Panobinostat_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Panobinostat perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Panobinostat_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 0.218307
TXNRD1 thioredoxin reductase 1 0.0464307
RTN4 reticulon 4 0.0461801
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.045958
MYH9 myosin, heavy chain 9, non-muscle 0.0444873
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0426867
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0400786
MKI67 marker of proliferation Ki-67 0.0397413
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0387852
TRIO trio Rho guanine nucleotide exchange factor 0.037534
GPHN gephyrin 0.0372587
MT2A metallothionein 2A 0.0355875
RPS2 ribosomal protein S2 0.0330696
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0305202
SYT1 synaptotagmin I 0.028152
RUSC2 RUN and SH3 domain containing 2 0.0274963
NCAPD2 non-SMC condensin I complex, subunit D2 0.0269429
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0269207
GOLGA4 golgin A4 0.0258798
KTN1 kinectin 1 (kinesin receptor) 0.0257408
KRT18 keratin 18, type I 0.0254891
CAVIN1 caveolae associated protein 1 0.0239817
ITGA6 integrin, alpha 6 0.0235
CENPF centromere protein F, 350/400kDa 0.0230933
RAB6A RAB6A, member RAS oncogene family 0.0228808
STC1 stanniocalcin 1 0.0227908
RB1CC1 RB1-inducible coiled-coil 1 0.0227784
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0226126
ALCAM activated leukocyte cell adhesion molecule 0.0222395
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0219973
CUL4B cullin 4B 0.0219428
DST dystonin 0.0213706
DTNA dystrobrevin, alpha 0.0211193
RECQL RecQ helicase-like 0.0210558
NUP58 nucleoporin 58 0.0209294
TMEM41B transmembrane protein 41B 0.0208367
PAWR PRKC, apoptosis, WT1, regulator 0.0208361
PFDN2 prefoldin subunit 2 0.0205349
PNN pinin, desmosome associated protein 0.0204937
SEPTIN9 septin 9 0.020447
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0202771
PCNX1 pecanex 1 0.0200357
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0197512
RPS6 ribosomal protein S6 0.0197178
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0193097
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0191332
NAMPT nicotinamide phosphoribosyltransferase 0.0190924
ADAM17 ADAM metallopeptidase domain 17 0.0190379
ENAH enabled homolog (Drosophila) 0.0190338
ERRFI1 ERBB receptor feedback inhibitor 1 0.0190257
GOLT1B golgi transport 1B 0.0189132
RPLP0 ribosomal protein, large, P0 0.0188066
PTPRM protein tyrosine phosphatase, receptor type, M 0.0185394
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0184883
EEIG2 EEIG family member 2 0.0184193
WASL Wiskott-Aldrich syndrome-like 0.0183847
CTTNBP2NL CTTNBP2 N-terminal like 0.0183262
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0183081
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0182454
CDK6 cyclin-dependent kinase 6 0.0181493
FOXN2 forkhead box N2 0.0181202
MED12L mediator complex subunit 12-like 0.017994
KDM7A lysine (K)-specific demethylase 7A 0.0179455
MSN moesin 0.0178251
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0177858
CLU clusterin 0.0175106
OSBPL6 oxysterol binding protein-like 6 0.0174996
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0170765
ADGRB3 adhesion G protein-coupled receptor B3 0.0170712
CLTC clathrin, heavy chain (Hc) 0.0168213
MYL12B myosin, light chain 12B, regulatory 0.0166996
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0166748
ATXN2 ataxin 2 0.0165429
LCORL ligand dependent nuclear receptor corepressor-like 0.0164986
BRWD3 bromodomain and WD repeat domain containing 3 0.0164599
ANLN anillin, actin binding protein 0.016452
SLMAP sarcolemma associated protein 0.0163696
CHD1 chromodomain helicase DNA binding protein 1 0.0160809
NGLY1 N-glycanase 1 0.0160796
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0159709
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0159294
JAZF1 JAZF zinc finger 1 0.0158068
SPIRE1 spire-type actin nucleation factor 1 0.0157415
SINHCAF SIN3-HDAC complex associated factor 0.0153938
CRACD capping protein inhibiting regulator of actin dynamics 0.0152976
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0152619
MYH10 myosin, heavy chain 10, non-muscle 0.0152141
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0149795
MSH6 mutS homolog 6 0.0149727
RAB10 RAB10, member RAS oncogene family 0.0148252
DCLK1 doublecortin-like kinase 1 0.0148212
H1-0 H1.0 linker histone 0.0148144
NALF1 NALCN channel auxiliary factor 1 0.0147438
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0147289
GHR growth hormone receptor 0.0147206
PHIP pleckstrin homology domain interacting protein 0.0146706
MIDEAS mitotic deacetylase associated SANT domain protein 0.0146257
PLEC plectin 0.0145926
MIS18BP1 MIS18 binding protein 1 0.0145592
SRPK1 SRSF protein kinase 1 0.0145244

decreased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.153572
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.145392
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.133311
THSD4 thrombospondin, type I, domain containing 4 -0.108937
UBC ubiquitin C -0.10823
MCL1 myeloid cell leukemia 1 -0.102305
TMSB10 thymosin beta 10 -0.0922372
RAD51B RAD51 paralog B -0.0897107
YBX3 Y box binding protein 3 -0.0857144
PDE4D phosphodiesterase 4D, cAMP-specific -0.0765264
EXOC4 exocyst complex component 4 -0.074952
AHNAK AHNAK nucleoprotein -0.0748828
PDE10A phosphodiesterase 10A -0.0700692
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0679699
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0675777
TAS2R14 taste receptor, type 2, member 14 -0.0637341
RPS27A ribosomal protein S27a -0.0637229
OSMR oncostatin M receptor -0.0636914
VIM vimentin -0.0633728
RIMS2 regulating synaptic membrane exocytosis 2 -0.0632648
HMGA2 high mobility group AT-hook 2 -0.0619535
WWOX WW domain containing oxidoreductase -0.0617059
PCBP2 poly(rC) binding protein 2 -0.0605695
USP34 ubiquitin specific peptidase 34 -0.0596181
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0580085
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0572318
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0569309
WDR70 WD repeat domain 70 -0.0565214
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.056449
EIF4A1 eukaryotic translation initiation factor 4A1 -0.051379
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0509789
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.050262
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0494187
RBM39 RNA binding motif protein 39 -0.0491508
TRIP12 thyroid hormone receptor interactor 12 -0.0491107
CSDE1 cold shock domain containing E1, RNA-binding -0.0477847
PRELID2 PRELI domain containing 2 -0.0477732
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0476456
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0474271
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.047311
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0472607
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0465368
ENO1 enolase 1, (alpha) -0.0458666
AFF3 AF4/FMR2 family, member 3 -0.0448451
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0445267
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0444978
SMYD3 SET and MYND domain containing 3 -0.0442562
RSF1 remodeling and spacing factor 1 -0.0440608
AEBP2 AE binding protein 2 -0.0440174
BCAS3 breast carcinoma amplified sequence 3 -0.043375
ATP11A ATPase, class VI, type 11A -0.0433053
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0423652
RPL23 ribosomal protein L23 -0.0419807
PRH1 proline-rich protein HaeIII subfamily 1 -0.0418951
NF1 neurofibromin 1 -0.041831
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0403653
ZNF638 zinc finger protein 638 -0.0389944
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.038701
GRAMD1B GRAM domain containing 1B -0.0385973
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0385893
ARB2A ARB2 cotranscriptional regulator A -0.0385209
RNF213 ring finger protein 213 -0.0383258
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0382786
SFPQ splicing factor proline/glutamine-rich -0.038083
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0377982
NCOA7 nuclear receptor coactivator 7 -0.0377789
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0369771
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0364682
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0359725
EML4 echinoderm microtubule associated protein like 4 -0.0357877
ATG7 autophagy related 7 -0.0356419
IGF1R insulin-like growth factor 1 receptor -0.0354276
RYR3 ryanodine receptor 3 -0.0354165
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.035415
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0349465
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0347691
FMNL2 formin-like 2 -0.0347511
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0347136
MBD5 methyl-CpG binding domain protein 5 -0.0339706
IFI6 interferon, alpha-inducible protein 6 -0.033941
ZBTB20 zinc finger and BTB domain containing 20 -0.033808
SPIDR scaffolding protein involved in DNA repair -0.0335403
VCP valosin containing protein -0.0330564
ATXN1 ataxin 1 -0.0319468
FNDC3B fibronectin type III domain containing 3B -0.0316651
EGFR epidermal growth factor receptor -0.031521
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0314675
YAP1 Yes-associated protein 1 -0.0313272
DENND1A DENN/MADD domain containing 1A -0.0306438
UBAP2L ubiquitin associated protein 2-like -0.0306049
PHF14 PHD finger protein 14 -0.0302271
FUS FUS RNA binding protein -0.0300067
SPDYA speedy/RINGO cell cycle regulator family member A -0.029895
CDK12 cyclin-dependent kinase 12 -0.0298121
NAP1L1 nucleosome assembly protein 1-like 1 -0.0296371
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0292758
RAB7A RAB7A, member RAS oncogene family -0.0290554
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0290505
BPTF bromodomain PHD finger transcription factor -0.0288242
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.028342