| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Panobinostat perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Panobinostat_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0909777 |
| TXNRD1 | thioredoxin reductase 1 | 0.0677593 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0655526 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0587093 |
| STK24 | serine/threonine kinase 24 | 0.0554786 |
| SMYD3 | SET and MYND domain containing 3 | 0.0528037 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0507748 |
| KYNU | kynureninase | 0.0485207 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0481208 |
| KRT17 | keratin 17, type I | 0.0476651 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0461424 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0440759 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.041797 |
| RIGI | RNA sensor RIG-I | 0.0417474 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0408372 |
| HPCAL1 | hippocalcin-like 1 | 0.0400384 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0385196 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0375458 |
| PLEC | plectin | 0.0367923 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.03649 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0362883 |
| TES | testin LIM domain protein | 0.0359554 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0358925 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0354663 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0346982 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0346534 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0342289 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0336283 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0335752 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0330268 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0323482 |
| TUFT1 | tuftelin 1 | 0.0323441 |
| MLEC | malectin | 0.0318141 |
| KIAA1217 | KIAA1217 | 0.0316895 |
| VCL | vinculin | 0.0314104 |
| CLEC16A | C-type lectin domain family 16, member A | 0.0313071 |
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter), member 4 | 0.0311536 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | 0.0308867 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0307339 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0303763 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0302101 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0301679 |
| PCBP3 | poly(rC) binding protein 3 | 0.0301269 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0300086 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0298321 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0297606 |
| ATF3 | activating transcription factor 3 | 0.0292672 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.028905 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0288922 |
| COPS2 | COP9 signalosome subunit 2 | 0.0287359 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0285901 |
| FLNA | filamin A, alpha | 0.0282283 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0281872 |
| GRB2 | growth factor receptor-bound protein 2 | 0.0281719 |
| DENND4A | DENN/MADD domain containing 4A | 0.02813 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0280208 |
| AK1 | adenylate kinase 1 | 0.0279932 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0277827 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0275954 |
| FRMD5 | FERM domain containing 5 | 0.0275782 |
| WDR43 | WD repeat domain 43 | 0.0275168 |
| UBAP2 | ubiquitin associated protein 2 | 0.0273392 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0273 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0272629 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0272024 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.0271003 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0266557 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0265727 |
| SRFBP1 | serum response factor binding protein 1 | 0.0264786 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0264569 |
| PARD3 | par-3 family cell polarity regulator | 0.0262236 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0261419 |
| CYTH3 | cytohesin 3 | 0.0261034 |
| KAZN | kazrin, periplakin interacting protein | 0.0260325 |
| VTA1 | vesicle (multivesicular body) trafficking 1 | 0.025837 |
| EXOC6B | exocyst complex component 6B | 0.0257464 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0255884 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0254412 |
| ATP11A | ATPase, class VI, type 11A | 0.0253389 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0253225 |
| FNBP4 | formin binding protein 4 | 0.0252599 |
| TNPO1 | transportin 1 | 0.0251726 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0251386 |
| TUSC3 | tumor suppressor candidate 3 | 0.0250754 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0250358 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0247109 |
| C3 | complement component 3 | 0.0246882 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0246756 |
| CA12 | carbonic anhydrase XII | 0.0246125 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0244728 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0244496 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0242429 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | 0.0242218 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0242047 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0241322 |
| CMIP | c-Maf inducing protein | 0.0241281 |
| PHF20L1 | PHD finger protein 20-like 1 | 0.0241149 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0237416 |
| RTN3 | reticulon 3 | 0.0236764 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0235933 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.20554 |
| NDRG1 | N-myc downstream regulated 1 | -0.107959 |
| PTMA | prothymosin, alpha | -0.0991966 |
| TMSB10 | thymosin beta 10 | -0.0875912 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0833904 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0816871 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0800079 |
| VIM | vimentin | -0.076493 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0735552 |
| CD109 | CD109 molecule | -0.0702208 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0629848 |
| POTEF | POTE ankyrin domain family, member F | -0.0629598 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0571608 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0546767 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0506664 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0505031 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0488753 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0480672 |
| LMO7 | LIM domain 7 | -0.0464141 |
| B2M | beta-2-microglobulin | -0.0463853 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.045341 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0451796 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0449957 |
| HELZ | helicase with zinc finger | -0.0447713 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0433436 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0432195 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0428323 |
| S100A10 | S100 calcium binding protein A10 | -0.042508 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0424805 |
| YAP1 | Yes-associated protein 1 | -0.0420737 |
| S100A6 | S100 calcium binding protein A6 | -0.0419806 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0412442 |
| RPS15 | ribosomal protein S15 | -0.0403668 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.040046 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0398319 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0395525 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0394682 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0394017 |
| HBP1 | HMG-box transcription factor 1 | -0.039191 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.039187 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0390871 |
| MYO1E | myosin IE | -0.0389993 |
| JMJD1C | jumonji domain containing 1C | -0.0385967 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0382383 |
| RCOR1 | REST corepressor 1 | -0.0380141 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0376241 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0375097 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0373505 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0367963 |
| RNF145 | ring finger protein 145 | -0.0358847 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0353461 |
| SETD5 | SET domain containing 5 | -0.035315 |
| RPS19 | ribosomal protein S19 | -0.0352648 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0351303 |
| TFG | TRK-fused gene | -0.0350654 |
| TPR | translocated promoter region, nuclear basket protein | -0.0345911 |
| FN1 | fibronectin 1 | -0.0345132 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0342969 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0342306 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0341318 |
| RPL35A | ribosomal protein L35a | -0.0329115 |
| RPL23 | ribosomal protein L23 | -0.032841 |
| SEPTIN7 | septin 7 | -0.0325256 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0323681 |
| FMN1 | formin 1 | -0.0318531 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.031761 |
| ENO1 | enolase 1, (alpha) | -0.031676 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0314861 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0314425 |
| RBM25 | RNA binding motif protein 25 | -0.0313764 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0313711 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0313502 |
| CALD1 | caldesmon 1 | -0.0309172 |
| GNAS | GNAS complex locus | -0.030906 |
| RAB5A | RAB5A, member RAS oncogene family | -0.030827 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0307597 |
| RBM39 | RNA binding motif protein 39 | -0.0304887 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0302547 |
| FAM162A | family with sequence similarity 162, member A | -0.0301362 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0300686 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0298578 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.029587 |
| ADAR | adenosine deaminase, RNA-specific | -0.0295207 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0291215 |
| TSC22D2 | TSC22 domain family, member 2 | -0.028889 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0283606 |
| PTK2 | protein tyrosine kinase 2 | -0.027997 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0277898 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0277472 |
| FAM13A | family with sequence similarity 13, member A | -0.0277133 |
| CCNI | cyclin I | -0.0273754 |
| MYO6 | myosin VI | -0.0270129 |
| WASF2 | WAS protein family, member 2 | -0.026926 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0269126 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0266846 |
| HMGA1 | high mobility group AT-hook 1 | -0.0266571 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0263092 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0261966 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0259911 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0259267 |
