| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Panobinostat perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Panobinostat_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.0894361 |
| RTN4 | reticulon 4 | 0.0387152 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0372371 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0336566 |
| DST | dystonin | 0.0311328 |
| STC1 | stanniocalcin 1 | 0.0299976 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0282172 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0273857 |
| TXNRD1 | thioredoxin reductase 1 | 0.0272102 |
| PM20D1 | peptidase M20 domain containing 1 | 0.026242 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0248773 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.024658 |
| YBX3 | Y box binding protein 3 | 0.0243101 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0231258 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0219296 |
| USP3 | ubiquitin specific peptidase 3 | 0.0217577 |
| WDR43 | WD repeat domain 43 | 0.0216975 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0216439 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0210822 |
| GPHN | gephyrin | 0.0206184 |
| SIK3 | SIK family kinase 3 | 0.0205969 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0202864 |
| FNBP1L | formin binding protein 1-like | 0.0201644 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0194669 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0185318 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0184872 |
| AHR | aryl hydrocarbon receptor | 0.018064 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0175187 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0171146 |
| FGB | fibrinogen beta chain | 0.0170313 |
| TPM3 | tropomyosin 3 | 0.0167738 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0164325 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0163794 |
| TPD52 | tumor protein D52 | 0.0162013 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0161221 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0159199 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0158316 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | 0.0156471 |
| DENND4A | DENN/MADD domain containing 4A | 0.015589 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0155322 |
| RPL3 | ribosomal protein L3 | 0.0154161 |
| FGG | fibrinogen gamma chain | 0.0153407 |
| FAM168A | family with sequence similarity 168, member A | 0.0150981 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0149856 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0145484 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.01451 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0143741 |
| HYOU1 | hypoxia up-regulated 1 | 0.0141467 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0138937 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0138603 |
| APP | amyloid beta (A4) precursor protein | 0.0137865 |
| ANXA1 | annexin A1 | 0.0135011 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.013496 |
| MRTFA | myocardin related transcription factor A | 0.0134928 |
| SMYD3 | SET and MYND domain containing 3 | 0.0134767 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0133901 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | 0.0132963 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0132127 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0131666 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0129958 |
| MTF2 | metal response element binding transcription factor 2 | 0.0129046 |
| THBS1 | thrombospondin 1 | 0.0128563 |
| ENAH | enabled homolog (Drosophila) | 0.0127306 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.012725 |
| OLA1 | Obg-like ATPase 1 | 0.0127211 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0126599 |
| FTO | fat mass and obesity associated | 0.0124974 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0123768 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0123576 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0122415 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0121641 |
| RNF145 | ring finger protein 145 | 0.0121598 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 0.0119823 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0119176 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0119148 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0118959 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0118584 |
| RORA | RAR-related orphan receptor A | 0.0117249 |
| KIF1B | kinesin family member 1B | 0.0117112 |
| QKI | QKI, KH domain containing, RNA binding | 0.0116492 |
| CCDC88A | coiled-coil domain containing 88A | 0.0116009 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | 0.0113989 |
| BMP6 | bone morphogenetic protein 6 | 0.011228 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.0111183 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.011106 |
| SPOPL | speckle-type POZ protein-like | 0.011022 |
| CNKSR3 | CNKSR family member 3 | 0.0109811 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0109696 |
| PFDN2 | prefoldin subunit 2 | 0.0109645 |
| PTEN | phosphatase and tensin homolog | 0.0109355 |
| NUP93 | nucleoporin 93kDa | 0.0109259 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0108234 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0107874 |
| DDHD1 | DDHD domain containing 1 | 0.0107518 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0106802 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0106719 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0105743 |
| FAT1 | FAT atypical cadherin 1 | 0.0105705 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0105637 |
| NUP58 | nucleoporin 58 | 0.0105603 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.203215 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.140418 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.138612 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0720731 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0710404 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0663609 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0651086 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0648205 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.064099 |
| VIM | vimentin | -0.0638638 |
| ACTG1 | actin gamma 1 | -0.05652 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0538076 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0446304 |
| IGF2 | insulin-like growth factor 2 | -0.0389389 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0380834 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0371895 |
| LDHA | lactate dehydrogenase A | -0.0340222 |
| PYGL | phosphorylase, glycogen, liver | -0.0333703 |
| TMSB10 | thymosin beta 10 | -0.0328599 |
| IER3 | immediate early response 3 | -0.0300976 |
| S100A6 | S100 calcium binding protein A6 | -0.0300723 |
| FTL | ferritin, light polypeptide | -0.0299996 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.029764 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0290979 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0289827 |
| MYOF | myoferlin | -0.0289745 |
| FAM107B | family with sequence similarity 107, member B | -0.0278734 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0269767 |
| FNDC3B | fibronectin type III domain containing 3B | -0.026601 |
| TPM4 | tropomyosin 4 | -0.0264312 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0263234 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0243148 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0241818 |
| FMNL2 | formin-like 2 | -0.0238196 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0233845 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0232566 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0232413 |
| RBM39 | RNA binding motif protein 39 | -0.0225355 |
| MCL1 | myeloid cell leukemia 1 | -0.0225131 |
| HLA-B | major histocompatibility complex, class I, B | -0.0223888 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0223573 |
| BICC1 | BicC family RNA binding protein 1 | -0.0223518 |
| RPS8 | ribosomal protein S8 | -0.0220711 |
| SNX14 | sorting nexin 14 | -0.0215443 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0211816 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0209179 |
| CALR | calreticulin | -0.0207587 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0205176 |
| SQSTM1 | sequestosome 1 | -0.0203023 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0201388 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0197151 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0193625 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.019127 |
| NHSL1 | NHS-like 1 | -0.0190477 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0184261 |
| EGR1 | early growth response 1 | -0.0182222 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0178594 |
| USP34 | ubiquitin specific peptidase 34 | -0.0176207 |
| OSMR | oncostatin M receptor | -0.0174757 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0173592 |
| PRDX1 | peroxiredoxin 1 | -0.0170053 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0169949 |
| RPL35A | ribosomal protein L35a | -0.0169844 |
| PDE8A | phosphodiesterase 8A | -0.016681 |
| ENO1 | enolase 1, (alpha) | -0.0166754 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0166522 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0165902 |
| S100A10 | S100 calcium binding protein A10 | -0.0163451 |
| NAV3 | neuron navigator 3 | -0.0161967 |
| KYNU | kynureninase | -0.0159498 |
| GNAS | GNAS complex locus | -0.0158983 |
| POTEF | POTE ankyrin domain family, member F | -0.0157708 |
| ANGPTL4 | angiopoietin-like 4 | -0.015758 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0157268 |
| H1-0 | H1.0 linker histone | -0.0156637 |
| EGFR | epidermal growth factor receptor | -0.0156168 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0154231 |
| ATXN10 | ataxin 10 | -0.0154059 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0151922 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0151834 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0151454 |
| RBM25 | RNA binding motif protein 25 | -0.0151186 |
| NF1 | neurofibromin 1 | -0.0150577 |
| CFDP1 | craniofacial development protein 1 | -0.0150572 |
| S100A11 | S100 calcium binding protein A11 | -0.0150512 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0149399 |
| HLA-A | major histocompatibility complex, class I, A | -0.0149319 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0148853 |
| MORF4L2 | mortality factor 4 like 2 | -0.0148466 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0147826 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0147609 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0146878 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.014432 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0144061 |
| IL6 | interleukin 6 | -0.0144003 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0141408 |
| NNMT | nicotinamide N-methyltransferase | -0.0140478 |
| RPL23 | ribosomal protein L23 | -0.0137775 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0137643 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.013742 |
