Palmatine (chloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.120545
AHNAK AHNAK nucleoprotein 0.116288
INTS6 integrator complex subunit 6 0.115293
CANX calnexin 0.102349
ANXA2 annexin A2 0.0850948
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0784416
SQSTM1 sequestosome 1 0.078304
RUNX1 runt-related transcription factor 1 0.0761286
KRT19 keratin 19, type I 0.0742808
EFNA5 ephrin-A5 0.072266
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0720416
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0691789
APLP2 amyloid beta (A4) precursor-like protein 2 0.0691265
SVIL supervillin 0.0667807
FN1 fibronectin 1 0.0662661
RNF213 ring finger protein 213 0.0633402
LPP LIM domain containing preferred translocation partner in lipoma 0.0606483
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0597024
CD44 CD44 molecule (Indian blood group) 0.0594168
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0560373
SEPTIN9 septin 9 0.0550045
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0547695
ZSWIM6 zinc finger, SWIM-type containing 6 0.0542863
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0527544
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.051764
ASPH aspartate beta-hydroxylase 0.0517477
SMAD3 SMAD family member 3 0.0496272
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0492337
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0489458
ZBTB20 zinc finger and BTB domain containing 20 0.0489269
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0483249
SP100 SP100 nuclear antigen 0.0465053
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0464683
ETV6 ets variant 6 0.0453919
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0452691
PGK1 phosphoglycerate kinase 1 0.0449326
CTBP2 C-terminal binding protein 2 0.04417
MX1 MX dynamin-like GTPase 1 0.0440897
RAD51B RAD51 paralog B 0.0433796
TRIO trio Rho guanine nucleotide exchange factor 0.0433224
MX2 MX dynamin-like GTPase 2 0.0426246
AEBP2 AE binding protein 2 0.0420164
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0418885
RIGI RNA sensor RIG-I 0.0415566
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0413653
NRP1 neuropilin 1 0.0411259
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0410701
LAMA4 laminin, alpha 4 0.0395005
TM4SF1 transmembrane 4 L six family member 1 0.039281
TPT1 tumor protein, translationally-controlled 1 0.0392796
PTK2 protein tyrosine kinase 2 0.0392186
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0388561
EMP1 epithelial membrane protein 1 0.0386924
SH3KBP1 SH3-domain kinase binding protein 1 0.0380107
EXT1 exostosin glycosyltransferase 1 0.0379569
STAT1 signal transducer and activator of transcription 1, 91kDa 0.03675
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0367143
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0359825
EXOC4 exocyst complex component 4 0.0358984
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0351283
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0348827
SMOC1 SPARC related modular calcium binding 1 0.0348446
CHD4 chromodomain helicase DNA binding protein 4 0.034481
KLF5 Kruppel-like factor 5 (intestinal) 0.0344805
OGA O-GlcNAcase 0.0343572
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0341883
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0340931
EFNB2 ephrin-B2 0.0335136
BZW1 basic leucine zipper and W2 domains 1 0.0332224
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0329017
ARID1B AT rich interactive domain 1B (SWI1-like) 0.032725
NABP1 nucleic acid binding protein 1 0.0326183
THSD4 thrombospondin, type I, domain containing 4 0.0326036
HMGA2 high mobility group AT-hook 2 0.0325404
HOMER1 homer scaffolding protein 1 0.0325278
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.032436
KRT18 keratin 18, type I 0.0318217
TRAPPC9 trafficking protein particle complex 9 0.031584
H1-0 H1.0 linker histone 0.0314825
LITAF lipopolysaccharide-induced TNF factor 0.0314353
RIMKLB ribosomal modification protein rimK-like family member B 0.0313676
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0311258
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.031123
FHIT fragile histidine triad 0.0309232
ENO1 enolase 1, (alpha) 0.0308212
DOCK1 dedicator of cytokinesis 1 0.0301809
PLSCR1 phospholipid scramblase 1 0.0300933
SKAP2 src kinase associated phosphoprotein 2 0.0300496
TBC1D5 TBC1 domain family, member 5 0.0300222
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0297916
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0294419
DSPP dentin sialophosphoprotein 0.0285311
HDLBP high density lipoprotein binding protein 0.0284878
IFI44L interferon-induced protein 44-like 0.028051
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0279522
MPRIP myosin phosphatase Rho interacting protein 0.0279461
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0277993
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0276972
ACTN4 actinin, alpha 4 0.0276773
FNDC3B fibronectin type III domain containing 3B 0.0276613

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153132
TMSB10 thymosin beta 10 -0.110864
POTEF POTE ankyrin domain family, member F -0.0949668
RPS6 ribosomal protein S6 -0.0903054
NDRG1 N-myc downstream regulated 1 -0.078713
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0783491
UGCG UDP-glucose ceramide glucosyltransferase -0.0761684
TMSB4X thymosin beta 4, X-linked -0.0743429
RPL35A ribosomal protein L35a -0.0726071
MUC4 mucin 4, cell surface associated -0.0696759
HMGA1 high mobility group AT-hook 1 -0.0660156
GOLGA4 golgin A4 -0.0642886
RPS19 ribosomal protein S19 -0.0633293
PRRC2C proline-rich coiled-coil 2C -0.0584791
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0576144
MYO6 myosin VI -0.0517289
FAM3C family with sequence similarity 3, member C -0.049333
LAMB3 laminin, beta 3 -0.049074
EIF1 eukaryotic translation initiation factor 1 -0.0453835
CCNL1 cyclin L1 -0.0452671
RIOK3 RIO kinase 3 -0.044655
TMF1 TATA element modulatory factor 1 -0.0446114
FOSL1 FOS-like antigen 1 -0.0417455
RPS12 ribosomal protein S12 -0.0410081
RPL5 ribosomal protein L5 -0.0400697
RPS23 ribosomal protein S23 -0.0396787
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0391484
RPL21 ribosomal protein L21 -0.0390827
ACTG1 actin gamma 1 -0.0382021
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0380749
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0377985
LOC112694756 uncharaterized LOC112694756 -0.0373699
FTH1 ferritin, heavy polypeptide 1 -0.0373569
RBM25 RNA binding motif protein 25 -0.0371459
KRT7 keratin 7, type II -0.0368629
RTN4 reticulon 4 -0.0355077
EGR1 early growth response 1 -0.0337491
RPL37A ribosomal protein L37a -0.033451
AKAP9 A kinase (PRKA) anchor protein 9 -0.0334275
CDCP1 CUB domain containing protein 1 -0.0332949
DSG2 desmoglein 2 -0.0332674
RPS14 ribosomal protein S14 -0.0331306
TAPBP TAP binding protein (tapasin) -0.0329342
VEGFA vascular endothelial growth factor A -0.0323435
ARHGAP29 Rho GTPase activating protein 29 -0.0319422
WWC1 WW and C2 domain containing 1 -0.0319128
RPL32 ribosomal protein L32 -0.031585
DIAPH3 diaphanous-related formin 3 -0.0313342
NCEH1 neutral cholesterol ester hydrolase 1 -0.0312243
RPL31 ribosomal protein L31 -0.0309659
B2M beta-2-microglobulin -0.0309586
KTN1 kinectin 1 (kinesin receptor) -0.030628
BRD4 bromodomain containing 4 -0.0304013
IGFBP3 insulin-like growth factor binding protein 3 -0.0303892
PLAT plasminogen activator, tissue -0.0301469
NEK7 NIMA-related kinase 7 -0.0295833
ADGRF1 adhesion G protein-coupled receptor F1 -0.0295268
RB1CC1 RB1-inducible coiled-coil 1 -0.0292037
RPL15 ribosomal protein L15 -0.0290518
RPL23 ribosomal protein L23 -0.0288457
RPS3 ribosomal protein S3 -0.0287193
RPS17 ribosomal protein S17 -0.0285944
PNN pinin, desmosome associated protein -0.028587
LAMC2 laminin, gamma 2 -0.0281052
THBS1 thrombospondin 1 -0.0279728
WDR45B WD repeat domain 45B -0.0274296
RACK1 receptor for activated C kinase 1 -0.0272926
SMC5 structural maintenance of chromosomes 5 -0.0269706
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0263782
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0260812
LY6E lymphocyte antigen 6 complex, locus E -0.0260803
ARRDC3 arrestin domain containing 3 -0.0258926
FTL ferritin, light polypeptide -0.0257181
C6ORF132 chromosome 6 open reading frame 132 -0.0256323
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0254046
PARD6B par-6 family cell polarity regulator beta -0.0252266
OPTN optineurin -0.0251648
RPS13 ribosomal protein S13 -0.0251392
PICALM phosphatidylinositol binding clathrin assembly protein -0.0249481
RPS15 ribosomal protein S15 -0.024921
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.024795
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0247905
RPL19 ribosomal protein L19 -0.0247791
RPS24 ribosomal protein S24 -0.0246577
PTEN phosphatase and tensin homolog -0.0245754
ATP5F1B ATP synthase F1 subunit beta -0.0241582
RPL8 ribosomal protein L8 -0.0240014
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0236929
DUSP5 dual specificity phosphatase 5 -0.0236624
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0235678
MIS18BP1 MIS18 binding protein 1 -0.0230925
KMT2E lysine (K)-specific methyltransferase 2E -0.0229835
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0228062
MBNL2 muscleblind-like splicing regulator 2 -0.0226847
TNIP1 TNFAIP3 interacting protein 1 -0.0226643
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0223919
RPS2 ribosomal protein S2 -0.0223874
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0223089
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0221528
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.021943