Palmatine (chloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.121184
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0798433
SMAD3 SMAD family member 3 0.0794609
MACF1 microtubule-actin crosslinking factor 1 0.0740254
SVIL supervillin 0.0677604
RORA RAR-related orphan receptor A 0.0665914
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0630094
TRIO trio Rho guanine nucleotide exchange factor 0.0563693
FMNL2 formin-like 2 0.054529
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0516302
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0498531
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0486145
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0470806
ANXA2 annexin A2 0.0460849
DPYD dihydropyrimidine dehydrogenase 0.0459568
VCL vinculin 0.0414831
NPAS2 neuronal PAS domain protein 2 0.0413532
ATXN1 ataxin 1 0.0411865
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0408911
BASP1 brain abundant, membrane attached signal protein 1 0.0407644
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0402026
PRKCA protein kinase C, alpha 0.039684
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.039146
BICD1 bicaudal D homolog 1 (Drosophila) 0.0371699
MBNL2 muscleblind-like splicing regulator 2 0.0359733
ARHGAP21 Rho GTPase activating protein 21 0.0358254
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0357589
SLC38A2 solute carrier family 38, member 2 0.0354821
ANO6 anoctamin 6 0.0351454
FBXL17 F-box and leucine-rich repeat protein 17 0.0348818
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0339166
ZBTB38 zinc finger and BTB domain containing 38 0.0338869
BCAR3 breast cancer anti-estrogen resistance 3 0.0335497
NALCN sodium leak channel, non selective 0.0327836
ITCH itchy E3 ubiquitin protein ligase 0.0326929
DST dystonin 0.0324505
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0322603
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0320152
KLF12 Kruppel-like factor 12 0.03173
ASXL1 additional sex combs like transcriptional regulator 1 0.0316274
ACTN1 actinin, alpha 1 0.030182
MBNL1 muscleblind-like splicing regulator 1 0.0298337
DGKD diacylglycerol kinase, delta 130kDa 0.0292365
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0289681
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0286419
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0285966
CEMIP2 cell migration inducing hyaluronidase 2 0.0285406
EXOC4 exocyst complex component 4 0.0285155
RASAL2 RAS protein activator like 2 0.0284624
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0280711
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0279788
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0274118
GPC6 glypican 6 0.0271203
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0267631
STK24 serine/threonine kinase 24 0.0266165
AKAP13 A kinase (PRKA) anchor protein 13 0.0265462
EGFR epidermal growth factor receptor 0.0262863
FMN1 formin 1 0.0262369
RHOBTB3 Rho-related BTB domain containing 3 0.0261781
PRSS23 protease, serine, 23 0.0261044
ATXN7L1 ataxin 7-like 1 0.0259954
FNDC3A fibronectin type III domain containing 3A 0.0259789
NAV2 neuron navigator 2 0.025904
SDC2 syndecan 2 0.0258856
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0256914
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0252835
TXNRD1 thioredoxin reductase 1 0.0252538
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0248011
ARL15 ADP-ribosylation factor-like 15 0.0246896
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0245916
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0245254
RTN4 reticulon 4 0.0245033
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0244975
PHF3 PHD finger protein 3 0.0244289
ANKRD28 ankyrin repeat domain 28 0.024409
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0243165
ZBTB20 zinc finger and BTB domain containing 20 0.02405
SCAF11 SR-related CTD-associated factor 11 0.023936
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.023924
SMYD3 SET and MYND domain containing 3 0.0238407
JARID2 jumonji, AT rich interactive domain 2 0.0237345
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0237224
CSNK1A1 casein kinase 1, alpha 1 0.0236218
WWC2 WW and C2 domain containing 2 0.0235388
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.023535
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0233464
AK1 adenylate kinase 1 0.023172
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0230427
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.0230234
SYAP1 synapse associated protein 1 0.0229346
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0228955
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0227561
TNRC18 trinucleotide repeat containing 18 0.0227407
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0226358
ZBTB44 zinc finger and BTB domain containing 44 0.022512
SEPTIN9 septin 9 0.0225062
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0224086
CDK17 cyclin-dependent kinase 17 0.0223275
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.0221112
UBAC2 UBA domain containing 2 0.0220603

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.209459
PTMA prothymosin, alpha -0.171342
VIM vimentin -0.139424
TMSB10 thymosin beta 10 -0.126885
TPT1 tumor protein, translationally-controlled 1 -0.101631
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0837215
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0810253
GNAS GNAS complex locus -0.0780084
RPL23 ribosomal protein L23 -0.0742909
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0668726
RPS3 ribosomal protein S3 -0.0657819
RPS6 ribosomal protein S6 -0.0648672
RPS27A ribosomal protein S27a -0.0647088
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0646326
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0635972
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0632644
UBC ubiquitin C -0.0630833
RPLP1 ribosomal protein, large, P1 -0.0620784
RPL35A ribosomal protein L35a -0.0606481
RPS8 ribosomal protein S8 -0.059519
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0585891
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0550316
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0543248
RPL26 ribosomal protein L26 -0.053684
LDHA lactate dehydrogenase A -0.0535067
RPL27A ribosomal protein L27a -0.0515645
RPL37 ribosomal protein L37 -0.047577
RPS13 ribosomal protein S13 -0.0473629
EEF2 eukaryotic translation elongation factor 2 -0.0472787
DLG1 discs, large homolog 1 (Drosophila) -0.0467858
BIRC3 baculoviral IAP repeat containing 3 -0.0466522
RBM39 RNA binding motif protein 39 -0.0450076
RPL31 ribosomal protein L31 -0.0448711
FTL ferritin, light polypeptide -0.0429949
PKM pyruvate kinase, muscle -0.0424527
RPS17 ribosomal protein S17 -0.0422711
PNISR PNN-interacting serine/arginine-rich protein -0.04226
EGR1 early growth response 1 -0.0421829
OASL 2'-5'-oligoadenylate synthetase-like -0.0412028
EIF1 eukaryotic translation initiation factor 1 -0.0409941
ENO1 enolase 1, (alpha) -0.0397852
ENO2 enolase 2 (gamma, neuronal) -0.03942
PRPF4B pre-mRNA processing factor 4B -0.0393015
RPL32 ribosomal protein L32 -0.0390895
RPL37A ribosomal protein L37a -0.039082
RACK1 receptor for activated C kinase 1 -0.0386044
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0375882
RPL19 ribosomal protein L19 -0.0368912
S100A9 S100 calcium binding protein A9 -0.0366885
DEK DEK proto-oncogene -0.0364738
B2M beta-2-microglobulin -0.0362544
RPS23 ribosomal protein S23 -0.0356649
SAFB scaffold attachment factor B -0.035392
S100A10 S100 calcium binding protein A10 -0.035336
SCFD1 sec1 family domain containing 1 -0.0353125
RPS25 ribosomal protein S25 -0.0349642
IER3 immediate early response 3 -0.0349011
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0348906
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0347928
RPL36 ribosomal protein L36 -0.0345229
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0343802
SDC4 syndecan 4 -0.0342059
RPL30 ribosomal protein L30 -0.0337834
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0336223
RPL15 ribosomal protein L15 -0.0335624
IGFBP3 insulin-like growth factor binding protein 3 -0.0332789
RPS15 ribosomal protein S15 -0.0329439
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0327182
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0321912
NAP1L1 nucleosome assembly protein 1-like 1 -0.032186
CHSY1 chondroitin sulfate synthase 1 -0.0320487
HLA-B major histocompatibility complex, class I, B -0.0318411
RPS29 ribosomal protein S29 -0.0318298
RPL5 ribosomal protein L5 -0.0316924
H3-3B H3.3 histone B -0.0313629
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.031265
RPL34 ribosomal protein L34 -0.0312553
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0310223
MARCHF6 membrane associated ring-CH-type finger 6 -0.0310135
RPS16 ribosomal protein S16 -0.0310039
RPL4 ribosomal protein L4 -0.0305791
OXSR1 oxidative stress responsive 1 -0.0300332
KTN1 kinectin 1 (kinesin receptor) -0.0299901
PCBP2 poly(rC) binding protein 2 -0.0296812
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0296465
HM13 histocompatibility (minor) 13 -0.0293538
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0291454
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0291086
TPX2 TPX2, microtubule-associated -0.0288048
UBB ubiquitin B -0.0286515
PRRC2C proline-rich coiled-coil 2C -0.0286239
NUP58 nucleoporin 58 -0.028376
CREBRF CREB3 regulatory factor -0.0283057
CSDE1 cold shock domain containing E1, RNA-binding -0.0282776
RPL12 ribosomal protein L12 -0.0281746
RPS27 ribosomal protein S27 -0.0281304
KHSRP KH-type splicing regulatory protein -0.0280281
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0279374
BRD4 bromodomain containing 4 -0.0277733
PICALM phosphatidylinositol binding clathrin assembly protein -0.0275305