Palmatine (chloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
YBX3 Y box binding protein 3 0.104438
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.104383
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.102242
TFPI2 tissue factor pathway inhibitor 2 0.0796233
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0750673
TXNRD1 thioredoxin reductase 1 0.0647336
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0598312
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0546631
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0544644
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0506889
RRM2 ribonucleotide reductase M2 0.0500744
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0480141
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0434169
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0412539
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0409948
TPM3 tropomyosin 3 0.0408174
DOCK5 dedicator of cytokinesis 5 0.0377643
ELL2 elongation factor, RNA polymerase II, 2 0.0372998
WWOX WW domain containing oxidoreductase 0.0368796
PCBP2 poly(rC) binding protein 2 0.0365131
RTN4 reticulon 4 0.0344461
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0344456
KTN1 kinectin 1 (kinesin receptor) 0.0333614
ATP11A ATPase, class VI, type 11A 0.0333223
GRAMD1B GRAM domain containing 1B 0.0323217
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0319758
YBX1 Y box binding protein 1 0.0312242
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.030978
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0308672
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0306647
MARCHF4 membrane associated ring-CH-type finger 4 0.0302719
SPAG9 sperm associated antigen 9 0.030267
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0301148
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0295099
SMC4 structural maintenance of chromosomes 4 0.0293009
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.029188
JMJD1C jumonji domain containing 1C 0.0276387
BRD2 bromodomain containing 2 0.0273694
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0268036
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0265349
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0261889
ATAD2 ATPase family, AAA domain containing 2 0.0260189
PPME1 protein phosphatase methylesterase 1 0.0260179
SSH2 slingshot protein phosphatase 2 0.0257032
IPO7 importin 7 0.0255678
CSNK1A1 casein kinase 1, alpha 1 0.0254843
PDE10A phosphodiesterase 10A 0.0252877
SNAP25 synaptosomal-associated protein, 25kDa 0.0252843
POTEF POTE ankyrin domain family, member F 0.0245143
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.024511
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0243103
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0240607
NCAPG2 non-SMC condensin II complex, subunit G2 0.0240435
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0239188
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0234588
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.023428
VMP1 vacuole membrane protein 1 0.0229186
SFPQ splicing factor proline/glutamine-rich 0.0227864
WAC WW domain containing adaptor with coiled-coil 0.0227224
FUS FUS RNA binding protein 0.0225975
EXT1 exostosin glycosyltransferase 1 0.0225911
OGA O-GlcNAcase 0.0225215
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0224317
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0223359
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0221439
BIRC3 baculoviral IAP repeat containing 3 0.0220836
CALD1 caldesmon 1 0.022071
AGFG1 ArfGAP with FG repeats 1 0.0219228
PHIP pleckstrin homology domain interacting protein 0.0211873
TUBA1B tubulin, alpha 1b 0.0208151
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0206795
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0205712
HELLS helicase, lymphoid-specific 0.0203709
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0202894
UBASH3B ubiquitin associated and SH3 domain containing B 0.0202889
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0201189
FLNA filamin A, alpha 0.0199526
ANXA5 annexin A5 0.0199027
GMDS GDP-mannose 4,6-dehydratase 0.0198448
HSPA8 heat shock 70kDa protein 8 0.0198194
LDHB lactate dehydrogenase B 0.0197846
NIPBL Nipped-B homolog (Drosophila) 0.0197786
PDLIM5 PDZ and LIM domain 5 0.0197608
NCKAP1 NCK-associated protein 1 0.0191546
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0189405
OLA1 Obg-like ATPase 1 0.0189339
AFG2A AFG2 AAA ATPase homolog A 0.0189311
CAPRIN2 caprin family member 2 0.0188874
TBK1 TANK-binding kinase 1 0.018743
SERBP1 SERPINE1 mRNA binding protein 1 0.0187365
BZW1 basic leucine zipper and W2 domains 1 0.018733
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.018696
IL6ST interleukin 6 signal transducer 0.0185995
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0185889
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0185096
BCLAF1 BCL2-associated transcription factor 1 0.0184625
LUZP1 leucine zipper protein 1 0.0184345
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0183971
EGLN1 egl-9 family hypoxia-inducible factor 1 0.01834
MSH6 mutS homolog 6 0.0181063

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.0856971
TMSB10 thymosin beta 10 -0.0815736
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0789748
AHNAK AHNAK nucleoprotein -0.0519409
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.047785
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0477249
HMGA2 high mobility group AT-hook 2 -0.0460305
EGR1 early growth response 1 -0.0443064
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0416509
RPL37 ribosomal protein L37 -0.0415199
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0389471
RPS21 ribosomal protein S21 -0.0360908
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0331149
RYR3 ryanodine receptor 3 -0.0318057
EEF2 eukaryotic translation elongation factor 2 -0.0316162
RAD51B RAD51 paralog B -0.0306129
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0286233
RPL26 ribosomal protein L26 -0.027834
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0277591
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0276807
AEBP2 AE binding protein 2 -0.0272577
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0271132
AFF3 AF4/FMR2 family, member 3 -0.026204
ATXN1 ataxin 1 -0.0256727
GLG1 golgi glycoprotein 1 -0.0248375
RSF1 remodeling and spacing factor 1 -0.0241796
PDIA4 protein disulfide isomerase family A, member 4 -0.0236057
GOLGB1 golgin B1 -0.0235368
RPL34 ribosomal protein L34 -0.0234516
VIM vimentin -0.0234164
CANX calnexin -0.0227663
RPL35A ribosomal protein L35a -0.0225586
PTMA prothymosin, alpha -0.0223436
RPL8 ribosomal protein L8 -0.0220929
FMN1 formin 1 -0.022091
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.021822
RPL32 ribosomal protein L32 -0.0216513
COPA coatomer protein complex, subunit alpha -0.021303
ZMYND8 zinc finger, MYND-type containing 8 -0.0209428
NCOA7 nuclear receptor coactivator 7 -0.0208096
MT2A metallothionein 2A -0.0207361
RPL36A ribosomal protein L36a -0.0204799
RPS3 ribosomal protein S3 -0.0202413
RPS13 ribosomal protein S13 -0.0202353
RPL23 ribosomal protein L23 -0.0202202
HLA-B major histocompatibility complex, class I, B -0.0201035
RPS6 ribosomal protein S6 -0.0200245
SRRM2 serine/arginine repetitive matrix 2 -0.0199896
CCND2 cyclin D2 -0.0199355
RPS19 ribosomal protein S19 -0.0196059
IGF2 insulin-like growth factor 2 -0.0195681
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.019448
PATJ PATJ crumbs cell polarity complex component -0.0193973
CAVIN1 caveolae associated protein 1 -0.0188819
TAS2R14 taste receptor, type 2, member 14 -0.018789
MACF1 microtubule-actin crosslinking factor 1 -0.01866
RNF213 ring finger protein 213 -0.0185388
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0183229
TPT1 tumor protein, translationally-controlled 1 -0.0182844
NTSR1 neurotensin receptor 1 (high affinity) -0.0182405
RPS24 ribosomal protein S24 -0.0181544
MON2 MON2 homolog (S. cerevisiae) -0.0178795
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0178178
RPS27 ribosomal protein S27 -0.0176297
TRIM56 tripartite motif containing 56 -0.0175806
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0174799
EIF1 eukaryotic translation initiation factor 1 -0.0169476
S100A6 S100 calcium binding protein A6 -0.0165198
GOLGA4 golgin A4 -0.0164254
LMAN1 lectin, mannose-binding, 1 -0.0162377
EGFR epidermal growth factor receptor -0.0161789
ENOSF1 enolase superfamily member 1 -0.0161321
RPL19 ribosomal protein L19 -0.0161041
MAP4 microtubule-associated protein 4 -0.0160149
FSCN1 fascin actin-bundling protein 1 -0.0154991
PDIA3 protein disulfide isomerase family A, member 3 -0.0154559
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0154456
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0153567
NF1 neurofibromin 1 -0.0153311
RPL38 ribosomal protein L38 -0.0153299
HDAC8 histone deacetylase 8 -0.0152011
RPL31 ribosomal protein L31 -0.0151302
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0150657
PHF3 PHD finger protein 3 -0.0148568
LMNA lamin A/C -0.0144814
BCAS3 breast carcinoma amplified sequence 3 -0.0144325
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0143227
RPL36 ribosomal protein L36 -0.014233
ZNF217 zinc finger protein 217 -0.0142285
CALR calreticulin -0.0141964
FNIP1 folliculin interacting protein 1 -0.0141914
LEKR1 leucine, glutamate and lysine rich 1 -0.0141104
RPL11 ribosomal protein L11 -0.0140923
CCDC7 coiled-coil domain containing 7 -0.0140723
ST7L suppression of tumorigenicity 7 like -0.0140604
RPS11 ribosomal protein S11 -0.0140428
MTA3 metastasis associated 1 family, member 3 -0.0139949
GOLGA3 golgin A3 -0.013968
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0139496
RPL5 ribosomal protein L5 -0.0137889