Palmatine (chloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.113841
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.107036
GRB10 growth factor receptor-bound protein 10 0.0937343
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0886298
GLCCI1 glucocorticoid induced 1 0.0879968
PCBP2 poly(rC) binding protein 2 0.0852761
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0833173
SMAD3 SMAD family member 3 0.0806291
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0795141
ANTXR2 anthrax toxin receptor 2 0.0705553
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0688019
FAM20C family with sequence similarity 20, member C 0.0642773
APLP2 amyloid beta (A4) precursor-like protein 2 0.0638218
BASP1 brain abundant, membrane attached signal protein 1 0.0592475
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0587292
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0586597
PARD3 par-3 family cell polarity regulator 0.0544192
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0521363
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0513829
MAML3 mastermind-like 3 (Drosophila) 0.0486107
NRP1 neuropilin 1 0.0479329
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0457107
RICTOR RPTOR independent companion of MTOR, complex 2 0.0456569
SEPTIN9 septin 9 0.0453547
MYO10 myosin X 0.043903
TGFB1 transforming growth factor, beta 1 0.0434654
COL7A1 collagen, type VII, alpha 1 0.0431706
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0427219
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0427103
PTK2 protein tyrosine kinase 2 0.0406944
WLS wntless Wnt ligand secretion mediator 0.0400787
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0394765
STK38L serine/threonine kinase 38 like 0.0388657
ADD3 adducin 3 (gamma) 0.0387046
PSD3 pleckstrin and Sec7 domain containing 3 0.0385778
SIK3 SIK family kinase 3 0.0383884
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0373904
MACF1 microtubule-actin crosslinking factor 1 0.0368902
IFI44L interferon-induced protein 44-like 0.0367598
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.036624
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0360215
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0354443
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0349567
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0344966
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0333467
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0331006
NTN4 netrin 4 0.0326747
NRG1 neuregulin 1 0.0325197
DPYD dihydropyrimidine dehydrogenase 0.0323851
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0321052
VEGFC vascular endothelial growth factor C 0.0317501
MEF2A myocyte enhancer factor 2A 0.0315755
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0305297
NAV1 neuron navigator 1 0.0300088
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0300087
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0298373
CTBP2 C-terminal binding protein 2 0.0298283
SFTPA2 surfactant protein A2 0.0296775
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0294137
SVIL supervillin 0.0293537
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0293338
SP100 SP100 nuclear antigen 0.029115
SHB Src homology 2 domain containing adaptor protein B 0.0290854
MCL1 myeloid cell leukemia 1 0.0286541
ZEB1 zinc finger E-box binding homeobox 1 0.0277323
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0274186
CAPRIN2 caprin family member 2 0.0272935
RCOR1 REST corepressor 1 0.0270858
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0268019
ARHGAP26 Rho GTPase activating protein 26 0.0266415
ECE1 endothelin converting enzyme 1 0.0266136
USP3 ubiquitin specific peptidase 3 0.0263866
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0263694
TGM2 transglutaminase 2 0.0263123
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0256728
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0256131
UBA6 ubiquitin-like modifier activating enzyme 6 0.0255669
FBXO11 F-box protein 11 0.0254633
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.025278
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0252278
NPAS2 neuronal PAS domain protein 2 0.0251782
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0248799
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0248663
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0247865
SDK1 sidekick cell adhesion molecule 1 0.0247674
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0241909
WAC WW domain containing adaptor with coiled-coil 0.024143
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0240426
MYH9 myosin, heavy chain 9, non-muscle 0.0237334
EZR ezrin 0.0236314
CNKSR3 CNKSR family member 3 0.0233677
LRMDA leucine rich melanocyte differentiation associated 0.0231922
PDLIM5 PDZ and LIM domain 5 0.0230768
WWTR1 WW domain containing transcription regulator 1 0.0229088
ERBIN erbb2 interacting protein 0.0228593
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0227423
FMNL2 formin-like 2 0.0226477
SMYD3 SET and MYND domain containing 3 0.0224718
FOXO3 forkhead box O3 0.0223674
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0221055

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.195231
TMSB10 thymosin beta 10 -0.185988
CXCL8 chemokine (C-X-C motif) ligand 8 -0.147819
GOLGA4 golgin A4 -0.126929
RPL35A ribosomal protein L35a -0.116518
IGFBP3 insulin-like growth factor binding protein 3 -0.0983739
AKAP12 A kinase (PRKA) anchor protein 12 -0.0966751
OSMR oncostatin M receptor -0.0963595
FTL ferritin, light polypeptide -0.0876186
EIF1 eukaryotic translation initiation factor 1 -0.0833172
NAMPT nicotinamide phosphoribosyltransferase -0.0800189
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0753718
RPS19 ribosomal protein S19 -0.0708007
CD44 CD44 molecule (Indian blood group) -0.069117
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.066363
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0652087
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.064791
RPL31 ribosomal protein L31 -0.0613138
RPS6 ribosomal protein S6 -0.0608318
MON2 MON2 homolog (S. cerevisiae) -0.0592505
RPL37A ribosomal protein L37a -0.058666
NPC1 Niemann-Pick disease, type C1 -0.0557332
LOX lysyl oxidase -0.0555008
RBM39 RNA binding motif protein 39 -0.054259
HM13 histocompatibility (minor) 13 -0.0514309
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0487505
RAB1A RAB1A, member RAS oncogene family -0.0481148
GCC2 GRIP and coiled-coil domain containing 2 -0.046845
PDIA3 protein disulfide isomerase family A, member 3 -0.0464772
TPT1 tumor protein, translationally-controlled 1 -0.0459491
DLG1 discs, large homolog 1 (Drosophila) -0.0454101
RPS13 ribosomal protein S13 -0.0441082
LMAN1 lectin, mannose-binding, 1 -0.0439034
RPS25 ribosomal protein S25 -0.0436157
BTG1 B-cell translocation gene 1, anti-proliferative -0.0431285
IER3 immediate early response 3 -0.0428223
FRMD4A FERM domain containing 4A -0.0415397
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.041471
AKAP9 A kinase (PRKA) anchor protein 9 -0.0401634
RPL23 ribosomal protein L23 -0.0397746
RPS24 ribosomal protein S24 -0.0389838
RPLP1 ribosomal protein, large, P1 -0.0386463
VMP1 vacuole membrane protein 1 -0.0383915
TM4SF1 transmembrane 4 L six family member 1 -0.0373621
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0371438
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0359877
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0355729
STC1 stanniocalcin 1 -0.0354013
FTH1 ferritin, heavy polypeptide 1 -0.035136
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0351015
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0350176
PTMA prothymosin, alpha -0.0346751
TAS2R14 taste receptor, type 2, member 14 -0.0343848
USP34 ubiquitin specific peptidase 34 -0.0343832
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0342949
RPL4 ribosomal protein L4 -0.0340228
PRRC2C proline-rich coiled-coil 2C -0.0338365
SEC31A SEC31 homolog A (S. cerevisiae) -0.0335996
ATM ATM serine/threonine kinase -0.0335905
SEPTIN2 septin 2 -0.0334621
EGFR epidermal growth factor receptor -0.03324
COPB1 coatomer protein complex, subunit beta 1 -0.0330797
RPL34 ribosomal protein L34 -0.0326357
ZBTB20 zinc finger and BTB domain containing 20 -0.0326194
FAM114A1 family with sequence similarity 114, member A1 -0.032467
RPS27 ribosomal protein S27 -0.0321474
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0321363
NDRG1 N-myc downstream regulated 1 -0.0318893
SEC24D SEC24 family member D -0.031848
VDAC1 voltage-dependent anion channel 1 -0.0318104
RAB5A RAB5A, member RAS oncogene family -0.0316275
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0313526
TTC3 tetratricopeptide repeat domain 3 -0.0309692
RPL5 ribosomal protein L5 -0.0308039
TMEM165 transmembrane protein 165 -0.0307715
RPS23 ribosomal protein S23 -0.0305761
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0305494
ENO2 enolase 2 (gamma, neuronal) -0.0301079
ELL2 elongation factor, RNA polymerase II, 2 -0.0297298
LRRC49 leucine rich repeat containing 49 -0.0295852
BPTF bromodomain PHD finger transcription factor -0.0292819
GNAS GNAS complex locus -0.0291619
MORF4L2 mortality factor 4 like 2 -0.0288563
RPS29 ribosomal protein S29 -0.0287822
GREB1L growth regulation by estrogen in breast cancer-like -0.0287275
KPNB1 karyopherin (importin) beta 1 -0.0286998
CDCP1 CUB domain containing protein 1 -0.0285694
RPS16 ribosomal protein S16 -0.0284637
SCFD1 sec1 family domain containing 1 -0.0284387
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0282807
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0281031
GOLGA3 golgin A3 -0.0280096
CEP95 centrosomal protein 95kDa -0.0279837
DENND4A DENN/MADD domain containing 4A -0.0279428
RPL7A ribosomal protein L7a -0.027694
IFITM3 interferon induced transmembrane protein 3 -0.0276909
PTEN phosphatase and tensin homolog -0.0274941
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0273972
ZC3H12C zinc finger CCCH-type containing 12C -0.0272088
SLC38A1 solute carrier family 38, member 1 -0.0271275