Panobinostat_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Panobinostat perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Panobinostat_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0588767
USP49 ubiquitin specific peptidase 49 0.0535969
SNX29 sorting nexin 29 0.0198962
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0195494
SBF2 SET binding factor 2 0.0194627
VWA8 von Willebrand factor A domain containing 8 0.0187583
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0184844
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0184689
TRAPPC9 trafficking protein particle complex 9 0.0175358
ZDHHC20 zinc finger, DHHC-type containing 20 0.0169674
CDK8 cyclin-dependent kinase 8 0.0168401
SPATA13 spermatogenesis associated 13 0.0167748
ARHGAP9 Rho GTPase activating protein 9 0.0167246
SKIC3 SKI3 subunit of superkiller complex 0.0166117
AFF1 AF4/FMR2 family, member 1 0.0165881
SMYD3 SET and MYND domain containing 3 0.0165144
TRERF1 transcriptional regulating factor 1 0.016427
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0162297
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0159661
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0159582
LRRC1 leucine rich repeat containing 1 0.0159115
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0156329
PCNX2 pecanex 2 0.0153442
BBS9 Bardet-Biedl syndrome 9 0.0152493
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0152088
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0151556
PTEN phosphatase and tensin homolog 0.0146129
MBNL2 muscleblind-like splicing regulator 2 0.0144102
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0139069
TASP1 taspase, threonine aspartase, 1 0.0137213
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.0136285
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0135732
ARHGAP26 Rho GTPase activating protein 26 0.0135502
FLNB filamin B, beta 0.0132742
MYH9 myosin, heavy chain 9, non-muscle 0.0132723
ARGLU1 arginine and glutamate rich 1 0.0132135
AOPEP aminopeptidase O (putative) 0.0131033
NKTR natural killer cell triggering receptor 0.0129027
AAK1 AP2 associated kinase 1 0.0125829
RNF149 ring finger protein 149 0.0125772
NCOA3 nuclear receptor coactivator 3 0.0125348
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0124455
CORO1C coronin, actin binding protein, 1C 0.012392
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0120042
CLEC16A C-type lectin domain family 16, member A 0.0119768
MACROD2 MACRO domain containing 2 0.0119289
SKAP2 src kinase associated phosphoprotein 2 0.011858
ADARB1 adenosine deaminase, RNA-specific, B1 0.0118289
TTBK2 tau tubulin kinase 2 0.0118256
EXOC6B exocyst complex component 6B 0.011662
FAF1 Fas (TNFRSF6) associated factor 1 0.0116071
ADD3 adducin 3 (gamma) 0.0115706
ZMYM2 zinc finger, MYM-type 2 0.0115271
TUFT1 tuftelin 1 0.0115132
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0114463
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0112975
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0112933
DIAPH3 diaphanous-related formin 3 0.011148
GOLM2 golgi membrane protein 2 0.0108492
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.0106934
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0106519
AFDN afadin, adherens junction formation factor 0.0104655
AGTPBP1 ATP/GTP binding protein 1 0.0104251
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.0103748
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0102384
CCDC14 coiled-coil domain containing 14 0.0102366
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0100309
ZFAND6 zinc finger, AN1-type domain 6 0.0100271
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0100174
WDR70 WD repeat domain 70 0.00999082
TBPL1 TBP-like 1 0.00991484
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0099008
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.00985801
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.00981051
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.00978763
SRPK2 SRSF protein kinase 2 0.00977338
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.00976825
GPHN gephyrin 0.00975509
FRMD5 FERM domain containing 5 0.00974499
RIC1 RAB6A GEF complex partner 1 0.00971611
SIMC1 SUMO-interacting motifs containing 1 0.00969133
ITFG1 integrin alpha FG-GAP repeat containing 1 0.00961139
TMEM245 transmembrane protein 245 0.00954707
SSBP3 single stranded DNA binding protein 3 0.00953782
TOR1AIP2 torsin A interacting protein 2 0.00945163
TTC3 tetratricopeptide repeat domain 3 0.00944434
MAPK8 mitogen-activated protein kinase 8 0.00940092
GLCE glucuronic acid epimerase 0.00926142
AHI1 Abelson helper integration site 1 0.00925772
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.00918097
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00914966
LRP6 low density lipoprotein receptor-related protein 6 0.00913496
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.00912325
UNC13B unc-13 homolog B (C. elegans) 0.00910573
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00895445
OLA1 Obg-like ATPase 1 0.00890541
SUN1 Sad1 and UNC84 domain containing 1 0.00890451
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.00889791
EVI5 ecotropic viral integration site 5 0.00888256
BCAS3 breast carcinoma amplified sequence 3 0.00885726

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.132764
EPSTI1 epithelial stromal interaction 1 (breast) -0.115243
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.109684
B2M beta-2-microglobulin -0.107748
LMO7 LIM domain 7 -0.10534
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.095495
TPT1 tumor protein, translationally-controlled 1 -0.0827895
ANXA2 annexin A2 -0.0726785
EGR1 early growth response 1 -0.0721252
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0661304
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0656473
RNF213 ring finger protein 213 -0.0612667
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0591844
INTS6 integrator complex subunit 6 -0.0580531
MX1 MX dynamin-like GTPase 1 -0.0560018
GCLC glutamate-cysteine ligase, catalytic subunit -0.0552347
LCN2 lipocalin 2 -0.0552004
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0526561
STS steroid sulfatase (microsomal), isozyme S -0.0525961
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.050776
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0500289
PKM pyruvate kinase, muscle -0.0492606
IFI6 interferon, alpha-inducible protein 6 -0.0481831
ZMYND8 zinc finger, MYND-type containing 8 -0.0459464
LYZ lysozyme -0.0458341
N4BP2L2 NEDD4 binding protein 2-like 2 -0.045257
LOC112694756 uncharaterized LOC112694756 -0.0449485
SP100 SP100 nuclear antigen -0.0445169
MX2 MX dynamin-like GTPase 2 -0.0422604
ERBIN erbb2 interacting protein -0.0420336
RIGI RNA sensor RIG-I -0.0414825
FNDC3B fibronectin type III domain containing 3B -0.0405571
PERP PERP, TP53 apoptosis effector -0.0405327
ACTG1 actin gamma 1 -0.0404535
UBC ubiquitin C -0.040445
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0397623
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.039328
PTMA prothymosin, alpha -0.0387054
C6ORF132 chromosome 6 open reading frame 132 -0.0382772
CALR calreticulin -0.0379309
RAB7A RAB7A, member RAS oncogene family -0.0377223
RPL23 ribosomal protein L23 -0.0371876
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0370366
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0363992
ITGA6 integrin, alpha 6 -0.0358449
NDRG1 N-myc downstream regulated 1 -0.0357502
MT2A metallothionein 2A -0.0357012
MACC1 metastasis associated in colon cancer 1 -0.0356106
HLA-B major histocompatibility complex, class I, B -0.0355929
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0351494
ASPH aspartate beta-hydroxylase -0.03428
NPSR1 neuropeptide S receptor 1 -0.034032
LAMA4 laminin, alpha 4 -0.0336123
ENO1 enolase 1, (alpha) -0.0331631
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0329315
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0325149
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0323083
PLSCR1 phospholipid scramblase 1 -0.0320264
PRKCA protein kinase C, alpha -0.0317157
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0314532
TSC22D1 TSC22 domain family, member 1 -0.0311676
PLSCR2 phospholipid scramblase 2 -0.0310895
AREG amphiregulin -0.0308864
JUN jun proto-oncogene -0.0308131
RPL19 ribosomal protein L19 -0.0306896
RPLP1 ribosomal protein, large, P1 -0.0306528
EZR ezrin -0.0302347
EXT1 exostosin glycosyltransferase 1 -0.0301491
IFI27 interferon, alpha-inducible protein 27 -0.0301218
XAF1 XIAP associated factor 1 -0.0300999
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0299948
GMDS GDP-mannose 4,6-dehydratase -0.0296821
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0290841
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0290526
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.02899
LPP LIM domain containing preferred translocation partner in lipoma -0.0288984
RPS6 ribosomal protein S6 -0.0287052
RPL35A ribosomal protein L35a -0.0279344
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.027332
MSI2 musashi RNA-binding protein 2 -0.0269782
HLA-E major histocompatibility complex, class I, E -0.02687
MCL1 myeloid cell leukemia 1 -0.0268323
IGFBP3 insulin-like growth factor binding protein 3 -0.0267973
CATSPERB catsper channel auxiliary subunit beta -0.026763
FTL ferritin, light polypeptide -0.0264466
PGK1 phosphoglycerate kinase 1 -0.0258673
LOC102724023 ES1 protein homolog, mitochondrial -0.0253742
RPL34 ribosomal protein L34 -0.0249441
VMP1 vacuole membrane protein 1 -0.0248992
LDHA lactate dehydrogenase A -0.024813
TM4SF1 transmembrane 4 L six family member 1 -0.0247316
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0243084
TM4SF19 transmembrane 4 L six family member 19 -0.0242575
RPL11 ribosomal protein L11 -0.0240765
EIF1 eukaryotic translation initiation factor 1 -0.0240066
RPS8 ribosomal protein S8 -0.0233862
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0232977
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0230069
MAML2 mastermind-like 2 (Drosophila) -0.0229885
TRIO trio Rho guanine nucleotide exchange factor -0.022907