Panobinostat_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Panobinostat perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Panobinostat_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.238342
MYH9 myosin, heavy chain 9, non-muscle 0.175209
NDRG1 N-myc downstream regulated 1 0.150847
FN1 fibronectin 1 0.124331
EXT1 exostosin glycosyltransferase 1 0.108389
TRIO trio Rho guanine nucleotide exchange factor 0.0990716
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0859153
CD44 CD44 molecule (Indian blood group) 0.0830334
COL1A1 collagen, type I, alpha 1 0.0641318
VIM vimentin 0.0604092
ENO1 enolase 1, (alpha) 0.0591165
ASPH aspartate beta-hydroxylase 0.0581295
TM4SF1 transmembrane 4 L six family member 1 0.0519257
PLEC plectin 0.050961
ALCAM activated leukocyte cell adhesion molecule 0.0461594
TMSB4X thymosin beta 4, X-linked 0.0453135
EEF2 eukaryotic translation elongation factor 2 0.0415345
STC1 stanniocalcin 1 0.0378512
APP amyloid beta (A4) precursor protein 0.0345193
CLIC4 chloride intracellular channel 4 0.0341085
INHBA inhibin, beta A 0.0328005
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0324726
SMYD3 SET and MYND domain containing 3 0.0321716
CALU calumenin 0.0319904
PGK1 phosphoglycerate kinase 1 0.0306478
DPYD dihydropyrimidine dehydrogenase 0.0304337
CAVIN1 caveolae associated protein 1 0.0293453
KMT2C lysine (K)-specific methyltransferase 2C 0.0267667
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0257537
RUNX1 runt-related transcription factor 1 0.0255331
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0244905
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0231535
ANXA2 annexin A2 0.0229759
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0223568
CNKSR3 CNKSR family member 3 0.021829
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0215544
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0212186
SHB Src homology 2 domain containing adaptor protein B 0.021206
MT1X metallothionein 1X 0.020723
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0204134
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0203463
NAP1L1 nucleosome assembly protein 1-like 1 0.0202765
FBXO32 F-box protein 32 0.0199077
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.0193985
ANLN anillin, actin binding protein 0.0189824
CTSB cathepsin B 0.0188759
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0187613
PRKCA protein kinase C, alpha 0.0184363
RPS8 ribosomal protein S8 0.0183824
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0183609
COL6A2 collagen, type VI, alpha 2 0.0180427
FGFR1 fibroblast growth factor receptor 1 0.0178935
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0177236
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0172233
FAM162A family with sequence similarity 162, member A 0.0170511
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0168416
CCDC47 coiled-coil domain containing 47 0.0168385
LMNA lamin A/C 0.016556
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0162803
DST dystonin 0.0162078
PKM pyruvate kinase, muscle 0.0161462
CORO1C coronin, actin binding protein, 1C 0.0160789
FYN FYN proto-oncogene, Src family tyrosine kinase 0.015975
FOXP1 forkhead box P1 0.0159446
AHCYL1 adenosylhomocysteinase-like 1 0.0158784
KDM3A lysine (K)-specific demethylase 3A 0.015689
DPYSL2 dihydropyrimidinase-like 2 0.015423
UBE2O ubiquitin-conjugating enzyme E2O 0.0153313
ACTN4 actinin, alpha 4 0.0153149
ATXN1 ataxin 1 0.0152462
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0151954
RRBP1 ribosome binding protein 1 0.0151542
IER3 immediate early response 3 0.0150607
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0149812
TSPAN5 tetraspanin 5 0.0145884
CD59 CD59 molecule, complement regulatory protein 0.0144573
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0144286
RACK1 receptor for activated C kinase 1 0.0143253
FBXL13 F-box and leucine-rich repeat protein 13 0.0143226
SEPTIN9 septin 9 0.0143003
ELL2 elongation factor, RNA polymerase II, 2 0.0142889
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0141727
STC2 stanniocalcin 2 0.0141687
TPM4 tropomyosin 4 0.0141564
NABP1 nucleic acid binding protein 1 0.0139918
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0139595
COL5A1 collagen, type V, alpha 1 0.0138588
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0138446
PTK2 protein tyrosine kinase 2 0.0137728
CANX calnexin 0.0137258
NGLY1 N-glycanase 1 0.0137213
SFTPA2 surfactant protein A2 0.0136567
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0136543
TXNRD1 thioredoxin reductase 1 0.0135812
LMAN1 lectin, mannose-binding, 1 0.0134702
GPHN gephyrin 0.013457
COL3A1 collagen, type III, alpha 1 0.013424
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0131203
MPRIP myosin phosphatase Rho interacting protein 0.0130814
AMOTL1 angiomotin like 1 0.0130165

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.320941
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.133237
CALR calreticulin -0.0857059
CDH13 cadherin 13 -0.0739602
HMGA2 high mobility group AT-hook 2 -0.0628209
PDE10A phosphodiesterase 10A -0.0622183
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0607394
FNDC3B fibronectin type III domain containing 3B -0.0537394
PSD3 pleckstrin and Sec7 domain containing 3 -0.051641
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0434949
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0419536
LOX lysyl oxidase -0.0362044
DPYSL3 dihydropyrimidinase-like 3 -0.0360341
FTH1 ferritin, heavy polypeptide 1 -0.0353252
LOXL2 lysyl oxidase-like 2 -0.0349281
GLIS3 GLIS family zinc finger 3 -0.0348296
VEGFC vascular endothelial growth factor C -0.0286066
MAP1B microtubule-associated protein 1B -0.0281263
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0279004
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0278399
VCAN versican -0.0263264
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0263149
NAV1 neuron navigator 1 -0.0257553
SQSTM1 sequestosome 1 -0.02493
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0248917
NRP1 neuropilin 1 -0.024672
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0246102
TGFBI transforming growth factor, beta-induced, 68kDa -0.0241876
DOCK5 dedicator of cytokinesis 5 -0.0238227
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0237817
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0232386
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0232071
ADAM12 ADAM metallopeptidase domain 12 -0.0225984
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0223759
MTSS1 metastasis suppressor 1 -0.0214993
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0212948
FBN1 fibrillin 1 -0.0212174
PDLIM5 PDZ and LIM domain 5 -0.0207835
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0198678
GRB10 growth factor receptor-bound protein 10 -0.0192721
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0191636
LPP LIM domain containing preferred translocation partner in lipoma -0.0187651
CADM1 cell adhesion molecule 1 -0.0186363
EGFR epidermal growth factor receptor -0.0185085
MRPS6 mitochondrial ribosomal protein S6 -0.0183101
RAB2A RAB2A, member RAS oncogene family -0.0181119
ZBTB38 zinc finger and BTB domain containing 38 -0.0178329
PRELID2 PRELI domain containing 2 -0.0175665
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0174778
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0173148
CPQ carboxypeptidase Q -0.0168669
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0168509
ZEB2 zinc finger E-box binding homeobox 2 -0.0168089
CLMP CXADR-like membrane protein -0.0167841
PDIA4 protein disulfide isomerase family A, member 4 -0.0167513
HIPK2 homeodomain interacting protein kinase 2 -0.0167187
CYB5R3 cytochrome b5 reductase 3 -0.0164606
LOC112694756 uncharaterized LOC112694756 -0.0161331
ZFPM2 zinc finger protein, FOG family member 2 -0.0158186
POTEF POTE ankyrin domain family, member F -0.0157925
IL6 interleukin 6 -0.0157764
ZNF644 zinc finger protein 644 -0.0157354
TFG TRK-fused gene -0.0156052
TAPBP TAP binding protein (tapasin) -0.0156003
SENP6 SUMO1/sentrin specific peptidase 6 -0.015387
PLSCR1 phospholipid scramblase 1 -0.0151218
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0143113
PTBP2 polypyrimidine tract binding protein 2 -0.0141915
INSIG1 insulin induced gene 1 -0.0141584
TRAM1 translocation associated membrane protein 1 -0.0139114
MBNL1 muscleblind-like splicing regulator 1 -0.0139113
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -0.0138359
MX2 MX dynamin-like GTPase 2 -0.0137226
BAIAP2 BAI1-associated protein 2 -0.0136746
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0134113
HAS2 hyaluronan synthase 2 -0.0130142
ANO6 anoctamin 6 -0.0130048
NRIP1 nuclear receptor interacting protein 1 -0.0125731
RBPMS RNA binding protein with multiple splicing -0.0123894
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0123882
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.0122148
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0122111
JAK2 Janus kinase 2 -0.0120801
AXL AXL receptor tyrosine kinase -0.0119398
COPA coatomer protein complex, subunit alpha -0.0116168
ITCH itchy E3 ubiquitin protein ligase -0.0114311
MACF1 microtubule-actin crosslinking factor 1 -0.0112323
TRPS1 trichorhinophalangeal syndrome I -0.0110811
SEC24D SEC24 family member D -0.0110193
WWTR1 WW domain containing transcription regulator 1 -0.010988
IFI44L interferon-induced protein 44-like -0.0108264
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.010779
SEC23A Sec23 homolog A (S. cerevisiae) -0.0107385
RYBP RING1 and YY1 binding protein -0.0106635
RFTN1 raftlin, lipid raft linker 1 -0.0106265
TNS3 tensin 3 -0.0105496
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0104297
WASF2 WAS protein family, member 2 -0.0103306
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0102748
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0102423