Palmatine (chloride)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0957967
BCAR3 breast cancer anti-estrogen resistance 3 0.0932172
PSD3 pleckstrin and Sec7 domain containing 3 0.0909804
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0897227
WWTR1 WW domain containing transcription regulator 1 0.0799368
VCL vinculin 0.0751424
CAPRIN2 caprin family member 2 0.0739854
DST dystonin 0.066443
RAD51B RAD51 paralog B 0.0530639
ADGRG6 adhesion G protein-coupled receptor G6 0.0505916
NPAS2 neuronal PAS domain protein 2 0.0504138
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0503867
DPYD dihydropyrimidine dehydrogenase 0.0500404
NCEH1 neutral cholesterol ester hydrolase 1 0.0497739
RUNX1 runt-related transcription factor 1 0.0496738
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0493144
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0488947
APLP2 amyloid beta (A4) precursor-like protein 2 0.0478381
FMNL2 formin-like 2 0.046459
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0453832
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0451248
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0431386
H1-0 H1.0 linker histone 0.0419973
GCLM glutamate-cysteine ligase, modifier subunit 0.0413629
SPAG9 sperm associated antigen 9 0.0410775
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0408176
PLK2 polo-like kinase 2 0.0405913
BIRC3 baculoviral IAP repeat containing 3 0.0405805
RTTN rotatin 0.0403977
PTK2 protein tyrosine kinase 2 0.0399962
VMP1 vacuole membrane protein 1 0.038047
PRELID2 PRELI domain containing 2 0.0373288
MACF1 microtubule-actin crosslinking factor 1 0.0368632
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0366642
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.036125
DNER delta/notch-like EGF repeat containing 0.0358613
SMAD3 SMAD family member 3 0.0357445
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0352431
EXOC4 exocyst complex component 4 0.0337683
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0336553
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0322619
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0315895
SMC4 structural maintenance of chromosomes 4 0.0313314
RAB27B RAB27B, member RAS oncogene family 0.0313062
SVIL supervillin 0.0311876
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0308392
SMYD3 SET and MYND domain containing 3 0.0307514
IFI6 interferon, alpha-inducible protein 6 0.0307077
PCBP2 poly(rC) binding protein 2 0.0305866
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0305865
SDCCAG8 serologically defined colon cancer antigen 8 0.0304854
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0304153
ANTXR2 anthrax toxin receptor 2 0.0301634
ERBIN erbb2 interacting protein 0.0298106
DIAPH3 diaphanous-related formin 3 0.0297447
ZNFX1 zinc finger, NFX1-type containing 1 0.0297442
SYAP1 synapse associated protein 1 0.0294368
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0293062
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0290569
ENO1 enolase 1, (alpha) 0.028963
RCOR1 REST corepressor 1 0.0289412
RPS2 ribosomal protein S2 0.0289321
CEP128 centrosomal protein 128kDa 0.0285942
WAC WW domain containing adaptor with coiled-coil 0.0285536
TP63 tumor protein p63 0.0284054
CD44 CD44 molecule (Indian blood group) 0.0281336
PUM1 pumilio RNA-binding family member 1 0.027903
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0277579
BIRC6 baculoviral IAP repeat containing 6 0.0276166
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0271522
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0270495
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0264926
ZBTB38 zinc finger and BTB domain containing 38 0.0263998
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0259352
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0256192
TRIP12 thyroid hormone receptor interactor 12 0.0253883
JMJD1C jumonji domain containing 1C 0.025311
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0250489
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0247636
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.024626
NT5E 5'-nucleotidase, ecto (CD73) 0.024588
F2R coagulation factor II (thrombin) receptor 0.0244402
LPP LIM domain containing preferred translocation partner in lipoma 0.0242498
CSNK1A1 casein kinase 1, alpha 1 0.0241877
LDHA lactate dehydrogenase A 0.0241084
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0241013
COL6A3 collagen, type VI, alpha 3 0.023456
RRM2 ribonucleotide reductase M2 0.0234355
ECT2 epithelial cell transforming 2 0.0233226
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0230425
SQSTM1 sequestosome 1 0.0228707
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0222725
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0222278
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0221213
TGM2 transglutaminase 2 0.0221
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0219397
CCDC88A coiled-coil domain containing 88A 0.0219075
TPM3 tropomyosin 3 0.0219048
CDK6 cyclin-dependent kinase 6 0.0216618
TPR translocated promoter region, nuclear basket protein 0.0216452

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.269359
VIM vimentin -0.237327
RPL35A ribosomal protein L35a -0.155888
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145352
RPS19 ribosomal protein S19 -0.125952
RPS6 ribosomal protein S6 -0.123285
FTL ferritin, light polypeptide -0.0988648
TMSB4X thymosin beta 4, X-linked -0.0984289
PTMA prothymosin, alpha -0.0840296
TPT1 tumor protein, translationally-controlled 1 -0.083107
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0793118
RPL31 ribosomal protein L31 -0.0703711
RPL23 ribosomal protein L23 -0.0678445
RPS8 ribosomal protein S8 -0.0647548
MT1X metallothionein 1X -0.0617136
RPLP1 ribosomal protein, large, P1 -0.0598234
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0597691
RPL37A ribosomal protein L37a -0.0563572
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.056224
RPS23 ribosomal protein S23 -0.0549989
RPL36A ribosomal protein L36a -0.0516156
RPL34 ribosomal protein L34 -0.0511854
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0508336
DLG1 discs, large homolog 1 (Drosophila) -0.0493324
RPS24 ribosomal protein S24 -0.0491957
RPS14 ribosomal protein S14 -0.0487114
RPL7A ribosomal protein L7a -0.0483171
ZMYND8 zinc finger, MYND-type containing 8 -0.0457053
RPLP2 ribosomal protein, large, P2 -0.0456981
EEF2 eukaryotic translation elongation factor 2 -0.0442342
RACK1 receptor for activated C kinase 1 -0.0420585
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0413643
RPL19 ribosomal protein L19 -0.0412208
RPS4X ribosomal protein S4, X-linked -0.0396176
RPL8 ribosomal protein L8 -0.0389466
RPL32 ribosomal protein L32 -0.0387093
RPL28 ribosomal protein L28 -0.0386342
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.037748
RPS27A ribosomal protein S27a -0.0376959
RPL5 ribosomal protein L5 -0.0375994
RPS25 ribosomal protein S25 -0.0372347
HMGA1 high mobility group AT-hook 1 -0.036299
RPL27A ribosomal protein L27a -0.0362417
RPL12 ribosomal protein L12 -0.0360925
EIF1 eukaryotic translation initiation factor 1 -0.0352686
RPS16 ribosomal protein S16 -0.0349147
RPL36 ribosomal protein L36 -0.0346994
EGR1 early growth response 1 -0.0344855
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0340756
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.034006
RPL26 ribosomal protein L26 -0.0339529
RPS29 ribosomal protein S29 -0.033905
RPS28 ribosomal protein S28 -0.0333955
EFNA5 ephrin-A5 -0.0332395
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0314991
RPL18 ribosomal protein L18 -0.0308858
RPL37 ribosomal protein L37 -0.0308317
ACTG1 actin gamma 1 -0.0298879
S100A10 S100 calcium binding protein A10 -0.0298451
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0296033
RPL38 ribosomal protein L38 -0.0286581
RPS3 ribosomal protein S3 -0.0280512
RPS17 ribosomal protein S17 -0.0280464
ARHGAP5 Rho GTPase activating protein 5 -0.0278484
ANXA1 annexin A1 -0.0274212
RPS5 ribosomal protein S5 -0.0272238
RPL11 ribosomal protein L11 -0.0262945
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0262202
LOC112694756 uncharaterized LOC112694756 -0.0261919
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0260554
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0260396
UPP1 uridine phosphorylase 1 -0.0257676
RPL35 ribosomal protein L35 -0.0242202
TNS3 tensin 3 -0.0240012
RPS13 ribosomal protein S13 -0.023982
RPLP0 ribosomal protein, large, P0 -0.0237856
VDAC1 voltage-dependent anion channel 1 -0.0236271
RPS21 ribosomal protein S21 -0.0231941
SRGN serglycin -0.0231424
S100A9 S100 calcium binding protein A9 -0.0227912
SDK1 sidekick cell adhesion molecule 1 -0.0226377
ANGPTL4 angiopoietin-like 4 -0.0224945
MYOF myoferlin -0.0223934
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0220691
RPL4 ribosomal protein L4 -0.0218288
RPS12 ribosomal protein S12 -0.0217172
RPL9 ribosomal protein L9 -0.0213218
S100A6 S100 calcium binding protein A6 -0.0210516
RPL27 ribosomal protein L27 -0.0210195
GNAS GNAS complex locus -0.0207435
RPL10A ribosomal protein L10a -0.0205302
RPS27 ribosomal protein S27 -0.0204307
NDRG1 N-myc downstream regulated 1 -0.0196283
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0190908
RPS20 ribosomal protein S20 -0.0189766
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0188654
KLF6 Kruppel-like factor 6 -0.0188504
RSL1D1 ribosomal L1 domain containing 1 -0.0187941
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.018519
RPS10 ribosomal protein S10 -0.0182491