Panobinostat_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Panobinostat perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

170 genes differentially expressed following the Panobinostat_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPH1 heat shock 105kDa/110kDa protein 1 0.0971505
H3-3B H3.3 histone B 0.0851444
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.077498
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0774908
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0721459
CALN1 calneuron 1 0.0703567
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0703155
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0690525
FMN1 formin 1 0.0661903
AKAP12 A kinase (PRKA) anchor protein 12 0.0623882
USP9X ubiquitin specific peptidase 9, X-linked 0.0619324
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.061376
MCL1 myeloid cell leukemia 1 0.059848
SQSTM1 sequestosome 1 0.0598329
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0596595
MYH9 myosin, heavy chain 9, non-muscle 0.0579824
APP amyloid beta (A4) precursor protein 0.0569795
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0559535
SND1 staphylococcal nuclease and tudor domain containing 1 0.0553374
CXCL8 chemokine (C-X-C motif) ligand 8 0.054024
MYO10 myosin X 0.0533916
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0531085
ITGA6 integrin, alpha 6 0.0526536
LPP LIM domain containing preferred translocation partner in lipoma 0.0526432
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0520027
GMDS GDP-mannose 4,6-dehydratase 0.0515575
SRPK2 SRSF protein kinase 2 0.0514563
EGR1 early growth response 1 0.051311
ZSWIM6 zinc finger, SWIM-type containing 6 0.0501621
ELL2 elongation factor, RNA polymerase II, 2 0.0484204
ERRFI1 ERBB receptor feedback inhibitor 1 0.0483714
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0447717
AKAP13 A kinase (PRKA) anchor protein 13 0.0445231
PEG10 paternally expressed 10 0.0437666
RPS6 ribosomal protein S6 0.0431983
IGF2R insulin-like growth factor 2 receptor 0.0422129
TFRC transferrin receptor 0.0421888
AREG amphiregulin 0.0420018
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.041635
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0412174
CD46 CD46 molecule, complement regulatory protein 0.0411707
TUFT1 tuftelin 1 0.040305
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0401252
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0399975
GLS2 glutaminase 2 (liver, mitochondrial) 0.0386966
ANKHD1 ankyrin repeat and KH domain containing 1 0.0367793
LMTK2 lemur tyrosine kinase 2 0.0362197
RPS8 ribosomal protein S8 0.0361714
RANBP10 RAN binding protein 10 0.0360257
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0356554
USP15 ubiquitin specific peptidase 15 0.0354612
SRSF7 serine/arginine-rich splicing factor 7 0.0353458
TMSB4X thymosin beta 4, X-linked 0.0352311
PTMA prothymosin, alpha 0.0351484
SLC38A1 solute carrier family 38, member 1 0.0346693
SKP1 S-phase kinase-associated protein 1 0.0342497
EIF5B eukaryotic translation initiation factor 5B 0.0338683
KTN1 kinectin 1 (kinesin receptor) 0.0338494
PIBF1 progesterone immunomodulatory binding factor 1 0.0337472
APLP2 amyloid beta (A4) precursor-like protein 2 0.0323415
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0309163
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0304828
PTGES2 prostaglandin E synthase 2 0.0292745
SPAG9 sperm associated antigen 9 0.0287193
THSD4 thrombospondin, type I, domain containing 4 0.0276252
RLF rearranged L-myc fusion 0.0270448
CCDC88A coiled-coil domain containing 88A 0.0265512
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0263951
HSPA1B heat shock 70kDa protein 1B 0.0251848
ANXA2 annexin A2 0.0249291
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0247931
HMGA1 high mobility group AT-hook 1 0.024104
SSBP2 single-stranded DNA binding protein 2 0.0237285
EZR ezrin 0.0231695
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.02293
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0227583
PICALM phosphatidylinositol binding clathrin assembly protein 0.0224972
ATF6 activating transcription factor 6 0.0224257
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0222348
TTC3 tetratricopeptide repeat domain 3 0.0217368
ZFAND3 zinc finger, AN1-type domain 3 0.0216781
ANKRD11 ankyrin repeat domain 11 0.0209975
ACTG1 actin gamma 1 0.0207824
ARHGAP26 Rho GTPase activating protein 26 0.0206001
ATG5 autophagy related 5 0.0203011
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0195389
EGFR epidermal growth factor receptor 0.0185409
VGF VGF nerve growth factor inducible 0.0172825
NAMPT nicotinamide phosphoribosyltransferase 0.0167168
ANKRD12 ankyrin repeat domain 12 0.0163232
SRRM2 serine/arginine repetitive matrix 2 0.015232
EML4 echinoderm microtubule associated protein like 4 0.012601
CSNK1A1 casein kinase 1, alpha 1 0.0111721
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0111446
NRG1 neuregulin 1 0.0106738
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0105155
TMSB10 thymosin beta 10 0.00991516
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00899453
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00869431
PRKCA protein kinase C, alpha 0.00817452

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.133455
EXT1 exostosin glycosyltransferase 1 -0.100124
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0993799
PDE10A phosphodiesterase 10A -0.089874
HDLBP high density lipoprotein binding protein -0.0848287
TPT1 tumor protein, translationally-controlled 1 -0.0844864
ZNF292 zinc finger protein 292 -0.0842203
EFNA5 ephrin-A5 -0.080918
PRRC2C proline-rich coiled-coil 2C -0.0764822
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0756495
PDE4D phosphodiesterase 4D, cAMP-specific -0.0737593
GOLGA4 golgin A4 -0.0725788
PSD3 pleckstrin and Sec7 domain containing 3 -0.0675835
KIF5B kinesin family member 5B -0.0674089
ASPH aspartate beta-hydroxylase -0.0659142
VIM vimentin -0.0575031
LOC102724023 ES1 protein homolog, mitochondrial -0.0508836
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0431989
DSCAM Down syndrome cell adhesion molecule -0.0423896
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0419321
ITCH itchy E3 ubiquitin protein ligase -0.0417489
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0402306
RBM39 RNA binding motif protein 39 -0.0397897
PKM pyruvate kinase, muscle -0.0387915
FTL ferritin, light polypeptide -0.0369437
ALCAM activated leukocyte cell adhesion molecule -0.0368709
FNDC3A fibronectin type III domain containing 3A -0.0366695
LMO7 LIM domain 7 -0.0356264
VCL vinculin -0.0347786
MACF1 microtubule-actin crosslinking factor 1 -0.0336163
FN1 fibronectin 1 -0.0330459
TBC1D5 TBC1 domain family, member 5 -0.032677
TXNIP thioredoxin interacting protein -0.0321745
RPL26 ribosomal protein L26 -0.0317178
SYT1 synaptotagmin I -0.0300003
RBM25 RNA binding motif protein 25 -0.0296705
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0267721
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0264424
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0245562
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0235972
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0232358
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0227037
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0218479
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0214652
DOCK4 dedicator of cytokinesis 4 -0.0196539
NAP1L1 nucleosome assembly protein 1-like 1 -0.0194085
NALF1 NALCN channel auxiliary factor 1 -0.0190875
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0180179
RPLP1 ribosomal protein, large, P1 -0.0168539
CANX calnexin -0.0166067
CALR calreticulin -0.0147547
FNDC3B fibronectin type III domain containing 3B -0.0143141
PGK1 phosphoglycerate kinase 1 -0.0129925
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0122245
LMNA lamin A/C -0.0122184
TRIO trio Rho guanine nucleotide exchange factor -0.0121751
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0121193
VMP1 vacuole membrane protein 1 -0.0112739
MORF4L2 mortality factor 4 like 2 -0.0103543
RAB7A RAB7A, member RAS oncogene family -0.00908112
FLNB filamin B, beta -0.0065244
MCTP1 multiple C2 domains, transmembrane 1 -0.00610826
MT2A metallothionein 2A -0.00578302
JMJD1C jumonji domain containing 1C -0.00401408
DST dystonin -0.0033906
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.00321975
ENO1 enolase 1, (alpha) -0.00310074
IGF2 insulin-like growth factor 2 -0.00192154
SLTM SAFB-like, transcription modulator -0.00110503
RTN4 reticulon 4 -0.00107289