Palmatine (chloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Palmatine (chloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.18488
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.118905
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.101764
SAMD4B sterile alpha motif domain containing 4B 0.0979424
ACTN4 actinin, alpha 4 0.0881824
FNDC3B fibronectin type III domain containing 3B 0.0817557
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0789895
SMAD3 SMAD family member 3 0.075445
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0751144
JMJD1C jumonji domain containing 1C 0.0750472
CD44 CD44 molecule (Indian blood group) 0.0727256
APLP2 amyloid beta (A4) precursor-like protein 2 0.0718802
ASPH aspartate beta-hydroxylase 0.0710551
WWTR1 WW domain containing transcription regulator 1 0.0703779
SEPTIN9 septin 9 0.0691839
MT2A metallothionein 2A 0.0657765
PTK2 protein tyrosine kinase 2 0.0653306
VMP1 vacuole membrane protein 1 0.05889
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0587647
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0571285
CSNK1A1 casein kinase 1, alpha 1 0.0568421
MACF1 microtubule-actin crosslinking factor 1 0.0555295
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0553809
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.053739
NUP98 nucleoporin 98kDa 0.0536244
SPRED2 sprouty-related, EVH1 domain containing 2 0.051608
SMYD3 SET and MYND domain containing 3 0.0515238
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0506965
ZFAND3 zinc finger, AN1-type domain 3 0.0500679
INTS6 integrator complex subunit 6 0.0496608
MCL1 myeloid cell leukemia 1 0.0484102
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0472295
DSCAM Down syndrome cell adhesion molecule 0.0459151
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0450795
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0445601
TRIO trio Rho guanine nucleotide exchange factor 0.0443041
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0441714
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0437727
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0436624
ERBIN erbb2 interacting protein 0.0431072
OGA O-GlcNAcase 0.0419081
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0413081
SATB2 SATB homeobox 2 0.0412497
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0410424
EXT1 exostosin glycosyltransferase 1 0.0407875
SFTPA2 surfactant protein A2 0.0404803
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0400333
ZSWIM6 zinc finger, SWIM-type containing 6 0.0397909
ZNF780B zinc finger protein 780B 0.0397274
ATXN1 ataxin 1 0.0397012
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0379519
CTNND1 catenin (cadherin-associated protein), delta 1 0.0379194
PCBP2 poly(rC) binding protein 2 0.0369618
EFNA5 ephrin-A5 0.0362037
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0356543
RAP1B RAP1B, member of RAS oncogene family 0.0350902
BRD2 bromodomain containing 2 0.0349702
SFPQ splicing factor proline/glutamine-rich 0.0337359
DST dystonin 0.0336542
PHF14 PHD finger protein 14 0.0335894
B2M beta-2-microglobulin 0.0333912
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0332523
NCEH1 neutral cholesterol ester hydrolase 1 0.0330861
ITGB5 integrin, beta 5 0.0329695
CELF1 CUGBP, Elav-like family member 1 0.0324921
TPM1 tropomyosin 1 (alpha) 0.0321478
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0315684
SHB Src homology 2 domain containing adaptor protein B 0.0315512
ANO6 anoctamin 6 0.0312926
RAB7A RAB7A, member RAS oncogene family 0.0312768
RPS3 ribosomal protein S3 0.0312533
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0312439
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0307487
PNISR PNN-interacting serine/arginine-rich protein 0.0303994
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0303677
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0303464
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0299195
NF1 neurofibromin 1 0.0298845
CCDC88A coiled-coil domain containing 88A 0.0298089
CAPZB capping protein (actin filament) muscle Z-line, beta 0.029738
RABGAP1L RAB GTPase activating protein 1-like 0.0295887
SMC4 structural maintenance of chromosomes 4 0.0293822
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0292974
CUL3 cullin 3 0.0292868
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0289899
FBXO11 F-box protein 11 0.0289373
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0287647
RASAL2 RAS protein activator like 2 0.0287645
RPS2 ribosomal protein S2 0.0287164
DOCK5 dedicator of cytokinesis 5 0.0284773
EXOC6B exocyst complex component 6B 0.0284248
ZNF148 zinc finger protein 148 0.0282347
EXOC4 exocyst complex component 4 0.0281563
RTN4 reticulon 4 0.0280703
TMEM41B transmembrane protein 41B 0.0280635
SLC38A2 solute carrier family 38, member 2 0.0277039
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.027679
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0275119
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0275042
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0274369

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.38995
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.119809
AHNAK AHNAK nucleoprotein -0.0946102
VIM vimentin -0.0896565
FBL fibrillarin -0.08534
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0815428
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0678245
TMSB10 thymosin beta 10 -0.0638134
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0609339
RPS16 ribosomal protein S16 -0.0596314
RPL35A ribosomal protein L35a -0.0389738
CAVIN1 caveolae associated protein 1 -0.0301997
RPL4 ribosomal protein L4 -0.0292423
HSPG2 heparan sulfate proteoglycan 2 -0.0286252
RPS24 ribosomal protein S24 -0.0264475
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0260929
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0260848
CTSD cathepsin D -0.0256499
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0240819
PTMA prothymosin, alpha -0.0236861
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0227464
PDIA3 protein disulfide isomerase family A, member 3 -0.0221601
ACTG1 actin gamma 1 -0.0214333
KPNB1 karyopherin (importin) beta 1 -0.0210795
PDGFB platelet-derived growth factor beta polypeptide -0.0202511
LOC112694756 uncharaterized LOC112694756 -0.0188667
TM4SF1 transmembrane 4 L six family member 1 -0.0188455
EIF1 eukaryotic translation initiation factor 1 -0.0184645
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0183842
GNAS GNAS complex locus -0.0182689
SOD2 superoxide dismutase 2, mitochondrial -0.018198
H1-0 H1.0 linker histone -0.0181341
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0173404
RSL1D1 ribosomal L1 domain containing 1 -0.0172461
HIPK2 homeodomain interacting protein kinase 2 -0.0167446
TMSB4X thymosin beta 4, X-linked -0.0162469
RPL34 ribosomal protein L34 -0.0162442
RPS25 ribosomal protein S25 -0.015674
S100A6 S100 calcium binding protein A6 -0.0153868
DDIT4 DNA-damage-inducible transcript 4 -0.0146046
TPD52 tumor protein D52 -0.0145262
MXI1 MAX interactor 1, dimerization protein -0.0144346
ZMYND8 zinc finger, MYND-type containing 8 -0.0143168
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0141205
BIRC3 baculoviral IAP repeat containing 3 -0.0140632
ICAM1 intercellular adhesion molecule 1 -0.0138387
RPS6 ribosomal protein S6 -0.0137949
FTL ferritin, light polypeptide -0.0135285
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.013487
SEC63 SEC63 homolog (S. cerevisiae) -0.0134751
LDHA lactate dehydrogenase A -0.0134295
ANGPTL4 angiopoietin-like 4 -0.0131509
NAV2 neuron navigator 2 -0.0129205
GOLGA4 golgin A4 -0.0125929
ZNF546 zinc finger protein 546 -0.0123372
ONECUT3 one cut homeobox 3 -0.0122791
SLC35F3 solute carrier family 35, member F3 -0.0119086
JPT2 Jupiter microtubule associated homolog 2 -0.011859
PLIN2 perilipin 2 -0.0118206
MATR3 matrin 3 -0.011768
WDR45B WD repeat domain 45B -0.0116446
SNX14 sorting nexin 14 -0.0115599
RPL6 ribosomal protein L6 -0.0114862
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0114447
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0109724
BCOR BCL6 corepressor -0.0106153
QKI QKI, KH domain containing, RNA binding -0.0102647
IRAK1 interleukin-1 receptor-associated kinase 1 -0.0102015
ARF1 ADP-ribosylation factor 1 -0.00987239
ARMC9 armadillo repeat containing 9 -0.00986485
TMEM165 transmembrane protein 165 -0.00986101
LRRC49 leucine rich repeat containing 49 -0.00952846
ZC3H6 zinc finger CCCH-type containing 6 -0.0094586
RPS5 ribosomal protein S5 -0.00945076
COL18A1 collagen, type XVIII, alpha 1 -0.00940098
MORF4L2 mortality factor 4 like 2 -0.00927318
BMAL2 basic helix-loop-helix ARNT like 2 -0.00921787
BTG1 B-cell translocation gene 1, anti-proliferative -0.00919936
CDV3 CDV3 homolog (mouse) -0.00919897
TGIF1 TGFB-induced factor homeobox 1 -0.00917573
RPL36A ribosomal protein L36a -0.00916608
APOLD1 apolipoprotein L domain containing 1 -0.00905057
MTCL1 microtubule crosslinking factor 1 -0.00895735
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.00893292
EEF2 eukaryotic translation elongation factor 2 -0.00891244
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.00889925
TPT1 tumor protein, translationally-controlled 1 -0.00883857
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.00879128
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.00878914
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0086503
TMEM123 transmembrane protein 123 -0.00864
LARS1 leucyl-tRNA synthetase 1 -0.00858318
ZNF217 zinc finger protein 217 -0.00847569
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.00838087
UGCG UDP-glucose ceramide glucosyltransferase -0.00837559
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.00831151
FSCN1 fascin actin-bundling protein 1 -0.00821214
TKT transketolase -0.00820863
PHF10 PHD finger protein 10 -0.00812585
MYOF myoferlin -0.00803362