Panhypopituitarism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

233 genes co-occuring with the disease Panhypopituitarism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PROP1 PROP paired-like homeobox 1 3.7
POU1F1 POU class 1 homeobox 1 3.549
HESX1 HESX homeobox 1 3.548
LHX4 LIM homeobox 4 3.487
LHX3 LIM homeobox 3 3.433
ESX1 ESX homeobox 1 3.398
POMC proopiomelanocortin 3.241
PRL prolactin 3.169
SOX3 SRY (sex determining region Y)-box 3 2.939
IGF1 insulin-like growth factor 1 (somatomedin C) 2.825
OTX2 orthodenticle homeobox 2 2.767
TSHB thyroid stimulating hormone, beta 2.754
PROKR2 prokineticin receptor 2 2.674
AVP arginine vasopressin 2.667
GHRHR growth hormone releasing hormone receptor 2.633
TRH thyrotropin-releasing hormone 2.542
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.506
GLI2 GLI family zinc finger 2 2.464
GHRH growth hormone releasing hormone 2.459
GH1 growth hormone 1 2.44
TBX19 T-box 19 2.41
IGSF1 immunoglobulin superfamily, member 1 2.285
ANOS1 anosmin 1 2.233
GH2 growth hormone 2 2.167
CHD7 chromodomain helicase DNA binding protein 7 2.162
GNRHR gonadotropin-releasing hormone receptor 2.159
INS insulin 2.158
IGFBP3 insulin-like growth factor binding protein 3 2.149
CRH corticotropin releasing hormone 2.13
TRHR thyrotropin-releasing hormone receptor 2.065
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.057
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.056
FSHB follicle stimulating hormone, beta polypeptide 2.056
CSH2 chorionic somatomammotropin hormone 2 2.047
TACR3 tachykinin receptor 3 2.025
KISS1R KISS1 receptor 2.025
PROK2 prokineticin 2 2.011
FGFR1 fibroblast growth factor receptor 1 2.008
SOX2 SRY (sex determining region Y)-box 2 2.003
IGSF10 immunoglobulin superfamily, member 10 1.995
CDON cell adhesion associated, oncogene regulated 1.954
SIX6 SIX homeobox 6 1.951
GHR growth hormone receptor 1.923
SST somatostatin 1.906
PITX1 paired-like homeodomain 1 1.891
SHH sonic hedgehog 1.884
TAC3 tachykinin 3 1.883
CCDC141 coiled-coil domain containing 141 1.878
SIX3 SIX homeobox 3 1.858
FGF8 fibroblast growth factor 8 (androgen-induced) 1.845
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.844
TBC1D32 TBC1 domain family, member 32 1.829
OXT oxytocin/neurophysin I prepropeptide 1.8
IL17RD interleukin 17 receptor D 1.768
PITX2 paired-like homeodomain 2 1.763
GCG glucagon 1.762
CD1A CD1a molecule 1.761
RNPC3 RNA-binding region (RNP1, RRM) containing 3 1.748
CD1E CD1e molecule 1.746
KISS1 KiSS-1 metastasis-suppressor 1.728
CD1B CD1b molecule 1.728
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.678
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.674
GPR161 G protein-coupled receptor 161 1.673
DMXL2 Dmx-like 2 1.658
GLI3 GLI family zinc finger 3 1.656
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.655
GHSR growth hormone secretagogue receptor 1.655
CD1C CD1c molecule 1.647
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 1.64
FLRT3 fibronectin leucine rich transmembrane protein 3 1.638
AMH anti-Mullerian hormone 1.634
OTUD4 OTU deubiquitinase 4 1.622
FEZF1 FEZ family zinc finger 1 1.613
SPRY4 sprouty homolog 4 (Drosophila) 1.611
RPH3A rabphilin 3A 1.601
CD1D CD1d molecule 1.6
PCSK1 proprotein convertase subtilisin/kexin type 1 1.597
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 1.594
HNF1A HNF1 homeobox A 1.592
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.574
BMP4 bone morphogenetic protein 4 1.564
RBM28 RNA binding motif protein 28 1.562
GHRL ghrelin/obestatin prepropeptide 1.555
TG thyroglobulin 1.552
AIP aryl hydrocarbon receptor interacting protein 1.542
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.54
ISL1 ISL LIM homeobox 1 1.538
LEP leptin 1.536
GPR101 G protein-coupled receptor 101 1.533
SHBG sex hormone-binding globulin 1.529
NKX2-1 NK2 homeobox 1 1.523
SYP synaptophysin 1.499
CD207 CD207 molecule, langerin 1.488
MEN1 multiple endocrine neoplasia I 1.478
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 1.477
VAX1 ventral anterior homeobox 1 1.46
RNF216 ring finger protein 216 1.459
CD68 CD68 molecule 1.459
TPO thyroid peroxidase 1.45
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.449
ZIC2 Zic family member 2 1.448
AFP alpha-fetoprotein 1.435
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 1.403
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 1.401
SHOX short stature homeobox 1.396
PAX6 paired box 6 1.393
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 1.391
SRY sex determining region Y 1.389
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 1.386
SOX10 SRY (sex determining region Y)-box 10 1.385
TGIF1 TGFB-induced factor homeobox 1 1.361
CRP C-reactive protein, pentraxin-related 1.356
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.353
CD274 CD274 molecule 1.351
SMIM10L2B small integral membrane protein 10 like 2B 1.351
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.345
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 1.336
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 1.336
FGF17 fibroblast growth factor 17 1.322
GATA2 GATA binding protein 2 1.319
EMX1 empty spiracles homeobox 1 1.319
LHX2 LIM homeobox 2 1.312
WDR11 WD repeat domain 11 1.306
ALB albumin 1.299
TMEM138 transmembrane protein 138 1.296
IFT172 intraflagellar transport 172 1.289
DISP1 dispatched homolog 1 (Drosophila) 1.288
PTCH1 patched 1 1.288
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.275
KIF7 kinesin family member 7 1.27
CEP41 centrosomal protein 41kDa 1.262
TCTN1 tectonic family member 1 1.261
DCAF17 DDB1 and CUL4 associated factor 17 1.259
NODAL nodal growth differentiation factor 1.253
LHX1 LIM homeobox 1 1.252
IRS4 insulin receptor substrate 4 1.251
INSL3 insulin-like 3 (Leydig cell) 1.249
PNPLA6 patatin-like phospholipase domain containing 6 1.247
GNAS GNAS complex locus 1.237
ACE angiotensin I converting enzyme 1.237
USP8 ubiquitin specific peptidase 8 1.236
HHIP hedgehog interacting protein 1.229
FOXA2 forkhead box A2 1.229
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 1.228
CC2D2A coiled-coil and C2 domain containing 2A 1.224
DUSP6 dual specificity phosphatase 6 1.223
REN renin 1.219
TMEM237 transmembrane protein 237 1.218
IHH indian hedgehog 1.21
MKRN3 makorin ring finger protein 3 1.207
SMR3A submaxillary gland androgen regulated protein 3A 1.2
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 1.2
MAGEL2 melanoma antigen family L2 1.192
LRRIQ3 leucine-rich repeats and IQ motif containing 3 1.188
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.188
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 1.168
HYLS1 hydrolethalus syndrome 1 1.163
CCDC168 coiled-coil domain containing 168 1.159
IGF2 insulin-like growth factor 2 1.158
FOXH1 forkhead box H1 1.153
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 1.153
GFAP glial fibrillary acidic protein 1.152
ARL13B ADP-ribosylation factor-like 13B 1.15
PTH parathyroid hormone 1.149
LIM2 lens intrinsic membrane protein 2, 19kDa 1.149
HHAT hedgehog acyltransferase 1.148
PROK1 prokineticin 1 1.147
IFNA1 interferon, alpha 1 1.144
DCHS1 dachsous cadherin-related 1 1.141
NF1 neurofibromin 1 1.141
ALPP alkaline phosphatase, placental 1.137
SOX21 SRY (sex determining region Y)-box 21 1.136
SCG2 secretogranin II 1.133
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 1.131
NEUROD4 neuronal differentiation 4 1.131
GLI1 GLI family zinc finger 1 1.129
TSHR thyroid stimulating hormone receptor 1.126
RAB2A RAB2A, member RAS oncogene family 1.107
POU3F4 POU class 3 homeobox 4 1.107
WNT4 wingless-type MMTV integration site family, member 4 1.105
IFNA17 interferon, alpha 17 1.104
LDB1 LIM domain binding 1 1.103
PDCD1 programmed cell death 1 1.1
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.098
TCTN3 tectonic family member 3 1.096
SSTR5 somatostatin receptor 5 1.089
GPR45 G protein-coupled receptor 45 1.084
RAX retina and anterior neural fold homeobox 1.081
IFNA7 interferon, alpha 7 1.08
OTX1 orthodenticle homeobox 1 1.08
IFNA16 interferon, alpha 16 1.08
IFNA21 interferon, alpha 21 1.079
IFNA14 interferon, alpha 14 1.079
IFNA8 interferon, alpha 8 1.079
IFNA10 interferon, alpha 10 1.079
IFNA2 interferon, alpha 2 1.078
IFNA6 interferon, alpha 6 1.078
IFNA5 interferon, alpha 5 1.077
FGF10 fibroblast growth factor 10 1.076
IFNA13 interferon, alpha 13 1.076
IFNA4 interferon, alpha 4 1.074
LHX9 LIM homeobox 9 1.07
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 1.07
USP53 ubiquitin specific peptidase 53 1.066
PNMA2 paraneoplastic Ma antigen 2 1.059
TMEM216 transmembrane protein 216 1.056
MKS1 Meckel syndrome, type 1 1.055
IGFALS insulin-like growth factor binding protein, acid labile subunit 1.053
PRR12 proline rich 12 1.051
TCTN2 tectonic family member 2 1.048
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.041
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 1.038
LHX8 LIM homeobox 8 1.036
OFD1 oral-facial-digital syndrome 1 1.034
TP53 tumor protein p53 1.033
TMEM67 transmembrane protein 67 1.029
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.027
FGF4 fibroblast growth factor 4 1.026
AHI1 Abelson helper integration site 1 1.023
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.022
CD4 CD4 molecule 1.019
CD34 CD34 molecule 1.018
SSTR2 somatostatin receptor 2 1.017
RPGRIP1L RPGRIP1-like 1.016
TBL1X transducin (beta)-like 1X-linked 1.015
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 1.015
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 1.013
NEUROD1 neuronal differentiation 1 1.011
FGF18 fibroblast growth factor 18 1.008
IGF1R insulin-like growth factor 1 receptor 1.006
ESR1 estrogen receptor 1 1.003
F2 coagulation factor II (thrombin) 1.0