Palmatine (chloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.100241
NCEH1 neutral cholesterol ester hydrolase 1 0.0935508
FAT1 FAT atypical cadherin 1 0.0822747
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0767747
BCL2L1 BCL2-like 1 0.0763181
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0761222
CEMIP cell migration inducing protein, hyaluronan binding 0.0747025
VCL vinculin 0.070843
NEBL nebulette 0.065369
MYO1E myosin IE 0.0649764
YAP1 Yes-associated protein 1 0.0621838
APLP2 amyloid beta (A4) precursor-like protein 2 0.061692
EZR ezrin 0.0603731
ANXA2 annexin A2 0.0558076
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0512441
EPS8 epidermal growth factor receptor pathway substrate 8 0.0498626
SHB Src homology 2 domain containing adaptor protein B 0.0471679
SAMD4A sterile alpha motif domain containing 4A 0.0459929
DSPP dentin sialophosphoprotein 0.0456157
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0452524
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.044585
ZSWIM6 zinc finger, SWIM-type containing 6 0.0436849
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0433503
CEMIP2 cell migration inducing hyaluronidase 2 0.0431894
SMAD3 SMAD family member 3 0.0431309
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0421463
TJP1 tight junction protein 1 0.0411804
CTBP2 C-terminal binding protein 2 0.0409938
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0406095
INTS6 integrator complex subunit 6 0.039522
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0392903
OSBPL10 oxysterol binding protein-like 10 0.03911
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0385211
ACTN4 actinin, alpha 4 0.0376033
ADAM19 ADAM metallopeptidase domain 19 0.0367348
UBE2H ubiquitin-conjugating enzyme E2H 0.0364498
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0359211
MYH9 myosin, heavy chain 9, non-muscle 0.0342293
CSNK1A1 casein kinase 1, alpha 1 0.0340147
HSPA8 heat shock 70kDa protein 8 0.033474
IFRD1 interferon-related developmental regulator 1 0.0330586
TGFA transforming growth factor, alpha 0.0328518
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0327091
PCLO piccolo presynaptic cytomatrix protein 0.0323652
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0320521
ZNRF3 zinc and ring finger 3 0.0319961
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0319076
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0312341
PLEC plectin 0.0310202
WWC1 WW and C2 domain containing 1 0.0309532
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0304759
ITGA6 integrin, alpha 6 0.0303425
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0303164
NHSL1 NHS-like 1 0.0300587
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.029909
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0296891
EXT1 exostosin glycosyltransferase 1 0.0293165
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0292546
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0291247
SEPTIN9 septin 9 0.0290455
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0290193
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0288272
LIMS1 LIM and senescent cell antigen-like domains 1 0.0284077
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0283387
CDK13 cyclin-dependent kinase 13 0.0281856
GSK3B glycogen synthase kinase 3 beta 0.0281535
AKAP13 A kinase (PRKA) anchor protein 13 0.0280744
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0278806
RUNX1 runt-related transcription factor 1 0.0278177
PARD3B par-3 family cell polarity regulator beta 0.0274759
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.027381
NKD1 naked cuticle homolog 1 (Drosophila) 0.0273684
VMP1 vacuole membrane protein 1 0.027137
RNF43 ring finger protein 43 0.0271008
ANXA11 annexin A11 0.0269908
FLNA filamin A, alpha 0.0265306
RBM39 RNA binding motif protein 39 0.0261446
DOCK4 dedicator of cytokinesis 4 0.0261246
DSCAM Down syndrome cell adhesion molecule 0.0259221
ETV6 ets variant 6 0.0257341
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0256847
MED13L mediator complex subunit 13-like 0.0253849
SPAG9 sperm associated antigen 9 0.0253624
SVIL supervillin 0.0249633
MACF1 microtubule-actin crosslinking factor 1 0.0248022
GOLGB1 golgin B1 0.0245681
AFDN afadin, adherens junction formation factor 0.0245674
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.024543
AHNAK AHNAK nucleoprotein 0.024395
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.024391
TUFT1 tuftelin 1 0.0243752
ARHGAP26 Rho GTPase activating protein 26 0.0243645
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0241776
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0241119
EFNB2 ephrin-B2 0.0239691
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0238091
RAB10 RAB10, member RAS oncogene family 0.0237146
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0236942
SQSTM1 sequestosome 1 0.0236762
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0236362

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.165277
PTMA prothymosin, alpha -0.127878
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0955255
KRT8 keratin 8, type II -0.0687049
RPS21 ribosomal protein S21 -0.0664187
FTL ferritin, light polypeptide -0.0652824
MAML2 mastermind-like 2 (Drosophila) -0.0567852
TMSB4X thymosin beta 4, X-linked -0.0503433
RPL18 ribosomal protein L18 -0.0495807
PERP PERP, TP53 apoptosis effector -0.0488281
GARS1 glycyl-tRNA synthetase 1 -0.0405318
KRT18 keratin 18, type I -0.0392227
DLG1 discs, large homolog 1 (Drosophila) -0.038477
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0375964
CBX3 chromobox homolog 3 -0.0375038
RPL32 ribosomal protein L32 -0.0373672
FTH1 ferritin, heavy polypeptide 1 -0.0372813
RPL35A ribosomal protein L35a -0.0365119
RPS6 ribosomal protein S6 -0.0347433
RPL12 ribosomal protein L12 -0.0344364
RPS24 ribosomal protein S24 -0.0340574
ZMYND8 zinc finger, MYND-type containing 8 -0.033947
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0326246
SOX4 SRY (sex determining region Y)-box 4 -0.0320472
EGR1 early growth response 1 -0.0319357
S100A6 S100 calcium binding protein A6 -0.0316843
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0307613
TPT1 tumor protein, translationally-controlled 1 -0.0300812
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0297404
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0296663
RPL8 ribosomal protein L8 -0.0295622
RPL36A ribosomal protein L36a -0.029175
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0283506
RBM25 RNA binding motif protein 25 -0.0282366
RPL23 ribosomal protein L23 -0.0278252
RPLP2 ribosomal protein, large, P2 -0.0276682
LOC112694756 uncharaterized LOC112694756 -0.0274532
GSTP1 glutathione S-transferase pi 1 -0.0264942
NDRG1 N-myc downstream regulated 1 -0.0250613
RPS3 ribosomal protein S3 -0.0246164
RPS13 ribosomal protein S13 -0.0244845
RPS19 ribosomal protein S19 -0.0242388
HLA-A major histocompatibility complex, class I, A -0.0233299
RPL34 ribosomal protein L34 -0.0228294
HMGA1 high mobility group AT-hook 1 -0.0226256
MYL12B myosin, light chain 12B, regulatory -0.0226183
GOLGA4 golgin A4 -0.0220479
MIDN midnolin -0.0215898
CCND1 cyclin D1 -0.0214347
TMEM123 transmembrane protein 123 -0.0213112
EPCAM epithelial cell adhesion molecule -0.0212577
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0212295
RPS14 ribosomal protein S14 -0.0210504
ZBTB7A zinc finger and BTB domain containing 7A -0.0208775
CTSD cathepsin D -0.0207167
LMNA lamin A/C -0.0203675
ATP5F1E ATP synthase F1 subunit epsilon -0.0203265
PFN1 profilin 1 -0.0200846
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.020054
RPS5 ribosomal protein S5 -0.020022
THOC2 THO complex 2 -0.0199257
AKAP12 A kinase (PRKA) anchor protein 12 -0.0198055
EIF1 eukaryotic translation initiation factor 1 -0.0197867
S100A9 S100 calcium binding protein A9 -0.0194155
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0191861
RPL15 ribosomal protein L15 -0.0189247
ASTN2 astrotactin 2 -0.0187131
SLC38A1 solute carrier family 38, member 1 -0.0186691
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0186259
RPL26 ribosomal protein L26 -0.0185721
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0185072
LDHA lactate dehydrogenase A -0.0182533
RPL27A ribosomal protein L27a -0.0181649
CCNI cyclin I -0.0180698
IFITM1 interferon induced transmembrane protein 1 -0.0180024
RPS15 ribosomal protein S15 -0.0175994
NFIA nuclear factor I/A -0.0174998
IFITM3 interferon induced transmembrane protein 3 -0.0174756
IER3 immediate early response 3 -0.017445
HDAC9 histone deacetylase 9 -0.0169834
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0169507
S100A11 S100 calcium binding protein A11 -0.0168572
B2M beta-2-microglobulin -0.0168223
RPS11 ribosomal protein S11 -0.0168143
MATR3 matrin 3 -0.0166711
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0162707
S100A10 S100 calcium binding protein A10 -0.0162087
PPARG peroxisome proliferator-activated receptor gamma -0.0160445
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0157535
ITGB4 integrin, beta 4 -0.0156756
LOC102724023 ES1 protein homolog, mitochondrial -0.0156576
MT1X metallothionein 1X -0.0156137
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.015387
CST3 cystatin C -0.0153687
UGCG UDP-glucose ceramide glucosyltransferase -0.0153199
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0152361
SDK1 sidekick cell adhesion molecule 1 -0.01521
UBE2C ubiquitin-conjugating enzyme E2C -0.0152099
RPL19 ribosomal protein L19 -0.015131
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0150435