Palmatine (chloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.117756
SGMS2 sphingomyelin synthase 2 0.0980729
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.097801
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0955737
FRMD6 FERM domain containing 6 0.0923724
ZNF438 zinc finger protein 438 0.0813614
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0798966
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0760348
ZEB1 zinc finger E-box binding homeobox 1 0.0752284
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0716257
ARHGAP22 Rho GTPase activating protein 22 0.0687562
HMGA2 high mobility group AT-hook 2 0.0664741
MT2A metallothionein 2A 0.0662952
IFI16 interferon, gamma-inducible protein 16 0.0656843
AGO2 argonaute RISC catalytic component 2 0.0642759
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0610582
NAV3 neuron navigator 3 0.0599611
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0572972
SP100 SP100 nuclear antigen 0.0547494
EXT1 exostosin glycosyltransferase 1 0.0528976
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0525683
MCL1 myeloid cell leukemia 1 0.0517204
IFI6 interferon, alpha-inducible protein 6 0.0492937
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0480522
RIGI RNA sensor RIG-I 0.0480412
ANK2 ankyrin 2, neuronal 0.0451711
HDAC9 histone deacetylase 9 0.0444298
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0438156
MX1 MX dynamin-like GTPase 1 0.0437415
ASPH aspartate beta-hydroxylase 0.041963
RAD51B RAD51 paralog B 0.041725
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0414762
EFNB2 ephrin-B2 0.0400432
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0391501
RPS2 ribosomal protein S2 0.0387371
STC1 stanniocalcin 1 0.0381192
NAV2 neuron navigator 2 0.0344716
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0342401
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0324751
SMYD3 SET and MYND domain containing 3 0.030771
EXOC4 exocyst complex component 4 0.0305733
ENO1 enolase 1, (alpha) 0.0304427
SERBP1 SERPINE1 mRNA binding protein 1 0.0303858
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0291797
RPS12 ribosomal protein S12 0.0285847
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0282432
RRM2 ribonucleotide reductase M2 0.028068
PTPRG protein tyrosine phosphatase, receptor type, G 0.0280578
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0276065
INTS6 integrator complex subunit 6 0.0275394
RCOR1 REST corepressor 1 0.027497
SFPQ splicing factor proline/glutamine-rich 0.0273723
RPL7 ribosomal protein L7 0.0272759
APLP2 amyloid beta (A4) precursor-like protein 2 0.0268301
TRAPPC9 trafficking protein particle complex 9 0.0265428
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.026504
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0262085
FHIT fragile histidine triad 0.0260188
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0258607
CAPRIN2 caprin family member 2 0.0257068
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0256453
CAST calpastatin 0.0256292
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0254784
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0254025
RAB7A RAB7A, member RAS oncogene family 0.0251391
SET SET nuclear proto-oncogene 0.0250353
WWOX WW domain containing oxidoreductase 0.0244456
PUM3 pumilio RNA binding family member 3 0.0243987
NRDC nardilysin convertase 0.0243766
CORO1C coronin, actin binding protein, 1C 0.0241234
TM4SF19 transmembrane 4 L six family member 19 0.0240622
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0239084
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0236771
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0235585
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0235379
ZSWIM6 zinc finger, SWIM-type containing 6 0.0235358
TM4SF1 transmembrane 4 L six family member 1 0.0233734
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0232809
ZFP36L1 ZFP36 ring finger protein-like 1 0.0231713
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0229738
ANXA2 annexin A2 0.0228745
THADA thyroid adenoma associated 0.0228541
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0226406
PLSCR1 phospholipid scramblase 1 0.022611
PA2G4 proliferation-associated 2G4, 38kDa 0.0225752
PHF14 PHD finger protein 14 0.0224937
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0224306
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0224098
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0223314
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0222024
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0220635
TPM3 tropomyosin 3 0.0218603
XRN2 5'-3' exoribonuclease 2 0.0218006
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0216261
EFL1 elongation factor like GTPase 1 0.0215425
ADTRP androgen-dependent TFPI-regulating protein 0.0215256
C6ORF62 chromosome 6 open reading frame 62 0.0214926
TASOR2 transcription activation suppressor family member 2 0.0212572
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0212215
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0209331

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.155893
DLC1 DLC1 Rho GTPase activating protein -0.111115
RPS6 ribosomal protein S6 -0.0988697
LAMB3 laminin, beta 3 -0.0802423
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0687454
TTR transthyretin -0.0635207
EEF2 eukaryotic translation elongation factor 2 -0.0572751
ACTG1 actin gamma 1 -0.0556908
GOLGA4 golgin A4 -0.0527603
ELL2 elongation factor, RNA polymerase II, 2 -0.0518289
RPS21 ribosomal protein S21 -0.0506401
ZFAND3 zinc finger, AN1-type domain 3 -0.0452675
KDM3A lysine (K)-specific demethylase 3A -0.0446009
RPS19 ribosomal protein S19 -0.0432973
KMT2C lysine (K)-specific methyltransferase 2C -0.0431018
TMSB10 thymosin beta 10 -0.0429611
RPL8 ribosomal protein L8 -0.0413751
ZNF292 zinc finger protein 292 -0.0405699
PRRC2B proline-rich coiled-coil 2B -0.0401351
TRIO trio Rho guanine nucleotide exchange factor -0.0388355
RPL35A ribosomal protein L35a -0.0382796
RAD21 RAD21 homolog (S. pombe) -0.0380346
RPL4 ribosomal protein L4 -0.037731
TPD52 tumor protein D52 -0.035335
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0352729
RPL34 ribosomal protein L34 -0.0351057
RRBP1 ribosome binding protein 1 -0.0345369
SRRM2 serine/arginine repetitive matrix 2 -0.0339932
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0332386
RPLP2 ribosomal protein, large, P2 -0.0331227
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0328898
USP3 ubiquitin specific peptidase 3 -0.0327833
NUP58 nucleoporin 58 -0.0326116
RPL26 ribosomal protein L26 -0.0322679
TXNRD1 thioredoxin reductase 1 -0.0313412
DIAPH3 diaphanous-related formin 3 -0.030561
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0295187
RB1CC1 RB1-inducible coiled-coil 1 -0.0293735
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0289958
RLF rearranged L-myc fusion -0.0288521
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0287204
EIF1 eukaryotic translation initiation factor 1 -0.0285733
RPL32 ribosomal protein L32 -0.0281723
RBM25 RNA binding motif protein 25 -0.0281157
GARS1 glycyl-tRNA synthetase 1 -0.0279319
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0278771
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0275804
GLG1 golgi glycoprotein 1 -0.0274034
RPL23 ribosomal protein L23 -0.0273906
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0273482
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0271654
USP34 ubiquitin specific peptidase 34 -0.0268652
JUN jun proto-oncogene -0.0266615
CHD7 chromodomain helicase DNA binding protein 7 -0.0266508
SBF2 SET binding factor 2 -0.0264297
RPL35 ribosomal protein L35 -0.0263045
RPL14 ribosomal protein L14 -0.0262293
FMNL2 formin-like 2 -0.0260526
BRWD3 bromodomain and WD repeat domain containing 3 -0.0258551
RPL37A ribosomal protein L37a -0.0258257
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.025712
CYRIB CYFIP related Rac1 interactor B -0.0256924
RPL12 ribosomal protein L12 -0.0255945
GNAS GNAS complex locus -0.0254951
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0253591
RPL13A ribosomal protein L13a -0.0252003
RPL19 ribosomal protein L19 -0.0248086
PCNX1 pecanex 1 -0.0247567
NF1 neurofibromin 1 -0.0246912
LCORL ligand dependent nuclear receptor corepressor-like -0.0245798
POU2F1 POU class 2 homeobox 1 -0.0243788
ARFGEF3 ARFGEF family member 3 -0.0243218
PHIP pleckstrin homology domain interacting protein -0.0241485
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0240799
NSD3 nuclear receptor binding SET domain protein 3 -0.0239276
RPLP1 ribosomal protein, large, P1 -0.023761
WDR45B WD repeat domain 45B -0.0235027
OLA1 Obg-like ATPase 1 -0.0234187
AHNAK AHNAK nucleoprotein -0.0232156
MARCHF6 membrane associated ring-CH-type finger 6 -0.0231671
RPS24 ribosomal protein S24 -0.0231634
AKAP9 A kinase (PRKA) anchor protein 9 -0.0231634
NDRG1 N-myc downstream regulated 1 -0.0230568
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0227647
MKI67 marker of proliferation Ki-67 -0.0226227
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0225008
ZMYM2 zinc finger, MYM-type 2 -0.0223144
PRRC2C proline-rich coiled-coil 2C -0.0221436
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0219472
CD2AP CD2-associated protein -0.0219223
HDLBP high density lipoprotein binding protein -0.021757
NIPBL Nipped-B homolog (Drosophila) -0.0213237
TM9SF3 transmembrane 9 superfamily member 3 -0.0211721
RAB2A RAB2A, member RAS oncogene family -0.0209767
CTIF CBP80/20-dependent translation initiation factor -0.0209419
SETX senataxin -0.0208025
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0207592
ENO2 enolase 2 (gamma, neuronal) -0.0205811
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0205382
KDM7A lysine (K)-specific demethylase 7A -0.0204004