Palmatine (chloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Palmatine (chloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Palmatine (chloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATXN1 ataxin 1 0.102769
AREG amphiregulin 0.101167
EGFR epidermal growth factor receptor 0.0923245
FAT1 FAT atypical cadherin 1 0.0875823
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0854349
RPS2 ribosomal protein S2 0.0824209
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0664746
NCEH1 neutral cholesterol ester hydrolase 1 0.0612602
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0529889
CPOX coproporphyrinogen oxidase 0.0494791
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0463146
HMGA2 high mobility group AT-hook 2 0.0449249
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0443914
RAD51B RAD51 paralog B 0.0437548
LAMA4 laminin, alpha 4 0.0416029
KITLG KIT ligand 0.0389184
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0384325
RNF43 ring finger protein 43 0.0374576
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0356551
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0354974
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0352621
FHL2 four and a half LIM domains 2 0.0344979
PDE4D phosphodiesterase 4D, cAMP-specific 0.0340672
RPL9 ribosomal protein L9 0.0331826
SGMS2 sphingomyelin synthase 2 0.0324201
ANXA2 annexin A2 0.0323415
YAP1 Yes-associated protein 1 0.031225
RPL12 ribosomal protein L12 0.0309289
APLP2 amyloid beta (A4) precursor-like protein 2 0.0307181
MTUS1 microtubule associated tumor suppressor 1 0.0307029
EXOC4 exocyst complex component 4 0.029822
NUP50 nucleoporin 50kDa 0.0294827
DPY19L1 dpy-19-like 1 (C. elegans) 0.0294537
ACTN4 actinin, alpha 4 0.0292876
EFNB2 ephrin-B2 0.0292529
ALCAM activated leukocyte cell adhesion molecule 0.0290255
ARHGAP42 Rho GTPase activating protein 42 0.0284995
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0281198
OSBPL10 oxysterol binding protein-like 10 0.0277438
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0274942
HSPA8 heat shock 70kDa protein 8 0.0269677
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0269609
VMP1 vacuole membrane protein 1 0.0266437
RPS12 ribosomal protein S12 0.0265344
EMP1 epithelial membrane protein 1 0.026388
SEPTIN9 septin 9 0.0261918
MT2A metallothionein 2A 0.0261627
NACA nascent polypeptide-associated complex alpha subunit 0.0259376
SLC30A10 solute carrier family 30, member 10 0.0256667
ITPKC inositol-trisphosphate 3-kinase C 0.025638
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0254413
CSNK1A1 casein kinase 1, alpha 1 0.0250923
SPATA13 spermatogenesis associated 13 0.0249707
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0245252
DUSP4 dual specificity phosphatase 4 0.0242803
FBXL17 F-box and leucine-rich repeat protein 17 0.0242238
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0239987
NEBL nebulette 0.0238791
HDAC4 histone deacetylase 4 0.0236843
CUX1 cut-like homeobox 1 0.0234551
CTSB cathepsin B 0.023282
MCL1 myeloid cell leukemia 1 0.0227553
RANBP9 RAN binding protein 9 0.0222737
SMAD3 SMAD family member 3 0.0222722
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0220812
SPRED2 sprouty-related, EVH1 domain containing 2 0.0220554
CMIP c-Maf inducing protein 0.02179
NTSR1 neurotensin receptor 1 (high affinity) 0.021762
SMYD3 SET and MYND domain containing 3 0.021547
FLNA filamin A, alpha 0.0210828
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.0209229
EEF1G eukaryotic translation elongation factor 1 gamma 0.0203519
TJP1 tight junction protein 1 0.0202744
BIRC3 baculoviral IAP repeat containing 3 0.0202141
BCL2L1 BCL2-like 1 0.0201621
NDUFA4 NDUFA4, mitochondrial complex associated 0.0201035
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0199068
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0198541
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0197656
NHSL1 NHS-like 1 0.0197501
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0197012
BBS9 Bardet-Biedl syndrome 9 0.0196353
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.019544
ABR active BCR-related 0.0195106
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0193062
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.0192306
ZHX2 zinc fingers and homeoboxes 2 0.0191519
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0190935
LGALS12 lectin, galactoside-binding, soluble, 12 0.0190301
PDAP1 PDGFA associated protein 1 0.0190108
SAMD4A sterile alpha motif domain containing 4A 0.0189302
DOCK5 dedicator of cytokinesis 5 0.0188638
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0183121
RPL36 ribosomal protein L36 0.0181213
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0180731
UBN2 ubinuclein 2 0.0180214
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0179143
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.017874
USP6NL USP6 N-terminal like 0.0176632
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0174909

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.181161
TMSB10 thymosin beta 10 -0.161804
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.148079
PTMA prothymosin, alpha -0.137329
RPL35A ribosomal protein L35a -0.132773
LAMB3 laminin, beta 3 -0.110481
RPS24 ribosomal protein S24 -0.0971225
RPL34 ribosomal protein L34 -0.0941314
RPS19 ribosomal protein S19 -0.0889216
IER3 immediate early response 3 -0.0831247
TPT1 tumor protein, translationally-controlled 1 -0.0819675
FERMT1 fermitin family member 1 -0.0808296
RPS6 ribosomal protein S6 -0.0775675
AKAP12 A kinase (PRKA) anchor protein 12 -0.0734338
ACTG1 actin gamma 1 -0.0657586
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0616141
S100A6 S100 calcium binding protein A6 -0.0612108
RPL23 ribosomal protein L23 -0.0582806
GOLGA4 golgin A4 -0.0577225
HDAC2 histone deacetylase 2 -0.0558247
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0531031
EGR1 early growth response 1 -0.0528365
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0515008
NDRG1 N-myc downstream regulated 1 -0.0514035
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0513188
RSL1D1 ribosomal L1 domain containing 1 -0.0504194
RPS14 ribosomal protein S14 -0.0497915
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0480733
RBM25 RNA binding motif protein 25 -0.0447151
CBX3 chromobox homolog 3 -0.043133
EZR ezrin -0.0413739
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0406844
ATP5F1B ATP synthase F1 subunit beta -0.0396843
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0394034
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0373514
RPS4X ribosomal protein S4, X-linked -0.0362882
GARS1 glycyl-tRNA synthetase 1 -0.0356649
EIF1 eukaryotic translation initiation factor 1 -0.0345963
COG5 component of oligomeric golgi complex 5 -0.034532
RPL11 ribosomal protein L11 -0.0344966
CD36 CD36 molecule (thrombospondin receptor) -0.0344375
MATR3 matrin 3 -0.0343624
MKI67 marker of proliferation Ki-67 -0.034121
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0332256
RPL4 ribosomal protein L4 -0.0331716
RPLP2 ribosomal protein, large, P2 -0.0328141
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0327335
IGFBP3 insulin-like growth factor binding protein 3 -0.032433
PRRC2C proline-rich coiled-coil 2C -0.0321228
AHNAK AHNAK nucleoprotein -0.0318526
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0290103
KDM3A lysine (K)-specific demethylase 3A -0.0288005
S100A10 S100 calcium binding protein A10 -0.0287994
RPS28 ribosomal protein S28 -0.0285889
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0282348
MAP4 microtubule-associated protein 4 -0.0272794
RPL31 ribosomal protein L31 -0.0267661
RPL8 ribosomal protein L8 -0.0267052
RPL7A ribosomal protein L7a -0.0259453
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0258271
MT1X metallothionein 1X -0.0257583
EEF2 eukaryotic translation elongation factor 2 -0.0257505
DLG1 discs, large homolog 1 (Drosophila) -0.0254393
USP3 ubiquitin specific peptidase 3 -0.0248402
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0247677
RPL32 ribosomal protein L32 -0.0246939
RPLP1 ribosomal protein, large, P1 -0.024413
RPS5 ribosomal protein S5 -0.0239392
UBE2K ubiquitin-conjugating enzyme E2K -0.0236063
KPNB1 karyopherin (importin) beta 1 -0.023572
MXI1 MAX interactor 1, dimerization protein -0.0234312
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0233143
TUBB tubulin, beta class I -0.0220171
CSDE1 cold shock domain containing E1, RNA-binding -0.0218962
NPEPPS aminopeptidase puromycin sensitive -0.0218567
OSBPL3 oxysterol binding protein-like 3 -0.0218367
LMNA lamin A/C -0.0217723
RPL27A ribosomal protein L27a -0.0216605
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.021613
PDIA3 protein disulfide isomerase family A, member 3 -0.0215857
BZW2 basic leucine zipper and W2 domains 2 -0.0215335
RLF rearranged L-myc fusion -0.0214464
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0214064
TPD52 tumor protein D52 -0.0213634
ZBTB7C zinc finger and BTB domain containing 7C -0.0213114
GNAS GNAS complex locus -0.0212454
TBC1D4 TBC1 domain family, member 4 -0.0212087
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0211449
AK1 adenylate kinase 1 -0.0211341
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0210192
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0208044
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0207403
SERINC5 serine incorporator 5 -0.0206317
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0205184
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0203041
NAP1L1 nucleosome assembly protein 1-like 1 -0.0202744
SLMAP sarcolemma associated protein -0.020179
RPL37A ribosomal protein L37a -0.0201662
VDAC1 voltage-dependent anion channel 1 -0.0201165
ESYT2 extended synaptotagmin-like protein 2 -0.0200979