014164
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0141311
TRIM44 tripartite motif containing 44 0.0140863
HSPA8 heat shock 70kDa protein 8 0.0140409
AOPEP aminopeptidase O (putative) 0.0139537
AHNAK2 AHNAK nucleoprotein 2 0.0138965
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.0137564
CLTC clathrin, heavy chain (Hc) 0.013749
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0137465
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0137402
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0137196
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0137126
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0136794
NLK nemo-like kinase 0.0136691
PARVA parvin, alpha 0.0135815
SAMD3 sterile alpha motif domain containing 3 0.0135122
ANKRD36 ankyrin repeat domain 36 0.0134302
SATB2 SATB homeobox 2 0.0134232
LOXL2 lysyl oxidase-like 2 0.0132411
DISC1 disrupted in schizophrenia 1 0.0131505
SACS sacsin molecular chaperone 0.0130566
BCAS3 breast carcinoma amplified sequence 3 0.0130508
MBNL1 muscleblind-like splicing regulator 1 0.0129622
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0128777

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.419752
TMSB10 thymosin beta 10 -0.236163
RPS6 ribosomal protein S6 -0.227219
AKAP12 A kinase (PRKA) anchor protein 12 -0.220637
DTNA dystrobrevin, alpha -0.196393
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133941
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.127855
MMP12 matrix metallopeptidase 12 -0.107124
LSAMP limbic system-associated membrane protein -0.107011
RPL23 ribosomal protein L23 -0.0873218
RPL35A ribosomal protein L35a -0.0865736
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0810281
RPS19 ribosomal protein S19 -0.0806811
EGR1 early growth response 1 -0.069604
PHACTR1 phosphatase and actin regulator 1 -0.0622698
EFNA5 ephrin-A5 -0.0589927
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0571288
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0556219
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0529565
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0528638
ELL2 elongation factor, RNA polymerase II, 2 -0.0506067
UGCG UDP-glucose ceramide glucosyltransferase -0.0504781
PKM pyruvate kinase, muscle -0.0481716
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0477257
NDRG1 N-myc downstream regulated 1 -0.0465946
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0456075
GPC6 glypican 6 -0.04511
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0439966
EEF2 eukaryotic translation elongation factor 2 -0.0425365
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0402472
PRKG1 protein kinase, cGMP-dependent, type I -0.0398163
CDH13 cadherin 13 -0.0396968
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0388245
JMJD1C jumonji domain containing 1C -0.038784
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0386422
HAS2 hyaluronan synthase 2 -0.0370647
ADAM9 ADAM metallopeptidase domain 9 -0.0366303
ACTG1 actin gamma 1 -0.036423
RPL34 ribosomal protein L34 -0.0363885
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0360285
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0349629
NUP58 nucleoporin 58 -0.0346214
PBX3 pre-B-cell leukemia homeobox 3 -0.0338963
RPS14 ribosomal protein S14 -0.0337505
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0333659
CSTB cystatin B (stefin B) -0.0332086
RPLP1 ribosomal protein, large, P1 -0.0329667
ENKUR enkurin, TRPC channel interacting protein -0.0323543
PICALM phosphatidylinositol binding clathrin assembly protein -0.0314818
PTMA prothymosin, alpha -0.0313759
RPL21 ribosomal protein L21 -0.0309494
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.030823
RPS25 ribosomal protein S25 -0.0307741
JUN jun proto-oncogene -0.0307536
MSN moesin -0.030749
RPL19 ribosomal protein L19 -0.0297409
GNAS GNAS complex locus -0.0296691
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0295644
KDM2A lysine (K)-specific demethylase 2A -0.0293112
ENO2 enolase 2 (gamma, neuronal) -0.0290618
BTG1 B-cell translocation gene 1, anti-proliferative -0.029026
WDR45B WD repeat domain 45B -0.0285816
GOLGA4 golgin A4 -0.0284251
RPL31 ribosomal protein L31 -0.0281757
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0281487
PDIA3 protein disulfide isomerase family A, member 3 -0.0278043
CD109 CD109 molecule -0.027521
RPL8 ribosomal protein L8 -0.027431
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0272782
PTPRD protein tyrosine phosphatase, receptor type, D -0.027205
POTEF POTE ankyrin domain family, member F -0.0270506
LMAN1 lectin, mannose-binding, 1 -0.0268367
PTK2 protein tyrosine kinase 2 -0.0267232
LIMA1 LIM domain and actin binding 1 -0.0265938
SBF2 SET binding factor 2 -0.026282
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0257708
TAOK1 TAO kinase 1 -0.0255742
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0252695
TXNIP thioredoxin interacting protein -0.0252051
MCL1 myeloid cell leukemia 1 -0.0246181
RPL11 ribosomal protein L11 -0.0245987
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0244449
ZNF292 zinc finger protein 292 -0.0242563
HILPDA hypoxia inducible lipid droplet-associated -0.0240065
RPL15 ribosomal protein L15 -0.0237327
HMGA1 high mobility group AT-hook 1 -0.0236918
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0236375
SPAG9 sperm associated antigen 9 -0.0236147
RPL28 ribosomal protein L28 -0.0235716
TPM4 tropomyosin 4 -0.0235453
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0235376
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0234912
RPS24 ribosomal protein S24 -0.0234718
USP34 ubiquitin specific peptidase 34 -0.0234708
RPL36A ribosomal protein L36a -0.0230051
KTN1 kinectin 1 (kinesin receptor) -0.0229844
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0229723
NAP1L1 nucleosome assembly protein 1-like 1 -0.0229483
EIF1 eukaryotic translation initiation factor 1 -0.022876
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0228345