| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum. (Chemical Entities of Biological Interest Ontology, CHEBI_28241) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4680 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Papaverine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NIBAN1 | niban apoptosis regulator 1 | 0.79 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.79 |
| FGF19 | fibroblast growth factor 19 | 0.72 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.67 |
| ARG2 | arginase 2 | 0.66 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.65 |
| ZNF22 | zinc finger protein 22 | 0.65 |
| SLFN5 | schlafen family member 5 | 0.62 |
| TSPAN31 | tetraspanin 31 | 0.58 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.57 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.55 |
| UPP1 | uridine phosphorylase 1 | 0.54 |
| HOXA9 | homeobox A9 | 0.53 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.53 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.53 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.52 |
| RNFT2 | ring finger protein, transmembrane 2 | 0.52 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.52 |
| GDF15 | growth differentiation factor 15 | 0.52 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.52 |
| MT1X | metallothionein 1X | 0.51 |
| HINT2 | histidine triad nucleotide binding protein 2 | 0.5 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.48 |
| FZD3 | frizzled class receptor 3 | 0.47 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.47 |
| PYGM | phosphorylase, glycogen, muscle | 0.47 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.47 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.46 |
| VWA5A | von Willebrand factor A domain containing 5A | 0.46 |
| MT2A | metallothionein 2A | 0.45 |
| FANCC | Fanconi anemia, complementation group C | 0.45 |
| NKD2 | naked cuticle homolog 2 (Drosophila) | 0.44 |
| H1-0 | H1.0 linker histone | 0.44 |
| TMEM260 | transmembrane protein 260 | 0.43 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.42 |
| NCBP2AS2 | NCBP2 antisense 2 (head to head) | 0.42 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.42 |
| CES2 | carboxylesterase 2 | 0.42 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.42 |
| NGFR | nerve growth factor receptor | 0.42 |
| ARPIN | actin-related protein 2/3 complex inhibitor | 0.41 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.41 |
| SYTL1 | synaptotagmin-like 1 | 0.41 |
| GHITM | growth hormone inducible transmembrane protein | 0.41 |
| KCTD6 | potassium channel tetramerization domain containing 6 | 0.41 |
| FAM219A | family with sequence similarity 219, member A | 0.4 |
| RBL2 | retinoblastoma-like 2 | 0.4 |
| KRT222 | keratin 222, type II | 0.4 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.39 |
| OSBPL7 | oxysterol binding protein-like 7 | 0.39 |
| PIGW | phosphatidylinositol glycan anchor biosynthesis, class W | 0.39 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | 0.39 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.39 |
| BANF1 | barrier to autointegration factor 1 | 0.39 |
| MTRES1 | mitochondrial transcription rescue factor 1 | 0.39 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | 0.39 |
| LAMC3 | laminin, gamma 3 | 0.38 |
| MT1E | metallothionein 1E | 0.38 |
| KDM4D | lysine (K)-specific demethylase 4D | 0.38 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.38 |
| COX5A | cytochrome c oxidase subunit Va | 0.38 |
| R3HDM4 | R3H domain containing 4 | 0.38 |
| FAM89A | family with sequence similarity 89, member A | 0.38 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.37 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.37 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.37 |
| MRPL12 | mitochondrial ribosomal protein L12 | 0.36 |
| MEX3A | mex-3 RNA binding family member A | 0.36 |
| DEDD2 | death effector domain containing 2 | 0.36 |
| PHGDH | phosphoglycerate dehydrogenase | 0.36 |
| C19ORF25 | chromosome 19 open reading frame 25 | 0.36 |
| TPCN1 | two pore segment channel 1 | 0.36 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.36 |
| SELENOH | selenoprotein H | 0.36 |
| TANGO2 | transport and golgi organization 2 homolog (Drosophila) | 0.36 |
| ADIRF | adipogenesis regulatory factor | 0.36 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.36 |
| COX5B | cytochrome c oxidase subunit Vb | 0.35 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.35 |
| ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative) | 0.35 |
| KIAA1191 | KIAA1191 | 0.35 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 0.35 |
| TMEM192 | transmembrane protein 192 | 0.35 |
| HBA1 | hemoglobin, alpha 1 | 0.35 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | 0.35 |
| CYHR1 | cysteine/histidine-rich 1 | 0.35 |
| E4F1 | E4F transcription factor 1 | 0.35 |
| CHID1 | chitinase domain containing 1 | 0.34 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.34 |
| ATXN1L | ataxin 1-like | 0.34 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | 0.34 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | 0.34 |
| SDSL | serine dehydratase-like | 0.34 |
| TRIB3 | tribbles pseudokinase 3 | 0.34 |
| GLRX2 | glutaredoxin 2 | 0.34 |
| CRAT | carnitine O-acetyltransferase | 0.33 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.33 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.33 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.33 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADPRH | ADP-ribosylarginine hydrolase | -3.08 |
| TRIM29 | tripartite motif containing 29 | -2.38 |
| KSR2 | kinase suppressor of ras 2 | -1.85 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -1.83 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | -1.54 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | -1.51 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -1.49 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | -1.46 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.38 |
| ADCY9 | adenylate cyclase 9 | -1.3 |
| DCHS1 | dachsous cadherin-related 1 | -1.25 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -1.2 |
| FGG | fibrinogen gamma chain | -1.07 |
| EPDR1 | ependymin related 1 | -1.01 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.93 |
| TRIB1 | tribbles pseudokinase 1 | -0.85 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | -0.83 |
| TDRD9 | tudor domain containing 9 | -0.82 |
| CARD8 | caspase recruitment domain family, member 8 | -0.8 |
| EGR1 | early growth response 1 | -0.77 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | -0.72 |
| DEPDC1B | DEP domain containing 1B | -0.7 |
| SHLD2 | shieldin complex subunit 2 | -0.67 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.67 |
| HMOX1 | heme oxygenase 1 | -0.64 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.63 |
| CCN3 | cellular communication network factor 3 | -0.62 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 | -0.6 |
| MITD1 | MIT, microtubule interacting and transport, domain containing 1 | -0.59 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.59 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.58 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.57 |
| KLHL21 | kelch-like family member 21 | -0.57 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.56 |
| NAGS | N-acetylglutamate synthase | -0.56 |
| TCHP | trichoplein, keratin filament binding | -0.55 |
| FAT4 | FAT atypical cadherin 4 | -0.55 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.54 |
| SUPT7L | suppressor of Ty 7 (S. cerevisiae)-like | -0.54 |
| TRIM11 | tripartite motif containing 11 | -0.51 |
| AEN | apoptosis enhancing nuclease | -0.51 |
| TRIML2 | tripartite motif family-like 2 | -0.51 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.51 |
| CPA4 | carboxypeptidase A4 | -0.5 |
| N4BP3 | NEDD4 binding protein 3 | -0.5 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.49 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.48 |
| RPUSD1 | RNA pseudouridylate synthase domain containing 1 | -0.48 |
| DEPDC7 | DEP domain containing 7 | -0.47 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | -0.47 |
| MYBPC1 | myosin binding protein C, slow type | -0.47 |
| ZNF484 | zinc finger protein 484 | -0.46 |
| LDLR | low density lipoprotein receptor | -0.46 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.46 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -0.45 |
| EWSR1 | EWS RNA-binding protein 1 | -0.45 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | -0.45 |
| TOB1 | transducer of ERBB2, 1 | -0.45 |
| TMEM222 | transmembrane protein 222 | -0.44 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.44 |
| DST | dystonin | -0.43 |
| PFN2 | profilin 2 | -0.43 |
| TTC31 | tetratricopeptide repeat domain 31 | -0.43 |
| CCNB1 | cyclin B1 | -0.43 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.43 |
| SPAG5 | sperm associated antigen 5 | -0.43 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | -0.43 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | -0.42 |
| CDC123 | cell division cycle 123 | -0.42 |
| BMP4 | bone morphogenetic protein 4 | -0.42 |
| WEE1 | WEE1 G2 checkpoint kinase | -0.42 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.42 |
| PLK1 | polo-like kinase 1 | -0.41 |
| JUN | jun proto-oncogene | -0.41 |
| HRH1 | histamine receptor H1 | -0.4 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.4 |
| SYDE1 | synapse defective 1, Rho GTPase, homolog 1 (C. elegans) | -0.4 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | -0.4 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.4 |
| ZNF160 | zinc finger protein 160 | -0.4 |
| SQSTM1 | sequestosome 1 | -0.4 |
| ZNF584 | zinc finger protein 584 | -0.4 |
| CDC6 | cell division cycle 6 | -0.39 |
| RPL26 | ribosomal protein L26 | -0.39 |
| SLX4 | SLX4 structure-specific endonuclease subunit | -0.39 |
| PTOV1 | prostate tumor overexpressed 1 | -0.39 |
| TENM2 | teneurin transmembrane protein 2 | -0.39 |
| DUSP14 | dual specificity phosphatase 14 | -0.39 |
| CCNB2 | cyclin B2 | -0.39 |
| JAGN1 | jagunal homolog 1 (Drosophila) | -0.38 |
| IP6K2 | inositol hexakisphosphate kinase 2 | -0.38 |
| CHSY3 | chondroitin sulfate synthase 3 | -0.38 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | -0.38 |
| DUSP5 | dual specificity phosphatase 5 | -0.37 |
| ABHD4 | abhydrolase domain containing 4 | -0.37 |
| FAM171A2 | family with sequence similarity 171, member A2 | -0.37 |
| MPHOSPH9 | M-phase phosphoprotein 9 | -0.37 |
| GPC1 | glypican 1 | -0.37 |
| IL6ST | interleukin 6 signal transducer | -0.37 |
| CCNA1 | cyclin A1 | -0.36 |
