Palmatine (chloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.0899825
PDE4D phosphodiesterase 4D, cAMP-specific 0.0747035
VCL vinculin 0.059325
FOXP1 forkhead box P1 0.0574588
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0538618
GLI3 GLI family zinc finger 3 0.046048
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0429648
EGFR epidermal growth factor receptor 0.0407747
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0401369
NBEA neurobeachin 0.0393951
TJP1 tight junction protein 1 0.0378395
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0377445
SOX6 SRY (sex determining region Y)-box 6 0.0370611
HDAC9 histone deacetylase 9 0.031607
PDGFC platelet derived growth factor C 0.030987
ZEB1 zinc finger E-box binding homeobox 1 0.0299886
GLI2 GLI family zinc finger 2 0.0282918
TTC28 tetratricopeptide repeat domain 28 0.0275444
EFNA5 ephrin-A5 0.0266271
NPAS2 neuronal PAS domain protein 2 0.0265343
LPP LIM domain containing preferred translocation partner in lipoma 0.0240965
GSE1 Gse1 coiled-coil protein 0.0240735
DPYD dihydropyrimidine dehydrogenase 0.0237928
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0235353
RAD51B RAD51 paralog B 0.0207917
MYO5C myosin VC 0.0207891
NAV2 neuron navigator 2 0.0206234
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0205048
TRERF1 transcriptional regulating factor 1 0.0202269
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0200148
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0193275
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0192849
SMC4 structural maintenance of chromosomes 4 0.0189322
TSC22D1 TSC22 domain family, member 1 0.0179561
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0179264
PTPRG protein tyrosine phosphatase, receptor type, G 0.017469
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0168111
MACROD2 MACRO domain containing 2 0.0167935
LOXL3 lysyl oxidase-like 3 0.0167185
SEPTIN9 septin 9 0.0165286
MBNL1 muscleblind-like splicing regulator 1 0.0160816
SAMD4A sterile alpha motif domain containing 4A 0.0157365
CAMKMT calmodulin-lysine N-methyltransferase 0.015216
BICD1 bicaudal D homolog 1 (Drosophila) 0.0148961
EXOC4 exocyst complex component 4 0.0148792
NFIA nuclear factor I/A 0.0145408
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0144745
CPED1 cadherin-like and PC-esterase domain containing 1 0.0141311
AHCYL2 adenosylhomocysteinase-like 2 0.0138573
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0137792
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0137144
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0135435
CUX1 cut-like homeobox 1 0.013413
TGFBR3 transforming growth factor, beta receptor III 0.0132838
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0132001
TACC2 transforming, acidic coiled-coil containing protein 2 0.0131412
BMP10 bone morphogenetic protein 10 0.0128473
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0128421
DLG1 discs, large homolog 1 (Drosophila) 0.0128147
MLIP muscular LMNA-interacting protein 0.0127242
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0125566
NFE2L2 nuclear factor, erythroid 2-like 2 0.0125307
KANK1 KN motif and ankyrin repeat domains 1 0.012454
ANKRD36 ankyrin repeat domain 36 0.0124405
SMYD3 SET and MYND domain containing 3 0.0124053
RAB27B RAB27B, member RAS oncogene family 0.0123381
ANXA3 annexin A3 0.0123196
PRELID2 PRELI domain containing 2 0.0122814
SDK1 sidekick cell adhesion molecule 1 0.0121468
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0120407
SMAD6 SMAD family member 6 0.0118928
RRM2 ribonucleotide reductase M2 0.0118881
ZNF438 zinc finger protein 438 0.0117908
ANKRD17 ankyrin repeat domain 17 0.0117426
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0117082
FHIT fragile histidine triad 0.0116728
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0116449
HEG1 heart development protein with EGF-like domains 1 0.011581
RFC3 replication factor C (activator 1) 3, 38kDa 0.0115625
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0115443
TBC1D5 TBC1 domain family, member 5 0.0115154
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0113295
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0112334
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0111984
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0111666
BMP2K BMP2 inducible kinase 0.0108712
FAM91A1 family with sequence similarity 91, member A1 0.0107452
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0107041
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.0106556
TMEM65 transmembrane protein 65 0.0106166
PDE7B phosphodiesterase 7B 0.0105789
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0105658
SPIDR scaffolding protein involved in DNA repair 0.010486
CRPPA CDP-L-ribitol pyrophosphorylase A 0.010469
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0103588
DST dystonin 0.0103562
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.010278
SFPQ splicing factor proline/glutamine-rich 0.0101458
CENPE centromere protein E, 312kDa 0.0100659
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0100309

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.253364
PTMA prothymosin, alpha -0.232405
RPS6 ribosomal protein S6 -0.129603
RPL35A ribosomal protein L35a -0.0872518
TPT1 tumor protein, translationally-controlled 1 -0.071976
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0714582
RPS19 ribosomal protein S19 -0.0703709
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0657031
RPS8 ribosomal protein S8 -0.0654226
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0613706
S100A6 S100 calcium binding protein A6 -0.059436
ACTG1 actin gamma 1 -0.0577255
RPL34 ribosomal protein L34 -0.0548589
TMSB4X thymosin beta 4, X-linked -0.0528563
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0516278
RPL23 ribosomal protein L23 -0.049252
RPS23 ribosomal protein S23 -0.0487641
EIF1 eukaryotic translation initiation factor 1 -0.0459907
RPLP2 ribosomal protein, large, P2 -0.0455714
RPLP1 ribosomal protein, large, P1 -0.0444883
EEF2 eukaryotic translation elongation factor 2 -0.0435283
RPL32 ribosomal protein L32 -0.0426906
RPL11 ribosomal protein L11 -0.0421255
RPS25 ribosomal protein S25 -0.0406247
RPL19 ribosomal protein L19 -0.0399854
RPS13 ribosomal protein S13 -0.0393924
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0389366
RPL31 ribosomal protein L31 -0.038316
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0358677
RPL12 ribosomal protein L12 -0.0355716
PFN1 profilin 1 -0.0352065
LDHA lactate dehydrogenase A -0.0345542
TMSB10 thymosin beta 10 -0.0336995
ENO2 enolase 2 (gamma, neuronal) -0.0322626
RPL8 ribosomal protein L8 -0.0316578
RPL26 ribosomal protein L26 -0.0315861
RPS3 ribosomal protein S3 -0.0307742
RPL7A ribosomal protein L7a -0.0307319
RPL37A ribosomal protein L37a -0.0304814
RPL36 ribosomal protein L36 -0.0303482
RPS11 ribosomal protein S11 -0.030294
ARL4C ADP-ribosylation factor-like 4C -0.030251
LOC112694756 uncharaterized LOC112694756 -0.0302441
RPS21 ribosomal protein S21 -0.0301197
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0298214
FTL ferritin, light polypeptide -0.0296565
RPL13A ribosomal protein L13a -0.029453
RPS27A ribosomal protein S27a -0.0294341
GARS1 glycyl-tRNA synthetase 1 -0.0294126
TXNIP thioredoxin interacting protein -0.0287215
GOLGA4 golgin A4 -0.0282871
PKM pyruvate kinase, muscle -0.0277351
B2M beta-2-microglobulin -0.0277039
RPS12 ribosomal protein S12 -0.0276251
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0274241
RPL9 ribosomal protein L9 -0.0271687
ZNF292 zinc finger protein 292 -0.0267225
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0261664
RACK1 receptor for activated C kinase 1 -0.0259041
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0258586
RPL5 ribosomal protein L5 -0.0258511
S100A9 S100 calcium binding protein A9 -0.0256499
EZR ezrin -0.0253538
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0252452
RPL28 ribosomal protein L28 -0.0247934
MT2A metallothionein 2A -0.0244356
RPLP0 ribosomal protein, large, P0 -0.0243692
RPS4X ribosomal protein S4, X-linked -0.0243121
RTN4 reticulon 4 -0.0242876
S100A10 S100 calcium binding protein A10 -0.0242018
RPL27A ribosomal protein L27a -0.0241426
PNISR PNN-interacting serine/arginine-rich protein -0.0239865
RPS29 ribosomal protein S29 -0.0239273
ZFAND3 zinc finger, AN1-type domain 3 -0.0237826
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0236915
RPL10A ribosomal protein L10a -0.0235897
ATF4 activating transcription factor 4 -0.0234009
RPS16 ribosomal protein S16 -0.0229459
RHOA ras homolog family member A -0.0229078
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0221855
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0220904
RPS14 ribosomal protein S14 -0.0217474
RPS17 ribosomal protein S17 -0.0213773
RPL37 ribosomal protein L37 -0.0211117
RPS24 ribosomal protein S24 -0.0209802
KDM3A lysine (K)-specific demethylase 3A -0.0201802
NAP1L1 nucleosome assembly protein 1-like 1 -0.020106
SMNDC1 survival motor neuron domain containing 1 -0.0200574
NAMPT nicotinamide phosphoribosyltransferase -0.0199558
GNAS GNAS complex locus -0.0197939
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0194755
RPS27 ribosomal protein S27 -0.0192137
RPL18 ribosomal protein L18 -0.0192059
RPS15 ribosomal protein S15 -0.0188338
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0186726
PGK1 phosphoglycerate kinase 1 -0.018496
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0184712
MYL12B myosin, light chain 12B, regulatory -0.0183407
RPL7 ribosomal protein L7 -0.0182251
CCND1 cyclin D1 -0.0181696