Palonosetron Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/6337614
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Genes

197 proteins with high or low expression in Palonosetron relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.62
ZNF175 zinc finger protein 175 2.54
ZSWIM9 zinc finger SWIM-type containing 9 1.53
RUSC2 RUN and SH3 domain containing 2 1.3
MAP3K11 mitogen-activated protein kinase kinase kinase 11 1.23
TMEM9 transmembrane protein 9 0.91
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.77
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.66
TSPAN3 tetraspanin 3 0.65
DESI2 desumoylating isopeptidase 2 0.58
ADAR adenosine deaminase, RNA-specific 0.58
ANKRD36C ankyrin repeat domain 36C 0.58
TTC14 tetratricopeptide repeat domain 14 0.56
DOCK4 dedicator of cytokinesis 4 0.54
KANK3 KN motif and ankyrin repeat domains 3 0.53
KIAA0513 KIAA0513 0.52
GLI2 GLI family zinc finger 2 0.51
CC2D2A coiled-coil and C2 domain containing 2A 0.5
CIC capicua transcriptional repressor 0.49
RIOX1 ribosomal oxygenase 1 0.49
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.48
ZNF777 zinc finger protein 777 0.47
KMT5B lysine methyltransferase 5B 0.46
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 0.45
TP53 tumor protein p53 0.45
CFAP410 cilia and flagella associated protein 410 0.45
POLH polymerase (DNA directed), eta 0.45
THBS2 thrombospondin 2 0.44
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.43
GREB1 growth regulation by estrogen in breast cancer 1 0.43
DUSP6 dual specificity phosphatase 6 0.42
MSH5 mutS homolog 5 0.42
GAS2L3 growth arrest-specific 2 like 3 0.41
SMO smoothened, frizzled class receptor 0.41
LTBP1 latent transforming growth factor beta binding protein 1 0.4
KIAA1324L KIAA1324-like 0.4
ZBTB45 zinc finger and BTB domain containing 45 0.4
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 0.39
KAT5 K(lysine) acetyltransferase 5 0.39
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.38
WEE1 WEE1 G2 checkpoint kinase 0.38
CCDC9B coiled-coil domain containing 9B 0.38
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.38
AUNIP aurora kinase A and ninein interacting protein 0.37
RNF130 ring finger protein 130 0.37
SARDH sarcosine dehydrogenase 0.37
PIMREG PICALM interacting mitotic regulator 0.37
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 0.37
KLHL29 kelch-like family member 29 0.37
CREB3L2 cAMP responsive element binding protein 3-like 2 0.37
ZNF823 zinc finger protein 823 0.37
MPV17L2 MPV17 mitochondrial membrane protein-like 2 0.36
SH2D3A SH2 domain containing 3A 0.35
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 0.35
JDP2 Jun dimerization protein 2 0.35
IQCB1 IQ motif containing B1 0.35
TMEM68 transmembrane protein 68 0.34
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.34
CCDC158 coiled-coil domain containing 158 0.33
FBXO31 F-box protein 31 0.32
LZTS1 leucine zipper, putative tumor suppressor 1 0.32
SYN1 synapsin I 0.32
TBX3 T-box 3 0.32
ADAM19 ADAM metallopeptidase domain 19 0.32
CTNND2 catenin (cadherin-associated protein), delta 2 0.32
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.32
FBXW8 F-box and WD repeat domain containing 8 0.32
CCNI cyclin I 0.32
KRIT1 KRIT1, ankyrin repeat containing 0.31
COPRS coordinator of PRMT5, differentiation stimulator 0.31
TRIB3 tribbles pseudokinase 3 0.31
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.31
ADCY9 adenylate cyclase 9 0.31
SULF2 sulfatase 2 0.3
ADGRG6 adhesion G protein-coupled receptor G6 0.3
LYRM1 LYR motif containing 1 0.3
FAN1 FANCD2/FANCI-associated nuclease 1 0.3
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.3
TNS4 tensin 4 0.3
HYLS1 hydrolethalus syndrome 1 0.3
SGO1 shugoshin 1 0.3
FAM161A family with sequence similarity 161, member A 0.3
CISD3 CDGSH iron sulfur domain 3 0.29
ZNF136 zinc finger protein 136 0.29
ARL13B ADP-ribosylation factor-like 13B 0.29
PRIMPOL primase and polymerase (DNA-directed) 0.29
NFYA nuclear transcription factor Y, alpha 0.29
IQGAP2 IQ motif containing GTPase activating protein 2 0.29
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.29
ZRANB1 zinc finger, RAN-binding domain containing 1 0.29
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.28
H3C1 H3 clustered histone 1 0.28
NTN1 netrin 1 0.28
DUSP7 dual specificity phosphatase 7 0.28
PEG10 paternally expressed 10 0.28
CYB5D2 cytochrome b5 domain containing 2 0.28
HSBP1 heat shock factor binding protein 1 0.28
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.28
AMZ2 archaelysin family metallopeptidase 2 0.28
CENPT centromere protein T 0.28

low expression

Symbol Name Standardized Value
KHK ketohexokinase (fructokinase) -0.72
PIP prolactin-induced protein -0.69
IFRD1 interferon-related developmental regulator 1 -0.66
FGFBP1 fibroblast growth factor binding protein 1 -0.64
DUSP5 dual specificity phosphatase 5 -0.63
FBXL8 F-box and leucine-rich repeat protein 8 -0.62
MSL3P1 male-specific lethal 3 homolog (Drosophila) pseudogene 1 -0.59
SPATA7 spermatogenesis associated 7 -0.58
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.57
COL17A1 collagen, type XVII, alpha 1 -0.56
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.54
MELTF melanotransferrin -0.5
RHOF ras homolog family member F (in filopodia) -0.5
CLSTN3 calsyntenin 3 -0.5
PPT1 palmitoyl-protein thioesterase 1 -0.5
NAAA N-acylethanolamine acid amidase -0.49
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.49
ATXN7L3 ataxin 7-like 3 -0.48
MRPL52 mitochondrial ribosomal protein L52 -0.46
GIGYF1 GRB10 interacting GYF protein 1 -0.46
DIPK1A divergent protein kinase domain 1A -0.46
PTBP1 polypyrimidine tract binding protein 1 -0.45
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -0.44
MAPKBP1 mitogen-activated protein kinase binding protein 1 -0.44
DNAH14 dynein, axonemal, heavy chain 14 -0.43
ZNF511 zinc finger protein 511 -0.43
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.43
CENPH centromere protein H -0.43
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -0.42
HMOX1 heme oxygenase 1 -0.42
MIGA2 mitoguardin 2 -0.42
ESAM endothelial cell adhesion molecule -0.42
LIPA lipase A, lysosomal acid, cholesterol esterase -0.42
MRPL30 mitochondrial ribosomal protein L30 -0.41
FEM1A fem-1 homolog a (C. elegans) -0.41
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.4
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.39
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -0.39
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.39
TACSTD2 tumor-associated calcium signal transducer 2 -0.39
C6ORF62 chromosome 6 open reading frame 62 -0.39
RNF170 ring finger protein 170 -0.39
IGFBP6 insulin-like growth factor binding protein 6 -0.38
ALG10B ALG10B, alpha-1,2-glucosyltransferase -0.38
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.38
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 -0.38
PLAUR plasminogen activator, urokinase receptor -0.38
SH3BP5L SH3-binding domain protein 5-like -0.37
SMG9 SMG9 nonsense mediated mRNA decay factor -0.37
CCNQ cyclin Q -0.37
HLA-C major histocompatibility complex, class I, C -0.37
HLA-B major histocompatibility complex, class I, B -0.37
ZDHHC21 zinc finger, DHHC-type containing 21 -0.37
NLGN2 neuroligin 2 -0.37
MRPL34 mitochondrial ribosomal protein L34 -0.36
PRUNE2 prune homolog 2 (Drosophila) -0.35
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -0.34
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.34
ZNF77 zinc finger protein 77 -0.34
PRSS8 protease, serine, 8 -0.34
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.34
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.33
ADGRG1 adhesion G protein-coupled receptor G1 -0.33
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.33
ZC3H12C zinc finger CCCH-type containing 12C -0.33
TMEM62 transmembrane protein 62 -0.32
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.32
MRPL13 mitochondrial ribosomal protein L13 -0.32
DNLZ DNL-type zinc finger -0.32
TMEM192 transmembrane protein 192 -0.32
SDF2 stromal cell-derived factor 2 -0.32
SDC4 syndecan 4 -0.32
CLN5 ceroid-lipofuscinosis, neuronal 5 -0.32
HLA-A major histocompatibility complex, class I, A -0.32
UGCG UDP-glucose ceramide glucosyltransferase -0.32
MT-ND1 NADH dehydrogenase, subunit 1 (complex I) -0.31
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -0.31
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.31
ACSL6 acyl-CoA synthetase long-chain family member 6 -0.31
MRPL57 mitochondrial ribosomal protein L57 -0.31
PLAU plasminogen activator, urokinase -0.31
MSMO1 methylsterol monooxygenase 1 -0.31
CCND3 cyclin D3 -0.31
NOVA2 neuro-oncological ventral antigen 2 -0.3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.3
TRIM62 tripartite motif containing 62 -0.3
MT-CO1 cytochrome c oxidase subunit I -0.3
TRIB1 tribbles pseudokinase 1 -0.3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 -0.3
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.3
RSPRY1 ring finger and SPRY domain containing 1 -0.3
HEMK1 HemK methyltransferase family member 1 -0.3
MRPS18A mitochondrial ribosomal protein S18A -0.3
DIXDC1 DIX domain containing 1 -0.29
FOSL1 FOS-like antigen 1 -0.29
MRPL37 mitochondrial ribosomal protein L37 -0.29
BEND7 BEN domain containing 7 -0.29