Palmatine (chloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.130369
PM20D1 peptidase M20 domain containing 1 0.0904026
TXNRD1 thioredoxin reductase 1 0.0759741
DOCK5 dedicator of cytokinesis 5 0.0745113
SLTM SAFB-like, transcription modulator 0.0669607
TBC1D22A TBC1 domain family, member 22A 0.0620435
PDE4D phosphodiesterase 4D, cAMP-specific 0.0590691
LAMA4 laminin, alpha 4 0.0561708
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0552611
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0547197
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0545805
GCLC glutamate-cysteine ligase, catalytic subunit 0.0539497
TOP1 topoisomerase (DNA) I 0.0538166
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0526366
BCAR3 breast cancer anti-estrogen resistance 3 0.0513201
SMYD3 SET and MYND domain containing 3 0.0489145
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0479099
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0473086
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.046669
CES1 carboxylesterase 1 0.0452869
MCL1 myeloid cell leukemia 1 0.0452731
LGALS12 lectin, galactoside-binding, soluble, 12 0.0443836
RICTOR RPTOR independent companion of MTOR, complex 2 0.0441394
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0439248
MYOF myoferlin 0.0427035
THSD4 thrombospondin, type I, domain containing 4 0.0422755
NPAS2 neuronal PAS domain protein 2 0.0422287
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0400228
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0391505
CEMIP cell migration inducing protein, hyaluronan binding 0.0386499
FAT1 FAT atypical cadherin 1 0.0386047
PCBP2 poly(rC) binding protein 2 0.0385971
APLP2 amyloid beta (A4) precursor-like protein 2 0.0382138
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0381475
MAML3 mastermind-like 3 (Drosophila) 0.0367897
PTK2 protein tyrosine kinase 2 0.0351949
USP34 ubiquitin specific peptidase 34 0.0343232
NTSR1 neurotensin receptor 1 (high affinity) 0.0342904
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0340038
DSCAM Down syndrome cell adhesion molecule 0.0331994
SCEL sciellin 0.0327633
SMAD3 SMAD family member 3 0.0326735
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0323733
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0323733
OGA O-GlcNAcase 0.0321783
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0309501
TRAPPC9 trafficking protein particle complex 9 0.0305483
SFPQ splicing factor proline/glutamine-rich 0.0302323
LRP12 low density lipoprotein receptor-related protein 12 0.03003
SEPTIN9 septin 9 0.0297871
CTBP2 C-terminal binding protein 2 0.0296238
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0294812
SIK3 SIK family kinase 3 0.0290765
BIRC6 baculoviral IAP repeat containing 6 0.0290254
RAB10 RAB10, member RAS oncogene family 0.0289034
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0288065
EXOC6B exocyst complex component 6B 0.0287725
GSK3B glycogen synthase kinase 3 beta 0.0286544
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0285887
TSC22D2 TSC22 domain family, member 2 0.0285052
PUM2 pumilio RNA-binding family member 2 0.0283864
RUNX1 runt-related transcription factor 1 0.0282986
ZNF148 zinc finger protein 148 0.0282794
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0282008
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0280007
BRWD1 bromodomain and WD repeat domain containing 1 0.0279321
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0277001
NCKAP1 NCK-associated protein 1 0.0273291
FOXP1 forkhead box P1 0.0272378
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0271399
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.027044
STRN3 striatin, calmodulin binding protein 3 0.0269516
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.026832
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0264803
VEGFC vascular endothelial growth factor C 0.0262071
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0261364
WWOX WW domain containing oxidoreductase 0.0261162
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0261024
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0257435
ELL2 elongation factor, RNA polymerase II, 2 0.0256713
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0255762
SHB Src homology 2 domain containing adaptor protein B 0.025467
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0254224
ATP13A3 ATPase type 13A3 0.0250482
UBA6 ubiquitin-like modifier activating enzyme 6 0.0250384
ERBIN erbb2 interacting protein 0.0249889
EZR ezrin 0.0249212
NRDC nardilysin convertase 0.0247493
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.024701
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0245109
RIMS2 regulating synaptic membrane exocytosis 2 0.024419
CSNK1A1 casein kinase 1, alpha 1 0.0242143
ANKRD17 ankyrin repeat domain 17 0.02419
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0241216
IRS2 insulin receptor substrate 2 0.0240698
EXT1 exostosin glycosyltransferase 1 0.0240315
YTHDC1 YTH domain containing 1 0.0239047
FBXL17 F-box and leucine-rich repeat protein 17 0.0238131
MYH9 myosin, heavy chain 9, non-muscle 0.0237698
VCL vinculin 0.0234211

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.320356
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.182461
TMSB10 thymosin beta 10 -0.177003
NDRG1 N-myc downstream regulated 1 -0.104148
EGR1 early growth response 1 -0.0805532
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0751382
TPT1 tumor protein, translationally-controlled 1 -0.0741743
S100A10 S100 calcium binding protein A10 -0.0716237
LAMC2 laminin, gamma 2 -0.0666334
RPL35A ribosomal protein L35a -0.0663664
LOC112694756 uncharaterized LOC112694756 -0.0638486
RPS24 ribosomal protein S24 -0.0582731
PTMA prothymosin, alpha -0.0560296
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0554725
EGFR epidermal growth factor receptor -0.0554017
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0544667
CAV1 caveolin 1, caveolae protein, 22kDa -0.0509953
FTL ferritin, light polypeptide -0.0506672
RPS25 ribosomal protein S25 -0.0494375
RPLP1 ribosomal protein, large, P1 -0.0490787
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0488148
ZMYND8 zinc finger, MYND-type containing 8 -0.0484729
RPL34 ribosomal protein L34 -0.0483404
MT2A metallothionein 2A -0.048186
SEC61G Sec61 gamma subunit -0.0472804
LRP1B low density lipoprotein receptor-related protein 1B -0.0471749
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0455709
RPL31 ribosomal protein L31 -0.0445793
AHNAK AHNAK nucleoprotein -0.0443266
CST3 cystatin C -0.0426747
RPS6 ribosomal protein S6 -0.042025
PTPRM protein tyrosine phosphatase, receptor type, M -0.0386278
SLC38A1 solute carrier family 38, member 1 -0.0385074
ANKRD12 ankyrin repeat domain 12 -0.0369045
B2M beta-2-microglobulin -0.0368887
HLA-B major histocompatibility complex, class I, B -0.0364581
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0361656
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0359899
GM2A GM2 ganglioside activator -0.035766
RPS19 ribosomal protein S19 -0.0355869
TRIM56 tripartite motif containing 56 -0.0349089
ACTG1 actin gamma 1 -0.0341924
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.03385
BTG1 B-cell translocation gene 1, anti-proliferative -0.0335589
RPL23 ribosomal protein L23 -0.0333406
RPS12 ribosomal protein S12 -0.0329491
LDHA lactate dehydrogenase A -0.0326042
RPL37A ribosomal protein L37a -0.0321287
NCOA7 nuclear receptor coactivator 7 -0.030927
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0302701
LAMB3 laminin, beta 3 -0.0301346
RPS23 ribosomal protein S23 -0.0299254
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0297826
IER3 immediate early response 3 -0.0296195
RPS8 ribosomal protein S8 -0.0295745
RPS27A ribosomal protein S27a -0.0295547
RPS27 ribosomal protein S27 -0.0291941
RPS3 ribosomal protein S3 -0.0289195
IGFBP3 insulin-like growth factor binding protein 3 -0.0289072
EIF1 eukaryotic translation initiation factor 1 -0.0288793
GNAS GNAS complex locus -0.0288506
FTH1 ferritin, heavy polypeptide 1 -0.0284136
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0275217
BZW1 basic leucine zipper and W2 domains 1 -0.0271027
RPL37 ribosomal protein L37 -0.0263701
RPL19 ribosomal protein L19 -0.0262741
RPS14 ribosomal protein S14 -0.0261104
H1-0 H1.0 linker histone -0.0258202
RPL11 ribosomal protein L11 -0.0256833
AHNAK2 AHNAK nucleoprotein 2 -0.0255391
ANKRD10 ankyrin repeat domain 10 -0.0253716
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0252003
RPL4 ribosomal protein L4 -0.0250821
SRRM2 serine/arginine repetitive matrix 2 -0.0250524
PKM pyruvate kinase, muscle -0.0249174
MYO1D myosin ID -0.0240891
AGR2 anterior gradient 2 -0.0240293
SOD2 superoxide dismutase 2, mitochondrial -0.023783
JUN jun proto-oncogene -0.0237405
RPS17 ribosomal protein S17 -0.0237266
DSG2 desmoglein 2 -0.0235383
BIRC3 baculoviral IAP repeat containing 3 -0.0232782
KRT7 keratin 7, type II -0.0226786
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0225185
RPL30 ribosomal protein L30 -0.0224263
C15ORF48 chromosome 15 open reading frame 48 -0.0221031
RPS21 ribosomal protein S21 -0.0220042
AKAP12 A kinase (PRKA) anchor protein 12 -0.0219564
FNIP1 folliculin interacting protein 1 -0.0215771
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0215592
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0213222
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0211773
RPL8 ribosomal protein L8 -0.0211079
PDIA3 protein disulfide isomerase family A, member 3 -0.0211051
KRT8 keratin 8, type II -0.0207899
IGFBP5 insulin-like growth factor binding protein 5 -0.0205264
ARMH4 armadillo like helical domain containing 4 -0.020516
ANGPTL4 angiopoietin-like 4 -0.0204081
ARF1 ADP-ribosylation factor 1 -0.0203326
RACK1 receptor for activated C kinase 1 -0.0201372