Panobinostat_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Panobinostat perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Panobinostat_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.185404
TBC1D22A TBC1 domain family, member 22A 0.106324
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0861592
MYH9 myosin, heavy chain 9, non-muscle 0.0763961
H1-0 H1.0 linker histone 0.0716344
TPT1 tumor protein, translationally-controlled 1 0.0665057
MT2A metallothionein 2A 0.0622229
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0553158
NAMPT nicotinamide phosphoribosyltransferase 0.0533401
MCTP1 multiple C2 domains, transmembrane 1 0.0528979
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0526546
ASPH aspartate beta-hydroxylase 0.0481624
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0453782
PLEC plectin 0.0447298
NGLY1 N-glycanase 1 0.0442055
KDM3A lysine (K)-specific demethylase 3A 0.0420288
RTN4 reticulon 4 0.0392776
LOC112694756 uncharaterized LOC112694756 0.0391589
MKI67 marker of proliferation Ki-67 0.0388006
ANKRD10 ankyrin repeat domain 10 0.0374455
PGK1 phosphoglycerate kinase 1 0.0371925
MT1X metallothionein 1X 0.0358185
APLP2 amyloid beta (A4) precursor-like protein 2 0.0349986
RPS3 ribosomal protein S3 0.0347263
CAMTA1 calmodulin binding transcription activator 1 0.0346088
AREG amphiregulin 0.0337664
EXT1 exostosin glycosyltransferase 1 0.0336695
STC1 stanniocalcin 1 0.0332259
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0331593
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0321428
SMAD3 SMAD family member 3 0.0318241
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0317882
NAP1L1 nucleosome assembly protein 1-like 1 0.0316006
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0314798
DTNA dystrobrevin, alpha 0.0310417
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0307497
ARGLU1 arginine and glutamate rich 1 0.0304767
SHB Src homology 2 domain containing adaptor protein B 0.0300686
RPS24 ribosomal protein S24 0.0299847
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0288172
PDIA4 protein disulfide isomerase family A, member 4 0.0284497
EIF4A2 eukaryotic translation initiation factor 4A2 0.0272868
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0272327
YBX3 Y box binding protein 3 0.027092
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0269824
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0269002
UBE2O ubiquitin-conjugating enzyme E2O 0.0266716
BIRC3 baculoviral IAP repeat containing 3 0.0257435
SPAG9 sperm associated antigen 9 0.0257123
SLC38A1 solute carrier family 38, member 1 0.0256457
APP amyloid beta (A4) precursor protein 0.0248489
EPAS1 endothelial PAS domain protein 1 0.0246116
CLU clusterin 0.0245329
PTMA prothymosin, alpha 0.0235798
LAMC2 laminin, gamma 2 0.0233768
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0231666
PPP4R4 protein phosphatase 4, regulatory subunit 4 0.0224787
RPL3 ribosomal protein L3 0.0224441
IER3 immediate early response 3 0.0223289
RAD51B RAD51 paralog B 0.0218397
ZNF217 zinc finger protein 217 0.0216896
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0214752
GPHN gephyrin 0.0214493
RPL4 ribosomal protein L4 0.0213372
RPS8 ribosomal protein S8 0.0212657
KIAA1217 KIAA1217 0.0212423
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0209147
DENND4A DENN/MADD domain containing 4A 0.0207858
NDE1 nudE neurodevelopment protein 1 0.0207855
CPNE4 copine IV 0.02078
SDC4 syndecan 4 0.0207699
GPC6 glypican 6 0.0206238
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.02037
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0200766
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0200764
IGF1R insulin-like growth factor 1 receptor 0.0200066
CTTN cortactin 0.0196796
PRELID2 PRELI domain containing 2 0.0196592
GUK1 guanylate kinase 1 0.0195961
PCNX2 pecanex 2 0.0193683
ANKRD17 ankyrin repeat domain 17 0.0193659
ZC3H12B zinc finger CCCH-type containing 12B 0.0193617
ENSA endosulfine alpha 0.0193441
RPLP0 ribosomal protein, large, P0 0.019074
TRAPPC9 trafficking protein particle complex 9 0.0189988
USP9X ubiquitin specific peptidase 9, X-linked 0.0189312
IPO7 importin 7 0.0187455
ARHGAP32 Rho GTPase activating protein 32 0.0186577
NONO non-POU domain containing, octamer-binding 0.0184953
RPS6 ribosomal protein S6 0.0183126
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0181865
EEF2 eukaryotic translation elongation factor 2 0.0181523
RRM2 ribonucleotide reductase M2 0.0180849
DNMBP dynamin binding protein 0.0180266
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0179058
BMERB1 bMERB domain containing 1 0.0178531
ZBTB20 zinc finger and BTB domain containing 20 0.0176993
SFTPA2 surfactant protein A2 0.0176826
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0176543
EIF4A1 eukaryotic translation initiation factor 4A1 0.0176137

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.309559
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115093
FTH1 ferritin, heavy polypeptide 1 -0.110225
LMO7 LIM domain 7 -0.108238
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0889076
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0851032
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0721404
EGFR epidermal growth factor receptor -0.0544644
PTPRM protein tyrosine phosphatase, receptor type, M -0.0499704
SLTM SAFB-like, transcription modulator -0.0495335
OSMR oncostatin M receptor -0.0485758
IGFBP3 insulin-like growth factor binding protein 3 -0.0475285
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0466623
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0462859
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0457262
S100A10 S100 calcium binding protein A10 -0.0453448
SEC61G Sec61 gamma subunit -0.04249
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0424622
EGR1 early growth response 1 -0.0414824
THSD4 thrombospondin, type I, domain containing 4 -0.0404214
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0388867
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.038808
MYOF myoferlin -0.0380045
SCEL sciellin -0.0372987
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0371332
PDLIM5 PDZ and LIM domain 5 -0.0358495
INTS6 integrator complex subunit 6 -0.0356262
KMT2E lysine (K)-specific methyltransferase 2E -0.0333849
PKM pyruvate kinase, muscle -0.0329993
CAV1 caveolin 1, caveolae protein, 22kDa -0.0328271
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0321357
FNDC3B fibronectin type III domain containing 3B -0.0318553
NDRG1 N-myc downstream regulated 1 -0.0315997
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0315038
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0314793
WASF2 WAS protein family, member 2 -0.0313945
TMSB10 thymosin beta 10 -0.0310583
TJP1 tight junction protein 1 -0.0309099
DOCK5 dedicator of cytokinesis 5 -0.030559
MYO1E myosin IE -0.0295981
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0289404
TMEM165 transmembrane protein 165 -0.0288871
BRD2 bromodomain containing 2 -0.0288598
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0278868
TSC22D2 TSC22 domain family, member 2 -0.0278833
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0277582
PCBP2 poly(rC) binding protein 2 -0.0275541
PATJ PATJ crumbs cell polarity complex component -0.0275487
USP34 ubiquitin specific peptidase 34 -0.0271798
AKAP9 A kinase (PRKA) anchor protein 9 -0.0271205
GSK3B glycogen synthase kinase 3 beta -0.0269414
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -0.0267594
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0266077
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0256502
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.025385
MGST1 microsomal glutathione S-transferase 1 -0.0251714
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0251542
CREBBP CREB binding protein -0.0251519
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0247884
MRPS6 mitochondrial ribosomal protein S6 -0.0240053
RAB27B RAB27B, member RAS oncogene family -0.0237197
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0237186
ANXA2 annexin A2 -0.023478
KRT7 keratin 7, type II -0.0233828
BCAR3 breast cancer anti-estrogen resistance 3 -0.023326
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0229426
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0228191
LRP1B low density lipoprotein receptor-related protein 1B -0.0225759
CAV2 caveolin 2 -0.0223339
SAMD4A sterile alpha motif domain containing 4A -0.0222551
POTEF POTE ankyrin domain family, member F -0.0222539
BRWD1 bromodomain and WD repeat domain containing 1 -0.0220999
TPM4 tropomyosin 4 -0.0220567
SEC31A SEC31 homolog A (S. cerevisiae) -0.0219756
GRB10 growth factor receptor-bound protein 10 -0.0219683
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0218733
VEGFC vascular endothelial growth factor C -0.0217627
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.021753
PAPOLA poly(A) polymerase alpha -0.021541
ARRDC3 arrestin domain containing 3 -0.021404
FTL ferritin, light polypeptide -0.0213119
S100A11 S100 calcium binding protein A11 -0.021205
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0206749
FBXO11 F-box protein 11 -0.0205824
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0203188
ATP11A ATPase, class VI, type 11A -0.0201616
CXCL8 chemokine (C-X-C motif) ligand 8 -0.020024
HMGA1 high mobility group AT-hook 1 -0.0199565
RCOR1 REST corepressor 1 -0.0199142
SPDYA speedy/RINGO cell cycle regulator family member A -0.0198105
HDLBP high density lipoprotein binding protein -0.0192762
NCOA2 nuclear receptor coactivator 2 -0.0192734
TRIP12 thyroid hormone receptor interactor 12 -0.0191512
ZNF638 zinc finger protein 638 -0.0190209
ATF4 activating transcription factor 4 -0.0189088
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0187607
COPA coatomer protein complex, subunit alpha -0.0186818
TNS3 tensin 3 -0.0186745
EIF1 eukaryotic translation initiation factor 1 -0.0184548
PER2 period circadian clock 2 -0.0181178