Panobinostat_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Panobinostat perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Panobinostat_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
H1-0 H1.0 linker histone 0.0664672
FAT1 FAT atypical cadherin 1 0.0620051
DSPP dentin sialophosphoprotein 0.0460533
NRXN3 neurexin 3 0.0338403
MYH9 myosin, heavy chain 9, non-muscle 0.0320659
DNM3 dynamin 3 0.0228524
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0223657
FLNB filamin B, beta 0.0220701
ARHGAP32 Rho GTPase activating protein 32 0.0204525
APP amyloid beta (A4) precursor protein 0.0203555
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0201604
ACTN4 actinin, alpha 4 0.019368
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0189979
KRT8 keratin 8, type II 0.018183
AREG amphiregulin 0.0180316
FOXP1 forkhead box P1 0.0173068
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0172619
USP6NL USP6 N-terminal like 0.0170612
ARL15 ADP-ribosylation factor-like 15 0.0169266
FOXO1 forkhead box O1 0.0167655
ITPRID2 ITPR interacting domain containing 2 0.016754
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0164791
AFDN afadin, adherens junction formation factor 0.0164765
WWC1 WW and C2 domain containing 1 0.0162655
HHLA2 HERV-H LTR-associating 2 0.0154541
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.01533
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0151738
SHROOM3 shroom family member 3 0.0150627
LMO7 LIM domain 7 0.014803
MED13L mediator complex subunit 13-like 0.014696
ASPH aspartate beta-hydroxylase 0.0145901
TMSB4X thymosin beta 4, X-linked 0.0145349
SAMD12 sterile alpha motif domain containing 12 0.0144613
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0143743
EFNA5 ephrin-A5 0.0143736
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0143122
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.013914
PELI1 pellino E3 ubiquitin protein ligase 1 0.0135536
ANXA1 annexin A1 0.0132802
TPM3 tropomyosin 3 0.013275
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0132518
KDM3A lysine (K)-specific demethylase 3A 0.0131806
PCNX2 pecanex 2 0.0129878
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0128245
MUC13 mucin 13, cell surface associated 0.0128114
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.012569
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0125144
SERINC5 serine incorporator 5 0.0124743
PLEC plectin 0.0122684
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0122423
EMP1 epithelial membrane protein 1 0.0120527
EXOC6B exocyst complex component 6B 0.011997
GDA guanine deaminase 0.0119583
SOX9 SRY (sex determining region Y)-box 9 0.0117041
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0115964
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0115636
NDRG1 N-myc downstream regulated 1 0.0115089
TSPAN5 tetraspanin 5 0.0115064
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.011413
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0113562
MACF1 microtubule-actin crosslinking factor 1 0.011284
DSG2 desmoglein 2 0.011249
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0111674
AFF1 AF4/FMR2 family, member 1 0.0111232
SPRED1 sprouty-related, EVH1 domain containing 1 0.0109688
DPYSL2 dihydropyrimidinase-like 2 0.0109155
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.0109009
RNF24 ring finger protein 24 0.0108613
CEMIP cell migration inducing protein, hyaluronan binding 0.0108448
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0108129
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.010797
ATXN1 ataxin 1 0.0107502
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0107336
ITGA6 integrin, alpha 6 0.01067
EML6 echinoderm microtubule associated protein like 6 0.010659
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0106335
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0105672
CADPS Ca++-dependent secretion activator 0.0104935
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0104338
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0103794
PTCH1 patched 1 0.0103392
MIDEAS mitotic deacetylase associated SANT domain protein 0.0101249
RPL3 ribosomal protein L3 0.00998524
WWC2 WW and C2 domain containing 2 0.00996002
UBE2H ubiquitin-conjugating enzyme E2H 0.00992469
AGTPBP1 ATP/GTP binding protein 1 0.00991922
OSBPL10 oxysterol binding protein-like 10 0.00991099
MINK1 misshapen-like kinase 1 0.00988877
TGFBR3 transforming growth factor, beta receptor III 0.00987446
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00982348
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.00978536
PDZD8 PDZ domain containing 8 0.00974827
RERE arginine-glutamic acid dipeptide (RE) repeats 0.009719
ATP13A3 ATPase type 13A3 0.00971401
EHF ets homologous factor 0.00971324
ZNRF3 zinc and ring finger 3 0.00969351
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.00967213
RNF43 ring finger protein 43 0.00960287
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.00957232
RREB1 ras responsive element binding protein 1 0.00955875

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.164944
TMSB10 thymosin beta 10 -0.15709
RPS6 ribosomal protein S6 -0.136757
TPT1 tumor protein, translationally-controlled 1 -0.131066
MUC6 mucin 6, oligomeric mucus/gel-forming -0.120858
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116745
RPL35A ribosomal protein L35a -0.10306
FTL ferritin, light polypeptide -0.0996257
RPS8 ribosomal protein S8 -0.0995603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0970906
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0765639
RPS19 ribosomal protein S19 -0.070949
RPL37A ribosomal protein L37a -0.0676168
RPS12 ribosomal protein S12 -0.067253
RPL9 ribosomal protein L9 -0.0657122
RPL23 ribosomal protein L23 -0.0628518
RPLP1 ribosomal protein, large, P1 -0.062726
RPL31 ribosomal protein L31 -0.0618118
RPLP2 ribosomal protein, large, P2 -0.0609875
ACTG1 actin gamma 1 -0.0592352
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0573922
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.057174
RPS29 ribosomal protein S29 -0.0567943
RPS23 ribosomal protein S23 -0.0566575
NPSR1 neuropeptide S receptor 1 -0.0561357
TPM4 tropomyosin 4 -0.0558711
RPL34 ribosomal protein L34 -0.0532892
EIF1 eukaryotic translation initiation factor 1 -0.0523884
RPS25 ribosomal protein S25 -0.0501485
RPS13 ribosomal protein S13 -0.0492638
GMDS GDP-mannose 4,6-dehydratase -0.0484597
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0447616
RPL36 ribosomal protein L36 -0.0442328
LDHA lactate dehydrogenase A -0.0428608
RPL19 ribosomal protein L19 -0.0427861
RPS3 ribosomal protein S3 -0.0427502
RPL11 ribosomal protein L11 -0.0424732
RPL26 ribosomal protein L26 -0.0413858
GOLGA4 golgin A4 -0.0410369
RPL12 ribosomal protein L12 -0.0409399
S100P S100 calcium binding protein P -0.0406985
RPS27A ribosomal protein S27a -0.039867
RPS24 ribosomal protein S24 -0.039791
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0395042
RPS27 ribosomal protein S27 -0.0391197
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0386465
RPL5 ribosomal protein L5 -0.0386149
RPS14 ribosomal protein S14 -0.0384024
VCL vinculin -0.037912
PDIA3 protein disulfide isomerase family A, member 3 -0.0368103
RPS17 ribosomal protein S17 -0.0366859
RPL37 ribosomal protein L37 -0.0354054
S100A10 S100 calcium binding protein A10 -0.0346163
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0332349
RPL28 ribosomal protein L28 -0.0327168
MT2A metallothionein 2A -0.0320978
RPS11 ribosomal protein S11 -0.0316803
FTH1 ferritin, heavy polypeptide 1 -0.0313301
CALR calreticulin -0.0313121
POTEF POTE ankyrin domain family, member F -0.0312011
S100A6 S100 calcium binding protein A6 -0.0310862
AGR2 anterior gradient 2 -0.031035
RPL13A ribosomal protein L13a -0.0306492
EXT1 exostosin glycosyltransferase 1 -0.0302707
RPL7 ribosomal protein L7 -0.0300581
RPL7A ribosomal protein L7a -0.0295692
TFF1 trefoil factor 1 -0.0295492
ENO1 enolase 1, (alpha) -0.0286967
RPLP0 ribosomal protein, large, P0 -0.0284855
RPS10 ribosomal protein S10 -0.0282894
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0278411
HMGA1 high mobility group AT-hook 1 -0.0274932
RPS20 ribosomal protein S20 -0.0274198
RPL36A ribosomal protein L36a -0.027263
RPL8 ribosomal protein L8 -0.0271575
ISG15 ISG15 ubiquitin-like modifier -0.0268783
RPL38 ribosomal protein L38 -0.0266416
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0262783
RPS16 ribosomal protein S16 -0.0262692
TUBB4B tubulin, beta 4B class IVb -0.0261709
ATF4 activating transcription factor 4 -0.0255353
GNAS GNAS complex locus -0.0250516
RPL15 ribosomal protein L15 -0.0249874
EIF5B eukaryotic translation initiation factor 5B -0.0249777
NUPR1 nuclear protein, transcriptional regulator, 1 -0.024938
AKAP9 A kinase (PRKA) anchor protein 9 -0.0249294
KRT18 keratin 18, type I -0.0248112
ATP5F1B ATP synthase F1 subunit beta -0.0247766
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0247159
RPL27 ribosomal protein L27 -0.0246888
IER3 immediate early response 3 -0.024215
TFF3 trefoil factor 3 (intestinal) -0.0241366
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0240246
RPL27A ribosomal protein L27a -0.0239595
SEC31A SEC31 homolog A (S. cerevisiae) -0.023925
GOLGB1 golgin B1 -0.0237337
IARS1 isoleucyl-tRNA synthetase 1 -0.0234395
RPL30 ribosomal protein L30 -0.0234345
RPS15 ribosomal protein S15 -0.0230871
VDAC1 voltage-dependent anion channel 1 -0.0229624